FlyBase Gene Report: Dmel\CycG

General Information

Symbol

Dmel\CycG

Species

D. melanogaster

Name

Cyclin G

Annotation Symbol

CG11525

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039858

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

Cyclin G (CycG) encodes a protein that belongs to the atypical cyclins. It interacts with diverse proteins such as the product of H, β-subunits of PP2a, the 9-1-1 complex, cyclin-dependent kinases and Enhancer of Trithorax and Polycomb proteins. The product of CycG contributes to DNA repair, cell cycle regulation, growth and metabolism, epigenetic gene regulation and developmental stability. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
UniProtKB
Interactive Fly

Also Known As

dCycG

Key Links

Genomic Location

Cytogenetic map

100C7-100C7

Sequence location

3R:31,596,642..31,612,664 [-]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31596642..31612664

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein phosphatase inhibitor activity

inferred from physical interaction with FLYBASE:wdb; FB:FBgn0027492,FLYBASE:wrd; FB:FBgn0042693

(Fischer et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from sequence or structural similarity

(Liang and Biggin, 1998)

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in double-strand break repair

inferred from mutant phenotype

(Nagel et al., 2012)

involved_in epithelium development

inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015

(Salvaing et al., 2008)

involved_in female meiotic nuclear division

inferred from mutant phenotype

(Nagel et al., 2012)

involved_in meiotic DNA repair synthesis

inferred from mutant phenotype

(Nagel et al., 2012)

involved_in negative regulation of G1/S transition of mitotic cell cycle

inferred from genetic interaction with FLYBASE:CycE; FB:FBgn0010382

(Faradji et al., 2011)

involved_in negative regulation of Notch signaling pathway

inferred from genetic interaction with FLYBASE:H; FB:FBgn0001169

(Nagel et al., 2016)

inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647

(Nagel et al., 2016)

involved_in positive regulation of growth

inferred from mutant phenotype

(Fischer et al., 2015)

involved_in positive regulation of insulin receptor signaling pathway

inferred from mutant phenotype

(Fischer et al., 2016)

involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferred from mutant phenotype

(Fischer et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G1/S transition of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in polytene chromosome

inferred from direct assay

(Salvaing et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Positive Regulators of Insulin-like Receptor Signaling Pathway

Negative Regulators of Notch Signaling Pathway

Protein Family (UniProt)

Belongs to the cyclin family. Cyclin G subfamily. (Q95TJ9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

Positive Regulators of Insulin-like Receptor Signaling Pathway -: Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Negative Regulators of Notch Signaling Pathway -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Protein Function (UniProtKB)

Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism (PubMed:18286205, PubMed:18667003, PubMed:21311225, PubMed:22976300, PubMed:25995770, PubMed:26274446). Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium (PubMed:18286205, PubMed:18667003). Involved in the transcriptional repression of the homeotic genes Scr and Ubx (PubMed:25995770). Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells (PubMed:22976300, PubMed:23121330). Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism (PubMed:26274446). Required for the formation of bilateral symmetry (PubMed:21998598). Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression (PubMed:21311225).

(UniProt, Q95TJ9)

Summary (Interactive Fly)

a transcriptional regulator that interacts with the chromatin factor Corto and controls expression of the homeotic gene Abdominal B - controls developmental stability by ensuring compensatory processes between cell growth and cell proliferation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CycG for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q95TJ9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CycG-RA

FBtr0085800

NM_079870

2289

566

CycG-RB

FBtr0085802

NM_170555

3132

566

CycG-RC

FBtr0085803

NM_170556

2687

566

CycG-RD

FBtr0085799

NM_170557

2545

566

CycG-RF

FBtr0333328

NM_001276217

4450

566

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CycG-PA

FBpp0085161

62.8

566

5.02

FBpp0085163

62.8

566

5.02

FBpp0085164

62.8

566

5.02

FBpp0085160

62.8

566

5.02

FBpp0305520

62.8

566

5.02

Q95TJ9

NP_001263146

AGB96525

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

566 aa isoforms: CycG-PA, CycG-PB, CycG-PC, CycG-PD, CycG-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with corto (PubMed:18286205). Interacts with the cyclin-dependent kinases Cdk2 and Cdk4 (PubMed:21311225). Interacts with Brca2 and Rad9 (PubMed:22976300). Interacts with polycomb protein Asx (PubMed:25995770). Interacts with protein phosphatase 2A subunit wdb (PubMed:26274446).

(UniProt, Q95TJ9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q95TJ9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycG using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CycG_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-2.15

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female & oogenesis

oocyte

(Nagel et al., 2012)

oogenesis & adult stage | female

germarium region 2

Comment: in oocyte

(Nagel et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in polytene chromosome

inferred from direct assay

(Salvaing et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycG in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CycG

View exonic expression by tissue for Dmel\CycG

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43724/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039858

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039858

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039858

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11525

Flygut - An atlas of the Drosophila adult midgut

FBgn0039858

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CycG

Transgenic constructs containing regulatory region of CycG

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^da.G32

lethal | male limited | third instar larval stage, with Scer\GAL4^NP3121

CycG^RNAi.UAS

lethal | pharate adult stage, with Scer\GAL4^Act.PU

CycG^RNAi.UAS

lethal | pharate adult stage, with Scer\GAL4^da.G32

CycG^RNAi.UAS

lethal | third instar larval stage, with Scer\GAL4^Act.PU

CycG^RNAi.UAS

lethal | third instar larval stage, with Scer\GAL4^da.G32

CycG^RNAi.UAS

partially lethal - majority die | female limited | pharate adult stage, with Scer\GAL4^NP3121

CycG^RNAi.UAS

partially lethal - majority die | male limited, with Scer\GAL4^da.G32

CycG^RNAi.UAS

partially lethal - majority live | female limited, with Scer\GAL4^da.G32

CycG^RNAi.UAS

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CycG^GD4244

viable, with Scer\GAL4^Mef2.PR

CycG^GD4244

viable, with Scer\GAL4^pnr-MD237

CycG^GD4244

viable, with Scer\GAL4^tin.CΔ4

CycG^GD4244

Sterility

Allele

female sterile

CycG^HR7

female sterile | recessive

CycG^eoC

fertile

CycG^PL00406

Other Phenotypes

Allele

abnormal body size | adult stage

CycG^HR7

abnormal body size | adult stage, with Scer\GAL4^da.PU

CycG^UASp.cNa

abnormal body size | adult stage (with CycG^eoC)

CycG^HR7

abnormal body size | adult stage (with CycG^HR7)

CycG^eoC

abnormal body size | adult stage | larval stage

CycG^eoC

abnormal body size | larval stage

CycG^HR7

abnormal body size | larval stage (with CycG^eoC)

CycG^HR7

abnormal body size | larval stage (with CycG^HR7)

CycG^eoC

abnormal developmental rate, with Scer\GAL4^da.G32

abnormal developmental rate (with CycG^eoC)

CycG^HR7

abnormal developmental rate (with CycG^HR7)

CycG^eoC

abnormal developmental rate | recessive

abnormal mitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

CycG^{UASp.mRFP(Unk)}

abnormal starvation stress response | adult stage

CycG^HR7

decreased body size | adult stage

CycG^HR7

decreased cell number | adult stage

CycG^HR7

decreased cell size, with Scer\GAL4^da.G32

CycG^{UASp.mRFP(Unk)}

decreased cell size | adult stage

CycG^HR7

increased cell size, with Scer\GAL4^da.G32

CycG^RNAi.UAS

Phenotype manifest in

Allele

abdominal tergite 4, with Scer\GAL4^da.G32

CycG^RNAi.UAS

abdominal tergite 4 | female limited, with Scer\GAL4^da.G32

CycG^RNAi.UAS

abdominal tergite 5, with Scer\GAL4^da.G32

CycG^RNAi.UAS

abdominal tergite 5 | female limited, with Scer\GAL4^da.G32

CycG^RNAi.UAS

abdominal tergite 6, with Scer\GAL4^da.G32

CycG^RNAi.UAS

abdominal tergite 6 | female limited, with Scer\GAL4^da.G32

CycG^RNAi.UAS

anterior dorsal histoblast nest abdominal 4, with Scer\GAL4^NP3121

CycG^RNAi.UAS

anterior dorsal histoblast nest abdominal 5, with Scer\GAL4^NP3121

CycG^RNAi.UAS

anterior dorsal histoblast nest abdominal 6, with Scer\GAL4^NP3121

CycG^RNAi.UAS

dorsal appendage | germline clone | maternal effect

CycG^HR7

dorsal appendage | maternal effect

CycG^HR7

egg chamber | oogenesis

CycG^CreD

embryonic/larval fat body

CycG^HR7

embryonic/larval fat body | larval stage

CycG^HR7

embryonic/larval oenocyte

CycG^HR7

embryonic/larval oenocyte | larval stage

embryonic/larval salivary gland | larval stage

CycG^HR7

karyosome

CycG^HR7

male genitalia, with Scer\GAL4^da.G32

nurse cell | oogenesis

CycG^CreD

ommatidium, with Scer\GAL4^ey.PH

posterior dorsal histoblast nest abdominal 4, with Scer\GAL4^NP3121

CycG^RNAi.UAS

posterior dorsal histoblast nest abdominal 5, with Scer\GAL4^NP3121

CycG^RNAi.UAS

posterior dorsal histoblast nest abdominal 6, with Scer\GAL4^NP3121

CycG^RNAi.UAS

wing, with Scer\GAL4^da.G32

wing blade

CycG^HR7

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

CycG^{UASp.mRFP(Unk)}

wing disc posterior compartment, with Scer\GAL4^en-e16E

CycG^{UASp.mRFP(Unk)}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\CCNG1

9 of 14

Yes

Hsap\CCNG2

9 of 14

Yes

Hsap\CCNI

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Ccng1

9 of 14

Yes

Rnor\Ccng2

9 of 14

Yes

Rnor\Ccni

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Ccng1

9 of 14

Yes

Mmus\Ccng2

9 of 14

Yes

Mmus\Ccni

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\ccng1

8 of 13

Yes

Xtro\ccng2

7 of 13

Yes

Xtro\ccni

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\foxred1

1 of 13

Xtro\LOC394448

1 of 13

Xtro\LOC100493210

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB997834

1 of 13

Xtro\zmpste24

1 of 13

Danio rerio (Zebrafish) (20)

Drer\ccng1

9 of 14

Yes

Drer\ccng2

9 of 14

Yes

Drer\ccni

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\cyb-2.1

2 of 14

Yes

Cele\cyb-2.2

2 of 14

Yes

Cele\C02B8.1

1 of 14

Yes

Cele\C03B8.2

1 of 14

Yes

Cele\C04C3.4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP001730

9 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (30)

Atha\AT1G20590

2 of 13

Yes

Atha\CYC1BAT

2 of 13

Yes

Atha\CYC3B

2 of 13

Yes

Atha\CYCA1;1

2 of 13

Yes

Atha\CYCA1;2

2 of 13

Yes

Atha\CYCA2;1

2 of 13

Yes

Atha\CYCA2;4

2 of 13

Yes

Atha\CYCA3;1

2 of 13

Yes

Atha\CYCA3;2

2 of 13

Yes

Atha\CYCA3;3

2 of 13

Yes

Atha\CYCA3;4

2 of 13

Yes

Atha\CYCB1;1

2 of 13

Yes

Atha\CYCB1;3

2 of 13

Yes

Atha\CYCB1;4

2 of 13

Yes

Atha\CYCB2;1

2 of 13

Yes

Atha\CYCB2;2

2 of 13

Yes

Atha\CYCB2;3

2 of 13

Yes

Atha\CYCB2;4

2 of 13

Yes

Atha\CYCB3;1

2 of 13

Yes

Atha\SDS

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\CLB1

2 of 13

Yes

Scer\CLB2

2 of 13

Yes

Scer\CLB3

2 of 13

Yes

Scer\CLB4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\cig2

2 of 12

Yes

Spom\puc1

2 of 12

Yes

Spom\cdc13

1 of 12

Spom\cig1

1 of 12

Spom\rem1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CycG. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CycG^JF02474

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

9 of 14

9 of 14

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CycG - Asx

anti tag coimmunoprecipitation, western blot, anti tag western blot, two hybrid

(Dupont et al., 2015)

CycG - Brca2

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Nagel et al., 2012)

CycG - CG8281

two hybrid

(Hu et al., 2017.6.13)

CycG - Cdk2

anti tag coimmunoprecipitation, anti tag western blot

(Faradji et al., 2011)

CycG - Cdk4

anti tag coimmunoprecipitation, anti tag western blot

(Faradji et al., 2011)

CycG - GstD1

two hybrid

(Hu et al., 2017.6.13)

CycG - H

two hybrid, anti bait coimmunoprecipitation, western blot

(Nagel et al., 2016)

CycG - Pp2A-29B

anti bait coimmunoprecipitation, western blot

(Fischer et al., 2016)

CycG - Rad9

anti bait coimmunoprecipitation, anti tag western blot

(Nagel et al., 2012)

CycG - corto

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, western blot

(Salvaing et al., 2008)

CycG - larp

two hybrid

(Hu et al., 2017.6.13)

CycG - mamo

two hybrid

(Hu et al., 2017.6.13)

CycG - mts

anti bait coimmunoprecipitation, western blot, two hybrid

(Fischer et al., 2016)

CycG - mxt

two hybrid

(Hu et al., 2017.6.13)

CycG - p53

two hybrid, anti tag coimmunoprecipitation, western blot

(Bayer et al., 2017)

CycG - stumps

two hybrid

(Battersby et al., 2003)

CycG - wdb

two hybrid, anti bait coimmunoprecipitation, western blot

(Hu et al., 2017.6.13, Fischer et al., 2016, Fischer et al., 2015)

CycG - wrd

two hybrid

(Fischer et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CycG

suppressible

Akt

(Fischer et al., 2015)

CycG

enhanceable

corto

(Salvaing et al., 2008)

CycG

suppressible

lok

(Nagel et al., 2012)

CycG

suppressible

mei-41

(Nagel et al., 2012)

CycG

suppressible

mei-W68

(Nagel et al., 2012)

CycG

enhanceable

spn-B

(Nagel et al., 2012)

CycG

suppressible

wdb

(Fischer et al., 2016, Fischer et al., 2015)

CycG

suppressible

wrd

(Fischer et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Abd-B

enhanceable

CycG

(Salvaing et al., 2008)

Abd-B

enhanceable

corto|CycG

(Salvaing et al., 2008)

Delta

enhanceable

CycG

(Nagel et al., 2016)

enhanceable

CycG

(Nagel et al., 2016)

enhanceable

CycG

(Nagel et al., 2016)

net

enhanceable

CycG

(Nagel et al., 2016)

rho

enhanceable

CycG

(Nagel et al., 2016)

Snr1

suppressible

CycG

(Tegeder et al., 2019)

spn-B

enhanceable

CycG

(Nagel et al., 2012)

suppressible

CycG

(Nagel et al., 2016)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q95TJ9 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68567

DroID - A comprehensive database of gene and protein interactions.

FBgn0039858

MIST (protein-protein) - An integrated Molecular Interaction Database

43724

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Insulin-like Receptor Signaling Pathway
Negative Regulators of Notch Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8IMG7

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100C7-100C7

Sequence location

3R:31,596,642..31,612,664 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100C7-100C7

Limits computationally determined from genome sequence between P{EP}pygo^EP1076 and P{PZ}ttk⁰²⁶⁶⁷&P{lacW}ttk^j6C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-99.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (658)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD46284

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039858

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039858

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Salvaing et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

CycG has a role in an early step of meiotic recombination repair.

(Nagel et al., 2012)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identification: as a protein that interacts with H in a yeast two-hybrid screen.

(Nagel et al., 2001)

Overexpression of CycG during eye imaginal development results in rough eyes that are smaller than normal.

(Nagel et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: CycG anon- EST:Liang-2.24 anon- EST:Liang-1.25

(Ashburner, 2004.6.30)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CycG CG11525

(Nagel, 2001.8.31, Nagel et al., 2001)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG 11525

(Nagel, 2001.8.31)

CG11525

(Hallier et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, Rach et al., 2009, Salvaing et al., 2008, Quinones-Coello, 2007, Molnar et al., 2006, Ashburner, 2004.6.30, Battersby et al., 2003)

anon-EST:Liang-1.25

anon-EST:Liang-2.24

chr3R:27424276..27424475

(Will et al., 2013)

clone 1.25

(Liang and Biggin, 1998)

clone 2.24

(Liang and Biggin, 1998)

cycG

(Bayer et al., 2017, Nagel et al., 2016, Nagel et al., 2012)

dCycG

(Szawinski et al., 2005, Nagel, 2001.8.31, Nagel et al., 2001)

i205

(Battersby et al., 2003)

i261

(Battersby et al., 2003)

Name Synonyms

Cyclin G

(Fischer et al., 2016, Nagel et al., 2016, Dupont et al., 2015, Fischer et al., 2015, Nagel et al., 2012, Debat et al., 2011, Faradji et al., 2011, Michaut et al., 2011, Salvaing et al., 2008, Zraly et al., 2006, Nagel et al., 2001)

cyclin G

(Hallier et al., 2015)

cyclin G1

(Van Hoof and Goris, 2003)

Secondary FlyBase IDs

FBgn0025961
FBgn0026001

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43724

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q95TJ9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q95TJ9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q95TJ9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43724/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039858

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039858

FlyMine - An integrated database for Drosophila genomics

FBgn0039858

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11525

MARRVEL_MODEL - MARRVEL (model organism gene)

43724

Linkouts

BioGRID - A database of protein and genetic interactions.

68567

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039858

DroID - A comprehensive database of gene and protein interactions.

FBgn0039858

DRSC - Results frm RNAi screens

FBgn0039858

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CycG_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039858

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039858

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11525

Flygut - An atlas of the Drosophila adult midgut

FBgn0039858

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001982

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43724

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8IMG7

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

-2.15

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