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Gene Dmel\CG11876

General Information
Symbol	Dmel\CG11876	Species	D. melanogaster
Name		Annotation symbol	CG11876
Feature type	protein_coding_gene	FlyBase ID	FBgn0039635
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98F10-98F10	Sequence location	3R:24,938,793..24,941,919 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11876 (FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: pyruvate dehydrogenase (acetyl-transferring) activity. There is experimental evidence that it is involved in the biological process: cytoplasmic microtubule organization. 4 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Domain of unknown function DUF1713, mitochondria; Transketolase, C-terminal; Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II; Transketolase-like, C-terminal; Transketolase-like, pyrimidine-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval trachea, adult ovary, adult male accessory gland. Gene sequence location is 3R:24938793..24941919.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA14420 BKN27865
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 6 of adulthood day 5 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 35 of adulthood day 23 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood spermatozoon day 34 of adulthood day 44 of adulthood day 14 of adulthood male day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98F10-98F10   Limits computationally determined from genome sequence between P{EP}EP3390EP3390 and P{PZ}l(3)0470804708
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11876 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11876-RA FBtr0085366  NM_170386   1455   365 CG11876-RB FBtr0085368  NM_170387   1025   273 CG11876-RC FBtr0085367  NM_170388   991   273 CG11876-RD FBtr0085369  NM_143411   1489   365
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11876-PA   FBpp0084735   39.4   365   7.92     NP_733265   AAN14149 CG11876-PB   FBpp0084737   31.2   273   11.02     NP_733266   AAN14150 CG11876-PC   FBpp0084736   31.2   273   11.02     NP_733267   AAN14151 CG11876-PD   FBpp0084738   39.4   365   7.92     NP_651668   AAF56855
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transketolase-like, pyrimidine-binding domain (IPR005475) Transketolase, C-terminal (IPR005476) Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (IPR009014) Domain of unknown function DUF1713, mitochondria (IPR013177) Transketolase-like, C-terminal (IPR015941) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME11876
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141813   AA567308   AA696272   AA697720   AA803256   AA803929   AA804009   AA940624   AE014297 AAF56855   AE014297 AAN14149   AE014297 AAN14150   AE014297 AAN14151   AI063738   AI108525   AI109324   AI134731   AI238072   AI259042   AI260500   AI294301   AI386565   AI402004   AI511821   AI945020   AW940306   AY047573 AAK77305   AY232099   BE976706   BF486858   BF487660   BF488842   BF489246   BF490778   BF491105   BF491239   BF495039   BF495046   BF495058   BF499365   BF500914   BG633776   BG635383   BI351839   BI352143   BI368430   BI371305   BI374857   BI563454   BI563890   BI563948   BI564285   BI565115   BI565374   BI565833   BI567057   BI567577   BI568604   BI570815   BI571122   BI571211   BI571257   BI571275   BI572827   BI573323   BI573324   BI575003   BI581959   BI584606   BI585594   BI586315   BI586420   BI586547   BI586706   BI586825   BI587792   BI589023   BI592119   BI592580   BI593166   BI604636   BI604638   BI604908   BI605270   BI605313   BI606719   BI609032   BI609110   BI609714   BI610488   BI611681   BI612111   BI612330   BI613288   BI613947   BI614246   BI614516   BI615186   BI616421   BI616561   BI618070   BI618892   BI618938   BI619735   BI619748   BI619987   BI624185   BI626795   BI629292   BI629456   BI629487   BI629584   BI629615   BI629869   BI630232   BI634592   BI638131   BI640688   BI640915   BT001756 AAN71511   BT024274   CO176900   CO177942   CO185442   CO268606   CO312781   CO331864   CO333288   CO344756   EC053202   EC073204   EC082251   EC194619   EC213830   EC217063   EC228136   EC228878   EC231794   EC235940   EC239514   EC239838   EC241487   EC241637   EC247882   EC253931   EL872314   EL872315   EL872432   EL872433   ES690099   EV575021   EV575627   EV578630   EV579456   GH946160   GH948487   GH953893   GH960402   GH965196   GH965260   GH967164   GH973505
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGJ4 Q8IML6 Q7K5K3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039635    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039635 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039635 expression level Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr    12719 embryo 20-22hr    16921 embryo 22-24hr    13413 larva L1    18505 larva L2    18163 larva L3 12hr old    18174 larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP    19040 pupae 4d postWPP    33568 adult male 01day    30233 adult male 05day    23051 adult male 30day    14309 adult female 01day    24550 adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5813) embryo 02-04hr  (1753) embryo 04-06hr  (3021) embryo 06-08hr  (4492) embryo 08-10hr  (4268) embryo 10-12hr  (6663) embryo 12-14hr  (4714) embryo 14-16hr  (8563) embryo 16-18hr  (8501) embryo 18-20hr  (12719) embryo 20-22hr  (16921) embryo 22-24hr  (13413) larva L1  (18505) larva L2  (18163) larva L3 12hr old  (18174) larva L3 puffstage 1-2  (7199) larva L3 puffstage 3-6  (5030) larva L3 puffstage 7-9  (3670) white prepupae new  (3432) white prepupae 12hr  (4291) white prepupae 24hr  (4804) pupae 2d postWPP  (8009) pupae 3d postWPP  (19040) pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  (14309) adult female 01day  (24550) adult female 05day  (8656) adult female 30day  (8007) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5813) embryo 02-04hr  (1753) embryo 04-06hr  (3021) embryo 06-08hr  (4492) embryo 08-10hr  (4268) embryo 10-12hr  (6663) embryo 12-14hr  (4714) embryo 14-16hr  (8563) embryo 16-18hr  (8501) embryo 18-20hr  (12719) embryo 20-22hr  (16921) embryo 22-24hr  (13413) larva L1  (18505) larva L2  (18163) larva L3 12hr old  (18174) larva L3 puffstage 1-2  (7199) larva L3 puffstage 3-6  (5030) larva L3 puffstage 7-9  (3670) white prepupae new  (3432) white prepupae 12hr  (4291) white prepupae 24hr  (4804) pupae 2d postWPP  (8009) pupae 3d postWPP  (19040) pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  (14309) adult female 01day  (24550) adult female 05day  (8656) adult female 30day  (8007) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr  (12719) embryo 20-22hr  (16921) embryo 22-24hr  (13413) larva L1  (18505) larva L2  (18163) larva L3 12hr old  (18174) larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP  (19040) pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  (14309) adult female 01day  (24550) adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr    12719 embryo 20-22hr    16921 embryo 22-24hr    13413 larva L1    18505 larva L2    18163 larva L3 12hr old    18174 larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP    19040 pupae 4d postWPP    33568 adult male 01day    30233 adult male 05day    23051 adult male 30day    14309 adult female 01day    24550 adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039635 expression level Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr    12719 embryo 20-22hr    16921 embryo 22-24hr    13413 larva L1    18505 larva L2    18163 larva L3 12hr old    18174 larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP    19040 pupae 4d postWPP    33568 adult male 01day    30233 adult male 05day    23051 adult male 30day    14309 adult female 01day    24550 adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5813) embryo 02-04hr  (1753) embryo 04-06hr  (3021) embryo 06-08hr  (4492) embryo 08-10hr  (4268) embryo 10-12hr  (6663) embryo 12-14hr  (4714) embryo 14-16hr  (8563) embryo 16-18hr  (8501) embryo 18-20hr  (12719) embryo 20-22hr  (16921) embryo 22-24hr  (13413) larva L1  (18505) larva L2  (18163) larva L3 12hr old  (18174) larva L3 puffstage 1-2  (7199) larva L3 puffstage 3-6  (5030) larva L3 puffstage 7-9  (3670) white prepupae new  (3432) white prepupae 12hr  (4291) white prepupae 24hr  (4804) pupae 2d postWPP  (8009) pupae 3d postWPP  (19040) pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  (14309) adult female 01day  (24550) adult female 05day  (8656) adult female 30day  (8007) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5813) embryo 02-04hr  1753 embryo 04-06hr  (3021) embryo 06-08hr  (4492) embryo 08-10hr  (4268) embryo 10-12hr  (6663) embryo 12-14hr  (4714) embryo 14-16hr  (8563) embryo 16-18hr  (8501) embryo 18-20hr  (12719) embryo 20-22hr  (16921) embryo 22-24hr  (13413) larva L1  (18505) larva L2  (18163) larva L3 12hr old  (18174) larva L3 puffstage 1-2  (7199) larva L3 puffstage 3-6  (5030) larva L3 puffstage 7-9  (3670) white prepupae new  (3432) white prepupae 12hr  (4291) white prepupae 24hr  (4804) pupae 2d postWPP  (8009) pupae 3d postWPP  (19040) pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  (14309) adult female 01day  (24550) adult female 05day  (8656) adult female 30day  (8007) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr  12719 embryo 20-22hr  16921 embryo 22-24hr  13413 larva L1  18505 larva L2  18163 larva L3 12hr old  18174 larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP  19040 pupae 4d postWPP  (33568) adult male 01day  (30233) adult male 05day  (23051) adult male 30day  14309 adult female 01day  (24550) adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5813 embryo 02-04hr    1753 embryo 04-06hr    3021 embryo 06-08hr    4492 embryo 08-10hr    4268 embryo 10-12hr    6663 embryo 12-14hr    4714 embryo 14-16hr    8563 embryo 16-18hr    8501 embryo 18-20hr    12719 embryo 20-22hr    16921 embryo 22-24hr    13413 larva L1    18505 larva L2    18163 larva L3 12hr old    18174 larva L3 puffstage 1-2    7199 larva L3 puffstage 3-6    5030 larva L3 puffstage 7-9    3670 white prepupae new    3432 white prepupae 12hr    4291 white prepupae 24hr    4804 pupae 2d postWPP    8009 pupae 3d postWPP    19040 pupae 4d postWPP    33568 adult male 01day    30233 adult male 05day    23051 adult male 30day    14309 adult female 01day    24550 adult female 05day    8656 adult female 30day    8007 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039635    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039635 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039635 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11876-RC;CG11876-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG11876 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele mitochondrion, with Scer\GAL4en-e16E CG11876NIG.11876R wing disc | third instar larval stage, with Scer\GAL4en-e16E CG11876NIG.11876R
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11876 Class Mutagen Stocks Known lesion CG11876MB05732 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11876 Class Mutagen Stocks Known lesion CG11876KK107865 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11876GD6677 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG11876NIG.11876R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6677} NA P{KK107865} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG11876MB05732 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoplasmic microtubule organization inferred from mutant phenotype (Hughes et al., 2008)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
pyruvate dehydrogenase (acetyl-transferring) activity inferred from sequence or structural similarity with Saccharomyces PDB1 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P08559 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
pyruvate metabolic process inferred from sequence or structural similarity with UniProtKB:P29803 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
pyruvate dehydrogenase complex inferred from sequence or structural similarity with Saccharomyces PDB1 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P08559 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11876 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68308 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039635 DroID - A comprehensive database of gene and protein interactions. • FBgn0039635 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43437
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23287 Dere\GG11642 Dgri\GH19645 Dmoj\GI22271 Dper\GL23909 Dpse\GA11252 Dsec\GM12765 Dsim\GD21413 Dvir\GJ24064 Dwil\GK11887 Dyak\GE23833
Curated drosophilid orthologs	Dpse\GA11252   Dyak\GE23833
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004338-PA Aedes aegypti (mosquito) AGAP010421-PA Anopheles gambiae (mosquito) XP_625073.2 Apis mellifera (honey bee) XP_001948556.1 Acyrthosiphon pisum (pea aphid) At5g50850.1 Arabidopsis thaliana (wall cress) 12599 Batrachochytrium dendrobatidis (chytrid fungus) 262193 Branchiostoma floridae (lancelet) 277554 Branchiostoma floridae (lancelet) XP_001894504.1 Brugia malayi (roundworm nematode) BGIBMGA002750-PA Bombyx mori (silk worm) ENSBTAP00000028958 Bos taurus (bovine) CAL0003677 Candida albicans (a form of yeast) CN24213 Caenorhabditis brenneri (small nematode) CBP11678 Caenorhabditis briggsae (nematode) CE27647 Caenorhabditis elegans (worm) ENSCAFP00000010899 Canis familiaris (dog) CAGL0K06831g Candida glabrata (haploid yeast) ENSCINP00000006609 Ciona intestinalis (sea squirt) JA12478 Caenorhabditis japonica (nematode) CMS327C Cyanidioschyzon merolae (red alga) cn09122 Cryptococcus neoformans (yeast-like fungus) CPIJ016430 Culex pipens (mosquito) ENSCPOP00000006048 Cavia porcellus (guinea pig) 139515 Chlamidomonas reinhardtii (green alga) RP22520 Caenorhabditis remanei (nematode) ENSCSAVP00000016352 Ciona savignyi (sedentary tunicate) 161753 Capitella spl (polychaete worm) DDB0229442 Dictyostelium discoideum (amoeba) DEHA2C09152g Debaryomyces Hansenii (yeast) 327265 Daphnia pulex (daphnia) ENSDARP00000002122 Danio rerio (zebra fish) ENSECAP00000004469 Equus caballus (horse) ENSGACP00000005204 Gymnopilus aculeatus (mushroom) ENSGALP00000011491 Gallus gallus (chicken) 155705 Hypsipyla robusta (cedar shoot borer) ENSP00000307241 Homo sapiens (human) ISCW009219-PA Ixodes scapularis (deer tick) KLLA0F09603g Kluyveromyces lactis (yeast) 226825 Lottia gigantea (owl limpet) LmjF25.1710 Leishmania major (virus) 12039 Monocosta brevicollis (choanoflagellate) ENSMODP00000002919 Monodelphis domestica (gray opossum) ENSMMUP00000020570 Macaca mulatta (rhesus monkey) ENSMUSP00000022268 Mus musculus (house mouse) 236978 Nematostella vectensis (starlet anemone) XP_001604584.1 Nasonia vitripennis (wasp) ENSORLP00000024298 Oryzias latipes (japanese killifish) LOC_Os08g42410.1 Oryza sativa (asian rice) 8513 Ostreococcus tauri (green alga) PF14_0441 Plasmodium falciparum (protozoal parasite) PHUM000015-PA Pediculus humanus (human body louse) PP27781 Pristionchus pacificus (nematode) 226541 Physcomitrella patens (moss) ENSPPYP00000015393 Pongo pygmaeus (orangutan) 71462 Phytophthora ramorum (sudden oak death pathogen) 122568 Phytophthora sojae (root rot pathogen) 414358 Populus trichocarpa (black cottonwood) ENSPTRP00000026010 Pan troglodytes (chimpanzee) PVX_118170 Plasmodium vivax (protozoal parasite) ENSRNOP00000010545 Rattus norvegicus (norway rat) 5000208 Sorghum bicolor (sorghum) YBR221C Saccharomyces cerevisiae (budding yeast) Smp_002510 Schistosoma mansoni (trematode parasite) SPBC30D10.13c Schizosaccharomyces pombe (fission yeast) 37016 Trichoplax adhaerens (metazoa) XP_970163.1 Tribolium castaneum (red flour beetle) Tc00.1047053510091.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510421.320 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009513 Tetraodon nigroviridis (green spotted pufferfish) 8778 Thalassiosira pseudonana (marine diatom) ENSTRUP00000005384 Takifugu rubripes (pufferfish Takifugu) 183.m00027 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000019009 Xenopus tropicalis (frog) YALI0E27005g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13940 LH11187 ISCW009219 FBgn0068475 FBgn0213898 FBgn0211149 FBgn0192849 FBgn0167701 JGI_V11_327265 FBgn0071306 FBgn0161499 FBgn0144999 FBgn0127109 FBgn0103939 FBgn0100281 CPIJ016430 BGIBMGA002750 ACYPI005282 GB17238 AGAP010421 AAEL004338 PHUM029050 GLEAN_11159
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	25306 w1118; Mi{ET1}CG11876MB05732
VDRC	v104022 P{KK107865}VIE-260B
Genomic Clones ( 2 )
	BACR11O03 BACR22E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 151 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08474 IP14839 RH05604
Other clones	DPiM_GH08474 yak-ad_CG11876
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03852 AT03862 AT03874 AT13911 AT16066 AT21406 AT22673 AT24496 AT25190 AT27360 AT27768 AT27938 AT29685 AT31956 GH03711 GH05365 GH07380 GH12269 GH14059 GH16685 GM05415 GM10466 GM10882 GM12517 GM16342 GM18061 HL01006 HL03041 LD22109 LD43353 LP02364 LP04387 LP07639 RE54396 RE58170 RE62542 RH05943 RH06046 RH06095 RH06117 RH08470 RH09741 RH10312 RH11116 RH13762 RH13854 RH14534 RH15979 RH18059 RH19813 RH23851 RH25211 RH26234 RH26364 RH26609 RH26791 RH26934 RH27560 RH28666 RH30685 RH34089 RH34622 RH34909 RH36163 RH36888 RH38105 RH38777 RH40227 RH40513 RH40762 RH42409 RH43217 RH43576 RH43893 RH44750 RH46365 RH46560 RH48594 RH49830 RH49887 RH50830 RH50848 RH51140 RH58136 RH58330 RH58364 RH58474 RH58512 RH58796 RH59234 RH62805 RH63138 RH63659 RH63703 RH67849 RH70067 RH70069 RH70410 RH70847 RH70894 RH73378 SD20344 SD23658 SD23945
Other clones	38756 76938 97096 104889 193631 214537.11 274303 281189 bs08a12 bs54h04 CK01.6B.G2 CK01.9D.C1 CK01.67B.B8 CK01.68B.D6 CK01.108A.F7 CK01.114A.G10 CK01.128A.B10 CK02497 Dmel_dig_007976_0657_0809 Dmel_dig_008991_0653_1823 Dmel_dig_014773_0585_3615 Dmel_dig_015534_0593_1909 EC053202 EK009457 EK051542 EK054747 EK092124 EK229957 EK301855 EK306412 EP19837 IP04255 IP04355 RH08995 RP004122440 RP004197320 RP004221902 RP004380381 RP004470630 RP004494636 RP004494752 RP004545702
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039635 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43437
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143411 NM_170386 NM_170387 NM_170388 RefSeq (Proteins) • NP_651668 NP_733265 NP_733266 NP_733267 DDBJ / EMBL / GenBank • AAF56855 AAK77305 AAN14149 AAN14150 AAN14151 AAN71511 AI063738 AI109324 AI945020 AW940306 AY047573 BI570815 BT001756 Entrez Gene - A searchable database of RefSeq genes. • 43437 UniProtKB/TrEMBL • Q7K5K3 Q8IGJ4 Q8IML6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transketolase-like, pyrimidine-binding domain (IPR005475) Transketolase, C-terminal (IPR005476) Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (IPR009014) Domain of unknown function DUF1713, mitochondria (IPR013177) Transketolase-like, C-terminal (IPR015941) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME11876
Linkouts
	BioGRID - A database of protein and genetic interactions • 68308 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039635 DroID - A comprehensive database of gene and protein interactions. • FBgn0039635 DRSC - Results from RNAi screens. • FBgn0039635 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039635 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11876-RC;CG11876-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039635 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43437 InParanoid A subset of ortholog calls from InParanoid. • AAEL004338-PA Aedes aegypti (mosquito) AGAP010421-PA Anopheles gambiae (mosquito) XP_625073.2 Apis mellifera (honey bee) XP_001948556.1 Acyrthosiphon pisum (pea aphid) At5g50850.1 Arabidopsis thaliana (wall cress) 12599 Batrachochytrium dendrobatidis (chytrid fungus) 262193 Branchiostoma floridae (lancelet) 277554 Branchiostoma floridae (lancelet) XP_001894504.1 Brugia malayi (roundworm nematode) BGIBMGA002750-PA Bombyx mori (silk worm) ENSBTAP00000028958 Bos taurus (bovine) CAL0003677 Candida albicans (a form of yeast) CN24213 Caenorhabditis brenneri (small nematode) CBP11678 Caenorhabditis briggsae (nematode) CE27647 Caenorhabditis elegans (worm) ENSCAFP00000010899 Canis familiaris (dog) CAGL0K06831g Candida glabrata (haploid yeast) ENSCINP00000006609 Ciona intestinalis (sea squirt) JA12478 Caenorhabditis japonica (nematode) CMS327C Cyanidioschyzon merolae (red alga) cn09122 Cryptococcus neoformans (yeast-like fungus) CPIJ016430 Culex pipens (mosquito) ENSCPOP00000006048 Cavia porcellus (guinea pig) 139515 Chlamidomonas reinhardtii (green alga) RP22520 Caenorhabditis remanei (nematode) ENSCSAVP00000016352 Ciona savignyi (sedentary tunicate) 161753 Capitella spl (polychaete worm) DDB0229442 Dictyostelium discoideum (amoeba) DEHA2C09152g Debaryomyces Hansenii (yeast) 327265 Daphnia pulex (daphnia) ENSDARP00000002122 Danio rerio (zebra fish) ENSECAP00000004469 Equus caballus (horse) ENSGACP00000005204 Gymnopilus aculeatus (mushroom) ENSGALP00000011491 Gallus gallus (chicken) 155705 Hypsipyla robusta (cedar shoot borer) ENSP00000307241 Homo sapiens (human) ISCW009219-PA Ixodes scapularis (deer tick) KLLA0F09603g Kluyveromyces lactis (yeast) 226825 Lottia gigantea (owl limpet) LmjF25.1710 Leishmania major (virus) 12039 Monocosta brevicollis (choanoflagellate) ENSMODP00000002919 Monodelphis domestica (gray opossum) ENSMMUP00000020570 Macaca mulatta (rhesus monkey) ENSMUSP00000022268 Mus musculus (house mouse) 236978 Nematostella vectensis (starlet anemone) XP_001604584.1 Nasonia vitripennis (wasp) ENSORLP00000024298 Oryzias latipes (japanese killifish) LOC_Os08g42410.1 Oryza sativa (asian rice) 8513 Ostreococcus tauri (green alga) PF14_0441 Plasmodium falciparum (protozoal parasite) PHUM000015-PA Pediculus humanus (human body louse) PP27781 Pristionchus pacificus (nematode) 226541 Physcomitrella patens (moss) ENSPPYP00000015393 Pongo pygmaeus (orangutan) 71462 Phytophthora ramorum (sudden oak death pathogen) 122568 Phytophthora sojae (root rot pathogen) 414358 Populus trichocarpa (black cottonwood) ENSPTRP00000026010 Pan troglodytes (chimpanzee) PVX_118170 Plasmodium vivax (protozoal parasite) ENSRNOP00000010545 Rattus norvegicus (norway rat) 5000208 Sorghum bicolor (sorghum) YBR221C Saccharomyces cerevisiae (budding yeast) Smp_002510 Schistosoma mansoni (trematode parasite) SPBC30D10.13c Schizosaccharomyces pombe (fission yeast) 37016 Trichoplax adhaerens (metazoa) XP_970163.1 Tribolium castaneum (red flour beetle) Tc00.1047053510091.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510421.320 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009513 Tetraodon nigroviridis (green spotted pufferfish) 8778 Thalassiosira pseudonana (marine diatom) ENSTRUP00000005384 Takifugu rubripes (pufferfish Takifugu) 183.m00027 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000019009 Xenopus tropicalis (frog) YALI0E27005g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43437 modMine - Data generated by the modENCODE project. • FBgn0039635 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13940 LH11187 ISCW009219 FBgn0068475 FBgn0213898 FBgn0211149 FBgn0192849 FBgn0167701 JGI_V11_327265 FBgn0071306 FBgn0161499 FBgn0144999 FBgn0127109 FBgn0103939 FBgn0100281 CPIJ016430 BGIBMGA002750 ACYPI005282 GB17238 AGAP010421 AAEL004338 PHUM029050 GLEAN_11159
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG11876 (Beller et al., 2006, Stuart et al., 2007, Dorus et al., 2006, Hughes et al., 2008, Takemori and Yamamoto, 2009, Keleman et al., 2009.8.5, Carpenter et al., 2009, Chen et al., 2008, Wasbrough et al., 2010, Cammarato et al., 2011) E1β (Chen et al., 2008) PDHB (Saj et al., 2010)
Name Synonym	Pyruvate dehydrogenase E1β subunit (Chen et al., 2008)
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 1 )
Recent research papers ( 1 )
	Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Show all research papers ...