FB2025_01 , released February 20, 2025
Gene: Dmel\gb
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General Information
Symbol
Dmel\gb
Species
D. melanogaster
Name
genderblind
Annotation Symbol
CG6070
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039487
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
genderblind (gb) encodes an amino acid transporter involved in glutamate secretion into the extracellular space. It regulates synaptic transmission and male courtship behavior by altering glutamate receptor abundance in the nervous system. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
97E2-97E2
Sequence location
Recombination map
3-92
RefSeq locus
NT_033777 REGION:27108467..27112270
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables amino acid transmembrane transporter activity
inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439
(Romero-Calderon et al., 2007)
enables L-amino acid transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000208507
(GO Reference Genome Project, 2011-)
enables transmembrane transporter activity
inferred from electronic annotation with InterPro:IPR002293
(InterPro Project Members, 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in chemosensory behavior
inferred from mutant phenotype
(Grosjean et al., 2008)
involved_in defense response to bacterium
inferred from mutant phenotype
(Gonzalez et al., 2013)
involved_in glutamate secretion
inferred from mutant phenotype
(Augustin et al., 2007)
involved_in male courtship behavior
inferred from mutant phenotype
(Grosjean et al., 2008)
involved_in phagocytosis
inferred from mutant phenotype
(Gonzalez et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in amino acid transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000208507
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439
(Romero-Calderon et al., 2007)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR002293
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in neuromuscular junction
inferred from direct assay
(Augustin et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR002293
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
genderblind (gb) encodes an amino acid transporter involved in glutamate secretion into the extracellular space. It regulates synaptic transmission and male courtship behavior by altering glutamate receptor abundance in the nervous system. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
L-TYPE AMINO ACID TRANSPORTERS -
L-type amino acid transporters (LATs) are system L, sodium-independent transporters responsible for transport of bulky neutral amino acids. LATs form the light chains or catalytic chains of the heterodimeric amino acid transporters (HATs). (Adapted from FBrf0207965 and PMID:14770310).
Summary (Interactive Fly)

glutamate permease - regulates ambient extracellular glutamate to suppress glutamatergic synapse strength - controls mate choice

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\gb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VB75)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Gene model reviewed during 6.03

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
gb-RA
FBtr0085132
NM_143279
2635
517
gb-RB
FBtr0345216
NM_001300626
2190
517
gb-RC
FBtr0347412
NM_001316513
2449
517
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
gb-PA
FBpp0084502
56.5
517
5.83
Q9VB75
NP_651536
AAF56667
gb-PB
FBpp0311411
56.5
517
5.83
Q9VB75
NP_001287555
AHN57554
gb-PC
FBpp0312562
56.5
517
5.83
Q9VB75
NP_001303442
ALI30642
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

517 aa isoforms: gb-PA, gb-PB, gb-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gb using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.07

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
crystal cell primordium

Comment: reported as crystal cell specific anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
procrystal cell
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
medial-most cell body glial cell
(Kearney et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head | faint
(Romero-Calderon et al., 2007)
adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
adult brain | restricted
(Grosjean et al., 2008)
adult gnathal ganglion | restricted
(Grosjean et al., 2008)
adult antennal lobe | restricted
(Grosjean et al., 2008)
calyx of adult mushroom body | restricted
(Grosjean et al., 2008)
adult CNS glial cell | subset
(Grosjean et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Expression of gb in the adult male brain is abundant in regions containing glutamatergic neurons.

(Grosjean et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in neuromuscular junction
inferred from direct assay
(Augustin et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\gb in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of gb
Transgenic constructs containing regulatory region of gb
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
Hsap\SLC7A5
8 of 14
Yes
No
Hsap\SLC7A6
7 of 14
No
No
1  
Hsap\SLC7A8
7 of 14
No
No
1  
Hsap\SLC7A7
6 of 14
No
No
Hsap\SLC7A9
6 of 14
No
No
Hsap\SLC7A11
6 of 14
No
No
Hsap\SLC7A10
5 of 14
No
No
1  
Hsap\SLC7A13
5 of 14
No
No
Hsap\SLC7A1
2 of 14
No
No
1  
Hsap\SLC7A2
2 of 14
No
No
Hsap\SLC7A3
2 of 14
No
No
Hsap\SLC7A4
2 of 14
No
No
Hsap\SLC7A5P1
2 of 14
No
Yes
Hsap\SLC7A5P2
2 of 14
No
Yes
Hsap\SLC7A14
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Slc7a5
9 of 14
Yes
No
Rnor\Slc7a8
8 of 14
No
No
Rnor\Slc7a6
7 of 14
No
No
Rnor\Slc7a7
6 of 14
No
No
Rnor\Slc7a9
6 of 14
No
No
Rnor\Slc7a11
6 of 14
No
No
Rnor\Slc7a15
6 of 14
No
No
Rnor\LOC688389
5 of 14
No
No
Rnor\Slc7a10
5 of 14
No
No
Rnor\Slc7a12
5 of 14
No
No
Rnor\Slc7a13
5 of 14
No
No
Rnor\Slc7a4
2 of 14
No
No
Rnor\LOC292543
1 of 14
No
No
Rnor\Slc7a1
1 of 14
No
No
Rnor\Slc7a2
1 of 14
No
No
Rnor\Slc7a3
1 of 14
No
No
Rnor\Slc7a14
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Slc7a5
9 of 14
Yes
No
Mmus\Slc7a8
8 of 14
No
No
Mmus\Slc7a6
7 of 14
No
No
Mmus\Slc7a7
7 of 14
No
No
Mmus\Slc7a9
6 of 14
No
No
Mmus\Slc7a10
6 of 14
No
No
Mmus\Slc7a15
6 of 14
No
No
Mmus\Slc7a11
5 of 14
No
No
Mmus\Slc7a12
5 of 14
No
No
Mmus\Slc7a13
5 of 14
No
No
Mmus\AU018091
2 of 14
No
No
Mmus\Slc7a4
2 of 14
No
No
Mmus\Slc7a1
1 of 14
No
No
Mmus\Slc7a2
1 of 14
No
No
Mmus\Slc7a3
1 of 14
No
No
Mmus\Slc7a14
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\XB985134
8 of 13
Yes
Yes
Xtro\slc7a6
7 of 13
No
No
Xtro\slc7a7
5 of 13
No
No
Xtro\slc7a10
5 of 13
No
No
Xtro\slc7a11
5 of 13
No
No
Xtro\slc7a15
5 of 13
No
No
Xtro\slc7a8
4 of 13
No
Yes
Xtro\slc7a13
4 of 13
No
No
Xtro\LOC100485192
3 of 13
No
Yes
Xtro\slc7a5
3 of 13
No
No
Xtro\slc7a9
3 of 13
No
No
Xtro\arhgap6
1 of 13
No
No
Xtro\havcr1
1 of 13
No
Yes
Xtro\psmd5
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\slc7a8a
9 of 14
Yes
Yes
Drer\slc7a8b
8 of 14
No
No
Drer\slc7a6
7 of 14
No
No
Drer\slc7a7
7 of 14
No
No
Drer\slc7a10b
7 of 14
No
No
Drer\si:ch73-352p4.8
6 of 14
No
No
Drer\si:dkeyp-120h9.1
6 of 14
No
No
Drer\slc7a5
6 of 14
No
No
Drer\slc7a10a
6 of 14
No
No
Drer\zmp:0000001267
6 of 14
No
No
Drer\slc7a9
5 of 14
No
No
Drer\slc7a11
5 of 14
No
No
Drer\slc7a1a
2 of 14
No
No
Drer\slc7a4
2 of 14
No
No
Drer\LOC100150834
1 of 14
No
Yes
Drer\slc7a1b
1 of 14
No
No
Drer\slc7a2
1 of 14
No
No
Drer\slc7a3a
1 of 14
No
No
Drer\slc7a3b
1 of 14
No
No
Drer\slc7a14a
1 of 14
No
No
Drer\slc7a14b
1 of 14
No
No
Drer\zgc:175280
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\aat-2
10 of 14
Yes
No
Cele\aat-1
7 of 14
No
No
Cele\aat-7
7 of 14
No
Yes
Cele\aat-8
7 of 14
No
Yes
Cele\aat-3
6 of 14
No
No
Cele\aat-4
6 of 14
No
Yes
Cele\aat-5
5 of 14
No
Yes
Cele\aat-6
5 of 14
No
Yes
Cele\aat-9
5 of 14
No
Yes
Cele\B0454.6
2 of 14
No
No
Cele\C50D2.2
2 of 14
No
No
Cele\F23F1.6
2 of 14
No
No
Cele\Y53F4B.12
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP003425
12 of 12
Yes
Yes
Agam\AgaP_AGAP001627
6 of 12
No
No
Agam\AgaP_AGAP001870
6 of 12
No
No
Agam\AgaP_AGAP005653
6 of 12
No
Yes
Agam\AgaP_AGAP012643
6 of 12
No
No
Agam\AgaP_AGAP011386
3 of 12
No
No
Agam\AgaP_AGAP013073
3 of 12
No
No
Agam\AgaP_AGAP010563
2 of 12
No
No
Agam\AgaP_AGAP010567
2 of 12
No
No
Agam\AgaP_AGAP001265
1 of 12
No
No
Agam\AgaP_AGAP010560
1 of 12
No
No
Agam\AgaP_AGAP010561
1 of 12
No
No
Agam\AgaP_AGAP010562
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\PUT1
5 of 13
Yes
Yes
Atha\PUT2
5 of 13
Yes
Yes
Atha\PUT4
5 of 13
Yes
Yes
Atha\PUT5
5 of 13
Yes
Yes
Atha\RMV1
5 of 13
Yes
Yes
Atha\CAT9
3 of 13
No
No
Atha\AAT1
2 of 13
No
No
Atha\CAT2
2 of 13
No
No
Atha\CAT3
2 of 13
No
No
Atha\CAT4
2 of 13
No
No
Atha\CAT5
2 of 13
No
No
Atha\CAT6
2 of 13
No
No
Atha\CAT7
2 of 13
No
No
Atha\CAT8
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (19)
Scer\MUP1
8 of 13
Yes
Yes
Scer\MUP3
8 of 13
Yes
Yes
Scer\AGP1
2 of 13
No
No
Scer\BAP2
2 of 13
No
No
Scer\BAP3
2 of 13
No
No
Scer\GNP1
2 of 13
No
No
Scer\HIP1
2 of 13
No
No
Scer\LYP1
2 of 13
No
No
Scer\MMP1
2 of 13
No
No
Scer\SAM3
2 of 13
No
No
Scer\TAT1
2 of 13
No
No
Scer\AGP3
1 of 13
No
No
Scer\ALP1
1 of 13
No
No
Scer\CAN1
1 of 13
No
No
Scer\GAP1
1 of 13
No
No
Scer\PUT4
1 of 13
No
No
Scer\SSY1
1 of 13
No
No
Scer\TAT2
1 of 13
No
No
Scer\UGA4
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (19)
Spom\per1
2 of 12
Yes
No
Spom\SPAC1039.01
2 of 12
Yes
No
Spom\SPBC15C4.04c
2 of 12
Yes
Yes
Spom\SPCC74.04
2 of 12
Yes
Yes
Spom\SPCC584.13
2 of 12
Yes
Yes
Spom\SPCC794.03
2 of 12
Yes
Yes
Spom\thi9
2 of 12
Yes
Yes
Spom\aat1
1 of 12
No
No
Spom\cat1
1 of 12
No
No
Spom\isp5
1 of 12
No
No
Spom\meu22
1 of 12
No
No
Spom\put4
1 of 12
No
No
Spom\SPAC11D3.08c
1 of 12
No
Yes
Spom\SPAPB24D3.02c
1 of 12
No
Yes
Spom\SPBC359.01
1 of 12
No
No
Spom\SPBC1652.02
1 of 12
No
No
Spom\SPBPB2B2.01
1 of 12
No
No
Spom\SPCC965.11c
1 of 12
No
No
Spom\SPCPB1C11.02
1 of 12
No
No
Escherichia coli (enterobacterium) (12)
Ecol\frlA
7 of 11
Yes
Yes
Ecol\adiC
3 of 11
No
Yes
Ecol\cadB
2 of 11
No
Yes
Ecol\potE
2 of 11
No
Yes
Ecol\ybaT
2 of 11
No
Yes
Ecol\ydgI
2 of 11
No
Yes
Ecol\yjeH
2 of 11
No
Yes
Ecol\cycA
1 of 11
No
No
Ecol\gadC
1 of 11
No
Yes
Ecol\pheP
1 of 11
No
No
Ecol\proY
1 of 11
No
No
Ecol\puuP
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:gb. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
mnd
10 of 13
CG1607
9 of 13
JhI-21
9 of 13
sbm
9 of 13
CG5535
1 of 13
CG7255
1 of 13
CG12531
1 of 13
CG13248
1 of 13
slif
1 of 13
tadr
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    gbGD315
    ameliorates  brain cancer
    modeled by bratKK113206
    (Rebelo and Homem, 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC7A5; solute carrier family 7 member 5
    8 of 14
    600182
        SLC7A6; solute carrier family 7 member 6
        7 of 14
        605641
             
            SLC7A8; solute carrier family 7 member 8
            7 of 14
            604235
                 
                SLC7A7; solute carrier family 7 member 7
                6 of 14
                603593
                SLC7A9; solute carrier family 7 member 9
                6 of 14
                604144
                SLC7A11; solute carrier family 7 member 11
                6 of 14
                607933
                    SLC7A10; solute carrier family 7 member 10
                    5 of 14
                    607959
                         
                        SLC7A13; solute carrier family 7 member 13
                        5 of 14
                        617256
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Other Interaction Browsers
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            Show/hide secondary interactors 
                            (data from AllianceMine provided by esyN)
                            esyN Network Key:
                            Suppression
                            Enhancement
                            Other Interaction Browsers
                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                            Please look at the allele data for full details of the genetic interactions
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            gb
                            suppressible
                            mGluR
                            (Grosjean et al., 2008)
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            External Data
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            FlyBase
                            External Links
                            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                            External Data
                            Linkouts
                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Class of Gene
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            3R
                            Recombination map
                            3-92
                            Cytogenetic map
                            97E2-97E2
                            Sequence location
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            97E2-97E2
                            Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            Experimentally Determined Recombination Data
                            Location

                            3-92

                            (FlyBase, 2016)

                            3-89.6

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (10)
                            Genomic Clones (13)
                             

                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                            cDNA Clones (111)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Cell Line Information
                              Publicly Available Cell Lines
                               
                                Other Stable Cell Lines
                                 
                                  Other Comments

                                  gb mutant males show no alteration in heterosexual courtship or copulation, but also show homosexual behaviour, attempting to court and copulate other males. This appears to be due to an effect on glutamatergic synapse strength.

                                  (Grosjean et al., 2008)

                                  gb inhibits glutamat receptor clustering.

                                  (Augustin et al., 2007)

                                  Area matching Drosophila EST AA201517.

                                  (Davies, 2001.3.15)
                                  Relationship to Other Genes
                                  Source for database merge of

                                  Source for merge of: CG6070 anon-WO0118547.295

                                  (FlyBase, 1996-)
                                  Additional comments

                                  Source for merge of CG6070 anon-WO0118547.295 was sequence comparison ( date:051113 ).

                                  (FlyBase, 1996-)
                                  Nomenclature History
                                  Source for database identify of

                                  Source for identity of: gb CG6070

                                  (Augustin et al., 2007)
                                  Nomenclature comments
                                  Etymology

                                  The gene is named "genderblind" based on the mutant phenotype; mutant males will court males as well as courting females.

                                  (Grosjean et al., 2008)

                                  The name "genderblind" is due to the striking increase in homosexual courtship displayed by mutant flies.

                                  (Augustin et al., 2007)
                                  Synonyms and Secondary IDs (7)
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  Study result (0)
                                  Result
                                  Result Type
                                  Title
                                  External Crossreferences and Linkouts ( 52 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                  Other crossreferences
                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  References (69)