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Gene Dmel\CcapR

General Information
Symbol	Dmel\CcapR	Species	D. melanogaster
Name	Cardioacceleratory peptide receptor	Annotation symbol	CG33344
Feature type	protein_coding_gene	FlyBase ID	FBgn0039396
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	CG6111
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96F8-96F8	Sequence location	3R:21,749,221..21,781,992 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cardioacceleratory peptide receptor is referred to in FlyBase by the symbol Dmel\CcapR (CG33344, FBgn0039396). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptide receptor activity; neuropeptide receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: G-protein coupled receptor signaling pathway. 14 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM; Vasopressin receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:21749221..21781992.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96F8-96F8   Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CcapR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CcapR-RC FBtr0304043  NM_206574   2986   494
Additional Transcript Data & Comments
Reported size (kB)	2.8 (northern blot) (Cazzamali et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CcapR-PC   FBpp0293006   54.5   494   9.64     NP_996297   AAF56536
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Vasopressin receptor (IPR001817) GPCR, rhodopsin-like, 7TM (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56536   AF522188 AAN10041   AX254479   AX254480   AX665934 CAD82892   AX665936 CAD82893   AY219842 AAO66429   BT023628   BT025096   BT083387   BT133202   CA806746   CO190531   EC080926   EL875619   EL875620   EL875912   EL875913   EL882765   EL882766
UniProtKB/Swiss-Prot	Q868T3
UniProtKB/TrEMBL	Q1RKW4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- larval stage     (Cazzamali et al., 2003) adult stage   head   (Cazzamali et al., 2003)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14547-RA;CG6111-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CcapRGD291 CcapRGD6276 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CcapR Class Mutagen Stocks Known lesion CcapRf00659 1 -- CcapRf01038 1 -- CcapRf01987 1 -- CcapRMB09926 1 -- CcapRMI03404 1 -- CcapRMI04741 1 -- CcapRMI05490 1 -- CcapRMI05804 1 -- CcapRPL00597 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CcapR Class Mutagen Stocks Known lesion CcapRGD6276 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CcapRJF01338 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CcapRKK113043 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CcapRGD291 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CcapRNIG.14547R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD291} NA P{GD6276} NA P{KK113043} NA P{NIG.14547R} NA P{TRiP.JF01338} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CcapRMI03404 NA Mi{MIC}CcapRMI04741 NA Mi{MIC}CcapRMI05490 NA Mi{MIC}CcapRMI05804 NA PBac{WH}CcapRf00659 NA PBac{WH}CcapRf01038 NA PBac{WH}CcapRf01987 NA insertion of enhancer trap binary system Mi{ET1}CcapRMB09926 No PBac{GAL4D,EYFP}CcapRPL00597 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
neuropeptide receptor activity inferred from direct assay (assigned by UniProtKB) (Cazzamali et al., 2003) peptide receptor activity inferred from direct assay (Park et al., 2002)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
neuropeptide receptor activity inferred from sequence or structural similarity (Hewes and Taghert, 2001) non-traceable author statement (Park, 2002.6.19) vasopressin receptor activity inferred from electronic annotation with InterPro:IPR001817 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000, Park et al., 2002)
Biological Process
CV term Evidence References
ecdysis, chitin-based cuticle traceable author statement (assigned by UniProtKB) (Cazzamali et al., 2003) G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR001817 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000, Hewes and Taghert, 2001, Park et al., 2002) non-traceable author statement (Park, 2002.6.19)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR001817 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000, Hewes and Taghert, 2001, Park, 2002.6.19) integral to plasma membrane inferred from sequence or structural similarity (Park et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CcapR allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77556 DroID - A comprehensive database of gene and protein interactions. • FBgn0039396 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768688
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6S7K8S Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6HHMZ4 Arthropod inclusive ortholog search EOG6CC2H0 Metazoa inclusive ortholog search EOG615V77
Orthologs in Drosophila Species (EOG6S7K8S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CcapR     Drosophila simulans   Dsim\GD18159 Y   Drosophila sechellia   Dsec\GM10207 Y   Drosophila erecta   Dere\GG12210 Y   Drosophila yakuba   Dyak\GE10655 Y   Drosophila ananassae   Dana\GF18226 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27348 Y   Drosophila persimilis   Dper\GL22022 Y   Drosophila willistoni   Dwil\GK14383 Y   Drosophila virilis   Dvir\GJ23325 Y   Drosophila mojavensis   Dmoj\GI22912 Y   Drosophila grimshawi   Dgri\GH18151 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6HHMZ4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54316   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016000   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22139   Atta cephalotes Leafcutter ant  Acep\ACEP19645   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23163   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14998   Linepithema humile Argentine ant  Lhum\LH17378   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14428   Solenopsis invicta Red fire ant  Sinv\SINV13990   Acyrthosiphon pisum Pea aphid  Apim\ACYPI081902   Acyrthosiphon pisum Pea aphid  Apim\ACYPI062442   Bombyx mori Silkmoth  Bmor\BGIBMGA014309   Pediculus humanus Human body louse  Phum\PHUM157220   Tribolium castaneum Red flour beetle  Tcas\ccapr1   Tribolium castaneum Red flour beetle  Tcas\TC013945
Orthologs in non-Insect Arthropods (EOG6CC2H0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CRYBA   Ixodes scapularis Deer tick  Isca\ISCW000563
Orthologs in non-Arthropod Metazoa (EOG615V77)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021292gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021291gn   Danio rerio Zebrafish  Drer\oxtrl   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030290   Gallus gallus Domestic chicken  Ggal\NPSR1   Mus musculus House mouse  Mmus\Npsr1   Rattus norvegicus Norway rat  Rnor\Npsr1   Homo sapiens Human  Hsap\ENSG00000187258
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000187258
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18159 Drosophila sechellia Dsec\GM10207 Drosophila erecta Dere\GG12210 Drosophila yakuba Dyak\GE10655 Drosophila ananassae Dana\GF18226 Drosophila pseudoobscura pseudoobscura Dpse\GA27348 Drosophila persimilis Dper\GL22022 Drosophila willistoni Dwil\GK14383 Drosophila virilis Dvir\GJ23325 Drosophila mojavensis Dmoj\GI22912 Drosophila grimshawi Dgri\GH18151
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	29074 w1118; Mi{ET1}CcapRMB09926 31490 y1 v1; P{TRiP.JF01338}attP2 37975 y1 w*; Mi{MIC}CcapRMI04741 40226 y1 w*; Mi{MIC}CcapRMI05490 40788 y1 w*; Mi{MIC}CcapRMI05804 37788 y1 w*; Mi{MIC}CG42235MI03404 Mi{MIC}CcapRMI03404
Harvard	- PBac{WH}CcapRf00659 - PBac{WH}CcapRf01038 - PBac{WH}CcapRf01987
VDRC	v102995 P{KK113043}VIE-260B v14767 w1118; P{GD6276}v14767 v14768 w1118; P{GD6276}v14768
	More stocks available...
Genomic Clones ( 2 )
	BACR13F13 BACR22N13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05712 IP12552
Other clones	FI18402 MIP05668
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	CK01.61C.H10 EK048463 ESG014d.E21_D10 IP05612 IP05812 IP12452
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768688
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CcapR anon-WO0170980.46 anon-WO0170980.47 (FlyBase, 1996-) Source for merge of: CG6111 CG14547 (Cazzamali et al., 2003)
Additional comments	Annotations CG6111 and CG14547 merged as CG33344 (which corresponds to CcapR) in release 3.2 of the genome annotation. (FlyBase Genome Annotators, 2004) Source for merge of CcapR anon-WO0170980.46 anon-WO0170980.47 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206574 RefSeq (Proteins) • NP_996297 DDBJ / EMBL / GenBank • AAF56536 AAF56536.2 AAF56536.3 AAF56537.1 AAN10041 AAO66429 ACZ95036 AF522188 AX254479 AX254480 AX665934 AX665936 AY219842 CAD82892 CAD82893 Entrez Gene - A searchable database of RefSeq genes. • 2768688 UniProtKB/Swiss-Prot • Q868T3 UniProtKB/TrEMBL • Q1RKW4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Vasopressin receptor (IPR001817) GPCR, rhodopsin-like, 7TM (IPR017452)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77556 DroID - A comprehensive database of gene and protein interactions. • FBgn0039396 DRSC - Results from RNAi screens. • FBgn0039396 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039396 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14547-RA;CG6111-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039396 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 2768688 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768688 modMine - Data generated by the modENCODE project. • FBgn0039396
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	anon-WO0170980.46   anon-WO0170980.47   CcapR (Japanese National Institute of Genetics, 2012.5.21) CCAP-R (Johnson et al., 2008) CCAP receptor (Veenstra et al., 2008) CG6111 (Inlow and Restifo, 2004, Cazzamali et al., 2003, Park et al., 2002, Vanden Broeck, 2001, Hewes and Taghert, 2001.7.31, Hewes and Taghert, 2001, Brody and Cravchik, 2000, Giot et al., 2003, Tian et al., 2002, Johnson et al., 2008) CG14547 (Cazzamali et al., 2003, ) CG33344 (Keleman et al., 2009.8.5, Ni et al., 2008) DCCAPR (Cazzamali et al., 2003)
Name Synonym	Cardioacceleratory peptide receptor (Cazzamali et al., 2003) CCAP receptor (Johnson et al., 2008)
Secondary FlyBase IDs
	FBgn0039397 FBgn0046531 FBgn0046532 FBgn0053344
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 3 ) Patent  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Fontana and Crews, 2012, Dev. Biol. 372(1): 131--142 Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation. [FBrf0219766] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...