Gene Dmel\AR-2

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General Information

Symbol

Dmel\AR-2

Species

D. melanogaster

Name

Allatostatin Receptor 2

Annotation symbol

CG10001

Feature type

protein_coding_gene

FlyBase ID

FBgn0039595

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

98E2-98E3

Sequence location

3R:24,562,831..24,569,855 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Allatostatin Receptor 2 is referred to in FlyBase by the symbol AR-2 (CG10001, FBgn0039595). It has the cytological map location 98E2-98E3. Its sequence location is 3R:24562831..24569855. Its molecular function is described as: allatostatin receptor activity; neuropeptide receptor activity; G-protein coupled receptor activity; galanin receptor activity. It is involved in the biological process G-protein coupled receptor protein signaling pathway. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

98E2-98E3

Limits computationally determined from genome sequence between P{PZ}l(3)06487⁰⁶⁴⁸⁷ and P{EP}EP3390^EP3390

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

(Lenz, 2000.4.7)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\AR-2 for information on other features

Comments on Gene Model

EST data suggest additional 5' exon(s)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

AR-2-RA

FBtr0085316

NM_079820

1624

357

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

AR-2-PA

FBpp0084685

40.6

357

9.61

NP_524544

AAF56809

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0039595

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

GPCR, rhodopsin-like (IPR000276)

Galanin receptor (IPR000405)

Allatostatin Receptor (IPR015690)

GPCR, rhodopsin-like superfamily (IPR017452)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9NBC8

Maps to

FBcl0298182

(Lenz et al., 2000)

Does NOT map to

Identified with

RE51580

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

11132

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039595

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0039595

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of AR-2	Class	Mutagen	Stocks	Known lesion
AR-2^MB01405			1	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of AR-2	Class	Mutagen	Stocks	Known lesion
AR-2^GD339		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)RR38

Useful duplication

Dp(3;3)501

Disrupted in

Df(3R)Exel6210

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD339}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

Mi{ET1}AR-2^MB01405

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 6 )

Molecular Function

CV term

Evidence

References

G-protein coupled receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002)

allatostatin receptor activity

inferred from sequence or structural similarity

(Lenz, 2000.4.7)

inferred from sequence or structural similarity with FLYBASE:AlstR; FB:FBgn0028961

(Brody and Cravchik, 2000)

galanin receptor activity

inferred from electronic annotation with InterPro:IPR000405

(FlyBase Curators et al., 2004-)

neuropeptide receptor activity

inferred from sequence or structural similarity

(Hewes and Taghert, 2001)

Biological Process

CV term

Evidence

References

G-protein coupled receptor protein signaling pathway

inferred from sequence or structural similarity

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity with FLYBASE:AlstR; FB:FBgn0028961

(Brody and Cravchik, 2000)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from sequence or structural similarity

(Hewes and Taghert, 2001)

inferred from sequence or structural similarity with FLYBASE:AlstR; FB:FBgn0028961

(Brody and Cravchik, 2000)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

AR-2 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68269

Orthologs

Genome-wide drosophilid orthologs

Dana\GF16432

Dere\GG12058

Dgri\GH14161

Dmoj\GI10533

Dper\GL13693

Dpse\GA10001

Dsec\GM12288

Dsim\GD18022

Dvir\GJ24185

Dwil\GK10988

Dyak\GE10499

Curated drosophilid orthologs

Dpse\GA10001

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

v1326

v1327

23178

y¹ w^67c23; Mi{ET1}AR-2^MB01405

Genomic Clones ( 1 )

BACR10P23

cDNA Clones ( 2 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE51580

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

EK186230

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0039595

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0039595

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: AR-2 anon-WO0131005.7 anon-WO0170980.115 anon-WO0170980.116 Source for merge of AR-2 anon-WO0131005.7 anon-WO0170980.115 anon-WO0170980.116 was sequence comparison (date:051113).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•