FlyBase Gene Report: Dmel\RpL6

General Information

Symbol

Dmel\RpL6

Species

D. melanogaster

Name

Ribosomal protein L6

Annotation Symbol

CG11522

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039857

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

100C7-100C7

Sequence location

3R:31,594,792..31,596,204 [-]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31594792..31596204

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000076315

(assigned by GO_Central )

(Gaudet et al., 2011)

enables structural constituent of ribosome

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000076315

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

inferred by curator from GO:0022626

(Anger et al., 2013, Alonso and Santaren, 2006)

inferred from biological aspect of ancestor with PANTHER:PTN000076315

(assigned by GO_Central )

(Gaudet et al., 2011)

traceable author statement

(Marygold et al., 2007)

involved_in ribosomal large subunit assembly

inferred from biological aspect of ancestor with PANTHER:PTN000076315

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000076315

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V9W3)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpL6-RA

FBtr0085804

NM_170554

910

243

RpL6-RB

FBtr0085805

NM_143619

967

262

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpL6-PA

FBpp0085165

27.7

243

11.37

FBpp0085166

29.7

262

11.42

Q9V9W3

NP_651876

AAF57167

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL6 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RpL6 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL6

View exonic expression by tissue for Dmel\RpL6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039857

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43723/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039857

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039857

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039857

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11522

Flygut - An atlas of the Drosophila adult midgut

FBgn0039857

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL6

Transgenic constructs containing regulatory region of RpL6

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Dp(3;2)GV-CH321-70F21

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^tin.CΔ4

RpL6^GD7320

Other Phenotypes

Allele

abnormal cell number | spermatogenesis, with Scer\GAL4^VP16.nos.UTR

RpL6^HMS00967

abnormal size | adult stage, with Scer\GAL4^VP16.nos.UTR

RpL6^HMS00967

increased cell number | spermatogenesis, with Scer\GAL4^NP1624

RpL6^HMS00967

neoplasia | progressive | spermatogenesis, with Scer\GAL4^NP1624

RpL6^HMS00967

some die during larval stage, with Scer\GAL4^tin.CΔ4

RpL6^GD7320

Phenotype manifest in

Allele

cyst cell of testis, with Scer\GAL4^VP16.nos.UTR

RpL6^HMS00967

cyst progenitor cell, with Scer\GAL4^NP1624

RpL6^HMS00967

hub cell, with Scer\GAL4^NP1624

RpL6^HMS00967

male germline stem cell, with Scer\GAL4^NP1624

RpL6^HMS00967

male germline stem cell, with Scer\GAL4^VP16.nos.UTR

RpL6^HMS00967

testis, with Scer\GAL4^VP16.nos.UTR

RpL6^HMS00967

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RPL6

14 of 15

Yes

Hsap\RPL14

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rpl6

13 of 15

Yes

Mmus\Rpl6l

4 of 15

Yes

Mmus\Gm6807

2 of 15

Yes

Mmus\Rpl14

1 of 15

Mmus\Rpl27

1 of 15

Rattus norvegicus (Norway rat) (6)

Rnor\Rpl6

12 of 13

Yes

Rnor\Rpl6-ps1

3 of 13

Yes

Rnor\LOC306079

1 of 13

Rnor\LOC681117

1 of 13

Yes

Rnor\RGD1561870

1 of 13

Rnor\Rpl27

1 of 13

Xenopus tropicalis (Western clawed frog) (3)

Xtro\rpl6

9 of 12

Yes

Xtro\rpl14

1 of 12

Xtro\rpl27

1 of 12

Danio rerio (Zebrafish) (4)

Drer\rpl6

14 of 15

Yes

Drer\LOC103910031

2 of 15

Yes

Drer\rpl14

1 of 15

Drer\rpl27

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rpl-6

12 of 15

Yes

Cele\rpl-27

1 of 15

Arabidopsis thaliana (thale-cress) (4)

Atha\AT1G18540

9 of 9

Yes

Atha\AT1G74050

9 of 9

Yes

Atha\AT1G74060

8 of 9

Yes

Atha\AT1G74055

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\RPL6A

11 of 15

Yes

Scer\RPL6B

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rpl6

10 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPL6; ribosomal protein L6

14 of 15

603703

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpL6 - InR

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL6 - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL6 - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL6 - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - Ras85D

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL6 - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL6 - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL6 - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL37a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL6 - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL6 - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL6 - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpL6 - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL6 - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68566

DroID - A comprehensive database of gene and protein interactions.

FBgn0039857

MIST (protein-protein) - An integrated Molecular Interaction Database

RpL6

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039857

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100C7-100C7

Sequence location

3R:31,594,792..31,596,204 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100C7-100C7

Limits computationally determined from genome sequence between P{EP}pygo^EP1076 and P{PZ}ttk⁰²⁶⁶⁷&P{lacW}ttk^j6C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Distal to Df(3R)tll-e and proximal to Df(3R)awd-KRB.

(Cook, 2006.1.31)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-99.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

15857

y¹ w^67c23; P{EPgy2}RpL6^EY02193

34004

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00967}attP2/TM3, Sb¹

FlyORF

F000987

M{UAS-RpL6.ORF.3xHA}ZH-86Fb

VDRC

v107302

P{KK108144}VIE-260B

v51715

w¹¹¹⁸; P{GD7320}v51715

v342242

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01901}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (578)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE08669

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039857

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039857

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43723

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

"RpL6" likely corresponds to "M(3)100CF".

(Marygold et al., 2007)

May correspond to M(3)100CF.

(Cook, 2006.1.31)

Other Comments

Haploinsufficient locus.

(Cook et al., 2012)

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Likely Minute gene.

(Marygold et al., 2007)

RpL6 lies in a gap in deletion coverage.

(Marygold et al., 2007)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43723

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V9W3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V9W3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039857

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039857

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43723/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039857

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039857

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039857

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11522

Flygut - An atlas of the Drosophila adult midgut

FBgn0039857

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039857

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43723

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030666

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11522

MARRVEL_MODEL - MARRVEL (model organism gene)

43723

modMine - A data warehouse for the modENCODE project

FBgn0039857

Linkouts

BioGRID - A database of protein and genetic interactions.

68566

DroID - A comprehensive database of gene and protein interactions.

FBgn0039857

DRSC - Results frm RNAi screens

FBgn0039857

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039857

FlyMine - An integrated database for Drosophila genomics

FBgn0039857

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

RpL6

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG11522

(Kolkhof et al., 2017, Schertel et al., 2013, Yoshigi et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Goshima et al., 2007, Marygold et al., 2007, Boutros et al., 2004, Fouix et al., 2003)

L6e

(Anger et al., 2013)

RPL6

(Gieger et al., 2011)

Rp L6

(Alonso and Santaren, 2006)

rpl6

(Hallacli et al., 2012)

Name Synonyms

Ribosomal protein L6

(Jaspers et al., 2012, Cammarato et al., 2011, Ashburner and Marygold, 2004.7.2)

ribosomal protein L6

(Sen and Cox, 2016)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (64)

The following external sites may use different assemblies or annotations than FlyBase.

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