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Gene Dmel\Ir100a

General Information
Symbol	Dmel\Ir100a	Species	D. melanogaster
Name	Ionotropic receptor 100a	Annotation symbol	CG11575
Feature type	protein_coding_gene	FlyBase ID	FBgn0039879
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100D2-100D2	Sequence location	3R:27,626,685..27,628,496 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 100a is referred to in FlyBase by the symbol Dmel\Ir100a (CG11575, FBgn0039879). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ligand-gated ion channel activity. There is experimental evidence that it is involved in the biological process: sensory perception of taste. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of extremely low expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637389_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ir100a. Gene sequence location is 3R:27626685..27628496.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100D2-100D2   Limits computationally determined from genome sequence between P{EP}pygoEP1076 and P{PZ}ttk02667&P{lacW}ttkj6C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir100a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir100a-RA FBtr0085846  NM_143641   1812   603
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir100a-PA   FBpp0085205   68.3   603   8.13     NP_651898   AAF57202
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57202
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V9T2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.1 Larval Midgut    3.4 Larval Hindgut    2.1 Larval Malpighian Tubules    6.5 Larval Fat Body    6.6 Larval Salivary Gland    2.3 Larval Trachea    5.125 Larval Carcass    7 Adult Head    4 Adult Eye    4.325 Adult Brain    1.6 Adult Thoracic-Abdominal Ganglion    1.9 Adult Crop    4 Adult Midgut    7.4 Adult Hindgut    4.6 Adult Malpighian Tubules    3.4 Adult Fat Body    4.9 Adult Salivary Gland    5.6 Adult Heart    2.6 Adult VirginFemale Spermatheca    1.5 Adult InseminatedFemale Spermatheca    5 Adult Ovary    2.2 Adult Testis    17.7 Adult Male Accessory Gland    6.2 Adult Carcass    3.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4   NA  Eye    4.325   NA  Brain    1.6   3.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.9   NA  Crop    4   3.4  Midgut    7.4   2.1  Hindgut    4.6   6.5  Malpighian Tubules    3.4   6.6  Fat Body    4.9   2.3  Salivary Gland    5.6   NA  Heart    2.6   5.125  Trachea    NA   NA  VirginFemale Spermatheca    1.5   NA  InseminatedFemale Spermatheca    5   NA  Ovary    2.2   NA  Testis    no informative data   NA  Male Accessory Gland    6.2   7  Carcass    3.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11575-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ir100aGD3146 Ir100aGD16777 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ir100a Class Mutagen Stocks Known lesion Ir100aG19846 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir100a Class Mutagen Stocks Known lesion Ir100aGD3146 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ir100aGD16777 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir100aKK103991 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir100aNIG.11575R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6220 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK103991} NA P{NIG.11575R} NA GAL4 construct P{Ir100a-GAL4.C} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Ir100aG19846 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
sensory perception of taste inferred from expression pattern (Croset et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process
CV term Evidence References
detection of chemical stimulus inferred from sequence or structural similarity with Ir92a (Benton et al., 2009)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir100a allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039879
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60023V Dipteran inclusive ortholog search EOG6RXZ7D Insect inclusive ortholog search EOG67SR8W Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG60023V)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir100a     Drosophila sechellia   Dsec\GM16454 Y   Drosophila erecta   Dere\GG11834 Y   Drosophila yakuba   Dyak\GE10968 Y   Drosophila ananassae   Dana\GF17490 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26481 Y   Drosophila persimilis   Dper\GL24026 Y   Drosophila willistoni   Dwil\GK12158 Y   Drosophila virilis   Dvir\GJ24458 Y   Drosophila mojavensis   Dmoj\GI24813 Y   Drosophila grimshawi   Dgri\GH13750 Y
Orthologs in non-Drosophila Dipterans (EOG6RXZ7D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015266 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015078 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015079 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015647 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008332 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015267 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015265 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000140 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012267 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012270 Y
Orthologs in non-Dipteran Insects (EOG67SR8W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008704 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008560 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008878 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006212 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015467 Y Tribolium castaneum Red flour beetle  Tcas\TC002654 Y Tribolium castaneum Red flour beetle  Tcas\TC009418 Y Tribolium castaneum Red flour beetle  Tcas\TC003059 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM16454 Drosophila erecta Dere\GG11834 Drosophila yakuba Dyak\GE10968 Drosophila ananassae Dana\GF17490 Drosophila pseudoobscura pseudoobscura Dpse\GA26481 Drosophila persimilis Dper\GL24026 Drosophila willistoni Dwil\GK12158 Drosophila virilis Dvir\GJ24458 Drosophila mojavensis Dmoj\GI24813 Drosophila grimshawi Dgri\GH13750
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31853 w1118; P{EP}Ir100aG19846 CG42233G19846
VDRC	v102826 P{KK103991}VIE-260B v30200 w1118; P{GD3146}v30200 v50014 w1118; P{GD16777}v50014 v30199 w1118; P{GD3146}v30199/TM3
Genomic Clones ( 2 )
	BACR16F16 BACR48C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43753
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir100a CG11575 (Benton et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143641 RefSeq (Proteins) • NP_651898 DDBJ / EMBL / GenBank • AAF57202 Entrez Gene - A searchable database of RefSeq genes. • 43753 UniProtKB/TrEMBL • Q9V9T2
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039879 DRSC - Results from RNAi screens. • FBgn0039879 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039879 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11575-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039879 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43753 modMine - Data generated by the modENCODE project. • FBgn0039879
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG11575 (Benton et al., 2009, Croset et al., 2010, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) DmelIR100a (Croset et al., 2010) Ir100a (Senthilan et al., 2012) IR100a (Benton et al., 2009, Croset et al., 2010)
Name Synonym	CG11575   ionotropic receptor 100a (Benton et al., 2009) Ionotropic receptor 100a
Secondary FlyBase IDs
References ( 14 )
Research paper	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Croset et al., 2010, PLoS Genet. 6(8): e1001064 Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. [FBrf0211681] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496]
Supplementary material	Croset et al., 2010, PLoS Genet. 6(8): Supporting Information: Table S3. [FBrf0219605] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2010.7.14, BDGP_2010_0715.GenExel.xml BDGP_2010_0715.GenExel.xml [FBrf0211255] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]