FlyBase Gene Report: Dmel\Cad99C

General Information

Symbol

Dmel\Cad99C

Species

D. melanogaster

Name

Cadherin 99C

Annotation Symbol

CG31009

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039709

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Snapshot

Cadherin 99C (Cad99C) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. Its roles include microvillus morphogenesis, tube elongation, endosome formation and immunity. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

CA-10

Key Links

Genomic Location

Cytogenetic map

99C4-99C4

Sequence location

3R:29,841,657..29,854,699 [+]

Recombination map

3-99

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

CADHERINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

myosin binding

Predictions / Assertions

calcium ion binding

Summaries

Gene Group (FlyBase)

CADHERINS -: The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).

Protein Function (UniProtKB)

Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794). Essential for female fertility (PubMed:16260500, PubMed:16507588). Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597). Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597). Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597). Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992). May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992). Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992). In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

(UniProt, Q9VAF5)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Cad99C or the JBrowse view of Dmel\Cad99C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cad99C-RA

FBtr0085488

NM_170435

5795

1706

Cad99C-RB

FBtr0303095

NM_001202382

5651

1706

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cad99C-PA

FBpp0084854

186.9

1706

4.50

NP_733314

AAF56955

Cad99C-PB

FBpp0292214

186.9

1706

4.50

NP_001189311

ADV37401

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1706 aa isoforms: Cad99C-PA, Cad99C-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via the cytoplasmic domain) with ck (PubMed:25236597, PubMed:27331610). Interacts (via the cytoplasmic domain) with Cul1 and Ubr3 (PubMed:27331610).

(UniProt, Q9VAF5)

Domain

The extracellular domain is necessary for conferring apical characteristics on the salivary gland membrane (PubMed:24718992). Necessary for regulating salivary gland membrane expansion and tube length, but is not required for cell rearrangement during tube elongation (PubMed:24718992). Sufficient to promote the outgrowth of follicle cell microvilli and the formation of microvilli bundles (PubMed:16260500, PubMed:24718992) Sufficient to promote formation of microvilli-like structures in the salivary glands and the follicle cell microvilli bundles (PubMed:16507588, PubMed:24718992). Dispensable for apical localization (PubMed:24718992). The cytoplasmic domain is necessary for the formation of uracil-induced endosomes. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain (By similarity).

(UniProt, Q9VAF5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad99C using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cad99C_1

Linkouts

Gene Ontology (20 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

myosin binding

inferred from physical interaction with FLYBASE:ck; FB:FBgn0000317

(Glowinski et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

calcium ion binding

inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence model

(Hill et al., 2001)

Biological Process (13 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

apical protein localization