FlyBase Gene Report: Dmel\Moca-cyp

General Information

Symbol

Dmel\Moca-cyp

Species

D. melanogaster

Name

Moca-cyp

Annotation Symbol

CG1866

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039581

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

peptidylprolyl isomerase (5.2.1.8)

Gene Summary

Moca-cyp (Moca-cyp) encodes a peptidyl-prolyl cis-trans isomerase. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

98C4-98C4

Sequence location

3R:28,340,334..28,345,169 [+]

Recombination map

3-95

RefSeq locus

NT_033777 REGION:28340334..28345169

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables peptidyl-prolyl cis-trans isomerase activity

inferred from direct assay

(Cavarec et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cyclosporin A binding

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

enables peptidyl-prolyl cis-trans isomerase activity

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR020892

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

involved_in protein folding

inferred from electronic annotation with InterPro:IPR020892

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Cavarec et al., 2002)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008511653

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000870467

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CYCLOPHILINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptidyl-prolyl cis-trans isomerase activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)

RHEA 16237:

Summaries

Gene Snapshot

Moca-cyp (Moca-cyp) encodes a peptidyl-prolyl cis-trans isomerase. [Date last reviewed: 2019-09-19]

Gene Group (FlyBase)

CYCLOPHILINS -: Cyclophilins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, cyclosporine A, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. Cyclophilins are characterized by the presence of a 'Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain' (IPR002130). (Adapted from PMID:25986569.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Moca-cyp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VAW1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Moca-cyp-RA

FBtr0085286

NM_170367

3168

970

Moca-cyp-RB

FBtr0085287

NM_143361

3726

685

Moca-cyp-RC

FBtr0300346

NM_001170287

3893

685

Additional Transcript Data and Comments

Reported size (kB)

4.3, 3.5 (northern blot)

(Cavarec et al., 2002)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Moca-cyp-PA

FBpp0084655

112.8

970

11.27

FBpp0084656

81.1

685

11.74

FBpp0289575

81.1

685

11.74

Q9VAW2

NP_001163758

ACZ95052

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

685 aa isoforms: Moca-cyp-PB, Moca-cyp-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

968 (aa); 120, 85 (kD)

(Cavarec et al., 2002)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Moca-cyp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Moca-cyp_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 1 -- 4

(Cavarec et al., 2002)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 5

organism

Comment: Transcript is not detected in pole cells at cellularization

(Cavarec et al., 2002)

embryonic stage 6 -- 10

mesoderm

(Cavarec et al., 2002)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 8 -- 13

embryonic/larval anterior midgut & embryonic/larval posterior midgut

(Cavarec et al., 2002)

presumptive embryonic/larval central nervous system

(Cavarec et al., 2002)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15

larval ventral nerve cord & hindgut

(Cavarec et al., 2002)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 7

• nucleus & cytoplasm

(Cavarec et al., 2002)

embryonic stage 6 -- 17

organism

• nucleus & cytoplasm

Comment: NOT pole cell

(Cavarec et al., 2002)

embryonic stage 9 -- 11

embryonic/larval anterior midgut & embryonic/larval posterior midgut

• nucleus & cytoplasm

(Cavarec et al., 2002)

presumptive embryonic/larval central nervous system

• nucleus & cytoplasm

(Cavarec et al., 2002)

mesoderm

• nucleus & cytoplasm

(Cavarec et al., 2002)

embryonic stage 14 -- 17

larval ventral nerve cord & hindgut & pharynx & proventriculus

(Cavarec et al., 2002)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 17

Comment: reference states 2-21 hr AEL

(Cavarec et al., 2002)

embryonic stage 12 -- 17

Comment: reference states 9-24 hr AEL

(Cavarec et al., 2002)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Cavarec et al., 2002)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}Moca-cyp^CPTI000049

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Moca-cyp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Moca-cyp

View exonic expression by tissue for Dmel\Moca-cyp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039581

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43374/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039581

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039581

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039581

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1866

Flygut - An atlas of the Drosophila adult midgut

FBgn0039581

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Moca-cyp

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Moca-cyp

Transgenic constructs containing regulatory region of Moca-cyp

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6259

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Moca-cyp^GD9626

viable, with Scer\GAL4^Mef2.PR

Moca-cyp^GD9626

viable, with Scer\GAL4^pnr-MD237

Moca-cyp^GD9626

viable, with Scer\GAL4^tin.CΔ4

Moca-cyp^GD9626

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal locomotor rhythm | adult stage, with Scer\GAL4^tim.UAS

Moca-cyp^GD9626

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (25)

Hsap\PPIG

11 of 14

Yes

Hsap\NKTR

8 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Ppig

11 of 14

Yes

Rnor\Nktr

6 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Ppil1

1 of 14

Rnor\Ppil2

1 of 14

Rnor\Ranbp2

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Ppig

10 of 14

Yes

Mmus\Nktr

8 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (23)

Xtro\ppig

9 of 13

Yes

Xtro\nktr

7 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ppwd1

1 of 13

Xtro\rhov

1 of 13

Danio rerio (Zebrafish) (18)

Drer\ppig

11 of 14

Yes

Drer\nktr

8 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\cyn-8

8 of 14

Yes

Cele\cyn-9

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP002952

10 of 12

Yes

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\AT3G63400

6 of 13

Yes

Atha\AT4G32420

6 of 13

Yes

Atha\AT2G21130

5 of 13

Atha\AT3G22920

5 of 13

Yes

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CYP71

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\CPR6

6 of 13

Yes

Scer\CPR7

5 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\wis2

5 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\ppiA

3 of 11

Yes

Ecol\ppiB

3 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Moca-cyp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPIG; peptidylprolyl isomerase G

11 of 14

606093

NKTR; natural killer cell triggering receptor

8 of 14

161565

PPIA; peptidylprolyl isomerase A

4 of 14

123840

PPIAL4A; peptidylprolyl isomerase A like 4A

4 of 14

PPIAL4C; peptidylprolyl isomerase A like 4C

4 of 14

PPIAL4D; peptidylprolyl isomerase A like 4D

4 of 14

PPIAL4E; peptidylprolyl isomerase A like 4E

4 of 14

608608

PPIAL4F; peptidylprolyl isomerase A like 4F

4 of 14

PPIAL4G; peptidylprolyl isomerase A like 4G

4 of 14

PPIAL4H; peptidylprolyl isomerase A like 4H

4 of 14

PPIB; peptidylprolyl isomerase B

4 of 14

123841

OSTEOGENESIS IMPERFECTA, TYPE IX; OI9

osteogenesis imperfecta type 9

PPIC; peptidylprolyl isomerase C

4 of 14

123842

PPID; peptidylprolyl isomerase D

4 of 14

601753

PPIF; peptidylprolyl isomerase F

4 of 14

604486

PPIH; peptidylprolyl isomerase H

3 of 14

606095

PPIL1; peptidylprolyl isomerase like 1

3 of 14

601301

PONTOCEREBELLAR HYPOPLASIA, TYPE 14; PCH14

pontocerebellar hypoplasia type 14

PPIL3; peptidylprolyl isomerase like 3

3 of 14

615811

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Moca-cyp - Drep2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Andlauer et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039581

MIST (protein-protein) - An integrated Molecular Interaction Database

43374

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-95

Cytogenetic map

98C4-98C4

Sequence location

3R:28,340,334..28,345,169 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

98C4-98C4

Limits computationally determined from genome sequence between P{PZ}l(3)06487⁰⁶⁴⁸⁷ and P{EP}EP3390^EP3390

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

98D1-98D2

(Cavarec, 2002.7.22)

98D1-98D2

(determined by in situ hybridisation)

(Cavarec et al., 2002)

Experimentally Determined Recombination Data

Location

3-95

(FlyBase, 2016)

3-93.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63737

w¹¹¹⁸; PBac{IT.GAL4}Moca-cyp^0663-G4

16389

y¹ w^67c23; P{EPgy2}Moca-cyp^EY06157

16530

y¹; ry⁵⁰⁶ P{SUPor-P}Moca-cyp^KG10533

56875

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04385}attP40

Kyoto

115006

w¹¹¹⁸; PBac{602.P.SVS-1}Moca-cyp^CPTI000049

NIG-Fly

HMJ22997

y¹ v¹; P{TRiP.HMJ22997}attP40/CyO

VDRC

v20670

w¹¹¹⁸; P{GD9626}v20670

v20669

w¹¹¹⁸; P{GD9626}v20669/CyO

v318671

PBac{fTRG00808.sfGFP-TVPTBF}VK00002

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (55)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH23813

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039581

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039581

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Cavarec et al., 2002)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

An alternative splice form of Moca-cyp mRNA, clone "3H44", results in the splitting of the long Moca-cyp open reading frame into two smaller potential open reading frames - "ORF1" (144 amino acids) and "ORF2" (685 amino acids). The first 131 residues of "ORF1" are identical to the first 131 amino acids of the long Moca-cyp protein, and "ORF2"is identical to the C-terminal tail of the long Moca-cyp protein.

(Cavarec et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Moca-cyp BEST:LD38313

(Rana, 2004.7.8)

Source for merge of: Moca-cyp anon-WO0147981.4 anon-WO0147981.5

(FlyBase, 1996-)

Source for merge of: Moca-cyp anon-WO0147981.13

(FlyBase, 1996-)

Additional comments

Source for merge of Moca-cyp anon-WO0147981.4 anon-WO0147981.5 was sequence comparison ( date:031211 ).

(FlyBase, 1996-)

Source for merge of Moca-cyp anon-WO0147981.13 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for identity of Moca-cyp CG1866 was sequence comparison ( date:021108 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Moca-cyp CG1866

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BEST:LD38313

CG1866

(National Institute of Genetics Fly Stocks, 2023-, Andlauer et al., 2014, Ni et al., 2010.12.1, Herold et al., 2009, Gonzalez-Aguero et al., 2005, Ramet et al., 2002)

Moca-cy

(Lee et al., 2024)

Moca-cyp

(Kang et al., 2025, McLamb et al., 2025, Pang et al., 2021, Clandinin and Owens, 2016-, Sarov et al., 2016, Matthews et al., 2015, Andlauer et al., 2014, Kwon et al., 2013, Friedman et al., 2011, Wasbrough et al., 2010, Herold et al., 2009, Yasuhara and Wakimoto, 2008)

anon-WO0147981.13

anon-WO0147981.4

anon-WO0147981.5

moca

(Merkling et al., 2015)

Name Synonyms

Moca-cyp

(Yasuhara and Wakimoto, 2008)

Secondary FlyBase IDs

FBgn0045066
FBgn0045067
FBgn0045068
FBgn0046249

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43374

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VAW1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VAW1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039581

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43374/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039581

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039581

FlyMine - An integrated database for Drosophila genomics

FBgn0039581

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1866

MARRVEL_MODEL - MARRVEL (model organism gene)

43374

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039581

DroID - A comprehensive database of gene and protein interactions.

FBgn0039581

DRSC - Results frm RNAi screens

FBgn0039581

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Moca-cyp_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039581

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039581

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1866

Flygut - An atlas of the Drosophila adult midgut

FBgn0039581

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004244

MIST (protein-protein) - An integrated Molecular Interaction Database

43374

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

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