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Gene Dmel\Smvt

General Information
Symbol	Dmel\Smvt	Species	D. melanogaster
Name	Sodium-dependent multivitamin transporter	Annotation symbol	CG2191
Feature type	protein_coding_gene	FlyBase ID	FBgn0039873
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D2-100D2	Sequence location	3R:27,585,126..27,587,299 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sodium-dependent multivitamin transporter is referred to in FlyBase by the symbol Dmel\Smvt (CG2191, FBgn0039873). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sodium-dependent multivitamin transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Sodium/solute symporter; Sodium/solute symporter, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1633425_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Smvt. Gene sequence location is 3R:27585126..27587299.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA15426 BKN24169
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D2-100D2   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Smvt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Smvt-RA FBtr0085860  NM_143634   1994   591
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Smvt-PA   FBpp0085219   65.1   591   7.82     NP_651891   AAF57193
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734) Sodium/solute symporter, subgroup (IPR019900)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57193   AI386560   AI388242   AI389780   AY089594 AAL90332   BI167223   BI168189   BI213479   BI484915   BI577738   BI579056   BT050561   CO179271   CO186530   CO187797   CO277545   CO289587   CO292138   CO319219   CO322133   CO339810   CO343092   CZ479143   EC071781   EC206626   EC217663   EC218003   EC218703   EC224071   EC230696   EC250413   EC250414   EC253229   EC254478   EV598646
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXJ9 Q9V9U1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039873    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039873 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039873 expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr    10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr  (566) embryo 04-06hr  (3603) embryo 06-08hr  (3877) embryo 08-10hr  (1990) embryo 10-12hr  (405) embryo 12-14hr  (197) embryo 14-16hr  (139) embryo 16-18hr  (249) embryo 18-20hr  (2322) embryo 20-22hr  (7608) embryo 22-24hr  (10368) larva L1  (5921) larva L2  (3453) larva L3 12hr old  (3017) larva L3 puffstage 1-2  (1049) larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr  (364) white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP  (2781) adult male 01day  (1429) adult male 05day  (1649) adult male 30day  (2627) adult female 01day  (1179) adult female 05day  (797) adult female 30day  (1383) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr  (3603) embryo 06-08hr  (3877) embryo 08-10hr  (1990) embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr  (2322) embryo 20-22hr  (7608) embryo 22-24hr  (10368) larva L1  (5921) larva L2  (3453) larva L3 12hr old  (3017) larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP  (2781) adult male 01day  1429 adult male 05day  (1649) adult male 30day  (2627) adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr  10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr    10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039873 expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr    10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr  (566) embryo 04-06hr  (3603) embryo 06-08hr  (3877) embryo 08-10hr  (1990) embryo 10-12hr  (405) embryo 12-14hr  (197) embryo 14-16hr  139 embryo 16-18hr  (249) embryo 18-20hr  (2322) embryo 20-22hr  (7608) embryo 22-24hr  (10368) larva L1  (5921) larva L2  (3453) larva L3 12hr old  (3017) larva L3 puffstage 1-2  (1049) larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr  (364) white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP  (2781) adult male 01day  (1429) adult male 05day  (1649) adult male 30day  (2627) adult female 01day  (1179) adult female 05day  (797) adult female 30day  (1383) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr  (3603) embryo 06-08hr  (3877) embryo 08-10hr  1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr  2322 embryo 20-22hr  (7608) embryo 22-24hr  (10368) larva L1  (5921) larva L2  (3453) larva L3 12hr old  (3017) larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP  (2781) adult male 01day  1429 adult male 05day  1649 adult male 30day  (2627) adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr  10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    566 embryo 04-06hr    3603 embryo 06-08hr    3877 embryo 08-10hr    1990 embryo 10-12hr    405 embryo 12-14hr    197 embryo 14-16hr    139 embryo 16-18hr    249 embryo 18-20hr    2322 embryo 20-22hr    7608 embryo 22-24hr    10368 larva L1    5921 larva L2    3453 larva L3 12hr old    3017 larva L3 puffstage 1-2    1049 larva L3 puffstage 3-6    93 larva L3 puffstage 7-9    28 white prepupae new    10 white prepupae 12hr    364 white prepupae 24hr    20 pupae 2d postWPP    36 pupae 3d postWPP    57 pupae 4d postWPP    2781 adult male 01day    1429 adult male 05day    1649 adult male 30day    2627 adult female 01day    1179 adult female 05day    797 adult female 30day    1383 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039873    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039873 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039873 expression level Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules    5508.6 Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules  (5508.6) Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules  (5508.6) Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules    5508.6 Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039873 expression level Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules    5508.6 Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules  (5508.6) Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules  (5508.6) Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.825 Larval Midgut    1.3 Larval Hindgut    16.3 Larval Malpighian Tubules    357.4 Larval Fat Body    4 Larval Salivary Gland    3.7 Larval Trachea    1.525 Larval Carcass    6.075 Adult Head    2.6 Adult Eye    0.875 Adult Brain    2.3 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    5.3 Adult Midgut    6 Adult Hindgut    199.8 Adult Malpighian Tubules    5508.6 Adult Fat Body    4.2 Adult Salivary Gland    1.5 Adult Heart    6.225 Adult VirginFemale Spermatheca    4.6 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    2.2 Adult Testis    1.4 Adult Male Accessory Gland    5.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.6   NA  Eye    0.875   NA  Brain    2.3   2.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.9   NA  Crop    5.3   1.3  Midgut    6   16.3  Hindgut    199.8   357.4  Malpighian Tubules    5508.6   4  Fat Body    4.2   3.7  Salivary Gland    1.5   NA  Heart    6.225   1.525  Trachea    NA   NA  VirginFemale Spermatheca    4.6   NA  InseminatedFemale Spermatheca    5.6   NA  Ovary    2.2   NA  Testis    1.4   NA  Male Accessory Gland    5.4   6.075  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039873 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2191-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Smvt Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 SmvtGD12439 viable Smvte01332 Sterility Allele fertile Smvte01332 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 SmvtGD12439 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 SmvtGD12439
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Smvt Class Mutagen Stocks Known lesion Smvte01332 piggyBac transposase 2 -- SmvtMB04530 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Smvt Class Mutagen Stocks Known lesion SmvtGD12439 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmvtKK105033 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6220 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK105033} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Smvte01332 NA insertion of enhancer trap binary system Mi{ET1}SmvtMB04530 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sodium-dependent multivitamin transmembrane transporter activity inferred from sequence or structural similarity with EMBL:AF069307 (FlyBase, 1992-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR001734 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR001734, InterPro:IPR019900 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Smvt allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039873
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23249 Dere\GG11854 Dgri\GH14123 Dmoj\GI10651 Dper\GL23434 Dpse\GA15292 Dsec\GM16417 Dsim\GD16294 Dvir\GJ23008 Dwil\GK14042 Dyak\GE23300
Curated drosophilid orthologs	Dpse\GA15292
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CAGL0K03157g Candida glabrata (haploid yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240500 FBgn0240499 FBgn0240497 FBgn0216051 FBgn0216050 FBgn0216049 FBgn0216048 FBgn0216047 FBgn0210113 FBgn0210111 FBgn0210110 FBgn0187938 FBgn0187931 FBgn0187921 FBgn0171334 FBgn0171333 FBgn0171332 FBgn0075316 FBgn0075314 FBgn0075313 FBgn0161026 FBgn0161025 FBgn0161024 FBgn0133418 FBgn0133417 FBgn0133416 FBgn0133415 FBgn0039872 FBgn0017448 FBgn0121600 FBgn0121599 FBgn0104151 FBgn0104150 FBgn0104149 FBgn0100246 FBgn0100244 FBgn0100243 CPIJ006087 AGAP002622 AAEL010650
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17945 w1118; PBac{RB}Smvte01332 24718 w1118; Mi{ET1}SmvtMB04530
Harvard	- PBac{RB}Smvte01332
VDRC	v102662 P{KK105033}VIE-260B v40650 w1118; P{GD12439}v40650/TM3
Genomic Clones ( 2 )
	BACR16F16 BACR48C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE18886
Other clones	FI02923
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16677 GH21040 RE07559 RE08769 RE68105 RE71463 RE73029
Other clones	7584 71416 175942 214373.38 214537.35 CK01.22C.E2 CK01.40A.C6 CK01.40A.H5 CK01.75A.G9 CK01.91B.C3 Dmel_neb_005399_0946_3138 EK020649 EK033524 EK058925 EK071410 EK125440 EK187406 EK199315 EK276663 EP09440 EP16104 GH19068
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039873 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43744
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Smvt CG2191 (Camporeale et al., 2007)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143634 RefSeq (Proteins) • NP_651891 DDBJ / EMBL / GenBank • AAF57193 AAL90332 AY089594 BI213479 CZ479143 Entrez Gene - A searchable database of RefSeq genes. • 43744 UniProtKB/TrEMBL • Q8SXJ9 Q9V9U1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734) Sodium/solute symporter, subgroup (IPR019900)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039873 DRSC - Results from RNAi screens. • FBgn0039873 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039873 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2191-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039873 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43744 InParanoid A subset of ortholog calls from InParanoid. • CAGL0K03157g Candida glabrata (haploid yeast) modMine - Data generated by the modENCODE project. • FBgn0039873 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240500 FBgn0240499 FBgn0240497 FBgn0216051 FBgn0216050 FBgn0216049 FBgn0216048 FBgn0216047 FBgn0210113 FBgn0210111 FBgn0210110 FBgn0187938 FBgn0187931 FBgn0187921 FBgn0171334 FBgn0171333 FBgn0171332 FBgn0075316 FBgn0075314 FBgn0075313 FBgn0161026 FBgn0161025 FBgn0161024 FBgn0133418 FBgn0133417 FBgn0133416 FBgn0133415 FBgn0039872 FBgn0017448 FBgn0121600 FBgn0121599 FBgn0104151 FBgn0104150 FBgn0104149 FBgn0100246 FBgn0100244 FBgn0100243 CPIJ006087 AGAP002622 AAEL010650
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG2191 (Camporeale et al., 2007, Keleman et al., 2009.8.5) SMVT (Camporeale et al., 2007) smvt (Camporeale et al., 2007) Smvt
Name Synonym	CG2191   Sodium-dependent multivitamin transporter   sodium-dependent multivitamin transporter (Camporeale et al., 2007)
Secondary FlyBase IDs
References ( 15 )
Research paper	Camporeale et al., 2007, J. Nutr. 137(4): 885--889 Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. [FBrf0201013]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] BDGP TI submission, 2007.10.30, batch763.xml batch763.xml [FBrf0200261] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]