FB2021_01, released Feb 18, 2021

Gene: Dmel\Gat

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General Information
Symbol
Dmel\Gat
Species
D. melanogaster
Name
GABA transporter
Annotation Symbol
CG1732
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039915
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
GABA transporter (Gat) encodes a protein belonging to the SLC family that is expressed primarily in astrocytes, where it is thought to be required for uptake of GABA and other small molecules. It likely plays an important role in setting the excitatory/inhibitory balance of the CNS. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
4:629,691..635,350 [+]
Recombination map

4-0

RefSeq locus
NC_004353 REGION:629691..635350
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables gamma-aminobutyric acid:sodium symporter activity
inferred from sequence model
(Thimgan et al., 2006)
inferred from biological aspect of ancestor with PANTHER:PTN000177868
(assigned by GO_Central )
(Gaudet et al., 2011)
enables neurotransmitter:sodium symporter activity
inferred from electronic annotation with InterPro:IPR037272
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in cellular response to mechanical stimulus
inferred from direct assay
(Muthukumar et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in gamma-aminobutyric acid transport
inferred from sequence model
(Thimgan et al., 2006)
involved_in sodium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in glial cell projection
inferred from direct assay
(Stork et al., 2014)
located_in plasma membrane
inferred from direct assay
(Stork et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence model
(Thimgan et al., 2006)
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN000177868
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -
Solute carrier family 6 (SLC6) members are Na+/Cl--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Gat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gat-RA
FBtr0089972
NM_143673
2895
636
Gat-RB
FBtr0089971
NM_166779
2853
508
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Gat-PA
FBpp0088910
72.3
636
7.20
NP_651930
AAF59327
Gat-PB
FBpp0088909
56.8
508
6.63
NP_726594
AAN06506
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gat using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
optic lobe neuroepithelial cell
(Wang et al., 2013)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Romero-Calderon et al., 2007)
adult thorax | faint

Comment: Thorax and abdomen assayed together. Band of 3.2kb detected.

(Romero-Calderon et al., 2007)
adult abdomen | faint

Comment: Thorax and abdomen assayed together. Band of 3.2kb detected.

(Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
astrocyte-like glial cell
(Stork et al., 2014)
third instar larval stage
ventral nerve cord
(Stork et al., 2014)
astrocyte-like glial cell
(Coutinho-Budd et al., 2017)
adult stage
astrocyte-like glial cell
(Muthukumar et al., 2014)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Muthukumar et al., 2014)
pharate adult stage P9 -- P15
adult brain
(Muthukumar et al., 2014)
pharate adult stage P8
adult brain | faint
(Muthukumar et al., 2014)
Additional Descriptive Data

Gat protein is exclusively detected in the membrane surface of astrocytes in embryos, larvae, pupae, and adults.

(Stork et al., 2014)
Marker for
 
astrocyte-like glial cell
(Coutinho-Budd et al., 2017)
Subcellular Localization
CV Term
Evidence
References
located_in glial cell projection
inferred from direct assay
(Stork et al., 2014)
located_in plasma membrane
inferred from direct assay
(Stork et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gat in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gat
Transgenic constructs containing regulatory region of Gat
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene disrupted in
Df(4)GatΔ64kb
(Stork et al., 2014)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC6A1
14 of 15
Yes
Yes
Hsap\SLC6A11
6 of 15
No
Yes
Hsap\SLC6A12
6 of 15
No
Yes
Hsap\SLC6A13
6 of 15
No
Yes
Hsap\SLC6A6
5 of 15
No
Yes
Hsap\SLC6A8
4 of 15
No
Yes
Hsap\SLC6A2
3 of 15
No
No
Hsap\SLC6A3
3 of 15
No
No
12  
Hsap\SLC6A4
3 of 15
No
No
1  
Hsap\SLC6A7
3 of 15
No
No
Hsap\SLC6A9
3 of 15
No
No
Hsap\SLC6A15
3 of 15
No
No
Hsap\SLC6A16
3 of 15
No
No
Hsap\SLC6A17
3 of 15
No
No
Hsap\SLC6A5
2 of 15
No
No
1  
Hsap\SLC6A14
2 of 15
No
No
Hsap\SLC6A18
2 of 15
No
No
Hsap\SLC6A19
2 of 15
No
No
Hsap\SLC6A20
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc6a1
13 of 15
Yes
Yes
Mmus\Slc6a11
6 of 15
No
Yes
Mmus\Slc6a12
6 of 15
No
Yes
Mmus\Slc6a13
6 of 15
No
Yes
Mmus\Slc6a6
5 of 15
No
Yes
Mmus\Slc6a8
5 of 15
No
Yes
Mmus\Slc6a2
3 of 15
No
No
Mmus\Slc6a3
3 of 15
No
No
Mmus\Slc6a4
3 of 15
No
No
Mmus\Slc6a7
3 of 15
No
No
Mmus\Slc6a9
3 of 15
No
No
Mmus\Slc6a15
3 of 15
No
No
Mmus\Slc6a21
3 of 15
No
No
Mmus\Slc6a5
2 of 15
No
No
Mmus\Slc6a14
2 of 15
No
No
Mmus\Slc6a16
2 of 15
No
No
Mmus\Slc6a17
2 of 15
No
No
Mmus\Slc6a18
2 of 15
No
No
Mmus\Slc6a19
2 of 15
No
No
Mmus\Slc6a20a
2 of 15
No
No
Mmus\Slc6a20b
2 of 15
No
No
Mmus\Wdr76
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (21)
Rnor\Slc6a1
12 of 13
Yes
Yes
Rnor\Slc6a11
6 of 13
No
Yes
Rnor\Slc6a12
6 of 13
No
Yes
Rnor\Slc6a13
6 of 13
No
Yes
Rnor\Slc6a6
5 of 13
No
Yes
Rnor\RGD1562492
3 of 13
No
No
Rnor\Slc6a2
3 of 13
No
No
Rnor\Slc6a3
3 of 13
No
No
Rnor\Slc6a4
3 of 13
No
No
Rnor\Slc6a7
3 of 13
No
No
Rnor\Slc6a8
3 of 13
No
Yes
Rnor\Slc6a9
3 of 13
No
No
Rnor\Slc6a16
3 of 13
No
No
Rnor\Slc6a17
3 of 13
No
No
Rnor\Slc6a5
2 of 13
No
No
Rnor\Slc6a14
2 of 13
No
No
Rnor\Slc6a15
2 of 13
No
No
Rnor\Slc6a18
2 of 13
No
No
Rnor\Slc6a19
2 of 13
No
No
Rnor\Slc6a20
2 of 13
No
No
Rnor\LOC103690061
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (23)
Xtro\LOC100127682
8 of 12
Yes
Yes
Xtro\slc6a1
7 of 12
No
Yes
Xtro\slc6a6
4 of 12
No
Yes
Xtro\slc6a8
4 of 12
No
Yes
Xtro\slc6a8
4 of 12
No
Yes
Xtro\slc6a13
4 of 12
No
Yes
Xtro\slc6a2
3 of 12
No
No
Xtro\slc6a3
3 of 12
No
No
Xtro\slc6a4
3 of 12
No
No
Xtro\slc6a7
3 of 12
No
No
Xtro\slc6a9
3 of 12
No
No
Xtro\slc6a12
3 of 12
No
Yes
Xtro\slc6a15
3 of 12
No
No
Xtro\slc6a17
3 of 12
No
No
Xtro\slc6a5
2 of 12
No
No
Xtro\slc6a14.2
2 of 12
No
No
Xtro\slc6a16
2 of 12
No
No
Xtro\slc6a19
2 of 12
No
No
Xtro\LOC100490052
1 of 12
No
Yes
Xtro\LOC100497766
1 of 12
No
Yes
Xtro\LOC101731472
1 of 12
No
Yes
Xtro\slc6a4
1 of 12
No
No
Xtro\slc6a14.1
1 of 12
No
Yes
Danio rerio (Zebrafish) (37)
Drer\slc6a1b
13 of 15
Yes
Yes
Drer\slc6a1l
11 of 15
No
Yes
Drer\slc6a1a
10 of 15
No
Yes
Drer\slc6a13
6 of 15
No
Yes
Drer\si:ch211-132b12.1
5 of 15
No
Yes
Drer\si:ch211-132b12.2
5 of 15
No
Yes
Drer\si:ch211-132b12.3
5 of 15
No
Yes
Drer\slc6a6a
5 of 15
No
Yes
Drer\slc6a8
5 of 15
No
Yes
Drer\slc6a11a
5 of 15
No
Yes
Drer\slc6a11b
5 of 15
No
Yes
Drer\slc6a22.1
5 of 15
No
Yes
Drer\slc6a22.2
5 of 15
No
Yes
Drer\si:ch211-117c9.5
4 of 15
No
Yes
Drer\zgc:158427
4 of 15
No
Yes
Drer\si:ch211-132b12.6
3 of 15
No
Yes
Drer\slc6a2
3 of 15
No
No
Drer\slc6a4a
3 of 15
No
No
Drer\slc6a4b
3 of 15
No
No
Drer\slc6a6b
3 of 15
No
Yes
Drer\slc6a7
3 of 15
No
No
Drer\slc6a9
3 of 15
No
No
Drer\slc6a15
3 of 15
No
No
Drer\slc6a16a
3 of 15
No
No
Drer\slc6a17
3 of 15
No
No
Drer\si:ch211-132b12.4
2 of 15
No
Yes
Drer\si:ch211-225b11.1
2 of 15
No
No
Drer\si:ch211-283g2.1
2 of 15
No
No
Drer\slc6a3
2 of 15
No
No
Drer\slc6a5
2 of 15
No
No
Drer\slc6a14
2 of 15
No
No
Drer\slc6a18
2 of 15
No
No
Drer\slc6a19a.1
2 of 15
No
No
Drer\slc6a19a.2
2 of 15
No
No
Drer\slc6a19b
2 of 15
No
No
Drer\slc6a16b
1 of 15
No
No
Drer\zgc:174946
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\snf-11
15 of 15
Yes
Yes
Cele\snf-3
3 of 15
No
Yes
Cele\snf-6
3 of 15
No
No
Cele\snf-9
3 of 15
No
No
Cele\dat-1
2 of 15
No
No
Cele\mod-5
2 of 15
No
No
Cele\snf-2
2 of 15
No
No
Cele\snf-7
2 of 15
No
No
Cele\snf-12
2 of 15
No
No
Cele\Y43D4A.1
2 of 15
No
No
Cele\C09E8.1
1 of 15
No
No
Cele\F56F4.3
1 of 15
No
No
Cele\snf-1
1 of 15
No
No
Cele\snf-5
1 of 15
No
No
Cele\snf-8
1 of 15
No
No
Cele\snf-10
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903RW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007093
Drosophila simulans
Dsim\GD27536
Drosophila sechellia
Dsec\GM26805
Drosophila erecta
Dere\GG16396
Drosophila yakuba
Dyak\GE14556
Drosophila ananassae
Dana\GF12191
Drosophila persimilis
Dper\GL18181
Drosophila willistoni
Dwil\GK13698
Drosophila virilis
Dvir\GJ13697
Drosophila mojavensis
Dmoj\GI11503
Drosophila grimshawi
Dgri\GH14803
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008714
Glossina morsitans
Tsetse fly
Gmor\GMOY010116
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04046
Mayetiola destructor
Hessian fly
Mdes\Mdes007550
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010681
Anopheles darlingi
American malaria mosquito
Adar\ADAC008397
Anopheles gambiae
Malaria mosquito
Agam\AGAP009768
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014421
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01X5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA014231
Bombyx mori
Silkmoth
Bmor\BGIBMGA004570
Bombyx mori
Silkmoth
Bmor\BGIBMGA006619
Danaus plexippus
Monarch butterfly
Dple\DPOGS213653-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212172-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201184-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012561
Heliconius melpomene
Postman butterfly
Hmel\HMEL017132
Heliconius melpomene
Postman butterfly
Hmel\HMEL005257
Apis florea
Little honeybee
Aflo\4467996132
Apis florea
Little honeybee
Aflo\4601163908
Apis florea
Little honeybee
Aflo\2413948564
Apis florea
Little honeybee
Aflo\2160512036
Apis mellifera
Western honey bee
Amel\GB51198
Apis mellifera
Western honey bee
Amel\GB40947
Apis mellifera
Western honey bee
Amel\GB49396
Apis mellifera
Western honey bee
Amel\Dat
Apis mellifera
Western honey bee
Amel\Gat-a
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25429
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22630
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21750
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17406
Bombus terrestris
Buff-tailed bumblebee
Bter\15214627
Bombus terrestris
Buff-tailed bumblebee
Bter\15207413
Bombus terrestris
Buff-tailed bumblebee
Bter\15205427
Bombus terrestris
Buff-tailed bumblebee
Bter\15213234
Linepithema humile
Argentine ant
Lhum\LH11173
Linepithema humile
Argentine ant
Lhum\LH24213
Linepithema humile
Argentine ant
Lhum\LH23378
Linepithema humile
Argentine ant
Lhum\LH13102
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e44
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0015c2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002611
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f3f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007974
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009766
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06674
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07922
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03083
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10009
Tribolium castaneum
Red flour beetle
Tcas\TC013646
Tribolium castaneum
Red flour beetle
Tcas\TC034283
Tribolium castaneum
Red flour beetle
Tcas\TC015882
Tribolium castaneum
Red flour beetle
Tcas\TC002347
Pediculus humanus
Human body louse
Phum\PHUM099770
Pediculus humanus
Human body louse
Phum\PHUM097380
Pediculus humanus
Human body louse
Phum\PHUM216350
Pediculus humanus
Human body louse
Phum\PHUM032740
Pediculus humanus
Human body louse
Phum\PHUM545460
Rhodnius prolixus
Kissing bug
Rpro\RPRC005392
Rhodnius prolixus
Kissing bug
Rpro\RPRC005733
Rhodnius prolixus
Kissing bug
Rpro\RPRC010141
Rhodnius prolixus
Kissing bug
Rpro\RPRC011303
Cimex lectularius
Bed bug
Clec\CLEC001639
Cimex lectularius
Bed bug
Clec\CLEC005940
Cimex lectularius
Bed bug
Clec\CLEC005051
Cimex lectularius
Bed bug
Clec\CLEC005939
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080057
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003286
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002859
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01772
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17431
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04850
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01ZN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008657
Strigamia maritima
European centipede
Smar\SMAR008484
Strigamia maritima
European centipede
Smar\SMAR009592
Strigamia maritima
European centipede
Smar\SMAR003062
Strigamia maritima
European centipede
Smar\SMAR007803
Strigamia maritima
European centipede
Smar\SMAR007234
Strigamia maritima
European centipede
Smar\SMAR015421
Strigamia maritima
European centipede
Smar\SMAR007877
Strigamia maritima
European centipede
Smar\SMAR002187
Strigamia maritima
European centipede
Smar\SMAR013482
Strigamia maritima
European centipede
Smar\SMAR011773
Strigamia maritima
European centipede
Smar\SMAR006384
Strigamia maritima
European centipede
Smar\SMAR011531
Strigamia maritima
European centipede
Smar\SMAR008124
Ixodes scapularis
Black-legged tick
Isca\ISCW013094
Ixodes scapularis
Black-legged tick
Isca\ISCW008752
Ixodes scapularis
Black-legged tick
Isca\ISCW023714
Ixodes scapularis
Black-legged tick
Isca\ISCW010973
Ixodes scapularis
Black-legged tick
Isca\ISCW005703
Ixodes scapularis
Black-legged tick
Isca\ISCW010971
Ixodes scapularis
Black-legged tick
Isca\ISCW017889
Ixodes scapularis
Black-legged tick
Isca\ISCW020003
Ixodes scapularis
Black-legged tick
Isca\ISCW016408
Ixodes scapularis
Black-legged tick
Isca\ISCW013626
Ixodes scapularis
Black-legged tick
Isca\ISCW023444
Ixodes scapularis
Black-legged tick
Isca\ISCW020974
Ixodes scapularis
Black-legged tick
Isca\ISCW023410
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58358.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77545.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61330.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72842.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74324.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67774.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57632.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61014.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g08110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g08610
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02660
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g04170
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g00200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07840
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g02090
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304891
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_315258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_55141
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_35506
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_224133
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_314292
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328816
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60804
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48062
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_203728
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_188047
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_46779
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_203278
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302045
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08PX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5-3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018760gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007581gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007205gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gat_3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sert
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Taut
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5-2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glyt_5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a5_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc6a2
Ciona intestinalis
Vase tunicate
Cint\LOC100178767
Ciona intestinalis
Vase tunicate
Cint\LOC100176370
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024700
Ciona intestinalis
Vase tunicate
Cint\LOC100179103
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008543
Ciona intestinalis
Vase tunicate
Cint\LOC100178874
Ciona intestinalis
Vase tunicate
Cint\LOC100187411
Ciona intestinalis
Vase tunicate
Cint\LOC100180033
Ciona intestinalis
Vase tunicate
Cint\LOC100183042
Ciona intestinalis
Vase tunicate
Cint\LOC100186059
Ciona intestinalis
Vase tunicate
Cint\LOC100176179
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021746
Ciona intestinalis
Vase tunicate
Cint\LOC100187294
Ciona intestinalis
Vase tunicate
Cint\slc6a17
Ciona intestinalis
Vase tunicate
Cint\LOC100176779
Ciona intestinalis
Vase tunicate
Cint\LOC100185022
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003845
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006841
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007757
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020950
Ciona intestinalis
Vase tunicate
Cint\LOC100177748
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005986
Gallus gallus
Domestic chicken
Ggal\LOC427923
Gallus gallus
Domestic chicken
Ggal\SLC6A18
Gallus gallus
Domestic chicken
Ggal\SLC6A9
Gallus gallus
Domestic chicken
Ggal\SLC6A4
Gallus gallus
Domestic chicken
Ggal\SLC6A20
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027982
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026545
Gallus gallus
Domestic chicken
Ggal\SLC6A11
Gallus gallus
Domestic chicken
Ggal\SLC6A14
Gallus gallus
Domestic chicken
Ggal\SLC6A12
Gallus gallus
Domestic chicken
Ggal\SLC6A17
Gallus gallus
Domestic chicken
Ggal\SLC6A13
Gallus gallus
Domestic chicken
Ggal\SLC6A5
Gallus gallus
Domestic chicken
Ggal\SLC6A15
Gallus gallus
Domestic chicken
Ggal\SLC6A6
Gallus gallus
Domestic chicken
Ggal\SLC6A7
Gallus gallus
Domestic chicken
Ggal\SLC6A1
Gallus gallus
Domestic chicken
Ggal\SLC6A2
Gallus gallus
Domestic chicken
Ggal\SLC6A19
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG1698
4 of 10
CG4476
4 of 10
CG8850
4 of 10
CG13796
4 of 10
CG15279
4 of 10
DAT
4 of 10
ine
4 of 10
List
4 of 10
NAAT1
4 of 10
Ntl
4 of 10
SerT
4 of 10
CG13793
3 of 10
CG13794
3 of 10
CG13795
3 of 10
CG33296
3 of 10
CG43066
3 of 10
GlyT
3 of 10
bdg
2 of 10
blot
2 of 10
CG10804
2 of 10
CG31904
2 of 10
natalisin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SLC6A8; solute carrier family 6 member 8
    model of  creatine transporter deficiency
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC6A1; solute carrier family 6 member 1
    14 of 15
    137165
      SLC6A11; solute carrier family 6 member 11
      6 of 15
      607952
          SLC6A12; solute carrier family 6 member 12
          6 of 15
          603080
              SLC6A13; solute carrier family 6 member 13
              6 of 15
              615097
                  SLC6A6; solute carrier family 6 member 6
                  5 of 15
                  186854
                      SLC6A8; solute carrier family 6 member 8
                      4 of 15
                      300036
                      SLC6A2; solute carrier family 6 member 2
                      3 of 15
                      163970
                      SLC6A3; solute carrier family 6 member 3
                      3 of 15
                      126455
                         
                        SLC6A4; solute carrier family 6 member 4
                        3 of 15
                        182138
                         
                        SLC6A7; solute carrier family 6 member 7
                        3 of 15
                        606205
                            SLC6A9; solute carrier family 6 member 9
                            3 of 15
                            601019
                              SLC6A15; solute carrier family 6 member 15
                              3 of 15
                              607971
                                  SLC6A16; solute carrier family 6 member 16
                                  3 of 15
                                  607972
                                      SLC6A17; solute carrier family 6 member 17
                                      3 of 15
                                      610299
                                        Functional Complementation Data
                                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                        Interactions
                                        Summary of Physical Interactions
                                        esyN Network Diagram
                                        Interactions Browser
                                        Summary of Genetic Interactions
                                        esyN Network Diagram
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        External Data
                                        Linkouts
                                        DroID - A comprehensive database of gene and protein interactions.
                                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                        Pathways
                                        Signaling Pathways (FlyBase)
                                        Metabolic Pathways
                                        External Data
                                        Linkouts
                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                        Genomic Location and Detailed Mapping Data
                                        Chromosome (arm)
                                        4
                                        Recombination map

                                        4-0

                                        Cytogenetic map
                                        102D1-102D1
                                        Sequence location
                                        4:629,691..635,350 [+]
                                        FlyBase Computed Cytological Location
                                        Cytogenetic map
                                        Evidence for location
                                        102D1-102D1
                                        Experimentally Determined Cytological Location
                                        Cytogenetic map
                                        Notes
                                        References
                                        Experimentally Determined Recombination Data
                                        Location

                                        4-0

                                        (FlyBase, 2016)
                                        Left of (cM)
                                        Right of (cM)
                                        Notes
                                        Stocks and Reagents
                                        Stocks (8)
                                        Genomic Clones (12)
                                         

                                        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                        cDNA Clones (93)
                                         

                                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                        cDNA clones, fully sequenced
                                        BDGP DGC clones
                                        Other clones
                                          Drosophila Genomics Resource Center cDNA clones

                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                          cDNA Clones, End Sequenced (ESTs)
                                          BDGP DGC clones
                                          Other clones
                                          RNAi and Array Information
                                          Linkouts
                                          DRSC - Results frm RNAi screens
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          Antibody Information
                                          Laboratory Generated Antibodies
                                           

                                          polyclonal

                                          (Stork et al., 2014)
                                          Commercially Available Antibodies
                                           
                                          Other Information
                                          Relationship to Other Genes
                                          Source for database identify of

                                          Source for identity of: Gat CG1732

                                          (Stork et al., 2014)
                                          Source for database merge of

                                          Source for merge of: CG1732 anon-WO0149848.11

                                          (FlyBase, 1996-)
                                          Additional comments

                                          Source for merge of CG1732 anon-WO0149848.11 was sequence comparison ( date:051113 ).

                                          (FlyBase, 1996-)
                                          Other Comments
                                          Origin and Etymology
                                          Discoverer
                                          Etymology
                                          Identification
                                          External Crossreferences and Linkouts ( 38 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          Flygut - An atlas of the Drosophila adult midgut
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          modMine - A data warehouse for the modENCODE project
                                          Linkouts
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Synonyms and Secondary IDs (9)
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          References (63)