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Gene Dmel\CG2135

General Information
Symbol	Dmel\CG2135	Species	D. melanogaster
Name		Annotation symbol	CG2135
Feature type	protein_coding_gene	FlyBase ID	FBgn0039874
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D2-100D2	Sequence location	3R:27,595,015..27,597,575 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG2135 (FBgn0039874). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: beta-glucuronidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: carbohydrate metabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Galactose-binding domain-like; Glycoside hydrolase, family 2; Glycoside hydrolase, family 2, N-terminal; Glycoside hydrolase, family 2, TIM barrel; Glycoside hydrolase, family 2, conserved site; Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich; Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain; Glycoside hydrolase, subgroup, catalytic domain; Glycoside hydrolase, superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval fat body, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1634412_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG2135. Gene sequence location is 3R:27595015..27597575.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA15419 BKN32924
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D2-100D2   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG2135 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG2135-RA FBtr0085858  NM_143636   2336   686
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG2135-PA   FBpp0085217   79.3   686   6.97     NP_651893   AAF57195
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 2 (IPR006101) Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich (IPR006102) Glycoside hydrolase, family 2, TIM barrel (IPR006103) Glycoside hydrolase, family 2, N-terminal (IPR006104) Galactose-binding domain-like (IPR008979) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain (IPR013812) Glycoside hydrolase, superfamily (IPR017853) Glycoside hydrolase, family 2, conserved site (IPR023230)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140857   AA140858   AA391574   AE014297 AAF57195   AI511736   AW942143   BG639084   BI358057   BI481580   BI638413   BI640947   BT010073 AAQ22542   CO276415   CO284586   CO288443   CO301227   CO303391   CZ479591   CZ479592   EC065654   EC079669   EC090241   EC194839   EC200262   EC208954   EC217066   EC218996   EC242422   ES690334   ES690367   ES690386
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V9T9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039874    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039874 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039874 expression level Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (819) embryo 02-04hr  (1166) embryo 04-06hr  (1298) embryo 06-08hr  (1162) embryo 08-10hr  (1070) embryo 10-12hr  (836) embryo 12-14hr  (1099) embryo 14-16hr  (749) embryo 16-18hr  (742) embryo 18-20hr  (428) embryo 20-22hr  (537) embryo 22-24hr  (527) larva L1  (480) larva L2  (796) larva L3 12hr old  (594) larva L3 puffstage 1-2  (729) larva L3 puffstage 3-6  (943) larva L3 puffstage 7-9  (1071) white prepupae new  (1158) white prepupae 12hr  (921) white prepupae 24hr  (1042) pupae 2d postWPP  (691) pupae 3d postWPP  (354) pupae 4d postWPP  (298) adult male 01day  (468) adult male 05day  (543) adult male 30day  (501) adult female 01day  (516) adult female 05day  (817) adult female 30day  (851) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039874 expression level Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (819) embryo 02-04hr  (1166) embryo 04-06hr  (1298) embryo 06-08hr  (1162) embryo 08-10hr  (1070) embryo 10-12hr  (836) embryo 12-14hr  (1099) embryo 14-16hr  (749) embryo 16-18hr  (742) embryo 18-20hr  (428) embryo 20-22hr  (537) embryo 22-24hr  (527) larva L1  (480) larva L2  (796) larva L3 12hr old  (594) larva L3 puffstage 1-2  (729) larva L3 puffstage 3-6  (943) larva L3 puffstage 7-9  (1071) white prepupae new  (1158) white prepupae 12hr  (921) white prepupae 24hr  (1042) pupae 2d postWPP  (691) pupae 3d postWPP  (354) pupae 4d postWPP  (298) adult male 01day  (468) adult male 05day  (543) adult male 30day  (501) adult female 01day  (516) adult female 05day  (817) adult female 30day  (851) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    819 embryo 02-04hr    1166 embryo 04-06hr    1298 embryo 06-08hr    1162 embryo 08-10hr    1070 embryo 10-12hr    836 embryo 12-14hr    1099 embryo 14-16hr    749 embryo 16-18hr    742 embryo 18-20hr    428 embryo 20-22hr    537 embryo 22-24hr    527 larva L1    480 larva L2    796 larva L3 12hr old    594 larva L3 puffstage 1-2    729 larva L3 puffstage 3-6    943 larva L3 puffstage 7-9    1071 white prepupae new    1158 white prepupae 12hr    921 white prepupae 24hr    1042 pupae 2d postWPP    691 pupae 3d postWPP    354 pupae 4d postWPP    298 adult male 01day    468 adult male 05day    543 adult male 30day    501 adult female 01day    516 adult female 05day    817 adult female 30day    851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039874    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039874 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval fat body, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039874 expression level Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039874 expression level Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    76.65 Larval Midgut    57.2 Larval Hindgut    42.9 Larval Malpighian Tubules    150.6 Larval Fat Body    137.6 Larval Salivary Gland    46 Larval Trachea    52.7 Larval Carcass    34.125 Adult Head    42.9 Adult Eye    23 Adult Brain    49.5 Adult Thoracic-Abdominal Ganglion    53.5 Adult Crop    39.4 Adult Midgut    61.3 Adult Hindgut    53.2 Adult Malpighian Tubules    112.6 Adult Fat Body    48.9 Adult Salivary Gland    64.9 Adult Heart    69.1 Adult VirginFemale Spermatheca    53.8 Adult InseminatedFemale Spermatheca    36.2 Adult Ovary    43 Adult Testis    32.9 Adult Male Accessory Gland    116.8 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    42.9   NA  Eye    23   NA  Brain    49.5   76.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    53.5   NA  Crop    39.4   57.2  Midgut    61.3   42.9  Hindgut    53.2   150.6  Malpighian Tubules    112.6   137.6  Fat Body    48.9   46  Salivary Gland    64.9   NA  Heart    69.1   52.7  Trachea    NA   NA  VirginFemale Spermatheca    53.8   NA  InseminatedFemale Spermatheca    36.2   NA  Ovary    43   NA  Testis    32.9   NA  Male Accessory Gland    116.8   34.125  Carcass    53.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039874 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2135-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG2135GD5639 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG2135 Class Mutagen Stocks Known lesion CG2135e01776 piggyBac transposase 1 -- CG2135EP3105 P-element activity 1 -- CG2135EP983 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG2135 Class Mutagen Stocks Known lesion CG2135GD5639 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG2135KK112924 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6220 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5639} NA P{KK112924} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG2135EP983 NA P{EP}CG2135EP3105 NA miscellaneous insertions PBac{RB}CG2135e01776 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
beta-glucuronidase activity inferred from sequence or structural similarity with UniProtKB:P12265 (FlyBase, 1992-) cation binding inferred from electronic annotation with InterPro:IPR013781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR006101, InterPro:IPR006102, InterPro:IPR006103, InterPro:IPR006104, InterPro:IPR013781, InterPro:IPR013812 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG2135 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039874 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43746
Orthologs
Genome-wide drosophilid orthologs	Dere\GG11851 Dsec\GM16415 Dyak\GE23298
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • 263381 Thalassiosira pseudonana (marine diatom) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240495 FBgn0219841 FBgn0206812 FBgn0171330 FBgn0245462 FBgn0149370 FBgn0143362 FBgn0130086 FBgn0104146 FBgn0088533
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	17206 w1118; P{EP}CG2135EP983
Harvard	- PBac{RB}CG2135e01776
Kyoto	122059 w1118; P{EP}CG2135EP3105
VDRC	v103338 P{KK112924}VIE-260B v16625 w1118; P{GD5639}v16625 v16628 w1118; P{GD5639}v16628
Genomic Clones ( 2 )
	BACR16F16 BACR48C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10588
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE44724 RE64156 SD20701 SD23989
Other clones	58262 121151 191120 CK01.23A.E8 CK01.86D.G9 CK01.100A.F9 CK01.114B.B6 CK01.147B.H6 CK00521 EK068525 EK120763 EK166343 EK180455 EK241238 LD43237
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039874 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43746
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143636 RefSeq (Proteins) • NP_651893 DDBJ / EMBL / GenBank • AA391574 AAF57195 AAQ22542 AW942143 BT010073 CZ479591 CZ479592 Entrez Gene - A searchable database of RefSeq genes. • 43746 UniProtKB/TrEMBL • Q9V9T9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase, family 2 (IPR006101) Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich (IPR006102) Glycoside hydrolase, family 2, TIM barrel (IPR006103) Glycoside hydrolase, family 2, N-terminal (IPR006104) Galactose-binding domain-like (IPR008979) Glycoside hydrolase, subgroup, catalytic domain (IPR013781) Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain (IPR013812) Glycoside hydrolase, superfamily (IPR017853) Glycoside hydrolase, family 2, conserved site (IPR023230)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039874 DRSC - Results from RNAi screens. • FBgn0039874 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039874 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2135-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039874 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43746 InParanoid A subset of ortholog calls from InParanoid. • 263381 Thalassiosira pseudonana (marine diatom) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43746 modMine - Data generated by the modENCODE project. • FBgn0039874 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240495 FBgn0219841 FBgn0206812 FBgn0171330 FBgn0245462 FBgn0149370 FBgn0143362 FBgn0130086 FBgn0104146 FBgn0088533
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG2135 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126704]