FB2020_06, released Dec 22, 2020

Gene: Dmel\CG1951

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General Information
Symbol
Dmel\CG1951
Species
D. melanogaster
Name
Annotation Symbol
CG1951
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039623
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
98F5-98F5
Sequence location
3R:29,027,236..29,030,938 [+]
Recombination map

3-97

RefSeq locus
NT_033777 REGION:29027236..29030938
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
NOT enables protein kinase activity
inferred from key residues
(Anamika et al., 2009)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in multicellular organism reproduction
inferred from expression pattern
(Swanson et al., 2001)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein phosphorylation
inferred from electronic annotation with InterPro:IPR000719
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2015-06-04 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SCYL PSEUDOKINASES -
The SCYL family of pseudokinases is found in almost all eukaryotes. Members of this family have been shown to be involved in intracellular trafficking, nuclear tRNA export and chromosome biology. (Adapted from PMID:26981075.)
PUTATIVE PSEUDOKINASES -
Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG1951 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG1951-RA
FBtr0085342
NM_143398
3224
835
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG1951-PA
FBpp0084711
93.5
835
8.20
NP_651655
AAF56841
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG1951 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG1951 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG1951
Transgenic constructs containing regulatory region of CG1951
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SCYL2
15 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Scyl2
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Scyl2
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\scyl2
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\si:ch211-244b2.1
14 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ZC581.9
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT1G22870
7 of 9
Yes
Yes
Atha\AT1G71410
7 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SCY1
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ppk32
10 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903AZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011875
Drosophila simulans
Dsim\GD21400
Drosophila sechellia
Dsec\GM12753
Drosophila erecta
Dere\GG11631
Drosophila yakuba
Dyak\GE23820
Drosophila ananassae
Dana\GF16268
Drosophila pseudoobscura pseudoobscura
Dpse\GA15148
Drosophila persimilis
Dper\GL24246
Drosophila willistoni
Dwil\GK22563
Drosophila virilis
Dvir\GJ24635
Drosophila mojavensis
Dmoj\GI23050
Drosophila grimshawi
Dgri\GH10138
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501XK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17026464
Musca domestica
House fly
Mdoa\17021326
Glossina morsitans
Tsetse fly
Gmor\GMOY011621
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03293
Mayetiola destructor
Hessian fly
Mdes\Mdes010821
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012247
Anopheles darlingi
American malaria mosquito
Adar\ADAC010006
Anopheles gambiae
Malaria mosquito
Agam\AGAP002142
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018850
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01AF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011283
Danaus plexippus
Monarch butterfly
Dple\DPOGS200594-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL001037
Apis florea
Little honeybee
Aflo\4109378788
Apis mellifera
Western honey bee
Amel\LOC412446
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15285
Bombus terrestris
Buff-tailed bumblebee
Bter\15208599
Linepithema humile
Argentine ant
Lhum\LH13921
Linepithema humile
Argentine ant
Lhum\LH10665
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0018d8
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019695
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02716
Tribolium castaneum
Red flour beetle
Tcas\TC011557
Pediculus humanus
Human body louse
Phum\PHUM105940
Rhodnius prolixus
Kissing bug
Rpro\RPRC012179
Cimex lectularius
Bed bug
Clec\CLEC007288
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007054
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17690
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X018J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010891
Ixodes scapularis
Black-legged tick
Isca\ISCW006568
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57018.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00600
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_1152
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01WY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Scyl2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Scyl2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001174
Gallus gallus
Domestic chicken
Ggal\SCYL2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bma
7 of 10
CG1344
2 of 10
yata
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SCYL2; SCY1 like pseudokinase 2
    15 of 15
    616365
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      baz
      enhanceable
      CG1951
      (Shao et al., 2010)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-97

      Cytogenetic map
      98F5-98F5
      Sequence location
      3R:29,027,236..29,030,938 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      98F5-98F5
      Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-97

      (FlyBase, 2016)

      3-94.6

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (8)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (52)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities are seen.

        (Bettencourt-Dias et al., 2004)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 31 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Synonyms and Secondary IDs (1)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (45)