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Gene Dmel\RpS8

General Information
Symbol	Dmel\RpS8	Species	D. melanogaster
Name	Ribosomal protein S8	Annotation symbol	CG7808
Feature type	protein_coding_gene	FlyBase ID	FBgn0039713
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	S8
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99C4-99C4	Sequence location	3R:25,687,619..25,689,624 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein S8 is referred to in FlyBase by the symbol Dmel\RpS8 (CG7808, FBgn0039713). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: neurogenesis. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein S8e; Ribosomal protein S8e, conserved site; Ribosomal protein S8e/ribosomal biogenesis NSA2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626931_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpS8. Gene sequence location is 3R:25687619..25689624.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translational elongation
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99C4-99C4   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Distal to Df(3R)01215 and quite likely lies proximal to Df(3R)X3F.   (Cook, 2006.1.31)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpS8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpS8-RC FBtr0085489  NM_143483   1045   208 RpS8-RE FBtr0310274  NM_001260433   726   208
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpS8-PC   FBpp0099686   23.8   208   11.16     NP_651740   AAN14192 RpS8-PE   FBpp0301957   23.8   208   11.16     NP_001247362   AFH06679
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S8e, conserved site (IPR018283) Ribosomal protein S8e (IPR001047) Ribosomal protein S8e/ribosomal biogenesis NSA2 (IPR022309)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202658   AA246301   AA246829   AA246895   AA264745   AA391101   AA391913   AA433187   AA438627   AA567171   AA567180   AA695357   AA695562   AA695571   AA696380   AA697054   AA735944   AA735965   AA801675   AA801894   AA802174   AA802215   AA803175   AA803230   AA803275   AA803291   AA803499   AA803542   AA803752   AA941736   AE014297 AAN14192   AE014297 AFH06679   AI061735   AI063722   AI064538   AI107191   AI107276   AI107376   AI107700   AI110032   AI124282   AI135943   AI257076   AI257922   AI258013   AI258081   AI259610   AI259934   AI261024   AI261155   AI295098   AI295456   AI295558   AI295925   AI296047   AI296150   AI296406   AI296879   AI297140   AI388603   AI389578   AI405482   AI455945   AI456213   AI517634   AI532382   AI532515   AI532527   AI534200   AI534536   AI542640   AI543483   AY118424 AAM48453   AY118446   AY231815   AY232059   BE977608   BF491767   BF501128   BF501393   BG635522   BG635616   BG635670   BG635779   BG635941   BG636798   BG637041   BG637120   BG637410   BG637514   BG640129   BG640136   BG640239   BG640249   BG640416   BG640823   BG641194   BG641384   BI141816   BI141887   BI141974   BI162232   BI162233   BI164886   BI168521   BI170651   BI170652   BI172126   BI213347   BI213484   BI214122   BI214869   BI216201   BI227469   BI230167   BI230464   BI230874   BI231364   BI234013   BI234843   BI236611   BI236813   BI236915   BI237705   BI237960   BI239385   BI240755   BI242194   BI242872   BI243293   BI351733   BI351904   BI351940   BI352122   BI352441   BI352471   BI352487   BI352525   BI352982   BI353080   BI353153   BI353293   BI353469   BI353580   BI353625   BI353682   BI353801   BI353820   BI354035   BI354126   BI354130   BI354187   BI354506   BI354563   BI354660   BI354734   BI354796   BI354881   BI354882   BI354988   BI354999   BI355002   BI355088   BI355257   BI355259   BI355282   BI355630   BI355824   BI355842   BI356775   BI357553   BI357601   BI361392   BI362658   BI362690   BI363369   BI363587   BI363968   BI364497   BI364952   BI365082   BI365247   BI365526   BI366296   BI366304   BI367844   BI368111   BI368800   BI371342   BI371468   BI372264   BI372798   BI375523   BI375673   BI375682   BI481561   BI482044   BI482046   BI482247   BI482260   BI483431   BI484446   BI485019   BI485463   BI486061   BI486415   BI486481   BI486797   BI563569   BI563664   BI564126   BI564139   BI564222   BI564354   BI564485   BI564831   BI565189   BI565733   BI566320   BI566406   BI566517   BI566527   BI566601   BI566713   BI566947   BI567232   BI567241   BI567246   BI567633   BI568123   BI568851   BI568852   BI568970   BI568971   BI569447   BI569480   BI569507   BI569620   BI569678   BI569747   BI569756   BI569821   BI569869   BI569931   BI570169   BI570244   BI570457   BI570950   BI571011   BI571627   BI571790   BI571843   BI571905   BI571914   BI571925   BI572049   BI572325   BI572334   BI572381   BI572392   BI572396   BI572964   BI573117   BI573460   BI573461   BI573624   BI574008   BI574009   BI574716   BI574748   BI575324   BI575363   BI575410   BI575840   BI576327   BI576457   BI576458   BI576466   BI576761   BI576830   BI577818   BI577844   BI578656   BI580835   BI580853   BI580999   BI581000   BI581316   BI581596   BI581721   BI581748   BI581889   BI581930   BI582121   BI582163   BI582270   BI582394   BI582855   BI583172   BI583259   BI583743   BI583939   BI584085   BI584348   BI585391   BI585526   BI586097   BI586235   BI586320   BI587124   BI587359   BI587382   BI587472   BI587485   BI587824   BI588051   BI588467   BI588650   BI589003   BI589111   BI589219   BI589706   BI589711   BI589722   BI589772   BI589786   BI589887   BI589909   BI589954   BI589983   BI590046   BI590129   BI590279   BI590586   BI590889   BI591396   BI591480   BI591489   BI591495   BI591859   BI591994   BI592004   BI592010   BI592332   BI592849   BI593001   BI593050   BI593141   BI593169   BI604246   BI605219   BI605254   BI605257   BI605289   BI605455   BI605676   BI605688   BI605854   BI605886   BI606003   BI606497   BI606676   BI606731   BI606922   BI607020   BI607328   BI607939   BI607961   BI607963   BI608191   BI608193   BI608457   BI608486   BI608948   BI609047   BI609089   BI609257   BI610166   BI610245   BI610429   BI611034   BI611856   BI612448   BI612718   BI612950   BI612957   BI613222   BI613366   BI613463   BI613578   BI613702   BI613804   BI614216   BI614407   BI614870   BI614914   BI614930   BI615003   BI615074   BI615178   BI615449   BI615618   BI615634   BI616361   BI616769   BI616788   BI616794   BI617088   BI617430   BI617546   BI617549   BI618457   BI618468   BI618946   BI619725   BI619842   BI620059   BI620312   BI620330   BI620520   BI620640   BI620841   BI621003   BI621261   BI621410   BI621518   BI621572   BI621605   BI621633   BI621871   BI622176   BI622194   BI622465   BI622580   BI622634   BI622640   BI622897   BI623243   BI623336   BI623503   BI623554   BI624295   BI624519   BI624661   BI624890   BI624984   BI624988   BI625025   BI625115   BI625167   BI625611   BI625678   BI626044   BI626484   BI626507   BI626967   BI627191   BI627478   BI627852   BI627959   BI628352   BI628439   BI628831   BI628897   BI629168   BI629846   BI630004   BI630030   BI630081   BI630282   BI630672   BI630977   BI631014   BI631154   BI631399   BI631548   BI632217   BI632498   BI632503   BI632992   BI633157   BI634414   BI634582   BI635778   BI635866   BI635872   BI635981   BI636032   BI636212   BI636269   BI636448   BI636641   BI637023   BI637227   BI637754   BI638610   BI638673   BI638759   BI638766   BI639558   BI639685   BI639931   BI639933   BI640001   BI640322   BI640393   BI640695   BI640939   BI641677   BI641729   BI641784   BP541254   BP541659   BP542220   BP543600   BP543601   BP545595   BP546179   BP546280   BP546685   BP546904   BP547081   BP547121   BP547513   BP547560   BP548601   BP548608   BP550235   BP550236   BP550750   BP550751   BP551181   BP551182   BP551508   BP551509   BP552538   BP552638   BP552639   BP552665   BP552666   BP553865   BP553866   BP555419   BP555437   BP555438   BP556063   BP556064   BP556696   BP556697   BP558261   BP558262   BP559520   BP559521   BP559568   BQ102741   BQ102915   BQ103352   BX041475   BX042262   BX042441   BX043914   BX046841   BX047624   BX048099   BX048900   BX048967   BX049125   BX049455   BX050410   BX050588   BX050989   BX054268   BX055844   BX055982   BX056296   BX059928   BX063029   BX063114   BX064817   BX064881   BX066371   BX066938   BX067920   BX069297   BX069566   BX071491   CA804833   CA805544   CA805987   CA806068   CK086542   CK131390   CK131492   CK131689   CK135184   CK135356   CK604629   CK604630   CK604659   CK604660   CK605055   CK605056   CK605162   CK605163   CK656954   CK657565   CK657584   CK657670   CK658631   CK659129   CK659889   CK660594   CK661353   CK661524   CO153176   CO153209   CO153239   CO153533   CO153759   CO153795   CO154042   CO154400   CO154728   CO154740   CO154752   CO154930   CO155023   CO155377   CO155545   CO155619   CO155656   CO155868   CO155884   CO156283   CO156411   CO156461   CO157009   CO157030   CO178167   CO181911   CO182307   CO183215   CO183992   CO191874   CO194873   CO274452   CO275252   CO277107   CO277343   CO277515   CO280494   CO285715   CO286374   CO286435   CO287326   CO297518   CO297841   CO299130   CO299943   CO303450   CO305823   CO307317   CO314925   CO315498   CO317277   CO325034   CO335314   CO335336   CO335374   CO335468   CO335631   CO335679   CO335719   CO335801   CO336032   CO336836   CO336960   CO337040   CO337128   CO337176   CO337392   CO337479   CO337579   CO337858   CO338192   CO338550   CO338553   CO338609   CO338800   CO338801   DN154510   EC058103   EC058538   EC061289   EC073740   EC074461   EC078198   EC083140   EC084194   EC084827   EC088399   EC088955   EC090103   EC195981   EC197033   EC200183   EC200923   EC203485   EC208829   EC210684   EC218552   EC230483   EC237654   EC238382   EC238632   EC243429   EC243686   EC243962   EC248970   EC261156   EC261234   EC261319   EC261673   EC262250   EC262946   EC263323   EC263395   EC263433   EC263468   EC263701   EC263899   EC264247   EC264264   EC264340   EC264606   EC264671   EC264702   EC264973   EC265000   EC265511   EC265610   EC265787   EC265802   EC265886   EC265940   EC266040   EC266081   EC266254   EC266323   EC266628   EC266792   EC267000   EC267150   EC267224   EC267260   EC267297   EC267319   EC267389   EC267419   EC267438   EC267479   EC267680   EC267688   EC267820   EC267914   EC268032   EC268052   EL877203   EL877634   EL877879   EV574801   EV575667   EV576132   EV579118   EV579132   EV580131   EV580413   EV580956   EV580977   EV581601   EV581748   EV581764   EV581867   EV581994   EV582487   EV583426   EV583574   EV583695   EV584091   EV584687   EV584742   EV584814   EV584831   EV584903   EV585182   EV585596   EV586217   EV586661   EV587954   EV590355   EV590807   EV592686   EV592748   EV593037   EV593113   EV593299   EV594031   EV594036   EV594595   EV594687   EV595921   EV597604   EV597969   EV598021   EV599298   EV599346   EV599544   EV599592   EV600540   EV600659   GH750127   GH751191   GH754919   GH755428   GH755814   GH770178   GH772436   GH772604   GH778940   GH779015   GH782512   GH787304   GH791917   GH794878   GH796498   GH798569   GH799187   GH808744   GH814107   GH815814   GH816682   GH818068   GH830448   GH835815   GH837290   GH845746   GH846786   GH852546   GH857415   GH862932   GH877376   GH890396   GH900938   GH904023   GH915754   GH919794   GH929992   GH930500   GH931298   GH935879
UniProtKB/Swiss-Prot	Q8MLY8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2420.475 Larval Midgut    3249.1 Larval Hindgut    3637.9 Larval Malpighian Tubules    3927.9 Larval Fat Body    5939.7 Larval Salivary Gland    6854.1 Larval Trachea    6102.55 Larval Carcass    4083.275 Adult Head    4365.1 Adult Eye    6302.825 Adult Brain    3025.9 Adult Thoracic-Abdominal Ganglion    3613.6 Adult Crop    4881.7 Adult Midgut    4513.6 Adult Hindgut    4805.9 Adult Malpighian Tubules    2066.3 Adult Fat Body    4997.8 Adult Salivary Gland    9268.5 Adult Heart    6800.85 Adult VirginFemale Spermatheca    2073.2 Adult InseminatedFemale Spermatheca    2626.9 Adult Ovary    3013.1 Adult Testis    881.7 Adult Male Accessory Gland    7700.1 Adult Carcass    5026.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2420.475) Larval Midgut  (3249.1) Larval Hindgut  (3637.9) Larval Malpighian Tubules  (3927.9) Larval Fat Body  (5939.7) Larval Salivary Gland  (6854.1) Larval Trachea  (6102.55) Larval Carcass  (4083.275) Adult Head  (4365.1) Adult Eye  (6302.825) Adult Brain  (3025.9) Adult Thoracic-Abdominal Ganglion  (3613.6) Adult Crop  (4881.7) Adult Midgut  (4513.6) Adult Hindgut  (4805.9) Adult Malpighian Tubules  (2066.3) Adult Fat Body  (4997.8) Adult Salivary Gland  (9268.5) Adult Heart  (6800.85) Adult VirginFemale Spermatheca  (2073.2) Adult InseminatedFemale Spermatheca  (2626.9) Adult Ovary  (3013.1) Adult Testis  (881.7) Adult Male Accessory Gland  (7700.1) Adult Carcass  (5026.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2420.475) Larval Midgut  (3249.1) Larval Hindgut  (3637.9) Larval Malpighian Tubules  (3927.9) Larval Fat Body  (5939.7) Larval Salivary Gland  (6854.1) Larval Trachea  (6102.55) Larval Carcass  (4083.275) Adult Head  (4365.1) Adult Eye  (6302.825) Adult Brain  (3025.9) Adult Thoracic-Abdominal Ganglion  (3613.6) Adult Crop  (4881.7) Adult Midgut  (4513.6) Adult Hindgut  (4805.9) Adult Malpighian Tubules  (2066.3) Adult Fat Body  (4997.8) Adult Salivary Gland  (9268.5) Adult Heart  (6800.85) Adult VirginFemale Spermatheca  (2073.2) Adult InseminatedFemale Spermatheca  (2626.9) Adult Ovary  (3013.1) Adult Testis    881.7 Adult Male Accessory Gland  (7700.1) Adult Carcass  (5026.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2420.475 Larval Midgut    3249.1 Larval Hindgut    3637.9 Larval Malpighian Tubules    3927.9 Larval Fat Body    5939.7 Larval Salivary Gland    6854.1 Larval Trachea    6102.55 Larval Carcass    4083.275 Adult Head    4365.1 Adult Eye    6302.825 Adult Brain    3025.9 Adult Thoracic-Abdominal Ganglion    3613.6 Adult Crop    4881.7 Adult Midgut    4513.6 Adult Hindgut    4805.9 Adult Malpighian Tubules    2066.3 Adult Fat Body    4997.8 Adult Salivary Gland    9268.5 Adult Heart    6800.85 Adult VirginFemale Spermatheca    2073.2 Adult InseminatedFemale Spermatheca    2626.9 Adult Ovary    3013.1 Adult Testis    881.7 Adult Male Accessory Gland    7700.1 Adult Carcass    5026.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2420.475 Larval Midgut    3249.1 Larval Hindgut    3637.9 Larval Malpighian Tubules    3927.9 Larval Fat Body    5939.7 Larval Salivary Gland    6854.1 Larval Trachea    6102.55 Larval Carcass    4083.275 Adult Head    4365.1 Adult Eye    6302.825 Adult Brain    3025.9 Adult Thoracic-Abdominal Ganglion    3613.6 Adult Crop    4881.7 Adult Midgut    4513.6 Adult Hindgut    4805.9 Adult Malpighian Tubules    2066.3 Adult Fat Body    4997.8 Adult Salivary Gland    9268.5 Adult Heart    6800.85 Adult VirginFemale Spermatheca    2073.2 Adult InseminatedFemale Spermatheca    2626.9 Adult Ovary    3013.1 Adult Testis    881.7 Adult Male Accessory Gland    7700.1 Adult Carcass    5026.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2420.475) Larval Midgut  (3249.1) Larval Hindgut  (3637.9) Larval Malpighian Tubules  (3927.9) Larval Fat Body  (5939.7) Larval Salivary Gland  (6854.1) Larval Trachea  (6102.55) Larval Carcass  (4083.275) Adult Head  (4365.1) Adult Eye  (6302.825) Adult Brain  (3025.9) Adult Thoracic-Abdominal Ganglion  (3613.6) Adult Crop  (4881.7) Adult Midgut  (4513.6) Adult Hindgut  (4805.9) Adult Malpighian Tubules  (2066.3) Adult Fat Body  (4997.8) Adult Salivary Gland  (9268.5) Adult Heart  (6800.85) Adult VirginFemale Spermatheca  (2073.2) Adult InseminatedFemale Spermatheca  (2626.9) Adult Ovary  (3013.1) Adult Testis  (881.7) Adult Male Accessory Gland  (7700.1) Adult Carcass  (5026.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2420.475) Larval Midgut  (3249.1) Larval Hindgut  (3637.9) Larval Malpighian Tubules  (3927.9) Larval Fat Body  (5939.7) Larval Salivary Gland  (6854.1) Larval Trachea  (6102.55) Larval Carcass  (4083.275) Adult Head  (4365.1) Adult Eye  (6302.825) Adult Brain  (3025.9) Adult Thoracic-Abdominal Ganglion  (3613.6) Adult Crop  (4881.7) Adult Midgut  (4513.6) Adult Hindgut  (4805.9) Adult Malpighian Tubules  (2066.3) Adult Fat Body  (4997.8) Adult Salivary Gland  (9268.5) Adult Heart  (6800.85) Adult VirginFemale Spermatheca  (2073.2) Adult InseminatedFemale Spermatheca  (2626.9) Adult Ovary  (3013.1) Adult Testis    881.7 Adult Male Accessory Gland  (7700.1) Adult Carcass  (5026.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2420.475 Larval Midgut    3249.1 Larval Hindgut    3637.9 Larval Malpighian Tubules    3927.9 Larval Fat Body    5939.7 Larval Salivary Gland    6854.1 Larval Trachea    6102.55 Larval Carcass    4083.275 Adult Head    4365.1 Adult Eye    6302.825 Adult Brain    3025.9 Adult Thoracic-Abdominal Ganglion    3613.6 Adult Crop    4881.7 Adult Midgut    4513.6 Adult Hindgut    4805.9 Adult Malpighian Tubules    2066.3 Adult Fat Body    4997.8 Adult Salivary Gland    9268.5 Adult Heart    6800.85 Adult VirginFemale Spermatheca    2073.2 Adult InseminatedFemale Spermatheca    2626.9 Adult Ovary    3013.1 Adult Testis    881.7 Adult Male Accessory Gland    7700.1 Adult Carcass    5026.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4365.1   NA  Eye    6302.825   NA  Brain    3025.9   2420.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3613.6   NA  Crop    4881.7   3249.1  Midgut    4513.6   3637.9  Hindgut    4805.9   3927.9  Malpighian Tubules    2066.3   5939.7  Fat Body    4997.8   6854.1  Salivary Gland    9268.5   NA  Heart    6800.85   6102.55  Trachea    NA   NA  VirginFemale Spermatheca    2073.2   NA  InseminatedFemale Spermatheca    2626.9   NA  Ovary    3013.1   NA  Testis    881.7   NA  Male Accessory Gland    7700.1   4083.275  Carcass    5026.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    980 central nervous system, larvae L3    805 central nervous system, pupae P8    358 head, virgin 1-day female    400 head, virgin 4-day female    625 head, virgin 20-day female    699 head, mated 1-day female    404 head, mated 4-day female    555 head, mated 20-day female    588 head, mated 1-day male    358 head, mated 4-day male    372 head, mated 20-day male    488 salivary gland, larvae L3 wandering    303 salivary gland, white prepupae    687 digestive system, larvae L3 wandering    600 digestive system, 1-day adult    574 digestive system, 4-day adult    479 digestive system, 20-day adult    577 fat body, larvae L3 wandering    648 fat body, white prepupae    337 fat body, pupae P8    898 carcass, larvae L3 wandering    794 carcass, 1-day adult    441 carcass, 4-day adult    537 carcass, 20-day adult    679 ovary, virgin 4-day female    605 ovary, mated 4-day female    604 testis, mated 4-day male    288 accessory gland, mated 4-day male    551 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (980) central nervous system, larvae L3  (805) central nervous system, pupae P8  (358) head, virgin 1-day female  (400) head, virgin 4-day female  (625) head, virgin 20-day female  (699) head, mated 1-day female  (404) head, mated 4-day female  (555) head, mated 20-day female  (588) head, mated 1-day male  (358) head, mated 4-day male  (372) head, mated 20-day male  (488) salivary gland, larvae L3 wandering  (303) salivary gland, white prepupae  (687) digestive system, larvae L3 wandering  (600) digestive system, 1-day adult  (574) digestive system, 4-day adult  (479) digestive system, 20-day adult  (577) fat body, larvae L3 wandering  (648) fat body, white prepupae  (337) fat body, pupae P8  (898) carcass, larvae L3 wandering  (794) carcass, 1-day adult  (441) carcass, 4-day adult  (537) carcass, 20-day adult  (679) ovary, virgin 4-day female  (605) ovary, mated 4-day female  (604) testis, mated 4-day male  (288) accessory gland, mated 4-day male  (551) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (980) central nervous system, larvae L3  (805) central nervous system, pupae P8  (358) head, virgin 1-day female  (400) head, virgin 4-day female  (625) head, virgin 20-day female  (699) head, mated 1-day female  (404) head, mated 4-day female  (555) head, mated 20-day female  (588) head, mated 1-day male  (358) head, mated 4-day male  (372) head, mated 20-day male  (488) salivary gland, larvae L3 wandering  (303) salivary gland, white prepupae  (687) digestive system, larvae L3 wandering  (600) digestive system, 1-day adult  (574) digestive system, 4-day adult  (479) digestive system, 20-day adult  (577) fat body, larvae L3 wandering  (648) fat body, white prepupae  (337) fat body, pupae P8  (898) carcass, larvae L3 wandering  (794) carcass, 1-day adult  (441) carcass, 4-day adult  (537) carcass, 20-day adult  (679) ovary, virgin 4-day female  (605) ovary, mated 4-day female  (604) testis, mated 4-day male  (288) accessory gland, mated 4-day male  (551) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    980 central nervous system, larvae L3    805 central nervous system, pupae P8    358 head, virgin 1-day female    400 head, virgin 4-day female    625 head, virgin 20-day female    699 head, mated 1-day female    404 head, mated 4-day female    555 head, mated 20-day female    588 head, mated 1-day male    358 head, mated 4-day male    372 head, mated 20-day male    488 salivary gland, larvae L3 wandering    303 salivary gland, white prepupae    687 digestive system, larvae L3 wandering    600 digestive system, 1-day adult    574 digestive system, 4-day adult    479 digestive system, 20-day adult    577 fat body, larvae L3 wandering    648 fat body, white prepupae    337 fat body, pupae P8    898 carcass, larvae L3 wandering    794 carcass, 1-day adult    441 carcass, 4-day adult    537 carcass, 20-day adult    679 ovary, virgin 4-day female    605 ovary, mated 4-day female    604 testis, mated 4-day male    288 accessory gland, mated 4-day male    551 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    980 central nervous system, larvae L3    805 central nervous system, pupae P8    358 head, virgin 1-day female    400 head, virgin 4-day female    625 head, virgin 20-day female    699 head, mated 1-day female    404 head, mated 4-day female    555 head, mated 20-day female    588 head, mated 1-day male    358 head, mated 4-day male    372 head, mated 20-day male    488 salivary gland, larvae L3 wandering    303 salivary gland, white prepupae    687 digestive system, larvae L3 wandering    600 digestive system, 1-day adult    574 digestive system, 4-day adult    479 digestive system, 20-day adult    577 fat body, larvae L3 wandering    648 fat body, white prepupae    337 fat body, pupae P8    898 carcass, larvae L3 wandering    794 carcass, 1-day adult    441 carcass, 4-day adult    537 carcass, 20-day adult    679 ovary, virgin 4-day female    605 ovary, mated 4-day female    604 testis, mated 4-day male    288 accessory gland, mated 4-day male    551 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (980) central nervous system, larvae L3  (805) central nervous system, pupae P8  (358) head, virgin 1-day female  (400) head, virgin 4-day female  (625) head, virgin 20-day female  (699) head, mated 1-day female  (404) head, mated 4-day female  (555) head, mated 20-day female  (588) head, mated 1-day male  (358) head, mated 4-day male  (372) head, mated 20-day male  (488) salivary gland, larvae L3 wandering  (303) salivary gland, white prepupae  (687) digestive system, larvae L3 wandering  (600) digestive system, 1-day adult  (574) digestive system, 4-day adult  (479) digestive system, 20-day adult  (577) fat body, larvae L3 wandering  (648) fat body, white prepupae  (337) fat body, pupae P8  (898) carcass, larvae L3 wandering  (794) carcass, 1-day adult  (441) carcass, 4-day adult  (537) carcass, 20-day adult  (679) ovary, virgin 4-day female  (605) ovary, mated 4-day female  (604) testis, mated 4-day male  (288) accessory gland, mated 4-day male  (551) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (980) central nervous system, larvae L3  (805) central nervous system, pupae P8  (358) head, virgin 1-day female  (400) head, virgin 4-day female  (625) head, virgin 20-day female  (699) head, mated 1-day female  (404) head, mated 4-day female  (555) head, mated 20-day female  (588) head, mated 1-day male  (358) head, mated 4-day male  (372) head, mated 20-day male  (488) salivary gland, larvae L3 wandering  (303) salivary gland, white prepupae  (687) digestive system, larvae L3 wandering  (600) digestive system, 1-day adult  (574) digestive system, 4-day adult  (479) digestive system, 20-day adult  (577) fat body, larvae L3 wandering  (648) fat body, white prepupae  (337) fat body, pupae P8  (898) carcass, larvae L3 wandering  (794) carcass, 1-day adult  (441) carcass, 4-day adult  (537) carcass, 20-day adult  (679) ovary, virgin 4-day female  (605) ovary, mated 4-day female  (604) testis, mated 4-day male  (288) accessory gland, mated 4-day male  (551) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    980 central nervous system, larvae L3    805 central nervous system, pupae P8    358 head, virgin 1-day female    400 head, virgin 4-day female    625 head, virgin 20-day female    699 head, mated 1-day female    404 head, mated 4-day female    555 head, mated 20-day female    588 head, mated 1-day male    358 head, mated 4-day male    372 head, mated 20-day male    488 salivary gland, larvae L3 wandering    303 salivary gland, white prepupae    687 digestive system, larvae L3 wandering    600 digestive system, 1-day adult    574 digestive system, 4-day adult    479 digestive system, 20-day adult    577 fat body, larvae L3 wandering    648 fat body, white prepupae    337 fat body, pupae P8    898 carcass, larvae L3 wandering    794 carcass, 1-day adult    441 carcass, 4-day adult    537 carcass, 20-day adult    679 ovary, virgin 4-day female    605 ovary, mated 4-day female    604 testis, mated 4-day male    288 accessory gland, mated 4-day male    551 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2252 embryo 02-04hr    3269 embryo 04-06hr    3190 embryo 06-08hr    3565 embryo 08-10hr    3810 embryo 10-12hr    4756 embryo 12-14hr    2669 embryo 14-16hr    3769 embryo 16-18hr    2998 embryo 18-20hr    3563 embryo 20-22hr    3377 embryo 22-24hr    2702 larva L1    4449 larva L2    3664 larva L3 12hr old    3016 larva L3 puffstage 1-2    2446 larva L3 puffstage 3-6    2341 larva L3 puffstage 7-9    2322 white prepupae new    2156 white prepupae 12hr    1962 white prepupae 24hr    1744 pupae 2d postWPP    1571 pupae 3d postWPP    1329 pupae 4d postWPP    1666 adult male 01day    1185 adult male 05day    1267 adult male 30day    1321 adult female 01day    2820 adult female 05day    2451 adult female 30day    2660 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2252) embryo 02-04hr  (3269) embryo 04-06hr  (3190) embryo 06-08hr  (3565) embryo 08-10hr  (3810) embryo 10-12hr  (4756) embryo 12-14hr  (2669) embryo 14-16hr  (3769) embryo 16-18hr  (2998) embryo 18-20hr  (3563) embryo 20-22hr  (3377) embryo 22-24hr  (2702) larva L1  (4449) larva L2  (3664) larva L3 12hr old  (3016) larva L3 puffstage 1-2  (2446) larva L3 puffstage 3-6  (2341) larva L3 puffstage 7-9  (2322) white prepupae new  (2156) white prepupae 12hr  (1962) white prepupae 24hr  (1744) pupae 2d postWPP  (1571) pupae 3d postWPP  (1329) pupae 4d postWPP  (1666) adult male 01day  (1185) adult male 05day  (1267) adult male 30day  (1321) adult female 01day  (2820) adult female 05day  (2451) adult female 30day  (2660) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (2252) embryo 02-04hr  (3269) embryo 04-06hr  (3190) embryo 06-08hr  (3565) embryo 08-10hr  (3810) embryo 10-12hr  (4756) embryo 12-14hr  (2669) embryo 14-16hr  (3769) embryo 16-18hr  (2998) embryo 18-20hr  (3563) embryo 20-22hr  (3377) embryo 22-24hr  (2702) larva L1  (4449) larva L2  (3664) larva L3 12hr old  (3016) larva L3 puffstage 1-2  (2446) larva L3 puffstage 3-6  (2341) larva L3 puffstage 7-9  (2322) white prepupae new  (2156) white prepupae 12hr  (1962) white prepupae 24hr  (1744) pupae 2d postWPP  (1571) pupae 3d postWPP  (1329) pupae 4d postWPP  (1666) adult male 01day  (1185) adult male 05day  (1267) adult male 30day  (1321) adult female 01day  (2820) adult female 05day  (2451) adult female 30day  (2660) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2252 embryo 02-04hr    3269 embryo 04-06hr    3190 embryo 06-08hr    3565 embryo 08-10hr    3810 embryo 10-12hr    4756 embryo 12-14hr    2669 embryo 14-16hr    3769 embryo 16-18hr    2998 embryo 18-20hr    3563 embryo 20-22hr    3377 embryo 22-24hr    2702 larva L1    4449 larva L2    3664 larva L3 12hr old    3016 larva L3 puffstage 1-2    2446 larva L3 puffstage 3-6    2341 larva L3 puffstage 7-9    2322 white prepupae new    2156 white prepupae 12hr    1962 white prepupae 24hr    1744 pupae 2d postWPP    1571 pupae 3d postWPP    1329 pupae 4d postWPP    1666 adult male 01day    1185 adult male 05day    1267 adult male 30day    1321 adult female 01day    2820 adult female 05day    2451 adult female 30day    2660 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2252 embryo 02-04hr    3269 embryo 04-06hr    3190 embryo 06-08hr    3565 embryo 08-10hr    3810 embryo 10-12hr    4756 embryo 12-14hr    2669 embryo 14-16hr    3769 embryo 16-18hr    2998 embryo 18-20hr    3563 embryo 20-22hr    3377 embryo 22-24hr    2702 larva L1    4449 larva L2    3664 larva L3 12hr old    3016 larva L3 puffstage 1-2    2446 larva L3 puffstage 3-6    2341 larva L3 puffstage 7-9    2322 white prepupae new    2156 white prepupae 12hr    1962 white prepupae 24hr    1744 pupae 2d postWPP    1571 pupae 3d postWPP    1329 pupae 4d postWPP    1666 adult male 01day    1185 adult male 05day    1267 adult male 30day    1321 adult female 01day    2820 adult female 05day    2451 adult female 30day    2660 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2252) embryo 02-04hr  (3269) embryo 04-06hr  (3190) embryo 06-08hr  (3565) embryo 08-10hr  (3810) embryo 10-12hr  (4756) embryo 12-14hr  (2669) embryo 14-16hr  (3769) embryo 16-18hr  (2998) embryo 18-20hr  (3563) embryo 20-22hr  (3377) embryo 22-24hr  (2702) larva L1  (4449) larva L2  (3664) larva L3 12hr old  (3016) larva L3 puffstage 1-2  (2446) larva L3 puffstage 3-6  (2341) larva L3 puffstage 7-9  (2322) white prepupae new  (2156) white prepupae 12hr  (1962) white prepupae 24hr  (1744) pupae 2d postWPP  (1571) pupae 3d postWPP  (1329) pupae 4d postWPP  (1666) adult male 01day  (1185) adult male 05day  (1267) adult male 30day  (1321) adult female 01day  (2820) adult female 05day  (2451) adult female 30day  (2660) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (2252) embryo 02-04hr  (3269) embryo 04-06hr  (3190) embryo 06-08hr  (3565) embryo 08-10hr  (3810) embryo 10-12hr  (4756) embryo 12-14hr  (2669) embryo 14-16hr  (3769) embryo 16-18hr  (2998) embryo 18-20hr  (3563) embryo 20-22hr  (3377) embryo 22-24hr  (2702) larva L1  (4449) larva L2  (3664) larva L3 12hr old  (3016) larva L3 puffstage 1-2  (2446) larva L3 puffstage 3-6  (2341) larva L3 puffstage 7-9  (2322) white prepupae new  (2156) white prepupae 12hr  (1962) white prepupae 24hr  (1744) pupae 2d postWPP  (1571) pupae 3d postWPP  (1329) pupae 4d postWPP  (1666) adult male 01day  (1185) adult male 05day  (1267) adult male 30day  (1321) adult female 01day  (2820) adult female 05day  (2451) adult female 30day  (2660) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2252 embryo 02-04hr    3269 embryo 04-06hr    3190 embryo 06-08hr    3565 embryo 08-10hr    3810 embryo 10-12hr    4756 embryo 12-14hr    2669 embryo 14-16hr    3769 embryo 16-18hr    2998 embryo 18-20hr    3563 embryo 20-22hr    3377 embryo 22-24hr    2702 larva L1    4449 larva L2    3664 larva L3 12hr old    3016 larva L3 puffstage 1-2    2446 larva L3 puffstage 3-6    2341 larva L3 puffstage 7-9    2322 white prepupae new    2156 white prepupae 12hr    1962 white prepupae 24hr    1744 pupae 2d postWPP    1571 pupae 3d postWPP    1329 pupae 4d postWPP    1666 adult male 01day    1185 adult male 05day    1267 adult male 30day    1321 adult female 01day    2820 adult female 05day    2451 adult female 30day    2660 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1848 Schneider line 2 Sg4    1374 embryonic 1182-4H    1940 embryonic GM2    590 embryonic Kc167    939 embryonic S1    1389 embryonic S3    1062 leg disc CME L1    1738 wing disc CME-W2    1035 wing disc ML-DmD8    1639 wing disc ML-DmD9    1624 wing disc ML-DmD16-c3    1059 wing disc ML-DmD21    2878 wing disc ML-DmD32    1350 haltere disc ML-DmD17-c3    957 eye-antennal disc ML-DmD11    2106 antennal disc ML-DmD20-c5    2237 mixed discs ML-DmD4-c1    1480 CNS ML-DmBG1-c1    1455 CNS ML-DmBG2-c2    960 tumorous blood cells mbn2    1008 ovary fGS/OSS    1132 ovary OSC    554 ovary OSS    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (1848) Schneider line 2 Sg4  (1374) embryonic 1182-4H  (1940) embryonic GM2  (590) embryonic Kc167  (939) embryonic S1  (1389) embryonic S3  (1062) leg disc CME L1  (1738) wing disc CME-W2  (1035) wing disc ML-DmD8  (1639) wing disc ML-DmD9  (1624) wing disc ML-DmD16-c3  (1059) wing disc ML-DmD21  (2878) wing disc ML-DmD32  (1350) haltere disc ML-DmD17-c3  (957) eye-antennal disc ML-DmD11  (2106) antennal disc ML-DmD20-c5  (2237) mixed discs ML-DmD4-c1  (1480) CNS ML-DmBG1-c1  (1455) CNS ML-DmBG2-c2  (960) tumorous blood cells mbn2  (1008) ovary fGS/OSS  (1132) ovary OSC  (554) ovary OSS  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (1848) Schneider line 2 Sg4  (1374) embryonic 1182-4H  (1940) embryonic GM2  (590) embryonic Kc167  (939) embryonic S1  (1389) embryonic S3  (1062) leg disc CME L1  (1738) wing disc CME-W2  (1035) wing disc ML-DmD8  (1639) wing disc ML-DmD9  (1624) wing disc ML-DmD16-c3  (1059) wing disc ML-DmD21  (2878) wing disc ML-DmD32  (1350) haltere disc ML-DmD17-c3  (957) eye-antennal disc ML-DmD11  (2106) antennal disc ML-DmD20-c5  (2237) mixed discs ML-DmD4-c1  (1480) CNS ML-DmBG1-c1  (1455) CNS ML-DmBG2-c2  (960) tumorous blood cells mbn2  (1008) ovary fGS/OSS  (1132) ovary OSC  (554) ovary OSS  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1848 Schneider line 2 Sg4    1374 embryonic 1182-4H    1940 embryonic GM2    590 embryonic Kc167    939 embryonic S1    1389 embryonic S3    1062 leg disc CME L1    1738 wing disc CME-W2    1035 wing disc ML-DmD8    1639 wing disc ML-DmD9    1624 wing disc ML-DmD16-c3    1059 wing disc ML-DmD21    2878 wing disc ML-DmD32    1350 haltere disc ML-DmD17-c3    957 eye-antennal disc ML-DmD11    2106 antennal disc ML-DmD20-c5    2237 mixed discs ML-DmD4-c1    1480 CNS ML-DmBG1-c1    1455 CNS ML-DmBG2-c2    960 tumorous blood cells mbn2    1008 ovary fGS/OSS    1132 ovary OSC    554 ovary OSS    333 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1848 Schneider line 2 Sg4    1374 embryonic 1182-4H    1940 embryonic GM2    590 embryonic Kc167    939 embryonic S1    1389 embryonic S3    1062 leg disc CME L1    1738 wing disc CME-W2    1035 wing disc ML-DmD8    1639 wing disc ML-DmD9    1624 wing disc ML-DmD16-c3    1059 wing disc ML-DmD21    2878 wing disc ML-DmD32    1350 haltere disc ML-DmD17-c3    957 eye-antennal disc ML-DmD11    2106 antennal disc ML-DmD20-c5    2237 mixed discs ML-DmD4-c1    1480 CNS ML-DmBG1-c1    1455 CNS ML-DmBG2-c2    960 tumorous blood cells mbn2    1008 ovary fGS/OSS    1132 ovary OSC    554 ovary OSS    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (1848) Schneider line 2 Sg4  (1374) embryonic 1182-4H  (1940) embryonic GM2  (590) embryonic Kc167  (939) embryonic S1  (1389) embryonic S3  (1062) leg disc CME L1  (1738) wing disc CME-W2  (1035) wing disc ML-DmD8  (1639) wing disc ML-DmD9  (1624) wing disc ML-DmD16-c3  (1059) wing disc ML-DmD21  (2878) wing disc ML-DmD32  (1350) haltere disc ML-DmD17-c3  (957) eye-antennal disc ML-DmD11  (2106) antennal disc ML-DmD20-c5  (2237) mixed discs ML-DmD4-c1  (1480) CNS ML-DmBG1-c1  (1455) CNS ML-DmBG2-c2  (960) tumorous blood cells mbn2  (1008) ovary fGS/OSS  (1132) ovary OSC  (554) ovary OSS  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (1848) Schneider line 2 Sg4  (1374) embryonic 1182-4H  (1940) embryonic GM2  (590) embryonic Kc167  (939) embryonic S1  (1389) embryonic S3  (1062) leg disc CME L1  (1738) wing disc CME-W2  (1035) wing disc ML-DmD8  (1639) wing disc ML-DmD9  (1624) wing disc ML-DmD16-c3  (1059) wing disc ML-DmD21  (2878) wing disc ML-DmD32  (1350) haltere disc ML-DmD17-c3  (957) eye-antennal disc ML-DmD11  (2106) antennal disc ML-DmD20-c5  (2237) mixed discs ML-DmD4-c1  (1480) CNS ML-DmBG1-c1  (1455) CNS ML-DmBG2-c2  (960) tumorous blood cells mbn2  (1008) ovary fGS/OSS  (1132) ovary OSC  (554) ovary OSS  (333) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1848 Schneider line 2 Sg4    1374 embryonic 1182-4H    1940 embryonic GM2    590 embryonic Kc167    939 embryonic S1    1389 embryonic S3    1062 leg disc CME L1    1738 wing disc CME-W2    1035 wing disc ML-DmD8    1639 wing disc ML-DmD9    1624 wing disc ML-DmD16-c3    1059 wing disc ML-DmD21    2878 wing disc ML-DmD32    1350 haltere disc ML-DmD17-c3    957 eye-antennal disc ML-DmD11    2106 antennal disc ML-DmD20-c5    2237 mixed discs ML-DmD4-c1    1480 CNS ML-DmBG1-c1    1455 CNS ML-DmBG2-c2    960 tumorous blood cells mbn2    1008 ovary fGS/OSS    1132 ovary OSC    554 ovary OSS    333 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    847 cold shock, 4-day adult    692 heat shock, 4-day adult    753 Cadmium 50 mM 6 hrs, larvae L3    887 Cadmium 50 mM 12 hrs, larvae L3    820 Cadmium 50 mM 48 hrs, 4-day adult    637 Cadmium 100 mM 48 hrs, 4-day adult    709 Copper 0.5 mM 12 hrs, larvae L3    756 Copper 15 mM 48 hrs, 4-day adult    421 Zinc 5 mM 12 hrs, larvae L3    699 Zinc 4.5 mM 48 hrs, 4-day adult    345 Ethanol 2.5% 3 hrs, larvae L3    895 Ethanol 5% 3 hrs, larvae L3    827 Ethanol 10% 3 hrs, larvae L3    885 Caffeine 1.5 mg/ml 4 hrs, larvae L3    854 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    787 Caffeine 25 mg/ml 48 hrs, 4-day adult    468 Paraquat 5 mM 48 hrs, 4-day adult    727 Paraquat 10 mM 48 hrs, 4-day adult    801 Rotenone 2 μg 12 hrs, larvae L3    892 Rotenone 8 μg 12 hrs, larvae L3    1199 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (847) cold shock, 4-day adult  (692) heat shock, 4-day adult  (753) Cadmium 50 mM 6 hrs, larvae L3  (887) Cadmium 50 mM 12 hrs, larvae L3  (820) Cadmium 50 mM 48 hrs, 4-day adult  (637) Cadmium 100 mM 48 hrs, 4-day adult  (709) Copper 0.5 mM 12 hrs, larvae L3  (756) Copper 15 mM 48 hrs, 4-day adult  (421) Zinc 5 mM 12 hrs, larvae L3  (699) Zinc 4.5 mM 48 hrs, 4-day adult  (345) Ethanol 2.5% 3 hrs, larvae L3  (895) Ethanol 5% 3 hrs, larvae L3  (827) Ethanol 10% 3 hrs, larvae L3  (885) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (854) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (787) Caffeine 25 mg/ml 48 hrs, 4-day adult  (468) Paraquat 5 mM 48 hrs, 4-day adult  (727) Paraquat 10 mM 48 hrs, 4-day adult  (801) Rotenone 2 μg 12 hrs, larvae L3  (892) Rotenone 8 μg 12 hrs, larvae L3  (1199) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (847) cold shock, 4-day adult  (692) heat shock, 4-day adult  (753) Cadmium 50 mM 6 hrs, larvae L3  (887) Cadmium 50 mM 12 hrs, larvae L3  (820) Cadmium 50 mM 48 hrs, 4-day adult  (637) Cadmium 100 mM 48 hrs, 4-day adult  (709) Copper 0.5 mM 12 hrs, larvae L3  (756) Copper 15 mM 48 hrs, 4-day adult  (421) Zinc 5 mM 12 hrs, larvae L3  (699) Zinc 4.5 mM 48 hrs, 4-day adult  (345) Ethanol 2.5% 3 hrs, larvae L3  (895) Ethanol 5% 3 hrs, larvae L3  (827) Ethanol 10% 3 hrs, larvae L3  (885) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (854) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (787) Caffeine 25 mg/ml 48 hrs, 4-day adult  (468) Paraquat 5 mM 48 hrs, 4-day adult  (727) Paraquat 10 mM 48 hrs, 4-day adult  (801) Rotenone 2 μg 12 hrs, larvae L3  (892) Rotenone 8 μg 12 hrs, larvae L3  (1199) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    847 cold shock, 4-day adult    692 heat shock, 4-day adult    753 Cadmium 50 mM 6 hrs, larvae L3    887 Cadmium 50 mM 12 hrs, larvae L3    820 Cadmium 50 mM 48 hrs, 4-day adult    637 Cadmium 100 mM 48 hrs, 4-day adult    709 Copper 0.5 mM 12 hrs, larvae L3    756 Copper 15 mM 48 hrs, 4-day adult    421 Zinc 5 mM 12 hrs, larvae L3    699 Zinc 4.5 mM 48 hrs, 4-day adult    345 Ethanol 2.5% 3 hrs, larvae L3    895 Ethanol 5% 3 hrs, larvae L3    827 Ethanol 10% 3 hrs, larvae L3    885 Caffeine 1.5 mg/ml 4 hrs, larvae L3    854 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    787 Caffeine 25 mg/ml 48 hrs, 4-day adult    468 Paraquat 5 mM 48 hrs, 4-day adult    727 Paraquat 10 mM 48 hrs, 4-day adult    801 Rotenone 2 μg 12 hrs, larvae L3    892 Rotenone 8 μg 12 hrs, larvae L3    1199 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    847 cold shock, 4-day adult    692 heat shock, 4-day adult    753 Cadmium 50 mM 6 hrs, larvae L3    887 Cadmium 50 mM 12 hrs, larvae L3    820 Cadmium 50 mM 48 hrs, 4-day adult    637 Cadmium 100 mM 48 hrs, 4-day adult    709 Copper 0.5 mM 12 hrs, larvae L3    756 Copper 15 mM 48 hrs, 4-day adult    421 Zinc 5 mM 12 hrs, larvae L3    699 Zinc 4.5 mM 48 hrs, 4-day adult    345 Ethanol 2.5% 3 hrs, larvae L3    895 Ethanol 5% 3 hrs, larvae L3    827 Ethanol 10% 3 hrs, larvae L3    885 Caffeine 1.5 mg/ml 4 hrs, larvae L3    854 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    787 Caffeine 25 mg/ml 48 hrs, 4-day adult    468 Paraquat 5 mM 48 hrs, 4-day adult    727 Paraquat 10 mM 48 hrs, 4-day adult    801 Rotenone 2 μg 12 hrs, larvae L3    892 Rotenone 8 μg 12 hrs, larvae L3    1199 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (847) cold shock, 4-day adult  (692) heat shock, 4-day adult  (753) Cadmium 50 mM 6 hrs, larvae L3  (887) Cadmium 50 mM 12 hrs, larvae L3  (820) Cadmium 50 mM 48 hrs, 4-day adult  (637) Cadmium 100 mM 48 hrs, 4-day adult  (709) Copper 0.5 mM 12 hrs, larvae L3  (756) Copper 15 mM 48 hrs, 4-day adult  (421) Zinc 5 mM 12 hrs, larvae L3  (699) Zinc 4.5 mM 48 hrs, 4-day adult  (345) Ethanol 2.5% 3 hrs, larvae L3  (895) Ethanol 5% 3 hrs, larvae L3  (827) Ethanol 10% 3 hrs, larvae L3  (885) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (854) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (787) Caffeine 25 mg/ml 48 hrs, 4-day adult  (468) Paraquat 5 mM 48 hrs, 4-day adult  (727) Paraquat 10 mM 48 hrs, 4-day adult  (801) Rotenone 2 μg 12 hrs, larvae L3  (892) Rotenone 8 μg 12 hrs, larvae L3  (1199) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (847) cold shock, 4-day adult  (692) heat shock, 4-day adult  (753) Cadmium 50 mM 6 hrs, larvae L3  (887) Cadmium 50 mM 12 hrs, larvae L3  (820) Cadmium 50 mM 48 hrs, 4-day adult  (637) Cadmium 100 mM 48 hrs, 4-day adult  (709) Copper 0.5 mM 12 hrs, larvae L3  (756) Copper 15 mM 48 hrs, 4-day adult  (421) Zinc 5 mM 12 hrs, larvae L3  (699) Zinc 4.5 mM 48 hrs, 4-day adult  (345) Ethanol 2.5% 3 hrs, larvae L3  (895) Ethanol 5% 3 hrs, larvae L3  (827) Ethanol 10% 3 hrs, larvae L3  (885) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (854) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (787) Caffeine 25 mg/ml 48 hrs, 4-day adult  (468) Paraquat 5 mM 48 hrs, 4-day adult  (727) Paraquat 10 mM 48 hrs, 4-day adult  (801) Rotenone 2 μg 12 hrs, larvae L3  (892) Rotenone 8 μg 12 hrs, larvae L3  (1199) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    847 cold shock, 4-day adult    692 heat shock, 4-day adult    753 Cadmium 50 mM 6 hrs, larvae L3    887 Cadmium 50 mM 12 hrs, larvae L3    820 Cadmium 50 mM 48 hrs, 4-day adult    637 Cadmium 100 mM 48 hrs, 4-day adult    709 Copper 0.5 mM 12 hrs, larvae L3    756 Copper 15 mM 48 hrs, 4-day adult    421 Zinc 5 mM 12 hrs, larvae L3    699 Zinc 4.5 mM 48 hrs, 4-day adult    345 Ethanol 2.5% 3 hrs, larvae L3    895 Ethanol 5% 3 hrs, larvae L3    827 Ethanol 10% 3 hrs, larvae L3    885 Caffeine 1.5 mg/ml 4 hrs, larvae L3    854 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    787 Caffeine 25 mg/ml 48 hrs, 4-day adult    468 Paraquat 5 mM 48 hrs, 4-day adult    727 Paraquat 10 mM 48 hrs, 4-day adult    801 Rotenone 2 μg 12 hrs, larvae L3    892 Rotenone 8 μg 12 hrs, larvae L3    1199 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_22 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • RH06886 SD17528 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039713 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7808-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal RpS8GD12288 lethal, with Scer\GAL4pnr-MD237 RpS8GD12288 lethal | pupal stage, with Scer\GAL4pnr-MD237 RpS8GD12288 Other Phenotypes Allele neuroanatomy defective | larval stage RpS8GD12288 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage RpS8GD12288 ganglion mother cell | larval stage RpS8GD12288
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of RpS8 Class Mutagen Stocks Known lesion RpS8DP01446 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpS8 Class Mutagen Stocks Known lesion RpS8GD12288 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RpS8KK108882 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpS8NIG.7808R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12288} NA P{KK108882} NA P{NIG.7808R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}RpS8DP01446 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from direct assay (Alonso and Santaren, 2006)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from biological aspect of ancestor with PANTHER:PTN000044490 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity (Liang and Biggin, 1998) inferred from sequence or structural similarity with NCBI_gi:4506743 (FlyBase, 1992-)
Biological Process
CV term Evidence References
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) inferred from biological aspect of ancestor with PANTHER:PTN000044490 (assigned by RefGenome) (Gaudet et al., 2010) translation inferred from sequence or structural similarity (Liang and Biggin, 1998) inferred from sequence or structural similarity with NCBI_gi:4506743 (FlyBase, 1992-) translational elongation inferred from biological aspect of ancestor with PANTHER:PTN000044490 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
cytosolic small ribosomal subunit inferred from biological aspect of ancestor with PANTHER:PTN000044490 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity (Liang and Biggin, 1998) inferred from sequence or structural similarity with NCBI_gi:4506743 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpS8 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68391 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039713 DroID - A comprehensive database of gene and protein interactions. • FBgn0039713 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43532
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6STSR1 Dipteran inclusive ortholog search EOG6MCX8J Insect inclusive ortholog search EOG6189JK Arthropod inclusive ortholog search EOG64TMR1 Metazoa inclusive ortholog search EOG6RZ9TQ
Orthologs in Drosophila Species (EOG6STSR1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RpS8     Drosophila simulans   Dsim\GD21475 Y   Drosophila sechellia   Dsec\GM12832 Y   Drosophila erecta   Dere\GG11702 Y   Drosophila yakuba   Dyak\GE23892 Y   Drosophila ananassae   Dana\GF18798 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20600 Y   Drosophila persimilis   Dper\GL10840     Drosophila persimilis   Dper\GL14033 Y   Drosophila willistoni   Dwil\GK13918 Y   Drosophila virilis   Dvir\GJ10625 Y   Drosophila mojavensis   Dmoj\GI10411 Y   Drosophila grimshawi   Dgri\GH14312 Y
Orthologs in non-Drosophila Dipterans (EOG6MCX8J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008103   Anopheles gambiae Malaria mosquito  Agam\AGAP002437   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011589
Orthologs in non-Dipteran Insects (EOG6189JK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Rps8   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007413   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18108   Atta cephalotes Leafcutter ant  Acep\ACEP19408   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12979   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15706   Linepithema humile Argentine ant  Lhum\LH21772   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21290   Acyrthosiphon pisum Pea aphid  Apim\ACYPI083436   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001578   Bombyx mori Silkmoth  Bmor\RpS8   Pediculus humanus Human body louse  Phum\PHUM212320   Tribolium castaneum Red flour beetle  Tcas\TC014757
Orthologs in non-Insect Arthropods (EOG64TMR1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303431   Ixodes scapularis Deer tick  Isca\ISCW015393
Orthologs in non-Arthropod Metazoa (EOG6RZ9TQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rps-8   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018866gn   Danio rerio Zebrafish  Drer\LOC100000836   Danio rerio Zebrafish  Drer\rps8   Xenopus tropicalis Western clawed frog  Xtro\rps8   Gallus gallus Domestic chicken  Ggal\RPS8   Mus musculus House mouse  Mmus\Gm5121   Mus musculus House mouse  Mmus\Rps8   Mus musculus House mouse  Mmus\Rps8-ps1   Mus musculus House mouse  Mmus\Gm11353   Rattus norvegicus Norway rat  Rnor\Rps8   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000001318   Rattus norvegicus Norway rat  Rnor\RGD1566369   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000012859   Rattus norvegicus Norway rat  Rnor\LOC297756   Homo sapiens Human  Hsap\RPS8
Human Orthologs (1)
Gene OMIM HGNC Hsap\RPS8
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21475 Drosophila sechellia Dsec\GM12832 Drosophila erecta Dere\GG11702 Drosophila yakuba Dyak\GE23892 Drosophila ananassae Dana\GF18798 Drosophila pseudoobscura pseudoobscura Dpse\GA20600 Drosophila persimilis Dper\GL14033 Drosophila willistoni Dwil\GK13918 Drosophila virilis Dvir\GJ10625 Drosophila mojavensis Dmoj\GI10411 Drosophila grimshawi Dgri\GH14312
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	22076 y1 w67c23; P{Mae-UAS.6.11}RpS8DP01446
VDRC	v106835 P{KK108882}VIE-260B v35277 w1118; P{GD12288}v35277 v35278 w1118; P{GD12288}v35278/CyO
Genomic Clones ( 1 )
	BACR02E15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 802 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH06886 SD17528
Other clones	yak-ad_CG7808 yak-em_CG7808
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT28583 GH03687 GH04990 GH06515 GH06618 GH09461 GH13869 GH19560 GH20791 GM03549 GM10168 GM10494 GM13321 GM13439 GM16662 GM16874 GM19658 GM25264 GM26386 GM27278 GM28089 GM28317 GM28689 GM28690 GM29140 GM29170 GM30131 GM30137 GM32507 GM32572 LD02832 LD05819 LD35682 LP01174 LP01382 LP03064 LP05087 LP05336 LP06112 LP06424 LP06576 LP09093 LP09691 LP09842 LP09976 LP10277 LP11006 LP11376 LP12665 LP15712 LP19288 LP20794 LP22830 LP24160 RE37670 RH38464 RH38765 RH42089 RH46840 RH46861 RH46870 RH47313 RH47764 RH47915 RH47919 RH49302 RH49315 RH49895 RH50820 RH50965 RH51222 RH51416 RH51441 RH51682 RH52279 RH52574 RH52746 RH52870 RH52932 RH52972 RH53007 RH53292 RH54012 RH54030 RH54338 RH54475 RH54538 RH54544 RH54934 RH55352 RH55474 RH55779 RH56722 RH56844 RH57584 RH57662 RH57990 RH58769 RH59046 RH59289 RH59955 RH60415 RH60573 RH60956 RH61138 RH63833 RH64086 RH64257 RH64767 RH64771 RH64824 RH64978 RH65170 RH66071 RH66146 RH66570 RH67442 RH67468 RH68135 RH68428 RH68812 RH69466 SD09069 SD11978 SD12474 SD12712 SD13475 SD15565 SD15853 SD15954 SD17388 SD17404 SD17533 SD17593 SD17901 SD18384 SD21027 SD21131 SD21138 SD22335 SD22654 SD22751 SD23148 SD23234 SD25406
Other clones	1640 7080 12762 19624 31452 39949 41752 50934 57116 61441 67366 118973 121334 146873 148616 158943 163541 165535 181750 521776 522128 522202 522523 522775 522809 522832 523073 523661 524059 524069 524083 524262 524350 524792 525056 525435 525672 525793 527823 527947 528024 533558 533813 533947 533993 534019 542567 542617 542662 542746 558043 561896 562018 562098 562191 562246 569056 569147 569257 569711 569713 571136 572787 572790 572842 575672 575674 AA433187 AT16362 AT16693 bs66g04 CK01.62A.G9 CK01.69C.E6 CK01.77C.G8 CK01.81A.C2 CK01.81B.F3 CK01.110B.D7 CK01.141A.E7 Dmel_dig_000212_0683_3705 Dmel_dig_000559_0622_3663 Dmel_dig_000761_0676_1959 Dmel_dig_002309_0625_0429 Dmel_dig_003026_0658_2101 Dmel_dig_005100_0686_1453 Dmel_dig_005557_0636_0283 Dmel_dig_007547_0661_2261 Dmel_dig_007908_0701_1764 Dmel_dig_008004_0622_0299 Dmel_dig_008340_0677_2563 Dmel_dig_008386_0602_1279 Dmel_dig_009036_0676_2230 Dmel_dig_009072_0710_1807 Dmel_dig_010131_0639_1294 Dmel_dig_012651_0681_1972 Dmel_dig_013360_0656_1313 Dmel_dig_014576_0716_0492 Dmel_dig_014743_0623_1448 Dmel_dig_014783_0637_0739 Dmel_dig_015761_0593_1650 Dmel_dig_016537_0583_2976 Dmel_dig_017194_0581_2720 Dmel_dig_017238_0602_0612 Dmel_dig_018621_0614_3260 Dmel_dig_018649_0651_1820 Dmel_dig_018662_0705_0560 Dmel_neb_005050_0585_0669 Dmel_neb_007723_0638_3541 Dmel_neb_009571_0824_2188 Dmel_neb_009892_0680_1308 Dmel_neb_010057_0933_0634 Dmel_neb_010630_0690_2540 Dmel_neb_011417_0332_2980 Dmel_neb_011600_0379_2676 Dmel_neb_011885_0824_2447 Dmel_neb_012078_0109_1790 Dmel_neb_012126_0884_1029 Dmel_neb_012244_0588_3028 Dmel_neb_012446_0901_0266 Dmel_neb_013029_0095_1282 Dmel_neb_013385_0829_2153 Dmel_neb_013562_0860_2291 Dmel_neb_014230_0702_0552 Dmel_neb_014276_0601_3365 Dmel_neb_014670_0699_0708 Dmel_neb_014967_0689_3393 Dmel_neb_015499_0606_1032 Dmel_neb_015581_0859_3295 Dmel_neb_016000_0859_3382 EC15653 EC22424 EC25085 EC26853 EC32319 EC39406 EC243429 EK055551 EK060460 EK062641 EK062822 EK065551 EK114157 EK116920 EK122953 EK123906 EK125354 EK154210 EK170008 EK170649 EK174606 EK176949 EK195434 EK238410 EK241459 EK249514 EK254336 EK261658 EK267611 EN01425 EN01507 EN01543 EN02311 EN02750 EN02835 EN03348 EN04046 EN04661 EN04713 EN04728 EN05043 EN05223 EN05934 EN06306 EN06433 EN06517 EN06903 EN06922 EN07738 EN08019 EN08116 EN09741 EN09803 EN10011 EN10043 EN10220 EN10512 EN10854 EN10955 EN11048 EN11234 EN11706 EN12861 EN13333 EN13547 EN13715 EN13862 EN13958 EN14444 EN14629 EN14837 EN15437 EN16145 EN17050 EN17053 EN17159 EN17633 EN17635 ESG0115b.B21_G06 ESG0118c.B21_G02 ESG0120c.B21_D10 ESG0120d.B21_F03 FGA011H08 FGC004A07 FGC010D09 FGC021D02 FGC032B07 FGH103F08 FGH104G02 FGH109A07 FGH111D02 FGH113C02 FGH113F06 FGH117G05 FGH118C04 FGH129E07 FGH129F03 FGM206A07 FGM208H07 FGM211D10 FGM213C05 FGM219C12 FGM219H08 FGM220A11 FGM226F12 FGM235B09 FGM235C07 FGM301B12 FGM305A07 FGM314A02 FGM321D07 FGM321F08 GH04188 GH05523 GH25493 GH28672 GM01202 GM01229 GM02677 GM03034 GM03046 GM03242 GM03968 GM04030 GM07574 GM09016 GM10212 GM10347 GM10432 GM10517 GM14187 GM15131 GM15895 GM17828 GM19283 GM19413 GM19488 GM21618 GM22139 GM22482 GM23032 GM23770 GM24294 GM24471 GM24720 GM25196 GM26049 GM26379 GM26749 GM27079 GM27782 GM29174 GM29443 GM30194 GM31663 IP07144 IP07625 IP07827 LD05163 LD05904 LD08426 LD10064 LD10842 LD12945 LD25909 LD34827 LD36084 LP03460 LP05289 LP08629 LP09229 LP16659 LP18009 LP21092 LP23968 LP24001 RE01608 RE04651 RE09279 RE12174 RE12175 RE14091 RE14146 RE16134 RE18730 RE18892 RE19834 RE21012 RE21422 RE23143 RE24526 RE29648 RE30610 RE32683 RE32933 RE33045 RE33982 RE34303 RE35860 RE39466 RE40341 RE40878 RE42981 RE44069 RE44129 RE45583 RE47274 RE47315 RE48158 RE48460 RE48970 RE49629 RE50158 RE50308 RE50492 RE50870 RE51805 RE51814 RE53692 RE54026 RE54839 RE58215 RE58365 RE59185 RE59970 RE63365 RE63536 RE63545 RE64134 RE64687 RE64689 RE64909 RE64929 RE66330 RE67549 RE68253 RE68787 RE69433 RE69841 RE69914 RE70264 RE71569 RE71596 RE72553 RE75072 RE75090 RH01035 RH01139 RH01217 RH01514 RH01558 RH01593 RH01726 RH01802 RH01888 RH01902 RH01978 RH02040 RH02135 RH02443 RH02533 RH02793 RH02973 RH03178 RH03183 RH03196 RH03258 RH03275 RH03403 RH03431 RH03482 RH03522 RH03602 RH03709 RH03874 RH04227 RH04576 RH05163 RH05261 RH05270 RH05277 RH05750 RH05819 RH07081 RH07146 RH07220 RH07229 RH07244 RH07384 RH07659 RH07813 RH07822 RH07879 RH07892 RH07896 RH08540 RH08826 RH09092 RH09190 RH09437 RH09575 RH09587 RH09594 RH09981 RH10636 RH10856 RH10932 RH11074 RH11120 RH12046 RH12071 RH12074 RH12371 RH12373 RH13007 RH13040 RH13668 RH13775 RH13831 RH14018 RH15108 RH15323 RH15923 RH17118 RH18294 RH18689 RH19119 RH19258 RH19289 RH19713 RH19768 RH20042 RH20114 RH20236 RH20444 RH21272 RH21706 RH21813 RH22426 RH22663 RH22856 RH23529 RH24940 RH25129 RH25845 RH26091 RH26243 RH26540 RH26575 RH27393 RH28016 RH28047 RH28157 RH28171 RH28712 RH28908 RH29061 RH29803 RH30038 RH30626 RH30654 RH30790 RH30940 RH31050 RH31583 RH32165 RH32866 RH33024 RH33025 RH33034 RH33391 RH33471 RH34225 RH34341 RH35532 RH35644 RH35838 RH35855 RH35986 RH36083 RH36095 RH36283 RH36439 RH36757 RH37119 RH37129 RH37139 RH37246 RH38170 RH39504 RH41320 RH41662 RH41969 RH41982 RH42332 RH42510 RH42622 RH42760 RH42920 RH43045 RH43541 RH43769 RH44358 RH44414 RH44431 RH44517 RH44596 RH44738 RH45089 RH45309 RH45329 RH46286 RH51830 RH52085 RH55854 RH58955 RH58985 RH60357 RH61770 RH62355 RH62895 RH63547 RH64609 RH69316 RH69547 RH70768 RH70830 RH70834 RH70868 RH71063 RH71532 RH71552 RH71846 RH71890 RH72066 RH72996 RH73291 RH73507 RH73779 RH73996 RH74374 RP003025411 RP003030125 RP003070003 RP003077153 RP003077247 RP003078470 RP003080104 RP003095527 RP003111769 RP003143220 RP003167563 RP003170677 RP003177939 RP003204217 RP003217941 RP003233730 RP003239750 RP003252304 RP003252570 RP003253812 RP003268837 RP003291188 RP003325076 RP003360580 RP003369915 RP003437028 RP003443822 RP003461908 RP003461913 RP003468201 RP003482145 RP003505656 RP003552281 RP003552579 RP003573133 RP003576338 RP003610395 RP003611617 RP003615873 RP003627803 SD03877 SD04052 SD04066 SD06769 SD07426 SD10253 SD11083 SD11092 SD11213 SD11225 SD11430 SD12958 SD13072 SD13137 SD13268 SD14584 SD14887 SD14981 SD15411 SD15744 SD17258 SD17826 SD18131 SD18907 SD19178 SD19823 SD20946 SD22170 SD22656 SD23666 SD23975 SD25209 SD25306 SD25883 SD26292 SD26301 SD26912 SD27155 UT01337 UT01356 UT01647 UT01725 UUGC0309 UUGC0755
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039713 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43532
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG7808 anon-EST:fe1A2 (Bayraktaroglu, 2000.11.2) Source for merge of: CG7808 BcDNA:RH06886 (FlyBase, 1996-) Source for merge of: RpS8 anon-EST:Liang-1.56 (FlyBase, 1996-)
Additional comments	"RpS8" likely corresponds to "M(3)99B". (Marygold et al., 2007) May correspond to M(3)99B. (Cook, 2006.1.31) Source for merge of CG7808 BcDNA:RH06886 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of RpS8 anon-EST:Liang-1.56 was sequence comparison (date:040623). (FlyBase, 1996-)
Other Comments
	Haploinsufficient locus. (Cook et al., 2012) Likely Minute gene. (Marygold et al., 2007) RpS8 lies in a gap in deletion coverage. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Identified with: SD17528 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>. (BDGP Project Members, 2000-) EST SD17528 is chimeric; the 5' portion matches part of AE on the opposite strand to Glt, the 3' portion corresponds to part of RpS8. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143483 NM_001260433 RefSeq (Proteins) • NP_651740 NP_001247362 DDBJ / EMBL / GenBank • AA433187 AAF56959.2 AAM48453 AAN14192 AAN14192.1 AAN14193.1 AFH06679 AI124282 AY118424 AY118446 BI571627 Entrez Gene - A searchable database of RefSeq genes. • 43532 UniProtKB/Swiss-Prot • Q8MLY8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S8e, conserved site (IPR018283) Ribosomal protein S8e (IPR001047) Ribosomal protein S8e/ribosomal biogenesis NSA2 (IPR022309) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH06886 SD17528
Linkouts
	BioGRID - A database of protein and genetic interactions • 68391 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039713 DroID - A comprehensive database of gene and protein interactions. • FBgn0039713 DRSC - Results from RNAi screens. • FBgn0039713 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039713 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7808-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039713 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43532 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43532 modMine - Data generated by the modENCODE project. • FBgn0039713
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-EST:fe1A2   anon-EST:Liang-1.56 (Ashburner, 2004.6.30, ) BcDNA:RH06886   BcDNA:SD17528   CG7808 (Ashburner, 2004.6.30, Boutros et al., 2004, Bolshakov et al., 2002, Cermelli et al., 2006, Huang et al., 2005, Stuart et al., 2007, Marygold et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) clone 1.56 (Liang and Biggin, 1998) RpS8 (Cermelli et al., 2006, Fischer et al., 2012, Kallappagoudar et al., 2010, Marygold et al., 2007, Nie et al., 2009, Neumüller et al., 2011, Xun et al., 2008, Abruzzi et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Cook et al., 2012, Pircs et al., 2012) Rps8 (Sims et al., 2009) Rp S8 (Alonso and Santaren, 2006) S8 (Brogna et al., 2002, Carpenter et al., 2009) unnamed (Schmid and Tautz, 1997)
Name Synonym	anon-fast-evolving-1A2   Ribosomal protein S8 (Ashburner and Marygold, 2004.7.2, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0025277 FBgn0025982 FBgn0062869 FBgn0062967
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Cook et al., 2012, Genome Biol. 13(3): R21 The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. [FBrf0219066] Fischer et al., 2012, Proc. Biol. Sci. 279(1738): 2636--2644 Conserved properties of Drosophila and human spermatozoal mRNA repertoires. [FBrf0218415] Pircs et al., 2012, PLoS ONE 7(8): e44214 Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila. [FBrf0219364] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...