FB2021_02, released April 13, 2021

Gene: Dmel\CycG

Open Close
General Information
Symbol
Dmel\CycG
Species
D. melanogaster
Name
Cyclin G
Annotation Symbol
CG11525
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039858
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Cyclin G (CycG) encodes a protein that belongs to the atypical cyclins. It interacts with diverse proteins such as the product of H, β-subunits of PP2a, the 9-1-1 complex, cyclin-dependent kinases and Enhancer of Trithorax and Polycomb proteins. The product of CycG contributes to DNA repair, cell cycle regulation, growth and metabolism, epigenetic gene regulation and developmental stability. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dCycG

Key Links
Genomic Location
Cytogenetic map
100C7-100C7
Sequence location
3R:31,596,642..31,612,664 [-]
Recombination map
3-102
RefSeq locus
NT_033777 REGION:31596642..31612664
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein phosphatase inhibitor activity
inferred from physical interaction with FLYBASE:wdb; FB:FBgn0027492, FLYBASE:wrd; FB:FBgn0042693
(Fischer et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cyclin-dependent protein serine/threonine kinase regulator activity
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Liang and Biggin, 1998)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in double-strand break repair
inferred from mutant phenotype
(Nagel et al., 2012)
involved_in epithelium development
inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015
(Salvaing et al., 2008)
involved_in female meiotic nuclear division
inferred from mutant phenotype
(Nagel et al., 2012)
involved_in meiotic DNA repair synthesis
inferred from mutant phenotype
(Nagel et al., 2012)
involved_in negative regulation of G1/S transition of mitotic cell cycle
inferred from genetic interaction with FLYBASE:CycE; FB:FBgn0010382
(Faradji et al., 2011)
involved_in negative regulation of Notch signaling pathway
inferred from genetic interaction with FLYBASE:H; FB:FBgn0001169
(Nagel et al., 2016)
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Nagel et al., 2016)
involved_in positive regulation of growth
inferred from mutant phenotype
(Fischer et al., 2015)
involved_in positive regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Fischer et al., 2016)
involved_in positive regulation of protein kinase B signaling
inferred from mutant phenotype
(Fischer et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitotic cell cycle phase transition
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in polytene chromosome
inferred from direct assay
(Salvaing et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cyclin-dependent protein kinase holoenzyme complex
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the cyclin family. Cyclin G subfamily. (Q95TJ9)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cyclin G (CycG) encodes a protein that belongs to the atypical cyclins. It interacts with diverse proteins such as the product of H, β-subunits of PP2a, the 9-1-1 complex, cyclin-dependent kinases and Enhancer of Trithorax and Polycomb proteins. The product of CycG contributes to DNA repair, cell cycle regulation, growth and metabolism, epigenetic gene regulation and developmental stability. [Date last reviewed: 2019-03-07]
Pathway (FlyBase)
Positive Regulators of Insulin-like Receptor Signaling Pathway -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Negative Regulators of Notch Signaling Pathway -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
Protein Function (UniProtKB)
Cyclin with roles in multiple processes including transcription, meiotic recombination repair, cell cycle regulation, and promotion of normal growth and metabolism (PubMed:18667003, PubMed:18286205, PubMed:21311225, PubMed:22976300, PubMed:25995770, PubMed:26274446). Binds to the promoter region of the homeobox gene Abd-B and is involved in maintaining Abd-B expression in the pupal epithelium (PubMed:18667003, PubMed:18286205). Involved in the transcriptional repression of the homeotic genes Scr and Ubx (PubMed:25995770). Plays a role in meiotic recombination repair of DNA double-strand breaks which ensures efficient translation of grk and promotes grk activity in the oocyte, leading to oocyte dorso-ventral axis formation following secretion of grk from the oocyte and its binding to Egfr in the directly overlying follicle cells (PubMed:23121330, PubMed:22976300). Negatively regulates the binding of serine/threonine-protein kinase Akt1 to the protein phosphatase 2A subunit wdb, promoting normal growth and metabolism (PubMed:26274446). Required for the formation of bilateral symmetry (PubMed:21998598). Negatively regulates cell cycle progression by preventing G1 to S transition and retarding S-phase progression (PubMed:21311225).
(UniProt, Q95TJ9)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CycG for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CycG-RA
FBtr0085800
NM_079870
2289
566
CycG-RB
FBtr0085802
NM_170555
3132
566
CycG-RC
FBtr0085803
NM_170556
2687
566
CycG-RD
FBtr0085799
NM_170557
2545
566
CycG-RF
FBtr0333328
NM_001276217
4450
566
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CycG-PA
FBpp0085161
62.8
566
5.02
NP_524609
AAF57168
CycG-PB
FBpp0085163
62.8
566
5.02
NP_733434
AAF57170
CycG-PC
FBpp0085164
62.8
566
5.02
NP_733435
AAF57169
CycG-PD
FBpp0085160
62.8
566
5.02
NP_733436
AAF57171
CycG-PF
FBpp0305520
62.8
566
5.02
NP_001263146
AGB96525
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

566 aa isoforms: CycG-PA, CycG-PB, CycG-PC, CycG-PD, CycG-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with corto (PubMed:18286205). Interacts with the cyclin-dependent kinases Cdk2 and Cdk4 (PubMed:21311225). Interacts with Brca2 and Rad9 (PubMed:22976300). Interacts with polycomb protein Asx (PubMed:25995770). Interacts with protein phosphatase 2A subunit wdb (PubMed:26274446).

(UniProt, Q95TJ9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycG using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female & oogenesis
oocyte
(Nagel et al., 2012)
oogenesis & adult stage | female
germarium region 2

Comment: in oocyte

(Nagel et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in polytene chromosome
inferred from direct assay
(Salvaing et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CycG in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CycG
Transgenic constructs containing regulatory region of CycG
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4da.G32
lethal | male limited | third instar larval stage, with Scer\GAL4NP3121
lethal | pharate adult stage, with Scer\GAL4Act.PU
lethal | pharate adult stage, with Scer\GAL4da.G32
lethal | third instar larval stage, with Scer\GAL4Act.PU
lethal | third instar larval stage, with Scer\GAL4da.G32
partially lethal - majority die | female limited | pharate adult stage, with Scer\GAL4NP3121
partially lethal - majority die | male limited, with Scer\GAL4da.G32
partially lethal - majority live | female limited, with Scer\GAL4da.G32
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile | recessive
fertile
Other Phenotypes
Allele
abnormal body size | adult stage
abnormal body size | adult stage, with Scer\GAL4da.PU
abnormal body size | adult stage (with CycGeoC)
abnormal body size | adult stage (with CycGHR7)
abnormal body size | adult stage | larval stage
abnormal body size | larval stage
abnormal body size | larval stage (with CycGeoC)
abnormal body size | larval stage (with CycGHR7)
abnormal developmental rate, with Scer\GAL4da.G32
abnormal developmental rate (with CycGeoC)
abnormal developmental rate (with CycGHR7)
abnormal developmental rate | recessive
abnormal mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
abnormal starvation stress response | adult stage
decreased body size | adult stage
decreased cell number | adult stage
decreased cell size, with Scer\GAL4da.G32
decreased cell size | adult stage
increased cell size, with Scer\GAL4da.G32
Phenotype manifest in
Allele
abdominal tergite 4, with Scer\GAL4da.G32
abdominal tergite 4 | female limited, with Scer\GAL4da.G32
abdominal tergite 5, with Scer\GAL4da.G32
abdominal tergite 5 | female limited, with Scer\GAL4da.G32
abdominal tergite 6, with Scer\GAL4da.G32
abdominal tergite 6 | female limited, with Scer\GAL4da.G32
anterior dorsal histoblast nest abdominal 4, with Scer\GAL4NP3121
anterior dorsal histoblast nest abdominal 5, with Scer\GAL4NP3121
anterior dorsal histoblast nest abdominal 6, with Scer\GAL4NP3121
dorsal appendage | germline clone | maternal effect
dorsal appendage | maternal effect
egg chamber | oogenesis | oogenesis
embryonic/larval fat body
embryonic/larval fat body | larval stage
embryonic/larval oenocyte
embryonic/larval oenocyte | larval stage
embryonic/larval salivary gland | larval stage
karyosome
male genitalia, with Scer\GAL4da.G32
nurse cell | oogenesis | oogenesis
ommatidium, with Scer\GAL4ey.PH
posterior dorsal histoblast nest abdominal 4, with Scer\GAL4NP3121
posterior dorsal histoblast nest abdominal 5, with Scer\GAL4NP3121
posterior dorsal histoblast nest abdominal 6, with Scer\GAL4NP3121
wing, with Scer\GAL4da.G32
wing blade
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing disc posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CCNG1
9 of 15
Yes
Yes
Hsap\CCNG2
8 of 15
No
Yes
Hsap\CCNI
4 of 15
No
Yes
1  
Hsap\CCNI2
3 of 15
No
Yes
Hsap\CCNA1
1 of 15
No
No
Hsap\CCNA2
1 of 15
No
No
Hsap\CCNB1
1 of 15
No
No
1  
Hsap\CCNB2
1 of 15
No
No
1  
Hsap\CCNB3
1 of 15
No
No
Hsap\CCNE1
1 of 15
No
No
1  
Hsap\CCNE2
1 of 15
No
No
1  
Hsap\CCNF
1 of 15
No
No
Hsap\CCNJL
1 of 15
No
No
Hsap\CCNO
1 of 15
No
No
Hsap\CNTD2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ccng1
9 of 15
Yes
Yes
Mmus\Ccng2
8 of 15
No
Yes
Mmus\Ccni
4 of 15
No
Yes
Mmus\Ccna1
1 of 15
No
No
Mmus\Ccna2
1 of 15
No
No
Mmus\Ccnb1
1 of 15
No
No
Mmus\Ccnb2
1 of 15
No
No
Mmus\Ccnb3
1 of 15
No
No
Mmus\Ccne1
1 of 15
No
No
Mmus\Ccne2
1 of 15
No
No
Mmus\Ccnf
1 of 15
No
No
Mmus\Ccnjl
1 of 15
No
No
Mmus\Ccno
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Ccng1
8 of 13
Yes
Yes
Rnor\Ccng2
8 of 13
Yes
Yes
Rnor\Ccni
4 of 13
No
Yes
Rnor\Ccna1
1 of 13
No
No
Rnor\Ccna2
1 of 13
No
No
Rnor\Ccnb3
1 of 13
No
No
Rnor\Ccne1
1 of 13
No
No
Rnor\Ccne2
1 of 13
No
No
Rnor\Ccnf
1 of 13
No
No
Rnor\Ccnjl
1 of 13
No
No
Rnor\Ccno
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\ccng1
8 of 12
Yes
Yes
Xtro\ccng2
5 of 12
No
Yes
Xtro\ccni2
3 of 12
No
Yes
Xtro\ccni
3 of 12
No
Yes
Xtro\ccna1
1 of 12
No
No
Xtro\ccna2
1 of 12
No
No
Xtro\ccnb1.2
1 of 12
No
No
Xtro\ccnb1
1 of 12
No
No
Xtro\ccnb2
1 of 12
No
No
Xtro\ccnb3
1 of 12
No
No
Xtro\ccne1
1 of 12
No
No
Xtro\ccne2
1 of 12
No
No
Xtro\ccnf
1 of 12
No
No
Xtro\ccno
1 of 12
No
No
Xtro\LOC100487861
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\ccng2
8 of 15
Yes
Yes
Drer\ccng1
6 of 15
No
Yes
Drer\ccni
4 of 15
No
Yes
Drer\ccni2
3 of 15
No
Yes
Drer\ccnb2
2 of 15
No
No
Drer\ccna1
1 of 15
No
No
Drer\ccna2
1 of 15
No
No
Drer\ccnb1
1 of 15
No
No
Drer\ccnb1l
1 of 15
No
No
Drer\ccnb3
1 of 15
No
No
Drer\ccne1
1 of 15
No
No
Drer\ccne2
1 of 15
No
No
Drer\cntd2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\C03B8.2
1 of 15
Yes
Yes
Cele\C04C3.4
1 of 15
Yes
Yes
Cele\cya-1
1 of 15
Yes
No
Cele\cya-2
1 of 15
Yes
No
Cele\cyb-2.1
1 of 15
Yes
No
Cele\cye-1
1 of 15
Yes
No
Cele\F08F1.9
1 of 15
Yes
No
Cele\R02F2.1
1 of 15
Yes
Yes
Cele\T12C9.7
1 of 15
Yes
No
Cele\T24A6.1
1 of 15
Yes
No
Cele\W05G11.2
1 of 15
Yes
No
Cele\ZK678.3
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (11)
Atha\CYCD3;1
2 of 9
Yes
Yes
Atha\CYCD3;2
2 of 9
Yes
Yes
Atha\CYCD3;3
2 of 9
Yes
Yes
Atha\CYCD6;1
2 of 9
Yes
Yes
Atha\CYCD1;1
1 of 9
No
Yes
Atha\CYCD2;1
1 of 9
No
Yes
Atha\CYCD4;1
1 of 9
No
Yes
Atha\CYCD4;2
1 of 9
No
Yes
Atha\CYCD5;1
1 of 9
No
Yes
Atha\CYCD7;1
1 of 9
No
Yes
Atha\SDS
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CLB1
1 of 15
Yes
No
Scer\CLB2
1 of 15
Yes
No
Scer\CLB3
1 of 15
Yes
No
Scer\CLB4
1 of 15
Yes
No
Scer\CLB5
1 of 15
Yes
No
Scer\CLB6
1 of 15
Yes
No
Scer\CLN1
1 of 15
Yes
No
Scer\CLN2
1 of 15
Yes
No
Scer\CLN3
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\crs1
1 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A28 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007390
Drosophila simulans
Dsim\GD15071
Drosophila sechellia
Dsec\GM16426
Drosophila erecta
Dere\GG11862
Drosophila yakuba
Dyak\GE23311
Drosophila ananassae
Dana\GF23259
Drosophila pseudoobscura pseudoobscura
Dpse\GA11050
Drosophila persimilis
Dper\GL23886
Drosophila willistoni
Dwil\GK11375
Drosophila virilis
Dvir\GJ24128
Drosophila mojavensis
Dmoj\GI24200
Drosophila grimshawi
Dgri\GH18942
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150544 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013295
Glossina morsitans
Tsetse fly
Gmor\GMOY011780
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05048
Mayetiola destructor
Hessian fly
Mdes\Mdes001365
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004865
Anopheles darlingi
American malaria mosquito
Adar\ADAC008344
Anopheles gambiae
Malaria mosquito
Agam\AGAP001730
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002694
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B9V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001790
Danaus plexippus
Monarch butterfly
Dple\DPOGS205031-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010808
Apis florea
Little honeybee
Aflo\2717986276
Apis mellifera
Western honey bee
Amel\GB54386
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17843
Bombus terrestris
Buff-tailed bumblebee
Bter\15206334
Linepithema humile
Argentine ant
Lhum\LH14348
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002daa
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021430
Tribolium castaneum
Red flour beetle
Tcas\TC001982
Pediculus humanus
Human body louse
Phum\PHUM598490
Rhodnius prolixus
Kissing bug
Rpro\RPRC006316
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00198
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0C6G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014528
Strigamia maritima
European centipede
Smar\SMAR010870
Ixodes scapularis
Black-legged tick
Isca\ISCW021860
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HQN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CycI
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CycG
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023812
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010347
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000011457
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000001718
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CycA
2 of 10
CycB3
2 of 10
CycB
2 of 10
CycE
2 of 10
CycJ
2 of 10
CycD
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    CycGJF02474
    exacerbates  atypical teratoid rhabdoid tumor
    modeled by Snr1KK101602
    (Tegeder et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCNG1; cyclin G1
    9 of 15
    601578
        CCNG2; cyclin G2
        8 of 15
        603203
            CCNI; cyclin I
            4 of 15
            618783
                 
                CCNI2; cyclin I family member 2
                3 of 15
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    CycG - Asx
                    anti tag coimmunoprecipitation, anti tag western blot, two hybrid, western blot
                    (Dupont et al., 2015)
                    CycG - Brca2
                    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
                    (Nagel et al., 2012)
                    CycG - CG8281
                    two hybrid
                    (Hu et al., 2017.6.13)
                    CycG - Cdk2
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Faradji et al., 2011)
                    CycG - Cdk4
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Faradji et al., 2011)
                    CycG - GstD1
                    two hybrid
                    (Hu et al., 2017.6.13)
                    CycG - H
                    anti bait coimmunoprecipitation, western blot, two hybrid
                    (Nagel et al., 2016)
                    CycG - Pp2A-29B
                    anti bait coimmunoprecipitation, western blot
                    (Fischer et al., 2016)
                    CycG - Rad9
                    anti bait coimmunoprecipitation, anti tag western blot
                    (Nagel et al., 2012)
                    CycG - corto
                    anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, anti bait coimmunoprecipitation, western blot, two hybrid
                    (Salvaing et al., 2008)
                    CycG - larp
                    two hybrid
                    (Hu et al., 2017.6.13)
                    CycG - mamo
                    two hybrid
                    (Hu et al., 2017.6.13)
                    CycG - mts
                    anti bait coimmunoprecipitation, western blot, two hybrid
                    (Fischer et al., 2016)
                    CycG - mxt
                    two hybrid
                    (Hu et al., 2017.6.13)
                    CycG - p53
                    anti tag coimmunoprecipitation, western blot, two hybrid
                    (Bayer et al., 2017)
                    CycG - stumps
                    two hybrid
                    (Battersby et al., 2003)
                    CycG - wdb
                    anti bait coimmunoprecipitation, western blot, two hybrid
                    (Hu et al., 2017.6.13, Fischer et al., 2016, Fischer et al., 2015)
                    CycG - wrd
                    two hybrid
                    (Fischer et al., 2016)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    CycG
                    suppressible
                    Akt
                    (Fischer et al., 2015)
                    CycG
                    enhanceable
                    corto
                    (Salvaing et al., 2008)
                    CycG
                    suppressible
                    lok
                    (Nagel et al., 2012)
                    CycG
                    suppressible
                    mei-41
                    (Nagel et al., 2012)
                    CycG
                    suppressible
                    mei-W68
                    (Nagel et al., 2012)
                    CycG
                    enhanceable
                    spn-B
                    (Nagel et al., 2012)
                    CycG
                    suppressible
                    wdb
                    (Fischer et al., 2016, Fischer et al., 2015)
                    CycG
                    suppressible
                    wrd
                    (Fischer et al., 2016)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Abd-B
                    enhanceable
                    CycG|corto
                    (Salvaing et al., 2008)
                    Abd-B
                    enhanceable
                    CycG
                    (Salvaing et al., 2008)
                    Dl
                    enhanceable
                    CycG
                    (Nagel et al., 2016)
                    H
                    enhanceable
                    CycG
                    (Nagel et al., 2016)
                    N
                    enhanceable
                    CycG
                    (Nagel et al., 2016)
                    net
                    enhanceable
                    CycG
                    (Nagel et al., 2016)
                    rho
                    enhanceable
                    CycG
                    (Nagel et al., 2016)
                    spn-B
                    enhanceable
                    CycG
                    (Nagel et al., 2012)
                    vn
                    suppressible
                    CycG
                    (Nagel et al., 2016)
                    External Data
                    Subunit Structure (UniProtKB)
                    Interacts with corto (PubMed:18286205). Interacts with the cyclin-dependent kinases Cdk2 and Cdk4 (PubMed:21311225). Interacts with Brca2 and Rad9 (PubMed:22976300). Interacts with polycomb protein Asx (PubMed:25995770). Interacts with protein phosphatase 2A subunit wdb (PubMed:26274446).
                    (UniProt, Q95TJ9 )
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Positive Regulators of Insulin-like Receptor Signaling Pathway -
                    Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
                    Negative Regulators of Notch Signaling Pathway -
                    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
                    Metabolic Pathways
                    External Data
                    Linkouts
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-102
                    Cytogenetic map
                    100C7-100C7
                    Sequence location
                    3R:31,596,642..31,612,664 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    100C7-100C7
                    Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-102

                    (FlyBase, 2016)

                    3-99.1

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (12)
                    Genomic Clones (14)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (685)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Salvaing et al., 2008)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: CycG CG11525

                    (Nagel, 2001.8.31, Nagel et al., 2001)
                    Source for database merge of

                    Source for merge of: CycG anon- EST:Liang-2.24 anon- EST:Liang-1.25

                    (Ashburner, 2004.6.30)
                    Additional comments
                    Other Comments

                    CycG has a role in an early step of meiotic recombination repair.

                    (Nagel et al., 2012)

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)

                    Identification: as a protein that interacts with H in a yeast two-hybrid screen.

                    (Nagel et al., 2001)

                    Overexpression of CycG during eye imaginal development results in rough eyes that are smaller than normal.

                    (Nagel et al., 2001)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 54 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    Other crossreferences
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DPiM - Drosophila Protein interaction map
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Synonyms and Secondary IDs (15)
                    Reported As
                    Symbol Synonym
                    CG 11525
                    (Nagel, 2001.8.31)
                    CG11525
                    (Hallier et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, Rach et al., 2009, Salvaing et al., 2008, Quinones-Coello, 2007, Molnar et al., 2006, Ashburner, 2004.6.30, Battersby et al., 2003)
                    CycG
                    (Tegeder et al., 2019, Gene Disruption Project members, 2018-, Landskron et al., 2018, Hu et al., 2017.6.13, Fischer et al., 2016, Nagel et al., 2016, Dupont et al., 2015, Fischer et al., 2015, DeSalvo et al., 2014, de Celis et al., 2013.9.11, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nagel et al., 2012, Nagel et al., 2012, Paik et al., 2012, Rodriguez et al., 2012, Debat et al., 2011, Faradji et al., 2011, Rach et al., 2009, Salvaing et al., 2008, Salvaing et al., 2008, Quinones-Coello, 2007, Salvaing et al., 2007, Molnar et al., 2006, Stanyon et al., 2004)
                    anon-EST:Liang-1.25
                    anon-EST:Liang-2.24
                    chr3R:27424276..27424475
                    (Will et al., 2013)
                    clone 1.25
                    (Liang and Biggin, 1998)
                    clone 2.24
                    (Liang and Biggin, 1998)
                    cycG
                    (Bayer et al., 2017, Nagel et al., 2016, Nagel et al., 2012)
                    dCycG
                    (Szawinski et al., 2005, Nagel, 2001.8.31, Nagel et al., 2001)
                    i205
                    (Battersby et al., 2003)
                    i261
                    (Battersby et al., 2003)
                    Name Synonyms
                    Cyclin G
                    (Fischer et al., 2016, Nagel et al., 2016, Dupont et al., 2015, Fischer et al., 2015, Nagel et al., 2012, Debat et al., 2011, Faradji et al., 2011, Michaut et al., 2011, Salvaing et al., 2008, Zraly et al., 2006, Nagel et al., 2001)
                    cyclin G
                    (Hallier et al., 2015)
                    cyclin G1
                    (Van Hoof and Goris, 2003)
                    Secondary FlyBase IDs
                    • FBgn0025961
                    • FBgn0026001
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (73)