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Gene Dmel\dgt1

General Information
Symbol	Dmel\dgt1	Species	D. melanogaster
Name	dim γ-tubulin 1	Annotation symbol	CG18041
Feature type	protein_coding_gene	FlyBase ID	FBgn0039710
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	NSL2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99C4-99C4	Sequence location	3R:25,680,417..25,683,213 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dim γ-tubulin 1 is referred to in FlyBase by the symbol Dmel\dgt1 (CG18041, FBgn0039710). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic G2 DNA damage checkpoint; neurogenesis. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: KAT8 regulatory NSL complex subunit 2; Potential DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627141_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dgt1. Gene sequence location is 3R:25680417..25683213.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99C4-99C4   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dgt1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dgt1-RA FBtr0085527  NM_143480   1712   484 dgt1-RB FBtr0335006  NM_001276154   1687   425 dgt1-RC FBtr0339942     2231   589
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dgt1-PA   FBpp0084893   56.0   484   8.15     NP_651737   AAF56956 dgt1-PB   FBpp0307014   49.4   425   8.83     NP_001263083   AGB96463 dgt1-PC   FBpp0308967   67.4   589   4.93
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Potential DNA-binding domain (IPR025927) KAT8 regulatory NSL complex subunit 2 (IPR026316)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390560   AA390562   AA392065   AA392246   AA440160   AA440209   AA540099   AA735253   AA735255   AA816549   AA951998   AE014297 AAF56956   AE014297 AGB96463   AI518318   AI518343   AW942236   AY061156 AAL28704   BI171049   BI172998   BP555285   CO287472   CO301705   CO316367   CO316451   CO320677   CO323693   CO333232   CZ484479   EC062799   EC066484   EC077957   EC085690   EC202342   EC216116   EC223359   EC251234   EV594196
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VAF4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    195.75 Larval Midgut    36.5 Larval Hindgut    79.9 Larval Malpighian Tubules    80.7 Larval Fat Body    72.3 Larval Salivary Gland    94.6 Larval Trachea    85.9 Larval Carcass    54.925 Adult Head    85.4 Adult Eye    73.975 Adult Brain    115.9 Adult Thoracic-Abdominal Ganglion    88 Adult Crop    71.6 Adult Midgut    55 Adult Hindgut    75 Adult Malpighian Tubules    67.5 Adult Fat Body    67 Adult Salivary Gland    115.8 Adult Heart    81.05 Adult VirginFemale Spermatheca    79.3 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    269.9 Adult Testis    85.6 Adult Male Accessory Gland    84.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    85.4   NA  Eye    73.975   NA  Brain    115.9   195.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    88   NA  Crop    71.6   36.5  Midgut    55   79.9  Hindgut    75   80.7  Malpighian Tubules    67.5   72.3  Fat Body    67   94.6  Salivary Gland    115.8   NA  Heart    81.05   85.9  Trachea    NA   NA  VirginFemale Spermatheca    79.3   NA  InseminatedFemale Spermatheca    78.1   NA  Ovary    269.9   NA  Testis    85.6   NA  Male Accessory Gland    84.2   54.925  Carcass    69.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female  26 ovary, mated 4-day female  26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female  26 ovary, mated 4-day female  26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    6 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    6 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    10 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    26 ovary, mated 4-day female    26 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr  (50) embryo 04-06hr  (41) embryo 06-08hr  (42) embryo 08-10hr  (34) embryo 10-12hr  (30) embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr  (50) embryo 04-06hr  (41) embryo 06-08hr  (42) embryo 08-10hr  (34) embryo 10-12hr  30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    50 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    34 embryo 10-12hr    30 embryo 12-14hr    19 embryo 14-16hr    21 embryo 16-18hr    17 embryo 18-20hr    11 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    9 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    8 adult male 05day    11 adult male 30day    11 adult female 01day    16 adult female 05day    25 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    16 Schneider line 2 Sg4    14 embryonic 1182-4H    10 embryonic GM2    5 embryonic Kc167    13 embryonic S1    15 embryonic S3    11 leg disc CME L1    16 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    9 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    9 ovary fGS/OSS    17 ovary OSC    10 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD12439 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039710 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18041-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dgt1GD9504 lethal | pupal stage, with Scer\GAL4pnr-MD237 dgt1GD9504 Other Phenotypes Allele neuroanatomy defective | larval stage dgt1GD9504 Phenotype manifest in Allele ganglion mother cell | larval stage dgt1GD9504
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of dgt1 Class Mutagen Stocks Known lesion dgt1EY04131 P-element activity 1 -- dgt1f01982 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dgt1 Class Mutagen Stocks Known lesion dgt1GD9504 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dgt1KK102569 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dgt1MtnA.C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dgt1MtnA.N.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)Ice (Xu et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK102569} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}dgt1EY04131 NA miscellaneous insertions PBac{WH}dgt1f01982 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
histone acetyltransferase complex inferred from electronic annotation with InterPro:IPR026316 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dgt1 - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dgt1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68388 DroID - A comprehensive database of gene and protein interactions. • FBgn0039710 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43529
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640XV Dipteran inclusive ortholog search EOG60S0Q8 Insect inclusive ortholog search EOG670SDB Arthropod inclusive ortholog search EOG62548Q Metazoa inclusive ortholog search EOG6PP9B8
Orthologs in Drosophila Species (EOG6640XV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dgt1     Drosophila simulans   Dsim\GD17628 Y   Drosophila sechellia   Dsec\GM12214 Y   Drosophila erecta   Dere\GG11995 Y   Drosophila yakuba   Dyak\GE10420 Y   Drosophila ananassae   Dana\GF16322 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14774 Y   Drosophila persimilis   Dper\GL13478 Y   Drosophila willistoni   Dwil\GK11447 Y   Drosophila virilis   Dvir\GJ14216 Y   Drosophila mojavensis   Dmoj\GI22340 Y   Drosophila grimshawi   Dgri\GH13995 Y
Orthologs in non-Drosophila Dipterans (EOG60S0Q8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004832   Anopheles gambiae Malaria mosquito  Agam\AGAP006680   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012916   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018194
Orthologs in non-Dipteran Insects (EOG670SDB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49040   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005240   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22218   Atta cephalotes Leafcutter ant  Acep\ACEP17630   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20054   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17145   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17160   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17989   Linepithema humile Argentine ant  Lhum\LH15237   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23093   Solenopsis invicta Red fire ant  Sinv\SINV13389   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009160   Bombyx mori Silkmoth  Bmor\BGIBMGA009773   Pediculus humanus Human body louse  Phum\PHUM354850
Orthologs in non-Insect Arthropods (EOG62548Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Nudt12   Ixodes scapularis Deer tick  Isca\ISCW000480
Orthologs in non-Arthropod Metazoa (EOG6PP9B8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C34E10.8   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004393gn   Danio rerio Zebrafish  Drer\ENSDARG00000056318   Xenopus tropicalis Western clawed frog  Xtro\c12orf41   Mus musculus House mouse  Mmus\2310037I24Rik   Mus musculus House mouse  Mmus\Gm4885   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000015907   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027686   Rattus norvegicus Norway rat  Rnor\LOC100364875   Homo sapiens Human  Hsap\KANSL2
Human Orthologs (1)
Gene OMIM HGNC Hsap\KANSL2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17628 Drosophila sechellia Dsec\GM12214 Drosophila erecta Dere\GG11995 Drosophila yakuba Dyak\GE10420 Drosophila ananassae Dana\GF16322 Drosophila pseudoobscura pseudoobscura Dpse\GA14774 Drosophila persimilis Dper\GL13478 Drosophila willistoni Dwil\GK11447 Drosophila virilis Dvir\GJ14216 Drosophila mojavensis Dmoj\GI22340 Drosophila grimshawi Dgri\GH13995
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	15924 y1 w67c23; P{EPgy2}dgt1EY04131/TM3, Sb1 Ser1
Harvard	- PBac{WH}dgt1f01982
VDRC	v108668 P{KK102569}VIE-260B v46033 w1118; P{GD9504}v46033 v46031 w1118; P{GD9504}v46031/TM3
Genomic Clones ( 1 )
	BACR02E15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD12439
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01682 LD01687 LD02050 LD09402 LD09485 LD11056 LD14760 LD14827 LD19460 LD28994 LD37795 LD37827 RE12714 RE15729
Other clones	58370 58858 60429 102949 160992 161042 182405 281297 Dmel_neb_014873_0655_0757 EK065937 EK181933 EK191151 EK264741 EK265011 EK286957 EK306248 FGM234D11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039710 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43529
Antibody Information
Other Information
Discoverer
Etymology
	Named "dim γ-tubulin 1" for the decreased γ-tubulin staining of the spindle pole following treatment of S2 cells with dgt1 dsRNA. (Goshima et al., 2007)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dgt1 CG18041 (Goshima et al., 2007)
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in decreased γ-tubulin staining of the centrosome and spindle and the formation of an aberrantly long spindle when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype is not observed without Cdc27 dsRNA. (Goshima et al., 2007) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143480 NM_001276154 RefSeq (Proteins) • NP_651737 NP_001263083 DDBJ / EMBL / GenBank • AA392065 AAF56956 AAL28704 AGB96463 AW942236 AY061156 CZ484479 Entrez Gene - A searchable database of RefSeq genes. • 43529 UniProtKB/TrEMBL • Q9VAF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Potential DNA-binding domain (IPR025927) KAT8 regulatory NSL complex subunit 2 (IPR026316) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD12439
Linkouts
	BioGRID - A database of protein and genetic interactions • 68388 DroID - A comprehensive database of gene and protein interactions. • FBgn0039710 DRSC - Results from RNAi screens. • FBgn0039710 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039710 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18041-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039710 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43529 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43529 modMine - Data generated by the modENCODE project. • FBgn0039710
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG18041 (Mendjan et al., 2006, Goshima et al., 2007, Nybakken et al., 2005, Keleman et al., 2009.8.5, Raja et al., 2010) Dgt1 (Goshima et al., 2007, Goshima et al., 2007, White et al., 2011) dgt1 (Hong et al., 2012) NSL2 (Mendjan et al., 2006, Prestel et al., 2010, Raja et al., 2010, Kondo and Perrimon, 2011)
Name Synonym	CG18041   dim γ-tubulin 1 (Goshima et al., 2007, ) non-specific lethal 2 (Prestel et al., 2010, Raja et al., 2010)
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) Website  ( 1 )
Recent research papers ( 4 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Hong et al., 2012, G3 (Bethesda) 2(8): 873--882 Microarray-Based Capture of Novel Expressed Cell Type-Specific Transfrags (CoNECT) to Annotate Tissue-Specific Transcription in Drosophila melanogaster. [FBrf0219214] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...