FlyBase Gene Report: Dmel\Gat

General Information

Symbol

Dmel\Gat

Species

D. melanogaster

Name

GABA transporter

Annotation Symbol

CG1732

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039915

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

GABA transporter (Gat) encodes a protein belonging to the SLC family that is expressed primarily in astrocytes, where it is thought to be required for uptake of GABA and other small molecules. It likely plays an important role in setting the excitatory/inhibitory balance of the CNS. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

4:629,691..635,350 [+]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:629691..635350

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity

Summaries

Gene Group (FlyBase)

SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -: Solute carrier family 6 (SLC6) members are Na⁺/Cl^--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Gat or the JBrowse view of Dmel\Gat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gat-RA

FBtr0089972

NM_143673

2895

636

Gat-RB

FBtr0089971

NM_166779

2853

508

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Gat-PA

FBpp0088910

72.3

636

7.20

NP_651930

AAF59327

Gat-PB

FBpp0088909

56.8

508

6.63

NP_726594

AAN06506

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gat using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

gamma-aminobutyric acid:sodium symporter activity

inferred from sequence model

(Thimgan et al., 2006)

neurotransmitter:sodium symporter activity

inferred from electronic annotation with InterPro:IPR037272

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

cellular response to mechanical stimulus

inferred from direct assay

(Muthukumar et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

gamma-aminobutyric acid transport

inferred from sequence model

(Thimgan et al., 2006)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

glial cell projection

inferred from direct assay

(Stork et al., 2014)

plasma membrane

inferred from direct assay

(Stork et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

integral component of membrane

inferred from electronic annotation with InterPro:IPR000175

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence model

(Thimgan et al., 2006)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000177662

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

third instar larval stage

optic lobe neuroepithelial cell

(Wang et al., 2013)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Romero-Calderon et al., 2007)

adult thorax | faint

Comment: Thorax and abdomen assayed together. Band of 3.2kb detected.

(Romero-Calderon et al., 2007)

adult abdomen | faint

Comment: Thorax and abdomen assayed together. Band of 3.2kb detected.

(Romero-Calderon et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

reticular neuropil associated glial cell

(Stork et al., 2014)

third instar larval stage

ventral nerve cord

(Stork et al., 2014)

reticular neuropil associated glial cell

(Coutinho-Budd et al., 2017)

adult stage

reticular neuropil associated glial cell

• membrane

(Muthukumar et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Muthukumar et al., 2014)

pharate adult stage P9 -- P15

adult brain

(Muthukumar et al., 2014)

pharate adult stage P8

adult brain | faint

(Muthukumar et al., 2014)

Additional Descriptive Data

Gat protein is exclusively detected in the membrane surface of astrocytes in embryos, larvae, pupae, and adults.

(Stork et al., 2014)

Marker for

reticular neuropil associated glial cell

(Coutinho-Budd et al., 2017)

Subcellular Localization

CV Term

Evidence

References

glial cell projection

inferred from direct assay

(Stork et al., 2014)

plasma membrane

inferred from direct assay

(Stork et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gat in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gat

View exonic expression by tissue for Dmel\Gat

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039915

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039915

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1732-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1732

Flygut - An atlas of the Drosophila adult midgut

FBgn0039915

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gat

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gat

Transgenic constructs containing regulatory region of Gat

Deletions and Duplications ( 1 )

Disrupted in

Df(4)Gat^Δ64kb

(Stork et al., 2014)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage

Gat^22-1

lethal - all die during embryonic stage (with Df(4)Gat^Δ64kb)

Gat^22-1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gat^GD5029

viable, with Scer\GAL4^Mef2.PR

Gat^GD5029

viable, with Scer\GAL4^nSyb.PS

Gat^KK107895

viable, with Scer\GAL4^pnr-MD237

Gat^GD5029

viable, with Scer\GAL4^repo.PU

Gat^KK107895

viable, with Scer\GAL4^tin.CΔ4

Gat^GD5029

Other Phenotypes

Allele

locomotor behavior defective | third instar larval stage, with Scer\GAL4^alrm.PD

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (19)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC6A1

15 of 15

Yes

Hsap\SLC6A11

5 of 15

Yes

Hsap\SLC6A12

5 of 15

Yes

Hsap\SLC6A13

5 of 15

Yes

Hsap\SLC6A6

4 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc6a1

15 of 15

Yes

Mmus\Slc6a11

5 of 15

Yes

Mmus\Slc6a12

5 of 15

Yes

Mmus\Slc6a13

5 of 15

Yes

Mmus\Slc6a6

4 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (19)

Rnor\Slc6a1

13 of 13

Yes

Rnor\Slc6a11

5 of 13

Yes

Rnor\Slc6a12

5 of 13

Yes

Rnor\Slc6a13

5 of 13

Yes

Rnor\Slc6a6

4 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (19)

Xtro\LOC100127682

8 of 12

Yes

Xtro\slc6a1

7 of 12

Yes

Xtro\slc6a8

3 of 12

Yes

Xtro\slc6a6

2 of 12

Yes

Xtro\slc6a15

2 of 12

Xtro\slc6a17

2 of 12

Xtro\LOC100497766

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\slc6a9

1 of 12

Xtro\slc6a12

1 of 12

Yes

Xtro\slc6a13

1 of 12

Yes

Xtro\slc6a14.2

1 of 12

Xtro\slc6a16

1 of 12

Xtro\slc6a19

1 of 12

Danio rerio (Zebrafish) (35)

Drer\slc6a1b

14 of 15

Yes

Drer\slc6a1l

12 of 15

Yes

Drer\slc6a1a

11 of 15

Yes

Drer\si:ch211-117c9.5

4 of 15

Yes

Drer\si:ch211-132b12.1

4 of 15

Yes

Drer\si:ch211-132b12.2

4 of 15

Yes

Drer\si:ch211-132b12.3

4 of 15

Yes

Drer\slc6a6a

4 of 15

Yes

Drer\slc6a11b

4 of 15

Yes

Drer\slc6a13

4 of 15

Yes

Drer\slc6a22.2

4 of 15

Yes

Drer\si:ch211-132b12.6

3 of 15

Yes

Drer\slc6a22.1

3 of 15

Yes

Drer\zgc:158427

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\slc6a9

2 of 15

Drer\slc6a11b

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\si:ch211-225b11.1

1 of 15

Drer\si:ch211-283g2.1

1 of 15

Drer\slc6a6b

1 of 15

Yes

Drer\slc6a16b

1 of 15

Drer\slc6a18

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\snf-11

15 of 15

Yes

Cele\snf-3

3 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\Y43D4A.1

1 of 15

Arabidopsis thaliana (thale-cress) (18)

Atha\AT1G19070

1 of 9

Yes

Atha\AT1G57980

1 of 9

Yes

Atha\AT2G33796

1 of 9

Yes

Atha\AT3G44060

1 of 9

Yes

Atha\AT3G44080

1 of 9

Yes

Atha\AT3G44090

1 of 9

Yes

Atha\AT3G44180

1 of 9

Yes

Atha\AT3G58920

1 of 9

Yes

Atha\AT3G58960

1 of 9

Yes

Atha\AT4G22280

1 of 9

Yes

Atha\AT5G12450

1 of 9

Yes

Atha\AT5G15620

1 of 9

Yes

Atha\PUP14

1 of 9

Yes

Atha\PUP16

1 of 9

Yes

Atha\PUP17

1 of 9

Yes

Atha\PUP18

1 of 9

Yes

Atha\PUP19

1 of 9

Yes

Atha\SAF1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\meu31

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903RW )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Gat

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila persimilis

Dper\GL18181

Drosophila willistoni

Dwil\GK13698

Drosophila virilis

Dvir\GJ13697

Drosophila mojavensis

Dmoj\GI11503

Drosophila grimshawi

Dgri\GH14803

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502IJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17008714

Glossina morsitans

Tsetse fly

Gmor\GMOY010116

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_04046

Mayetiola destructor

Hessian fly

Mdes\Mdes007550

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010681

Anopheles darlingi

American malaria mosquito

Adar\ADAC008397

Anopheles gambiae

Malaria mosquito

Agam\AGAP009768

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014421

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01X5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA014231

Bombyx mori

Silkmoth

Bmor\BGIBMGA004570

Bombyx mori

Silkmoth

Bmor\BGIBMGA006619

Danaus plexippus

Monarch butterfly

Dple\DPOGS213653-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS212172-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201184-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012561

Heliconius melpomene

Postman butterfly

Hmel\HMEL017132

Heliconius melpomene

Postman butterfly

Hmel\HMEL005257

Apis florea

Little honeybee

Aflo\4467996132

Apis florea

Little honeybee

Aflo\4601163908

Apis florea

Little honeybee

Aflo\2413948564

Apis florea

Little honeybee

Aflo\2160512036

Apis mellifera

Western honey bee

Amel\GB51198

Apis mellifera

Western honey bee

Amel\GB40947

Apis mellifera

Western honey bee

Amel\GB49396

Apis mellifera

Western honey bee

Amel\Dat

Apis mellifera

Western honey bee

Amel\Gat-a

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25429

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22630

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21750

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17406

Bombus terrestris

Buff-tailed bumblebee

Bter\15214627

Bombus terrestris

Buff-tailed bumblebee

Bter\15207413

Bombus terrestris

Buff-tailed bumblebee

Bter\15205427

Bombus terrestris

Buff-tailed bumblebee

Bter\15213234

Linepithema humile

Argentine ant

Lhum\LH11173

Linepithema humile

Argentine ant

Lhum\LH24213

Linepithema humile

Argentine ant

Lhum\LH23378

Linepithema humile

Argentine ant

Lhum\LH13102

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001e44

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0015c2

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002611

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000f3f

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007974

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009766

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06674

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07922

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03083

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10009

Tribolium castaneum

Red flour beetle

Tcas\TC013646

Tribolium castaneum

Red flour beetle

Tcas\TC034283

Tribolium castaneum

Red flour beetle

Tcas\TC015882

Tribolium castaneum

Red flour beetle

Tcas\TC002347

Pediculus humanus

Human body louse

Phum\PHUM099770

Pediculus humanus

Human body louse

Phum\PHUM097380

Pediculus humanus

Human body louse

Phum\PHUM216350

Pediculus humanus

Human body louse

Phum\PHUM032740

Pediculus humanus

Human body louse

Phum\PHUM545460

Rhodnius prolixus

Kissing bug

Rpro\RPRC005392

Rhodnius prolixus

Kissing bug

Rpro\RPRC005733

Rhodnius prolixus

Kissing bug

Rpro\RPRC010141

Rhodnius prolixus

Kissing bug

Rpro\RPRC011303

Cimex lectularius

Bed bug

Clec\CLEC001639

Cimex lectularius

Bed bug

Clec\CLEC005940

Cimex lectularius

Bed bug

Clec\CLEC005051

Cimex lectularius

Bed bug

Clec\CLEC005939

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI080057

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003286

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002859

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01772

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17431

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04850

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01ZN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008657

Strigamia maritima

European centipede

Smar\SMAR008484

Strigamia maritima

European centipede

Smar\SMAR009592

Strigamia maritima

European centipede

Smar\SMAR003062

Strigamia maritima

European centipede

Smar\SMAR007803

Strigamia maritima

European centipede

Smar\SMAR007234

Strigamia maritima

European centipede

Smar\SMAR015421

Strigamia maritima

European centipede

Smar\SMAR007877

Strigamia maritima

European centipede

Smar\SMAR002187

Strigamia maritima

European centipede

Smar\SMAR013482

Strigamia maritima

European centipede

Smar\SMAR011773

Strigamia maritima

European centipede

Smar\SMAR006384

Strigamia maritima

European centipede

Smar\SMAR011531

Strigamia maritima

European centipede

Smar\SMAR008124

Ixodes scapularis

Black-legged tick

Isca\ISCW013094

Ixodes scapularis

Black-legged tick

Isca\ISCW008752

Ixodes scapularis

Black-legged tick

Isca\ISCW023714

Ixodes scapularis

Black-legged tick

Isca\ISCW010973

Ixodes scapularis

Black-legged tick

Isca\ISCW005703

Ixodes scapularis

Black-legged tick

Isca\ISCW010971

Ixodes scapularis

Black-legged tick

Isca\ISCW017889

Ixodes scapularis

Black-legged tick

Isca\ISCW020003

Ixodes scapularis

Black-legged tick

Isca\ISCW016408

Ixodes scapularis

Black-legged tick

Isca\ISCW013626

Ixodes scapularis

Black-legged tick

Isca\ISCW023444

Ixodes scapularis

Black-legged tick

Isca\ISCW020974

Ixodes scapularis

Black-legged tick

Isca\ISCW023410

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58358.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77545.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61330.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72842.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74324.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67774.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57632.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61014.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur20g00590

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g08110

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00580

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04880

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g08610

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g02660

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g04170

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g00200

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07840

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g02090

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_304891

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_315258

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_42690

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_55141

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_35506

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_224133

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_314292

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_328816

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_60804

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_48062

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_203728

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_188047

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_46779

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_203278

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_302045

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08PX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5-3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_018760gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glyt

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gat_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007581gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glyt_6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a2_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007205gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glyt_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a13

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glyt_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gat_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gat

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gat_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sert

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Taut

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5-2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glyt_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a5_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc6a2

Ciona intestinalis

Vase tunicate

Cint\LOC100178767

Ciona intestinalis

Vase tunicate

Cint\LOC100176370

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024700

Ciona intestinalis

Vase tunicate

Cint\LOC100179103

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008543

Ciona intestinalis

Vase tunicate

Cint\LOC100178874

Ciona intestinalis

Vase tunicate

Cint\LOC100187411

Ciona intestinalis

Vase tunicate

Cint\LOC100180033

Ciona intestinalis

Vase tunicate

Cint\LOC100183042

Ciona intestinalis

Vase tunicate

Cint\LOC100186059

Ciona intestinalis

Vase tunicate

Cint\LOC100176179

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021746

Ciona intestinalis

Vase tunicate

Cint\LOC100187294

Ciona intestinalis

Vase tunicate

Cint\slc6a17

Ciona intestinalis

Vase tunicate

Cint\LOC100176779

Ciona intestinalis

Vase tunicate

Cint\LOC100185022

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003845

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000006841

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007757

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020950

Ciona intestinalis

Vase tunicate

Cint\LOC100177748

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005986

Gallus gallus

Domestic chicken

Ggal\LOC427923

Gallus gallus

Domestic chicken

Ggal\SLC6A18

Gallus gallus

Domestic chicken

Ggal\SLC6A9

Gallus gallus

Domestic chicken

Ggal\SLC6A4

Gallus gallus

Domestic chicken

Ggal\SLC6A20

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027982

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026545

Gallus gallus

Domestic chicken

Ggal\SLC6A11

Gallus gallus

Domestic chicken

Ggal\SLC6A14

Gallus gallus

Domestic chicken

Ggal\SLC6A12

Gallus gallus

Domestic chicken

Ggal\SLC6A17

Gallus gallus

Domestic chicken

Ggal\SLC6A13

Gallus gallus

Domestic chicken

Ggal\SLC6A5

Gallus gallus

Domestic chicken

Ggal\SLC6A15

Gallus gallus

Domestic chicken

Ggal\SLC6A6

Gallus gallus

Domestic chicken

Ggal\SLC6A7

Gallus gallus

Domestic chicken

Ggal\SLC6A1

Gallus gallus

Domestic chicken

Ggal\SLC6A2

Gallus gallus

Domestic chicken

Ggal\SLC6A19

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (20)

Gene Symbol

Score

Source

Alignment

Ntl

6 of 10

DAT

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

ine

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC6A1; solute carrier family 6 member 1

15 of 15

137165

MYOCLONIC-ATONIC EPILEPSY; MAE

SLC6A11; solute carrier family 6 member 11

5 of 15

607952

SLC6A12; solute carrier family 6 member 12

5 of 15

603080

SLC6A13; solute carrier family 6 member 13

5 of 15

615097

SLC6A6; solute carrier family 6 member 6

4 of 15

186854

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039915

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43805

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102D1-102D1

Sequence location

4:629,691..635,350 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102D1-102D1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

60775

y¹; Mi{MIC}Gat^MI04635

29422

y¹ v¹; P{TRiP.JF03358}attP2

83256

y¹ w^*; TI{CRIMIC.TG4.0}Gat^{CR01191-TG4.0}

60866

y¹; Mi{MIC}Gat^MI14399/In(4)ci^D, ci^D pan^ciD

VDRC

v106638

P{KK107895}VIE-260B

v13359

w¹¹¹⁸; P{GD5029}v13359

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (93)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039915

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039915

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43805

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Stork et al., 2014)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Gat CG1732

(Stork et al., 2014)

Source for database merge of

Source for merge of: CG1732 anon-WO0149848.11

(FlyBase, 1996-)

Additional comments

Source for merge of CG1732 anon-WO0149848.11 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43805

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039915

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039915

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1732

Flygut - An atlas of the Drosophila adult midgut

FBgn0039915

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43805

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1732

modMine - A data warehouse for the modENCODE project

FBgn0039915

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039915

DRSC - Results frm RNAi screens

FBgn0039915

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039915

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1732-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039915

FlyMine - An integrated database for Drosophila genomics

FBgn0039915

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43805

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1732a

(Miller et al., 2008)

DmGAT

(Miller et al., 2008)

GAT

(Freeman, 2015, Huang et al., 2015, Muthukumar et al., 2014)

Gat

(Mazaud et al., 2019, Croset et al., 2018, Gene Disruption Project members, 2018-, Losada-Perez, 2018, Weiler et al., 2017, Stork et al., 2014)

anon-WO0149848.11

dGAT

(Romero-Calderon et al., 2007)

gat

(Stork et al., 2014)

Name Synonyms

GABA transporter

(Freeman, 2015, Neckameyer and Cooper, 1998)

Secondary FlyBase IDs

FBgn0045955

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (56)

Report Sections

Open Close