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Gene Dmel\Obp99b

General Information
Symbol	Dmel\Obp99b	Species	D. melanogaster
Name	Odorant-binding protein 99b	Annotation symbol	CG7592
Feature type	protein_coding_gene	FlyBase ID	FBgn0039685
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	tsx, 99b, Obp99d
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99B8-99B8	Sequence location	3R:25,541,976..25,542,618 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Odorant-binding protein 99b is referred to in FlyBase by the symbol Dmel\Obp99b (CG7592, FBgn0039685). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: odorant binding. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Pheromone/general odorant binding protein; Pheromone/general odorant binding protein, PBP/GOBP, domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of no expression detected. Peak expression observed during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623675_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Obp99b. Gene sequence location is 3R:25541976..25542618.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99B8-99B8   Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Obp99b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Obp99b-RA FBtr0085462  NM_143456   574   149 Obp99b-RB FBtr0333198  NM_001276149   586   149
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Obp99b-PA   FBpp0084828   17.2   149   6.59     NP_651713   AAF56921 Obp99b-PB   FBpp0305400   17.2   149   6.59     NP_001263078   AGB96458
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pheromone/general odorant binding protein (IPR006170) Pheromone/general odorant binding protein, PBP/GOBP, domain (IPR023316)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56921   AE014297 AGB96458   AI257280   AI257413   AI257568   AI257659   AI258227   AI258853   AI261107   AI261132   AI293437   AI294313   AI295380   AI295834   AY119044 AAM50904   CA803263   CA803327   CA803375   CA803503   CA803565   CA803587   CA803616   CA803848   CA804084   CA804402   CA804449   CA804556   CA804653   CA804840   CA804872   CA805307   CA805378   CA805483   CA805538   CA805699   CA806063   CA806198   CA806864   CA807069   CA807087   CA807404   CA807420   CA807595   CK131715   CK131785   CK131925   CK657320   CK657765   CK657787   CK659401   CK659555   CK660462   CK661362   CK662090   CK662235   CK662354   CO179769   CO179796   CO179857   CO179916   CO179937   CO179938   CO179967   CO180015   CO180178   CO180228   CO180292   CO180357   CO180376   CO180409   CO180450   CO180451   CO180453   CO180504   CO180538   CO180566   CO180571   CO180643   CO180734   CO180772   CO180817   CO180848   CO180863   CO180899   CO180916   CO180968   CO181004   CO181005   CO181007   CO181039   CO181132   CO181184   CO181214   CO181294   CO181298   CO181313   CO181329   CO181387   CO181481   CO181505   CO181568   CO181741   CO181787   CO181789   CO181796   CO181803   CO181811   CO181856   CO182077   CO182153   CO182206   CO182220   CO182236   CO182252   CO182268   CO182271   CO182274   CO182297   CO182315   CO182324   CO182351   CO182372   CO182513   CO182562   CO182576   CO182604   CO182620   CO182636   CO182647   CO182758   CO182773   CO182815   CO182816   CO182821   CO182842   CO182879   CO182983   CO183028   CO183051   CO183056   CO183081   CO183172   CO183210   CO183230   CO183336   CO183429   CO183443   CO183485   CO183513   CO183568   CO183639   CO183643   CO183795   CO183830   CO183898   CO183906   CO183913   CO183925   CO183982   CO183989   CO184018   CO184027   CO184188   CO184217   CO184282   CO184306   CO184346   CO184353   CO184405   CO184413   CO184436   CO184479   CO184526   CO184550   CO184594   CO184598   CO184648   CO184665   CO184717   CO184735   CO184857   CO184923   CO184965   CO184992   CO184995   CO185049   CO185073   CO185135   CO185146   CO185163   CO185164   CO185202   CO191141   CO191142   CO191143   CO191175   CO191210   CO191310   CO191319   CO191368   CO191391   CO191505   CO191572   CO191631   CO191634   CO191669   CO191681   CO191742   CO191744   CO191748   CO191757   CO191808   CO191920   CO191980   CO192002   CO192009   CO192066   CO192084   CO192143   CO192182   CO192244   CO192281   CO192350   CO192373   CO192399   CO192469   CO192575   CO192600   CO192706   CO192728   CO192790   CO192798   CO192818   CO192851   CO192889   CO192904   CO192953   CO192954   CO192963   CO193036   CO193093   CO193132   CO193174   CO193193   CO193222   CO193226   CO193235   CO193440   CO193474   CO193580   CO193702   CO193794   CO193798   CO193812   CO193891   CO193918   CO194078   CO194110   CO194132   CO194304   CO194383   CO194446   CO194586   CO194671   CO194721   CO194725   CO194757   CO194850   CO194867   CO194916   CO194951   CO194970   CO195096   CO195134   CO195175   CO195199   CO195210   CO195219   CO195256   CO195350   CO195381   CO195457   CO195512   CO195547   CO195695   CO195732   CO195787   CO195812   CO195828   CO195908   CO195951   CO195955   CO195968   CO195998   EC060138   EL887347   EL887489   GH971752
UniProtKB/Swiss-Prot	Q9VAI6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000436001 3R:25,542,508..25,545,503 evidence=Reporter construct (in vivo) (Galindo and Smith, 2001, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) embryonic stage 13 -- 16   yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut    1840.5 Larval Malpighian Tubules    974.3 Larval Fat Body    11135.6 Larval Salivary Gland    5167.9 Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut  (1840.5) Larval Malpighian Tubules  (974.3) Larval Fat Body  (11135.6) Larval Salivary Gland  (5167.9) Larval Trachea  (594.275) Larval Carcass  (889.85) Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut  (1840.5) Larval Malpighian Tubules    974.3 Larval Fat Body  (11135.6) Larval Salivary Gland  (5167.9) Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut    1840.5 Larval Malpighian Tubules    974.3 Larval Fat Body    11135.6 Larval Salivary Gland    5167.9 Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut    1840.5 Larval Malpighian Tubules    974.3 Larval Fat Body    11135.6 Larval Salivary Gland    5167.9 Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut  (1840.5) Larval Malpighian Tubules  (974.3) Larval Fat Body  (11135.6) Larval Salivary Gland  (5167.9) Larval Trachea  594.275 Larval Carcass  (889.85) Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut  (1840.5) Larval Malpighian Tubules    974.3 Larval Fat Body  (11135.6) Larval Salivary Gland  (5167.9) Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.85 Larval Midgut    16.2 Larval Hindgut    1840.5 Larval Malpighian Tubules    974.3 Larval Fat Body    11135.6 Larval Salivary Gland    5167.9 Larval Trachea    594.275 Larval Carcass    889.85 Adult Head    386.3 Adult Eye    226.35 Adult Brain    14.2 Adult Thoracic-Abdominal Ganglion    18 Adult Crop    10.8 Adult Midgut    8.2 Adult Hindgut    10.4 Adult Malpighian Tubules    3.7 Adult Fat Body    253.5 Adult Salivary Gland    4.5 Adult Heart    378.7 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    3.5 Adult Testis    0.9 Adult Male Accessory Gland    1.5 Adult Carcass    322.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    386.3   NA  Eye    226.35   NA  Brain    no informative data   18.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    8.2   1840.5  Hindgut    no informative data   974.3  Malpighian Tubules    3.7   11135.6  Fat Body    253.5   5167.9  Salivary Gland    4.5   NA  Heart    378.7   594.275  Trachea    NA   NA  VirginFemale Spermatheca    45.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    3.5   NA  Testis    0.9   NA  Male Accessory Gland    1.5   889.85  Carcass    322.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3    135 central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male    111 head, mated 20-day male    282 salivary gland, larvae L3 wandering    459 salivary gland, white prepupae    1441 digestive system, larvae L3 wandering    705 digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    27728 fat body, white prepupae    10860 fat body, pupae P8    5741 carcass, larvae L3 wandering    355 carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (49) central nervous system, larvae L3  (135) central nervous system, pupae P8  (44) head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female  (59) head, mated 1-day male  (36) head, mated 4-day male  (111) head, mated 20-day male  (282) salivary gland, larvae L3 wandering  (459) salivary gland, white prepupae  (1441) digestive system, larvae L3 wandering  (705) digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering  (27728) fat body, white prepupae  (10860) fat body, pupae P8  (5741) carcass, larvae L3 wandering  (355) carcass, 1-day adult  (77) carcass, 4-day adult    15 carcass, 20-day adult  (28) ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3  (135) central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male  (111) head, mated 20-day male  (282) salivary gland, larvae L3 wandering  (459) salivary gland, white prepupae  (1441) digestive system, larvae L3 wandering  (705) digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering  (27728) fat body, white prepupae  (10860) fat body, pupae P8  (5741) carcass, larvae L3 wandering  (355) carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3    135 central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male    111 head, mated 20-day male    282 salivary gland, larvae L3 wandering    459 salivary gland, white prepupae    1441 digestive system, larvae L3 wandering    705 digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    27728 fat body, white prepupae    10860 fat body, pupae P8    5741 carcass, larvae L3 wandering    355 carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    137 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3    135 central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male    111 head, mated 20-day male    282 salivary gland, larvae L3 wandering    459 salivary gland, white prepupae    1441 digestive system, larvae L3 wandering    705 digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    27728 fat body, white prepupae    10860 fat body, pupae P8    5741 carcass, larvae L3 wandering    355 carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (49) central nervous system, larvae L3  (135) central nervous system, pupae P8  (44) head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female  (59) head, mated 1-day male  (36) head, mated 4-day male  (111) head, mated 20-day male  (282) salivary gland, larvae L3 wandering  (459) salivary gland, white prepupae  (1441) digestive system, larvae L3 wandering  (705) digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering  (27728) fat body, white prepupae  (10860) fat body, pupae P8  (5741) carcass, larvae L3 wandering  (355) carcass, 1-day adult  (77) carcass, 4-day adult    15 carcass, 20-day adult  28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male  (137) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3  135 central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male  111 head, mated 20-day male  (282) salivary gland, larvae L3 wandering  (459) salivary gland, white prepupae  (1441) digestive system, larvae L3 wandering  (705) digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering  (27728) fat body, white prepupae  (10860) fat body, pupae P8  (5741) carcass, larvae L3 wandering  (355) carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male  137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    49 central nervous system, larvae L3    135 central nervous system, pupae P8    44 head, virgin 1-day female    12 head, virgin 4-day female    1 head, virgin 20-day female    3 head, mated 1-day female    12 head, mated 4-day female    1 head, mated 20-day female    59 head, mated 1-day male    36 head, mated 4-day male    111 head, mated 20-day male    282 salivary gland, larvae L3 wandering    459 salivary gland, white prepupae    1441 digestive system, larvae L3 wandering    705 digestive system, 1-day adult    23 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    27728 fat body, white prepupae    10860 fat body, pupae P8    5741 carcass, larvae L3 wandering    355 carcass, 1-day adult    77 carcass, 4-day adult    15 carcass, 20-day adult    28 ovary, virgin 4-day female    2 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    137 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of no expression detected. Peak expression observed during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    137 larva L3 puffstage 1-2    17840 larva L3 puffstage 3-6    15429 larva L3 puffstage 7-9    8405 white prepupae new    6814 white prepupae 12hr    3389 white prepupae 24hr    2596 pupae 2d postWPP    2303 pupae 3d postWPP    907 pupae 4d postWPP    889 adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr  (48) embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (137) larva L3 puffstage 1-2  (17840) larva L3 puffstage 3-6  (15429) larva L3 puffstage 7-9  (8405) white prepupae new  (6814) white prepupae 12hr  (3389) white prepupae 24hr  (2596) pupae 2d postWPP  (2303) pupae 3d postWPP  (907) pupae 4d postWPP  (889) adult male 01day  (81) adult male 05day  (79) adult male 30day  (39) adult female 01day  (65) adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (137) larva L3 puffstage 1-2  (17840) larva L3 puffstage 3-6  (15429) larva L3 puffstage 7-9  (8405) white prepupae new  (6814) white prepupae 12hr  (3389) white prepupae 24hr  (2596) pupae 2d postWPP  (2303) pupae 3d postWPP  (907) pupae 4d postWPP  (889) adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    137 larva L3 puffstage 1-2    17840 larva L3 puffstage 3-6    15429 larva L3 puffstage 7-9    8405 white prepupae new    6814 white prepupae 12hr    3389 white prepupae 24hr    2596 pupae 2d postWPP    2303 pupae 3d postWPP    907 pupae 4d postWPP    889 adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    137 larva L3 puffstage 1-2    17840 larva L3 puffstage 3-6    15429 larva L3 puffstage 7-9    8405 white prepupae new    6814 white prepupae 12hr    3389 white prepupae 24hr    2596 pupae 2d postWPP    2303 pupae 3d postWPP    907 pupae 4d postWPP    889 adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr  (48) embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  (137) larva L3 puffstage 1-2  (17840) larva L3 puffstage 3-6  (15429) larva L3 puffstage 7-9  (8405) white prepupae new  (6814) white prepupae 12hr  (3389) white prepupae 24hr  (2596) pupae 2d postWPP  (2303) pupae 3d postWPP  (907) pupae 4d postWPP  (889) adult male 01day  (81) adult male 05day  (79) adult male 30day  (39) adult female 01day  (65) adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old  137 larva L3 puffstage 1-2  (17840) larva L3 puffstage 3-6  (15429) larva L3 puffstage 7-9  (8405) white prepupae new  (6814) white prepupae 12hr  (3389) white prepupae 24hr  (2596) pupae 2d postWPP  (2303) pupae 3d postWPP  (907) pupae 4d postWPP  (889) adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    14 embryo 10-12hr    48 embryo 12-14hr    19 embryo 14-16hr    20 embryo 16-18hr    6 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    137 larva L3 puffstage 1-2    17840 larva L3 puffstage 3-6    15429 larva L3 puffstage 7-9    8405 white prepupae new    6814 white prepupae 12hr    3389 white prepupae 24hr    2596 pupae 2d postWPP    2303 pupae 3d postWPP    907 pupae 4d postWPP    889 adult male 01day    81 adult male 05day    79 adult male 30day    39 adult female 01day    65 adult female 05day    3 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2169 cold shock, 4-day adult    2232 heat shock, 4-day adult    1042 Cadmium 50 mM 6 hrs, larvae L3    4854 Cadmium 50 mM 12 hrs, larvae L3    6066 Cadmium 50 mM 48 hrs, 4-day adult    893 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    3292 Copper 15 mM 48 hrs, 4-day adult    132 Zinc 5 mM 12 hrs, larvae L3    2651 Zinc 4.5 mM 48 hrs, 4-day adult    367 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    2100 Ethanol 10% 3 hrs, larvae L3    2549 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1780 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1659 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2439 Rotenone 8 μg 12 hrs, larvae L3    1703 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (2169) cold shock, 4-day adult  (2232) heat shock, 4-day adult  (1042) Cadmium 50 mM 6 hrs, larvae L3  (4854) Cadmium 50 mM 12 hrs, larvae L3  (6066) Cadmium 50 mM 48 hrs, 4-day adult  (893) Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (3292) Copper 15 mM 48 hrs, 4-day adult  (132) Zinc 5 mM 12 hrs, larvae L3  (2651) Zinc 4.5 mM 48 hrs, 4-day adult  (367) Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3  (2100) Ethanol 10% 3 hrs, larvae L3  (2549) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1780) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult  (1659) Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3  (2439) Rotenone 8 μg 12 hrs, larvae L3  (1703) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (2169) cold shock, 4-day adult  (2232) heat shock, 4-day adult  (1042) Cadmium 50 mM 6 hrs, larvae L3  (4854) Cadmium 50 mM 12 hrs, larvae L3  (6066) Cadmium 50 mM 48 hrs, 4-day adult  (893) Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (3292) Copper 15 mM 48 hrs, 4-day adult  (132) Zinc 5 mM 12 hrs, larvae L3  (2651) Zinc 4.5 mM 48 hrs, 4-day adult  (367) Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3  (2100) Ethanol 10% 3 hrs, larvae L3  (2549) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1780) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult  (1659) Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3  (2439) Rotenone 8 μg 12 hrs, larvae L3  (1703) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2169 cold shock, 4-day adult    2232 heat shock, 4-day adult    1042 Cadmium 50 mM 6 hrs, larvae L3    4854 Cadmium 50 mM 12 hrs, larvae L3    6066 Cadmium 50 mM 48 hrs, 4-day adult    893 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    3292 Copper 15 mM 48 hrs, 4-day adult    132 Zinc 5 mM 12 hrs, larvae L3    2651 Zinc 4.5 mM 48 hrs, 4-day adult    367 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    2100 Ethanol 10% 3 hrs, larvae L3    2549 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1780 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1659 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2439 Rotenone 8 μg 12 hrs, larvae L3    1703 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2169 cold shock, 4-day adult    2232 heat shock, 4-day adult    1042 Cadmium 50 mM 6 hrs, larvae L3    4854 Cadmium 50 mM 12 hrs, larvae L3    6066 Cadmium 50 mM 48 hrs, 4-day adult    893 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    3292 Copper 15 mM 48 hrs, 4-day adult    132 Zinc 5 mM 12 hrs, larvae L3    2651 Zinc 4.5 mM 48 hrs, 4-day adult    367 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    2100 Ethanol 10% 3 hrs, larvae L3    2549 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1780 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1659 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2439 Rotenone 8 μg 12 hrs, larvae L3    1703 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (2169) cold shock, 4-day adult  (2232) heat shock, 4-day adult  (1042) Cadmium 50 mM 6 hrs, larvae L3  (4854) Cadmium 50 mM 12 hrs, larvae L3  (6066) Cadmium 50 mM 48 hrs, 4-day adult  (893) Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (3292) Copper 15 mM 48 hrs, 4-day adult  (132) Zinc 5 mM 12 hrs, larvae L3  (2651) Zinc 4.5 mM 48 hrs, 4-day adult  (367) Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3  (2100) Ethanol 10% 3 hrs, larvae L3  (2549) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1780) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult  (1659) Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3  (2439) Rotenone 8 μg 12 hrs, larvae L3  (1703) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (2169) cold shock, 4-day adult  (2232) heat shock, 4-day adult  (1042) Cadmium 50 mM 6 hrs, larvae L3  (4854) Cadmium 50 mM 12 hrs, larvae L3  (6066) Cadmium 50 mM 48 hrs, 4-day adult  (893) Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (3292) Copper 15 mM 48 hrs, 4-day adult  132 Zinc 5 mM 12 hrs, larvae L3  (2651) Zinc 4.5 mM 48 hrs, 4-day adult  (367) Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3  (2100) Ethanol 10% 3 hrs, larvae L3  (2549) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1780) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult  (1659) Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3  (2439) Rotenone 8 μg 12 hrs, larvae L3  (1703) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2169 cold shock, 4-day adult    2232 heat shock, 4-day adult    1042 Cadmium 50 mM 6 hrs, larvae L3    4854 Cadmium 50 mM 12 hrs, larvae L3    6066 Cadmium 50 mM 48 hrs, 4-day adult    893 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    3292 Copper 15 mM 48 hrs, 4-day adult    132 Zinc 5 mM 12 hrs, larvae L3    2651 Zinc 4.5 mM 48 hrs, 4-day adult    367 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    2100 Ethanol 10% 3 hrs, larvae L3    2549 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1780 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    1659 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2439 Rotenone 8 μg 12 hrs, larvae L3    1703 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • LP06572 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039685 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7592-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Obp99b Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Obp99bGD1298 Other Phenotypes Allele mating defective | female, with Scer\GAL4Act5C.PI Obp99bScer\UAS.T:SV5\V5 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Obp99b Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Obp99b Class Mutagen Stocks Known lesion Obp99bGD1298 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Obp99bKK110375 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Obp99bScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Obp99b-lacZ.G} No UAS construct P{GD1298} NA P{KK110375} NA P{UAS-Obp99b.V5} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
odorant binding inferred from sequence alignment with UniProtKB:P34174 (Hekmat-Scafe et al., 2002) inferred from sequence or structural similarity with lush (Vieira and Rozas, 2011) inferred from sequence or structural similarity with UniProtKB:P34174 (Galindo and Smith, 2001) non-traceable author statement (assigned by UniProtKB) (Kim and Smith, 2001)
Biological Process
CV term Evidence References
olfactory behavior inferred from sequence or structural similarity with UniProtKB:O02372 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1) response to pheromone inferred from sequence or structural similarity with UniProtKB:O02372 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1) sensory perception of chemical stimulus inferred from sequence alignment with UniProtKB:P34174 (Hekmat-Scafe et al., 2002) inferred from sequence or structural similarity with lush (Vieira and Rozas, 2011) inferred from sequence or structural similarity with UniProtKB:P34174 (Galindo and Smith, 2001)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence model (Vieira and Rozas, 2011) inferred from sequence or structural similarity with UniProtKB:O02372 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Obp99b - CG4390 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Obp99b allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039685
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZGQ00 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG67D8CS Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6ZGQ00)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Obp99b     Drosophila simulans   Dsim\Obp99b Y   Drosophila sechellia   Dsec\Obp99b Y   Drosophila yakuba   Dyak\Obp99b Y   Drosophila ananassae   Dana\Obp99b-2     Drosophila ananassae   Dana\Obp99b-1 Y   Drosophila ananassae   Dana\Obp99b-3     Drosophila pseudoobscura pseudoobscura   Dpse\Obp99b Y   Drosophila persimilis   Dper\Obp99b Y   Drosophila willistoni   Dwil\Obp99b Y   Drosophila virilis   Dvir\Obp99b Y   Drosophila mojavensis   Dmoj\Obp99b Y   Drosophila grimshawi   Dgri\Obp99b Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG67D8CS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\OBP88 Y Nasonia vitripennis Parasitic wasp  Nvit\OBP87 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022801 Y Bombyx mori Silkmoth  Bmor\Bmo.10038 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012615 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010011 Y Tribolium castaneum Red flour beetle  Tcas\OBP-C17 Y Tribolium castaneum Red flour beetle  Tcas\OBP-C18 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Obp99b Drosophila sechellia Dsec\Obp99b Drosophila yakuba Dyak\Obp99b Drosophila ananassae Dana\Obp99b-1 Drosophila pseudoobscura pseudoobscura Dpse\Obp99b Drosophila persimilis Dper\Obp99b Drosophila willistoni Dwil\Obp99b Drosophila virilis Dvir\Obp99b Drosophila mojavensis Dmoj\Obp99b Drosophila grimshawi Dgri\Obp99b
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v6286 w1118; P{GD1298}v6286/CyO
Genomic Clones ( 2 )
	BACR02O03 BACR10L12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 295 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP06572
Other clones	DPiM_LP06572
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP01364 LP02149 LP05187 LP05240 LP05592 LP05770 LP05972 LP06081 LP07651 LP08986 LP09587 LP12706 LP12789 LP13022 LP17139 LP17393 LP19069 LP20812 LP22294 LP22485 LP23517 LP24318 LP24356
Other clones	CK01.170D.F2 EC00163 EC00221 EC00367 EC00517 EC00568 EC00569 EC00662 EC00767 EC01150 EC01255 EC01365 EC01450 EC01474 EC01517 EC01568 EC01569 EC01572 EC01919 EC02021 EC02062 EC02068 EC02960 EC03606 EC06090 EC12702 EC13022 EC13047 EC13123 EC13160 EC13260 EC13329 EC13330 EC13333 EC13372 EC13591 EC13712 EC13804 EC13986 EC13993 EC14025 EC14051 EC14216 EC14401 EC14440 EC14560 EC14909 EC14976 EC14979 EC14992 EC15013 EC15025 EC15109 EC22066 EC22174 EC22263 EC22285 EC22309 EC22329 EC22353 EC22359 EC22362 EC22403 EC22434 EC22444 EC22483 EC22519 EC22905 EC22971 EC22990 EC23154 EC23424 EC23465 EC23514 EC23901 EC24005 EC24069 EC24070 EC24075 EC24119 EC24212 EC24381 EC24438 EC24478 EC24485 EC24530 EC25037 EC25080 EC25207 EC25485 EC25717 EC25736 EC25805 EC25884 EC25971 EC26076 EC26082 EC26387 EC26502 EC26621 EC26645 EC26659 EC26681 EC26823 EC26841 EC26922 EC26941 EC27381 EC27751 EC27864 EC27948 EC27962 EC28049 EC28057 EC28087 EC28150 EC28219 EC28247 EC28303 EC28307 EC28368 EC28385 EC28464 EC28490 EC28691 EC28794 EC28993 EC29059 EC29065 EC29232 EC29276 EC29460 EC29724 EC29765 EC29769 EC29924 EC30191 EC30196 EC30201 EC30338 EC30447 EC30674 EC30701 EC30764 EC30801 EC31213 EC31427 EC31562 EC31565 EC31640 EC31661 EC31746 EC31749 EC31757 EC31771 EC32129 EC32411 EC32525 EC32565 EC32582 EC32761 EC32853 EC33244 EC33309 EC33420 EC33472 EC33564 EC33595 EC33632 EC33814 EC34091 EC34130 EC34321 EC34365 EC34496 EC34520 EC34565 EC34644 EC34718 EC34752 EC34889 EC34891 EC34912 EC35021 EC35114 EC35180 EC35246 EC35267 EC35317 EC35321 EC35340 EC35794 EC35981 EC36429 EC36651 EC36817 EC36821 EC36840 EC36959 EC36994 EC37387 EC37461 EC37502 EC37807 EC38413 EC38580 EC38860 EC39006 EC39114 EC39120 EC39174 EC39353 EC39392 EC39462 EC39511 EC39535 EC39705 EC39752 EC39815 EC39855 EC39868 EC39879 EC39936 EC40095 EC40236 EC40390 EC40505 EC40552 EC40791 EC40854 EC40965 EC41020 EC41043 EC43514 EC43722 EC43730 EC43764 EC43843 ESG011b.E7_D05 ESG011b.E21_D05 ESG011c.E7_D11 ESG011c.E21_D11 ESG011c.E21_G12 ESG011d.E7.1_C04 ESG011d.E21_C04 ESG012b.E21_D11 ESG015b.E21_E12 ESG016a.E21_F03 ESG016a.E21_H12 ESG017d.E21_C07 ESG017d.E21_E12 ESG018c.E21.1_F06 ESG0110d.E21_G06 ESG0112a.B21_B06 ESG0113b.B21.1_H08 ESG0113c.B21_F01 ESG0114a.B21_G08 ESG0114c.B21_F09 ESG0115b.B21_H06 ESG0115c.B21_D07 ESG0117c.B21_C05 ESG0117d.B21_H04 ESG0118b.B21_F12 ESG0118c.B21_F03 ESG0119b.B21_C11 ESG0120d.B21_E03 IP18549 IP18749 LP22054 RP004407489
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43497
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Obp99b tsx (Fujii and Amrein, 2002)
Source for database merge of	Source for merge of: Obp99b BcDNA:LP06572 (FlyBase, 1996-)
Additional comments	FlyBase curator comment: The gene referred to as "Obp99d" in FBrf0151651 is not the same gene as the one referred to as "Obp99d" in FlyBase (FBgn0039684). The gene referred to as "Obp99d" in FBrf0151651 actually corresponds to FBgn0039685 which is referred to in FlyBase with the symbol "Obp99b" (and corresponds to release 3 annotation CG7592). (Hekmat-Scafe, 2002.3.5) FlyBase curator comment: The gene referred to as "Obp99d" in FBrf0151704 is not the same gene as the one referred to as "Obp99d" in FlyBase (FBgn0039684). The gene referred to as "Obp99d" in FBrf0151704 actually corresponds to FBgn0039685 which is referred to in FlyBase with the symbol "Obp99b" (and corresponds to release 3 annotation CG7592). (Hekmat-Scafe et al., 2002) Source for merge of Obp99b BcDNA:LP06572 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143456 NM_001276149 RefSeq (Proteins) • NP_651713 NP_001263078 DDBJ / EMBL / GenBank • AAF56921 AAM50904 AGB96458 AI261132 AI293437 AY119044 Entrez Gene - A searchable database of RefSeq genes. • 43497 UniProtKB/Swiss-Prot • Q9VAI6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pheromone/general odorant binding protein (IPR006170) Pheromone/general odorant binding protein, PBP/GOBP, domain (IPR023316) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP06572
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039685 DRSC - Results from RNAi screens. • FBgn0039685 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039685 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7592-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43497 modMine - Data generated by the modENCODE project. • FBgn0039685 REDfly - A database of transcriptional regulatory elements. • FBgn0039685
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	99b (Graham and Davies, 2002, Smith, 2002.1.14, Galindo and Smith, 2001) BcDNA:LP06572   CG7592 (Gorski et al., 2003, Vierstraete et al., 2003, Fujii and Amrein, 2002, Hekmat-Scafe et al., 2002, Hekmat-Scafe, 2002.3.5, Graham, 2002.6.18, Vogt et al., 2002, McDonald and Rosbash, 2001, Liu et al., 2009, Fujikawa et al., 2009, Lai et al., 2007, Keleman et al., 2009.8.5, Reumer et al., 2009) DmelObp99b (Vieira and Rozas, 2011) Obp99b (Wang et al., 2007, Wang et al., 2007, Farhadian et al., 2012, Allen and Spradling, 2008, Dworkin et al., 2009, Fujikawa et al., 2009, Graze et al., 2009, Vieira et al., 2007, Carney, 2007, Zhou et al., 2009, Anholt and Williams, 2010, Fernández-Ayala et al., 2010, Buffin and Gho, 2010, Wang et al., 2010, Cherbas et al., 2011, Dalton et al., 2010, Xun et al., 2008) OBP99b (Reumer et al., 2009) Obp99d (Hekmat-Scafe et al., 2002, Hekmat-Scafe, 2002.3.5) tsx (Wolfner, 2003, Fujii and Amrein, 2002, Anonymous, 2002, Goldman and Arbeitman, 2007, Fernández-Ayala et al., 2010)
Name Synonym	General odorant-binding protein 99b precursor (Reumer et al., 2009) Odorant-binding protein 99b (Galindo and Smith, 2001, Zhang et al., 2011, Carney, 2007, Buffin and Gho, 2010) Odorant Binding Protein 99b (Lorbeck et al., 2011) Odorant binding protein 99B (Mosqueira et al., 2010) Odordant-binding protein 99b (Liu et al., 2009) turn on sex-specificity (Anonymous, 2002, Goldman and Arbeitman, 2007)
Secondary FlyBase IDs
	FBgn0063111 FBgn0064137
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Farhadian et al., 2012, Physiol. Behav. 105(2): 544--553 Post-fasting olfactory, transcriptional, and feeding responses in Drosophila. [FBrf0216753] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Lorbeck et al., 2011, PLoS ONE 6(4): e18412 Microarray analysis uncovers a role for tip60 in nervous system function and general metabolism. [FBrf0213446] Swarup et al., 2011, Genes Brain Behav. 10(6): 648--657 Functional dissection of Odorant binding protein genes in Drosophila melanogaster. [FBrf0214592] Vieira and Rozas, 2011, Genome Biol. Evol. 3: 476--490 Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System. [FBrf0214323] Zhang et al., 2011, J. Exp. Biol. 214(23): 4021--4029 Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster. [FBrf0216629] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...