Gene model reviewed during 5.47
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
The extracellular domain is necessary for conferring apical characteristics on the salivary gland membrane (PubMed:24718992). Necessary for regulating salivary gland membrane expansion and tube length, but is not required for cell rearrangement during tube elongation (PubMed:24718992). Sufficient to promote the outgrowth of follicle cell microvilli and the formation of microvilli bundles (PubMed:16260500, PubMed:24718992) Sufficient to promote formation of microvilli-like structures in the salivary glands and the follicle cell microvilli bundles (PubMed:16507588, PubMed:24718992). Dispensable for apical localization (PubMed:24718992).
The cytoplasmic domain is necessary for the formation of uracil-induced endosomes.
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad99C using the Feature Mapper tool.
Cad99C is expressed in oogenesis stages S4-8 in the anterior and posterior follicle cells and in follicle cells that migrate to contact the ooctye at stage S9.
Cad99C protein is detected at the border between follicle cells and the oocyte at the anterior and posterior poles of the egg chamber at oogenesis stages 4-8. During stages 9-14, signal is detected in structures at the entire border between the oocyte and the follicle cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cad99C in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Cad99C CA-10
Source for merge of: CG7805 CG15511
Annotations CG15511, CG7805 merged as CG31009 in release 3 of the genome annotation.
The extracellular (and transmembrane) domain of Cad99C is sufficient to confer apical character on membranes but does not affect cell rearrangement during tube elongation.
Loss of Cad99C results in shorter microvilli and overexpression in longer microvilli than in wild-type, indicating that the concentration of Cad99C is positively correlated with the length of microvilli in follicle cells.
Expression is highly increased in the A/P organizer region.