Gene Dmel\mav

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General Information

Symbol

Dmel\mav

Species

D. melanogaster

Name

maverick

Annotation symbol

CG1901

Feature type

protein_coding_gene

FlyBase ID

FBgn0039914

Gene Model Status

Current

Stock availability

2 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

102D1-102D1

Sequence location

4:643,845..646,657 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene maverick is referred to in FlyBase by the symbol Dmel\mav (CG1901, FBgn0039914). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transforming growth factor beta receptor binding. Based on sequence similarity, it is predicted to be involved in the biological process: transforming growth factor beta receptor signaling pathway. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Transforming growth factor beta, conserved site; Transforming growth factor-beta, C-terminal; Transforming growth factor-beta, N-terminal; Transforming growth factor-beta-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, adult heart, adult ovary, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633723_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of mav. Gene sequence location is 4:643845..646657.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102D1-102D1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

102C-102C

(Nguyen, 2000.4.4)

102C-102C

(determined by in situ hybridisation)

(Nguyen et al., 2000)

Experimentally Determined Recombination Data

Location

(Nguyen et al., 2000)

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\mav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

mav-RA

FBtr0089103

NM_079887

2705

701

Additional Transcript Data & Comments

Reported size (kB)

2.8 (northern blot)

(Nguyen et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

mav-PA

FBpp0088172

81.1

701

10.38

NP_524626

AAF59328

Additional Polypeptide Data & Comments

Reported size (kDa)

701, 433 (aa)

(Nguyen et al., 2000)

Comments

mav protein belongs to the TGF-β superfamily but is not easily assigned to either the TGF-β, the BMP or activin subfamilies. It shows the highest sequence similarity with BMP-related ligands from other organisms.

(Nguyen et al., 2000)

The shorter predicted mav protein isoform lacks a signal sequence suggesting that it may not be secreted.

(Nguyen et al., 2000)

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Transforming growth factor-beta, N-terminal (IPR001111)

Transforming growth factor-beta, C-terminal (IPR001839)

Transforming growth factor-beta-related (IPR015615)

Transforming growth factor beta, conserved site (IPR017948)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | uniform

(Nguyen et al., 2000)

Comment:maternal contribution

embryonic stage 4

pole cell

(Nguyen et al., 2000)

embryonic stage 5

organism | ubiquitous

(Nguyen et al., 2000)

embryonic stage 5 -- 11

organism | ubiquitous

(Nguyen et al., 2000)

embryonic stage 6 -- 11

organism | ubiquitous

(Nguyen et al., 2000)

Comment:expressed at low levels

embryonic stage 7 -- 9

endoderm

(Nguyen et al., 2000)

mesoderm

(Nguyen et al., 2000)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Nguyen et al., 2000)

posterior midgut primordium

(Nguyen et al., 2000)

hindgut proper primordium

(Nguyen et al., 2000)

embryonic stage 11

anterior midgut primordium

(Nguyen et al., 2000)

foregut primordium

(Nguyen et al., 2000)

embryonic stage 11 -- 12

embryonic foregut

(Nguyen et al., 2000)

embryonic stage 11 -- 14

epidermis | dorso-lateral & segmentally repeated

(Nguyen et al., 2000)

embryonic stage 12

embryonic hindgut | restricted

(Nguyen et al., 2000)

embryonic/larval pharynx | precursor

(Nguyen et al., 2000)

esophagus primordium

(Nguyen et al., 2000)

embryonic stage 12 -- 17

pharynx

(Nguyen et al., 2000)

embryonic esophagus

(Nguyen et al., 2000)

embryonic hindgut

(Nguyen et al., 2000)

embryonic stage 13

visceral mesoderm of posterior embryonic/larval midgut

(Nguyen et al., 2000)

visceral mesoderm of anterior embryonic/larval midgut

(Nguyen et al., 2000)

embryonic stage 13 -- 14

visceral mesoderm | intense

(Nguyen et al., 2000)

embryonic stage 13 -- 17

embryonic/larval gut | faint

(Nguyen et al., 2000)

adult stage | male

testis | apical

(Schulz et al., 2004)

oogenesis stage S10 & adult stage | female

nurse cell

(Nguyen et al., 2000)

adult stage oogenesis stage S10 -- S14

oocyte

(Nguyen et al., 2000)

nurse cell

(Nguyen et al., 2000)

oogenesis stage S10 -- S14 & adult stage | female

oocyte

(Nguyen et al., 2000)

spermatogenesis

male germline stem cell

(Schulz et al., 2004)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Nguyen et al., 2000)

embryonic stage 1 -- third instar larval stage & adult stage

organism

(Nguyen et al., 2000)

Comment:P-stage not assayed

adult stage | male

organism

(Nguyen et al., 2000)

adult stage | female

organism

(Nguyen et al., 2000)

Additional Descriptive Data

Expression is observed in early germ cells in the apical testis tip.

(Schulz et al., 2004)

Marker for

male germline stem cell

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult hindgut, adult heart, adult ovary, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		3612.7
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		(621.175)
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		(3612.7)
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		(3612.7)
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		3612.7
Adult Carcass		103.8
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		3612.7
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		(3612.7)
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		(3612.7)
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		96.125
Larval Midgut		41.9
Larval Hindgut		246.8
Larval Malpighian Tubules		19.5
Larval Fat Body		83.7
Larval Salivary Gland		22.3
Larval Trachea		621.175
Larval Carcass		410.75
Adult Head		146.7
Adult Eye		184.775
Adult Brain		134.3
Adult Thoracic-Abdominal Ganglion		116.5
Adult Crop		523.5
Adult Midgut		42
Adult Hindgut		273.5
Adult Malpighian Tubules		17.3
Adult Fat Body		29.5
Adult Salivary Gland		22.7
Adult Heart		131.7
Adult VirginFemale Spermatheca		32.1
Adult InseminatedFemale Spermatheca		31
Adult Ovary		359.4
Adult Testis		34.4
Adult Male Accessory Gland		3612.7
Adult Carcass		103.8
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	146.7
NA	Eye	184.775
NA	Brain	134.3
96.125	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	116.5
NA	Crop	523.5
41.9	Midgut	42
246.8	Hindgut	273.5
19.5	Malpighian Tubules	no informative data
83.7	Fat Body	29.5
22.3	Salivary Gland	no informative data
NA	Heart	131.7
621.175	Trachea	NA
NA	VirginFemale Spermatheca	32.1
NA	InseminatedFemale Spermatheca	31
NA	Ovary	359.4
NA	Testis	34.4
NA	Male Accessory Gland	3612.7
410.75	Carcass	103.8

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(28)
central nervous system, larvae L3		16
central nervous system, pupae P8		(36)
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		(34)
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		(50)
ovary, mated 4-day female		(45)
testis, mated 4-day male		3
accessory gland, mated 4-day male		(49)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		(36)
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		(34)
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		(50)
ovary, mated 4-day female		(45)
testis, mated 4-day male		3
accessory gland, mated 4-day male		(49)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		16
central nervous system, pupae P8		36
head, virgin 1-day female		24
head, virgin 4-day female		13
head, virgin 20-day female		8
head, mated 1-day female		15
head, mated 4-day female		11
head, mated 20-day female		6
head, mated 1-day male		25
head, mated 4-day male		20
head, mated 20-day male		17
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		5
digestive system, 4-day adult		7
digestive system, 20-day adult		3
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		26
carcass, larvae L3 wandering		34
carcass, 1-day adult		13
carcass, 4-day adult		12
carcass, 20-day adult		7
ovary, virgin 4-day female		50
ovary, mated 4-day female		45
testis, mated 4-day male		3
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		(29)
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		(27)
embryo 10-12hr		14
embryo 12-14hr		(29)
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		(29)
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		19
embryo 02-04hr		29
embryo 04-06hr		26
embryo 06-08hr		24
embryo 08-10hr		27
embryo 10-12hr		14
embryo 12-14hr		29
embryo 14-16hr		11
embryo 16-18hr		25
embryo 18-20hr		15
embryo 20-22hr		19
embryo 22-24hr		29
larva L1		8
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		20
white prepupae new		20
white prepupae 12hr		12
white prepupae 24hr		22
pupae 2d postWPP		26
pupae 3d postWPP		21
pupae 4d postWPP		7
adult male 01day		13
adult male 05day		10
adult male 30day		8
adult female 01day		6
adult female 05day		17
adult female 30day		14
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		(27)
leg disc CME L1		7
wing disc CME-W2		(29)
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		(27)
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		(37)
ovary OSC		(33)
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		(37)
ovary OSC		(33)
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		18
Schneider line 2 Sg4		6
embryonic 1182-4H		8
embryonic GM2		1
embryonic Kc167		9
embryonic S1		11
embryonic S3		27
leg disc CME L1		7
wing disc CME-W2		29
wing disc ML-DmD8		17
wing disc ML-DmD9		9
wing disc ML-DmD16-c3		27
wing disc ML-DmD21		5
wing disc ML-DmD32		12
haltere disc ML-DmD17-c3		3
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		1
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		26
ovary fGS/OSS		37
ovary OSC		33
ovary OSS		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		(30)
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		(33)
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		(45)
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(36)
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		(33)
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		(45)
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(36)
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		5
heat shock, 4-day adult		15
Cadmium 50 mM 6 hrs, larvae L3		9
Cadmium 50 mM 12 hrs, larvae L3		30
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		33
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		45
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		15
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		18
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		36
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		25
Paraquat 10 mM 48 hrs, 4-day adult		18
Rotenone 2 μg 12 hrs, larvae L3		16
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039914

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG1901-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

mav^GD9672

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of mav	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mav	Mutagen	Stocks	Known lesion
mav^GL01025	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
mav^HMS01125	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
mav^GD9672	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
mav^NIG.1901R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
mav^Scer\UAS.cGa	in vitro construct - regulatory fusion	0	Yes
mav^Scer\UAS.cNa	in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

growth factor activity

inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948

(FlyBase Curators et al., 2004-)

transforming growth factor beta receptor binding

inferred from sequence or structural similarity with human TGFB3

(FlyBase, 1992-)

non-traceable author statement

(Nguyen, 2000.4.4)

Biological Process

CV term

Evidence

References

growth

inferred from electronic annotation with InterPro:IPR001111

(FlyBase Curators et al., 2004-)

transforming growth factor beta receptor signaling pathway

inferred from sequence or structural similarity with human TGFB3 AND inferred from sequence or structural similarity with mouse Bmp2

(FlyBase, 1992-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mav allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

68636

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039914

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

43804

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q59DQ3

Orthologs

OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6HT9BQ

Dipteran inclusive ortholog search

EOG6QZ7V3

Insect inclusive ortholog search

EOG68SFP5

Arthropod inclusive ortholog search

EOG6ZPC9B

Metazoa inclusive ortholog search

EOG6KHFMZ

Orthologs in Drosophila Species (EOG6HT9BQ)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15119

Drosophila persimilis

Dper\GL18182

Drosophila willistoni

Dwil\GK13699

Drosophila virilis

Dvir\GJ14763

Drosophila mojavensis

Dmoj\GI14122

Drosophila grimshawi

Dgri\GH23994

Orthologs in non-Drosophila Dipterans (EOG6QZ7V3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002974

Anopheles gambiae

Malaria mosquito

Agam\AGAP012076

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010282

Orthologs in non-Dipteran Insects (EOG68SFP5)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB55516

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005030

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH12660

Atta cephalotes

Leafcutter ant

Acep\ACEP18574

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO14008

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL13459

Linepithema humile

Argentine ant

Lhum\LH14977

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB19254

Solenopsis invicta

Red fire ant

Sinv\SINV18887

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI45229

Pediculus humanus

Human body louse

Phum\PHUM193220

Tribolium castaneum

Red flour beetle

Tcas\Mav

Orthologs in non-Insect Arthropods (EOG6ZPC9B)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\rmeR

Ixodes scapularis

Deer tick

Isca\ISCW020646

Orthologs in non-Arthropod Metazoa (EOG6KHFMZ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_018248gn

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15119

Drosophila persimilis

Dper\GL18182

Drosophila willistoni

Dwil\GK13699

Drosophila virilis

Dvir\GJ14763

Drosophila mojavensis

Dmoj\GI14122

Drosophila grimshawi

Dgri\GH23994

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

Bloomington

34650

y¹ sc^* v¹; P{TRiP.HMS01125}attP2

36809

y¹ sc^* v¹; P{TRiP.GL01025}attP40

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 154 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones