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Gene Dmel\salt

General Information
Symbol	Dmel\salt	Species	D. melanogaster
Name	salty dog	Annotation symbol	CG2196
Feature type	protein_coding_gene	FlyBase ID	FBgn0039872
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D2-100D2	Sequence location	3R:27,577,547..27,580,413 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene salty dog is referred to in FlyBase by the symbol Dmel\salt (CG2196, FBgn0039872). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sodium:iodide symporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Sodium/solute symporter; Sodium/solute symporter, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1633002_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of salt. Gene sequence location is 3R:27577547..27580413.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN33232 HFA15427
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D2-100D2   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\salt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) salt-RB FBtr0300915  NM_143632   2100   622
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein salt-PB   FBpp0290137   68.2   622   7.27     NP_651889   AAF57191
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734) Sodium/solute symporter, subgroup (IPR019900)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57191   AI388702   AW940750   AY060746 AAL28294   CK658373
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95SK1 Q9V9U2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039872    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039872 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039872 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr  (192) embryo 06-08hr  (218) embryo 08-10hr  (172) embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr  (679) embryo 20-22hr  (2027) embryo 22-24hr  (2777) larva L1  (3900) larva L2  (2640) larva L3 12hr old  (2718) larva L3 puffstage 1-2  (2127) larva L3 puffstage 3-6  (602) larva L3 puffstage 7-9  (152) white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP  (388) adult male 01day  (2033) adult male 05day  (2139) adult male 30day  (1695) adult female 01day  (1466) adult female 05day  (685) adult female 30day  (683) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr  (2027) embryo 22-24hr  (2777) larva L1  (3900) larva L2  (2640) larva L3 12hr old  (2718) larva L3 puffstage 1-2  (2127) larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day  (2033) adult male 05day  (2139) adult male 30day  (1695) adult female 01day  1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039872 expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr  (192) embryo 06-08hr  (218) embryo 08-10hr  (172) embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr  (679) embryo 20-22hr  (2027) embryo 22-24hr  (2777) larva L1  (3900) larva L2  (2640) larva L3 12hr old  (2718) larva L3 puffstage 1-2  (2127) larva L3 puffstage 3-6  (602) larva L3 puffstage 7-9  (152) white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP  (388) adult male 01day  (2033) adult male 05day  (2139) adult male 30day  (1695) adult female 01day  (1466) adult female 05day  (685) adult female 30day  (683) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr  2027 embryo 22-24hr  (2777) larva L1  (3900) larva L2  (2640) larva L3 12hr old  (2718) larva L3 puffstage 1-2  2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day  2033 adult male 05day  2139 adult male 30day  1695 adult female 01day  1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    22 embryo 04-06hr    192 embryo 06-08hr    218 embryo 08-10hr    172 embryo 10-12hr    89 embryo 12-14hr    56 embryo 14-16hr    18 embryo 16-18hr    85 embryo 18-20hr    679 embryo 20-22hr    2027 embryo 22-24hr    2777 larva L1    3900 larva L2    2640 larva L3 12hr old    2718 larva L3 puffstage 1-2    2127 larva L3 puffstage 3-6    602 larva L3 puffstage 7-9    152 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    17 pupae 2d postWPP    19 pupae 3d postWPP    77 pupae 4d postWPP    388 adult male 01day    2033 adult male 05day    2139 adult male 30day    1695 adult female 01day    1466 adult female 05day    685 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039872    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039872 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039872 expression level Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules    4099.9 Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules    7247.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules  (4099.9) Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules  (7247.8) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules  (4099.9) Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules  (7247.8) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules    4099.9 Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules    7247.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039872 expression level Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules    4099.9 Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules    7247.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules  (4099.9) Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules  (7247.8) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules  (4099.9) Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules  (7247.8) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.25 Larval Midgut no informative data Larval Hindgut    85.4 Larval Malpighian Tubules    4099.9 Larval Fat Body    5.2 Larval Salivary Gland no informative data Larval Trachea    4 Larval Carcass    2.075 Adult Head    3.8 Adult Eye    1.675 Adult Brain    6.5 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop    7.4 Adult Midgut    8.1 Adult Hindgut    70.2 Adult Malpighian Tubules    7247.8 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.9 Adult Ovary    4.3 Adult Testis    6.3 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.8   NA  Eye    1.675   NA  Brain    6.5   17.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.5   NA  Crop    7.4   no informative data  Midgut    8.1   85.4  Hindgut    70.2   4099.9  Malpighian Tubules    7247.8   5.2  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   4  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.9   NA  Ovary    4.3   NA  Testis    6.3   NA  Male Accessory Gland    no informative data   2.075  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2196-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 saltGD12732 Other Phenotypes Allele stress response defective, with Scer\GAL4c42 saltdsRNA.WIZ.Scer\UAS Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of salt Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of salt Class Mutagen Stocks Known lesion saltGD12732 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes saltKK113232 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes saltdsRNA.WIZ.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes saltGD574 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes saltScer\UAS.T:Avic\GFP-Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6220 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-salt.RNAi.WIZ} NA P{UAS-salt.Venus} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
basolateral plasma membrane inferred from direct assay (Stergiopoulos et al., 2009)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
sodium:iodide symporter activity inferred from sequence or structural similarity with EMBL:D87920 (FlyBase, 1992-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR001734 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions salt allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039872
Orthologs
Genome-wide drosophilid orthologs	Dere\GG11856 Dper\GL23436 Dsim\GD16315
Curated drosophilid orthologs	Dpse\GA15294
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240500 FBgn0240499 FBgn0240497 FBgn0216051 FBgn0216050 FBgn0216049 FBgn0216048 FBgn0216047 FBgn0210113 FBgn0210111 FBgn0210110 FBgn0187938 FBgn0187931 FBgn0187921 FBgn0171334 FBgn0171333 FBgn0171332 FBgn0075316 FBgn0075314 FBgn0075313 FBgn0161026 FBgn0161025 FBgn0161024 FBgn0133418 FBgn0133417 FBgn0133416 FBgn0133415 FBgn0039873 FBgn0017448 FBgn0121600 FBgn0121599 FBgn0104151 FBgn0104150 FBgn0104149 FBgn0100246 FBgn0100244 FBgn0100243 CPIJ006087 AGAP002622 AAEL010650
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v108782 P{KK113232}VIE-260B v28349 w1118; P{GD12732}v28349/TM3 v28350 w1118; P{GD12732}v28350/TM3
Genomic Clones ( 1 )
	BACR48C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH19680
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP15253
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43742
Antibody Information
Other Information
Discoverer
Etymology
	The gene has been named "salty dog" based on its role as a determinant of survival upon salt stress. (Stergiopoulos et al., 2009)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: salt CG2196 (Stergiopoulos et al., 2009)
Source for database merge of
Additional comments	One of the introns of CG2196 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG2196 intron is mir-1014. (Ruby et al., 2007)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143632 RefSeq (Proteins) • NP_651889 DDBJ / EMBL / GenBank • AAF57191 AAL28294 AI388702 AW940750 AY060746 Entrez Gene - A searchable database of RefSeq genes. • 43742 UniProtKB/TrEMBL • Q9V9U2 Q95SK1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734) Sodium/solute symporter, subgroup (IPR019900)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039872 DRSC - Results from RNAi screens. • FBgn0039872 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039872 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2196-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039872 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43742 modMine - Data generated by the modENCODE project. • FBgn0039872 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240500 FBgn0240499 FBgn0240497 FBgn0216051 FBgn0216050 FBgn0216049 FBgn0216048 FBgn0216047 FBgn0210113 FBgn0210111 FBgn0210110 FBgn0187938 FBgn0187931 FBgn0187921 FBgn0171334 FBgn0171333 FBgn0171332 FBgn0075316 FBgn0075314 FBgn0075313 FBgn0161026 FBgn0161025 FBgn0161024 FBgn0133418 FBgn0133417 FBgn0133416 FBgn0133415 FBgn0039873 FBgn0017448 FBgn0121600 FBgn0121599 FBgn0104151 FBgn0104150 FBgn0104149 FBgn0100246 FBgn0100244 FBgn0100243 CPIJ006087 AGAP002622 AAEL010650
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG2196 (Wang et al., 2004, Ruby et al., 2007, Stergiopoulos et al., 2009, Keleman et al., 2009.8.5, Fernández-Ayala et al., 2010) salt (Stergiopoulos et al., 2009)
Name Synonym	salty dog (Stergiopoulos et al., 2009, )
Secondary FlyBase IDs
References ( 15 )
Research paper	Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Stergiopoulos et al., 2009, Physiol. Genomics 37(1): 1--11 Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. [FBrf0206888] Wang et al., 2004, GenomeBiol. 5(9): R69 Function-informed transcriptome analysis of Drosophila renal tubule. [FBrf0180324]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Ruby et al., 2007, Nature 448(7149): Supplementary information. [FBrf0202573]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]