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Gene Dmel\Gfat2

General Information
Symbol	Dmel\Gfat2	Species	D. melanogaster
Name	Glutamine:fructose-6-phosphate aminotransferase 2	Annotation symbol	CG1345
Feature type	protein_coding_gene	FlyBase ID	FBgn0039580
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98C4-98C4	Sequence location	3R:24,162,741..24,165,487 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Glutamine:fructose-6-phosphate aminotransferase 2 is referred to in FlyBase by the symbol Dmel\Gfat2 (CG1345, FBgn0039580). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: carbohydrate biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Class II glutamine amidotransferase domain; Glucosamine-fructose-6-phosphate aminotransferase, isomerising; Glutamine amidotransferase type 2 domain; Sugar isomerase (SIS). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635153_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gfat2. Gene sequence location is 3R:24162741..24165487.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98C4-98C4   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gfat2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gfat2-RA FBtr0085297  NM_143360   2545   683
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gfat2-PA   FBpp0084666   76.5   683   6.61     NP_651617   AAF56785
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Class II glutamine amidotransferase domain (IPR000583) Sugar isomerase (SIS) (IPR001347) Glucosamine-fructose-6-phosphate aminotransferase, isomerising (IPR005855) Glutamine amidotransferase type 2 domain (IPR017932)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698134   AE014297 AAF56785   AI064679   AI135098   AI294637   AI520647   AI531837   AI534539   AI535004   AI535026   AI541656   AI543473   AI945672   AY095175 AAM12268   BG636094   BG636440   BG640273   BG640801   BI166407   BI215311   BI371215   BI617238   BI617800   BI618155   BI618479   BI631076   BI631767   BI632303   BI633504   BI635924   BI636300   BI636794   BI637025   BI638680   BI639469   BI639775   BI641311   BP547400   CO155996   CO277193   CO294411   CO317010   CO319152   CO319879   EC066567   EC215828   EC215992   EC224607   EC227401   EC234825   EC243630   EC267570   GH740577   GH762870   GH764203
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VAW3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) fat body/gonad primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) garland cell primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) proventriculus primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic optic lobe   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic proventriculus inner layer   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut    1221 Larval Hindgut    656.6 Larval Malpighian Tubules    2244.3 Larval Fat Body    842.8 Larval Salivary Gland    2356.2 Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules    2301.7 Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut  (1221) Larval Hindgut  (656.6) Larval Malpighian Tubules  (2244.3) Larval Fat Body  (842.8) Larval Salivary Gland  (2356.2) Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut  (675.8) Adult Hindgut    363.3 Adult Malpighian Tubules  (2301.7) Adult Fat Body    139.1 Adult Salivary Gland  (863.8) Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland  (675.6) Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut  (1221) Larval Hindgut    656.6 Larval Malpighian Tubules  (2244.3) Larval Fat Body    842.8 Larval Salivary Gland  (2356.2) Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules  (2301.7) Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut    1221 Larval Hindgut    656.6 Larval Malpighian Tubules    2244.3 Larval Fat Body    842.8 Larval Salivary Gland    2356.2 Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules    2301.7 Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut    1221 Larval Hindgut    656.6 Larval Malpighian Tubules    2244.3 Larval Fat Body    842.8 Larval Salivary Gland    2356.2 Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules    2301.7 Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut  (1221) Larval Hindgut  656.6 Larval Malpighian Tubules  (2244.3) Larval Fat Body  (842.8) Larval Salivary Gland  (2356.2) Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut  675.8 Adult Hindgut    363.3 Adult Malpighian Tubules  (2301.7) Adult Fat Body    139.1 Adult Salivary Gland  (863.8) Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland  675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut  1221 Larval Hindgut    656.6 Larval Malpighian Tubules  (2244.3) Larval Fat Body    842.8 Larval Salivary Gland  (2356.2) Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules  (2301.7) Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    279.675 Larval Midgut    1221 Larval Hindgut    656.6 Larval Malpighian Tubules    2244.3 Larval Fat Body    842.8 Larval Salivary Gland    2356.2 Larval Trachea    292.875 Larval Carcass    339 Adult Head    204.4 Adult Eye    166.575 Adult Brain    291.7 Adult Thoracic-Abdominal Ganglion    292.7 Adult Crop    372.9 Adult Midgut    675.8 Adult Hindgut    363.3 Adult Malpighian Tubules    2301.7 Adult Fat Body    139.1 Adult Salivary Gland    863.8 Adult Heart    137.325 Adult VirginFemale Spermatheca    268.1 Adult InseminatedFemale Spermatheca    306.5 Adult Ovary    264.2 Adult Testis    124.1 Adult Male Accessory Gland    675.6 Adult Carcass    146.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    204.4   NA  Eye    166.575   NA  Brain    291.7   279.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    292.7   NA  Crop    372.9   1221  Midgut    675.8   656.6  Hindgut    363.3   2244.3  Malpighian Tubules    2301.7   842.8  Fat Body    139.1   2356.2  Salivary Gland    863.8   NA  Heart    137.325   292.875  Trachea    NA   NA  VirginFemale Spermatheca    268.1   NA  InseminatedFemale Spermatheca    306.5   NA  Ovary    264.2   NA  Testis    124.1   NA  Male Accessory Gland    675.6   339  Carcass    146.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  (28) central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae  (31) digestive system, larvae L3 wandering  (30) digestive system, 1-day adult  (61) digestive system, 4-day adult  (30) digestive system, 20-day adult  (47) fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male  (32) accessory gland, mated 4-day male  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae  31 digestive system, larvae L3 wandering  30 digestive system, 1-day adult  (61) digestive system, 4-day adult  30 digestive system, 20-day adult  (47) fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male  32 accessory gland, mated 4-day male  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    28 central nervous system, pupae P8    19 head, virgin 1-day female    11 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    14 head, mated 20-day male    18 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    31 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    61 digestive system, 4-day adult    30 digestive system, 20-day adult    47 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    19 carcass, larvae L3 wandering    24 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    12 ovary, virgin 4-day female    20 ovary, mated 4-day female    16 testis, mated 4-day male    32 accessory gland, mated 4-day male    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-18 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr  (29) embryo 04-06hr  (33) embryo 06-08hr  (51) embryo 08-10hr  (57) embryo 10-12hr  (86) embryo 12-14hr  (48) embryo 14-16hr  (61) embryo 16-18hr  (47) embryo 18-20hr  (46) embryo 20-22hr  (33) embryo 22-24hr  (34) larva L1  (64) larva L2  (61) larva L3 12hr old  (55) larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (44) white prepupae new  (49) white prepupae 12hr  (36) white prepupae 24hr  (47) pupae 2d postWPP  (30) pupae 3d postWPP    18 pupae 4d postWPP  (29) adult male 01day  (37) adult male 05day  (38) adult male 30day  (48) adult female 01day  (51) adult female 05day  (51) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr  29 embryo 04-06hr  (33) embryo 06-08hr  (51) embryo 08-10hr  (57) embryo 10-12hr  (86) embryo 12-14hr  (48) embryo 14-16hr  (61) embryo 16-18hr  (47) embryo 18-20hr  (46) embryo 20-22hr  (33) embryo 22-24hr  (34) larva L1  (64) larva L2  (61) larva L3 12hr old  (55) larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (51) larva L3 puffstage 7-9  (44) white prepupae new  (49) white prepupae 12hr  (36) white prepupae 24hr  (47) pupae 2d postWPP  30 pupae 3d postWPP    18 pupae 4d postWPP  29 adult male 01day  (37) adult male 05day  (38) adult male 30day  (48) adult female 01day  (51) adult female 05day  (51) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    29 embryo 04-06hr    33 embryo 06-08hr    51 embryo 08-10hr    57 embryo 10-12hr    86 embryo 12-14hr    48 embryo 14-16hr    61 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    33 embryo 22-24hr    34 larva L1    64 larva L2    61 larva L3 12hr old    55 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    51 larva L3 puffstage 7-9    44 white prepupae new    49 white prepupae 12hr    36 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    29 adult male 01day    37 adult male 05day    38 adult male 30day    48 adult female 01day    51 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1    118 embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    112 mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    108 ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  (104) embryonic 1182-4H  (69) embryonic GM2  (61) embryonic Kc167  (84) embryonic S1  (118) embryonic S3  (87) leg disc CME L1  (99) wing disc CME-W2  (41) wing disc ML-DmD8  (30) wing disc ML-DmD9    21 wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (48) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5  (112) mixed discs ML-DmD4-c1  (88) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (32) tumorous blood cells mbn2  (108) ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1  (118) embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5  (112) mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2  (108) ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1    118 embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    112 mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    108 ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1    118 embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    112 mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    108 ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  (104) embryonic 1182-4H  (69) embryonic GM2  (61) embryonic Kc167  (84) embryonic S1  (118) embryonic S3  (87) leg disc CME L1  (99) wing disc CME-W2  (41) wing disc ML-DmD8  30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (48) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11  (35) antennal disc ML-DmD20-c5  (112) mixed discs ML-DmD4-c1  (88) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  32 tumorous blood cells mbn2  (108) ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  113 Schneider line 2 Sg4  104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1  118 embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5  112 mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2  108 ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    104 embryonic 1182-4H    69 embryonic GM2    61 embryonic Kc167    84 embryonic S1    118 embryonic S3    87 leg disc CME L1    99 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    48 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    35 antennal disc ML-DmD20-c5    112 mixed discs ML-DmD4-c1    88 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    108 ovary fGS/OSS    9 ovary OSC    4 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult  (28) Cadmium 50 mM 6 hrs, larvae L3  (67) Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3  (29) Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3  (62) Ethanol 10% 3 hrs, larvae L3  (44) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult  28 Cadmium 50 mM 6 hrs, larvae L3  (67) Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3  29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3  (62) Ethanol 10% 3 hrs, larvae L3  (44) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (33) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    28 Cadmium 50 mM 6 hrs, larvae L3    67 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    29 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    62 Ethanol 10% 3 hrs, larvae L3    44 Caffeine 1.5 mg/ml 4 hrs, larvae L3    33 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH12731 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039580 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1345-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gfat2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Gfat2GD8023 viable, with Scer\GAL4pnr-MD237 Gfat2GD8023 Phenotype manifest in Allele embryonic/larval brain | larval stage Gfat2GD8023
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Gfat2 Class Mutagen Stocks Known lesion Gfat2EY21762 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gfat2 Class Mutagen Stocks Known lesion Gfat2GD8023 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gfat2HMS01220 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gfat2KK101769 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6259 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8023} NA P{KK101769} NA P{TRiP.HMS01220} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EY04595 NA P{EPgy2}Gfat2EY21762 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
carbohydrate binding inferred from electronic annotation with InterPro:IPR001347 (FlyBase Curators et al., 2004-) glutamine-fructose-6-phosphate transaminase (isomerizing) activity inferred from sequence or structural similarity with Saccharomyces GFA1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
carbohydrate biosynthetic process inferred from electronic annotation with InterPro:IPR005855 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR005855 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gfat2 - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Aats-glupro experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG12237 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG12262 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG12264 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG1371 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG1444 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG1516 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG17259 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG17834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG1907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG31051 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG33303 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG3523 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG3530 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG4169 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG4968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG5854 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG8199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - CG8258 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Ca-P60A experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Cctγ experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Chc experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Cnx99A experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Cp1 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - CycK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Cyp12d1-p experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - EfTuM experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Gfat2 - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Gie anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Gp93 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Hel25E experimental knowledge based (Guruharsha et al., 2011) Gfat2 - MRP experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Mcm7 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Mec2 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Mpcp experimental knowledge based (Guruharsha et al., 2011) Gfat2 - OstΔ experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Pp2A-29B experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Rab5 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Gfat2 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Ranbp9 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Rpn1 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Rpt1 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Rpt6 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Sucb experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Syx17 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Tace anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - Tcp-1ζ experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Vha68-2 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - Vps4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Gfat2 - cathD experimental knowledge based (Guruharsha et al., 2011) Gfat2 - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) Gfat2 - or anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gfat2 - r experimental knowledge based (Guruharsha et al., 2011) Gfat2 - skap experimental knowledge based (Guruharsha et al., 2011) Gfat2 - wal experimental knowledge based (Guruharsha et al., 2011) Gfat2 - βCop experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gfat2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68252 DroID - A comprehensive database of gene and protein interactions. • FBgn0039580 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43373
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6H46P7 Dipteran inclusive ortholog search EOG6BZN9P Insect inclusive ortholog search EOG6S7HK1 Arthropod inclusive ortholog search EOG63N5TP Metazoa inclusive ortholog search EOG6KQ63T
Orthologs in Drosophila Species (EOG6H46P7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gfat2     Drosophila simulans   Dsim\GD18034 Y   Drosophila sechellia   Dsec\GM16296 Y   Drosophila erecta   Dere\GG12070 Y   Drosophila yakuba   Dyak\GE10514 Y   Drosophila ananassae   Dana\GF16128 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12297 Y   Drosophila persimilis   Dper\GL23864 Y   Drosophila willistoni   Dwil\GK12142 Y   Drosophila virilis   Dvir\GJ22773 Y   Drosophila mojavensis   Dmoj\GI22771 Y   Drosophila grimshawi   Dgri\GH17445 Y
Orthologs in non-Drosophila Dipterans (EOG6BZN9P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009510 Y Anopheles gambiae Malaria mosquito  Agam\AGAP011352 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006770 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006769 Y
Orthologs in non-Dipteran Insects (EOG6S7HK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49534 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010062 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15875 Y Atta cephalotes Leafcutter ant  Acep\ACEP14407 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20088 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16512 Y Linepithema humile Argentine ant  Lhum\LH17816 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11708 Y Solenopsis invicta Red fire ant  Sinv\SINV14850 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003246 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007517 Y Pediculus humanus Human body louse  Phum\PHUM536560 Y Tribolium castaneum Red flour beetle  Tcas\TC002585 Y
Orthologs in non-Insect Arthropods (EOG63N5TP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_329474 Y Ixodes scapularis Deer tick  Isca\ISCW009866 Y
Orthologs in non-Arthropod Metazoa (EOG6KQ63T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F22B3.4 Y Caenorhabditis elegans Nematode  Cele\F07A11.2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023834gn Y Danio rerio Zebrafish  Drer\gfpt2 Y Danio rerio Zebrafish  Drer\gfpt1 Y Xenopus tropicalis Western clawed frog  Xtro\gfpt1 Y Xenopus tropicalis Western clawed frog  Xtro\gfpt2 Y Gallus gallus Domestic chicken  Ggal\GFPT2 Y Gallus gallus Domestic chicken  Ggal\GFPT1 Y Mus musculus House mouse  Mmus\Gfpt2 Y Mus musculus House mouse  Mmus\ENSMUSG00000029992 Y Rattus norvegicus Norway rat  Rnor\Gfpt1 Y Rattus norvegicus Norway rat  Rnor\Gfpt2 Y Homo sapiens Human  Hsap\ENSG00000198380 Y Homo sapiens Human  Hsap\GFPT2 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000198380     Hsap\GFPT2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18034 Drosophila sechellia Dsec\GM16296 Drosophila erecta Dere\GG12070 Drosophila yakuba Dyak\GE10514 Drosophila ananassae Dana\GF16128 Drosophila pseudoobscura pseudoobscura Dpse\GA12297 Drosophila persimilis Dper\GL23864 Drosophila willistoni Dwil\GK12142 Drosophila virilis Dvir\GJ22773 Drosophila mojavensis Dmoj\GI22771 Drosophila grimshawi Dgri\GH17445
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	22502 y1 w67c23; P{EPgy2}Gfat2EY21762 34740 y1 sc* v1; P{TRiP.HMS01220}attP2/TM3, Sb1
VDRC	v105129 P{KK101769}VIE-260B v17187 w1118; P{GD8023}v17187/CyO
Genomic Clones ( 2 )
	BACR14L13 BACR28F20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12731
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02906 HL03827 LP08054 RE06525 RE21676 RE58062 RH47510 RH48241 RH48733 RH49327 RH60481 RH61412 SD01337 SD01390 SD03116 SD05918 SD07429 SD10240 SD11250 SD11950 SD13686 SD14154 SD17462 SD17936 SD18619 SD18910 SD21034 SD22049 SD22447 SD24540 SD26044 SD27611
Other clones	1835 60069 78482 162558 174895 177609 292487 bs15e05 EK123260 EK206864 EK266712 EK276413 EK281304 EN07156 FGH116E10 RP001013681 RP001031527 RP001035144
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039580 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43373
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143360 RefSeq (Proteins) • NP_651617 DDBJ / EMBL / GenBank • AAF56785 AAM12268 AI135098 AI520647 AI945672 AY095175 Entrez Gene - A searchable database of RefSeq genes. • 43373 UniProtKB/TrEMBL • Q9VAW3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Class II glutamine amidotransferase domain (IPR000583) Sugar isomerase (SIS) (IPR001347) Glucosamine-fructose-6-phosphate aminotransferase, isomerising (IPR005855) Glutamine amidotransferase type 2 domain (IPR017932) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH12731
Linkouts
	BioGRID - A database of protein and genetic interactions • 68252 DroID - A comprehensive database of gene and protein interactions. • FBgn0039580 DRSC - Results from RNAi screens. • FBgn0039580 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039580 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1345-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039580 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43373 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43373 modMine - Data generated by the modENCODE project. • FBgn0039580
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG1345 (Chandonia and Cohen, 2003, Pile et al., 2003, Graack et al., 2001, Coulier et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) Dmel/GFAT2 (Graack et al., 2001) Gfat2 (Lindquist et al., 2011, Ayroles et al., 2009, Spresser et al., 2008, Malone et al., 2012)
Name Synonym	Glutamine:fructose-6-phosphate aminotransferase 2 (Graack et al., 2001)
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Show all research papers ...