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Gene Dmel\CG11148

General Information
Symbol	Dmel\CG11148	Species	D. melanogaster
Name		Annotation symbol	CG11148
Feature type	protein_coding_gene	FlyBase ID	FBgn0039936
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102E5-102E5	Sequence location	4:876,026..887,651 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11148 (FBgn0039936). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: GYF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval hindgut, adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, adult hindgut, larval Malpighian tubules, larval/adult fat body, virgin spermatheca, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1625646_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of CG11148. Gene sequence location is 4:876026..887651.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102E5-102E5
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11148 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11148-RD FBtr0300882  NM_143693   4892   1567 CG11148-RF FBtr0300884  NM_205878   4898   1567 CG11148-RG FBtr0300885  NM_001169356   4919   1574 CG11148-RH FBtr0300886  NM_001169357   4913   1574
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11148-PD   FBpp0290104   172.9   1567   7.05     NP_651950   AAF59406 CG11148-PF   FBpp0290106   172.9   1567   7.05     NP_995600   AAS64612 CG11148-PG   FBpp0290107   173.7   1574   7.11     NP_001162827   ACZ95096 CG11148-PH   FBpp0290108   173.7   1574   7.11     NP_001162828   ACZ95097
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GYF (IPR003169)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201721   AA264770   AA390519   AA440117   AA538963   AA695263   AA696556   AA699110   AA735282   AA802434   AA803394   AA816798   AA949313   AA979085   AE014135 AAF59406   AE014135 AAS64612   AE014135 ACZ95096   AE014135 ACZ95097   AI134101   AI405096   AW940962   AY051607 AAK93031   BG637760   BG638706   BI238216   BI610595   BI611672   BI620051   BP542061   BP542553   BT056314   BT125874   CK658701   CO153118   CO184467   CO185653   CO185894   CO186420   CO187227   CO195549   CO265017   CO267374   CO269617   CO273321   CO281044   CO281760   CO283179   CO283990   CO286644   CO288264   CO293102   CO298728   CO301857   CO304811   CO310049   CO315409   CO315563   CO315848   CO316546   CO318192   CO320305   CO324540   CO325788   CO332083   CO333693   CO340054   CO343410   EC060466   EC062316   EC063703   EC067765   EC068795   EC069504   EC074504   EC077170   EC079940   EC080116   EC086912   EC089423   EC090030   EC197419   EC202040   EC204010   EC206472   EC211147   EC211400   EC214620   EC216565   EC216769   EC222004   EC223963   EC226719   EC226752   EC233625   EC238224   EC238419   EC238699   EC245518   EC253316   EC257338   EC264505   EL878191   EL878192   EL878307   EL878308   EV575714   EV582182   EV584431   EV585458   EV594959   GH742408   GH744483   GH761500   GH762744   GH763724   GH764938   GH765388   GH766689   GH767414   GH768427   GH768474   GH769433   GH779343
UniProtKB/Swiss-Prot	Q7KQM6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) mitotic spindle inferred from direct assay (Müller et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval hindgut, adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, adult hindgut, larval Malpighian tubules, larval/adult fat body, virgin spermatheca, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary    1109.4 Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass    1041 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (694.775) Larval Midgut    303.3 Larval Hindgut  504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland  (598.7) Larval Trachea  (897.75) Larval Carcass    368.25 Adult Head    377.9 Adult Eye  (661.425) Adult Brain  (814.9) Adult Thoracic-Abdominal Ganglion  (940.1) Adult Crop  513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules  (567.9) Adult Fat Body    330.9 Adult Salivary Gland  (672.5) Adult Heart  (648.525) Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca  (587.8) Adult Ovary  (1109.4) Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass  (1041) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary  (1109.4) Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass  1041 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary    1109.4 Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass    1041 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary    1109.4 Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass    1041 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  694.775 Larval Midgut    303.3 Larval Hindgut  504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland  598.7 Larval Trachea  (897.75) Larval Carcass    368.25 Adult Head    377.9 Adult Eye  661.425 Adult Brain  (814.9) Adult Thoracic-Abdominal Ganglion  (940.1) Adult Crop  513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules  567.9 Adult Fat Body    330.9 Adult Salivary Gland  672.5 Adult Heart  648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca  587.8 Adult Ovary  (1109.4) Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass  (1041) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary  1109.4 Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass  1041 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    694.775 Larval Midgut    303.3 Larval Hindgut    504.5 Larval Malpighian Tubules    415.7 Larval Fat Body    295.5 Larval Salivary Gland    598.7 Larval Trachea    897.75 Larval Carcass    368.25 Adult Head    377.9 Adult Eye    661.425 Adult Brain    814.9 Adult Thoracic-Abdominal Ganglion    940.1 Adult Crop    513.9 Adult Midgut    289.4 Adult Hindgut    482.3 Adult Malpighian Tubules    567.9 Adult Fat Body    330.9 Adult Salivary Gland    672.5 Adult Heart    648.525 Adult VirginFemale Spermatheca    472.6 Adult InseminatedFemale Spermatheca    587.8 Adult Ovary    1109.4 Adult Testis    243.2 Adult Male Accessory Gland    414.4 Adult Carcass    1041 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    377.9   NA  Eye    661.425   NA  Brain    814.9   694.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    940.1   NA  Crop    513.9   303.3  Midgut    289.4   504.5  Hindgut    482.3   415.7  Malpighian Tubules    567.9   295.5  Fat Body    330.9   598.7  Salivary Gland    672.5   NA  Heart    648.525   897.75  Trachea    NA   NA  VirginFemale Spermatheca    472.6   NA  InseminatedFemale Spermatheca    587.8   NA  Ovary    1109.4   NA  Testis    243.2   NA  Male Accessory Gland    414.4   368.25  Carcass    1041 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female    193 ovary, mated 4-day female    210 testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (69) central nervous system, pupae P8  (70) head, virgin 1-day female  (66) head, virgin 4-day female  (54) head, virgin 20-day female    25 head, mated 1-day female  (60) head, mated 4-day female  (38) head, mated 20-day female  (27) head, mated 1-day male  (66) head, mated 4-day male  (54) head, mated 20-day male  (50) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  26 digestive system, 1-day adult    20 digestive system, 4-day adult  (32) digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae  (31) fat body, pupae P8  (41) carcass, larvae L3 wandering  (45) carcass, 1-day adult  (48) carcass, 4-day adult  (51) carcass, 20-day adult  (28) ovary, virgin 4-day female  (193) ovary, mated 4-day female  (210) testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female  (193) ovary, mated 4-day female  (210) testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female    193 ovary, mated 4-day female    210 testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female    193 ovary, mated 4-day female    210 testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (69) central nervous system, pupae P8  (70) head, virgin 1-day female  (66) head, virgin 4-day female  (54) head, virgin 20-day female    25 head, mated 1-day female  (60) head, mated 4-day female  (38) head, mated 20-day female  27 head, mated 1-day male  (66) head, mated 4-day male  (54) head, mated 20-day male  (50) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (48) digestive system, larvae L3 wandering  26 digestive system, 1-day adult    20 digestive system, 4-day adult  32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae  31 fat body, pupae P8  (41) carcass, larvae L3 wandering  (45) carcass, 1-day adult  (48) carcass, 4-day adult  (51) carcass, 20-day adult  28 ovary, virgin 4-day female  (193) ovary, mated 4-day female  (210) testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female  (193) ovary, mated 4-day female  (210) testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    69 central nervous system, pupae P8    70 head, virgin 1-day female    66 head, virgin 4-day female    54 head, virgin 20-day female    25 head, mated 1-day female    60 head, mated 4-day female    38 head, mated 20-day female    27 head, mated 1-day male    66 head, mated 4-day male    54 head, mated 20-day male    50 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    48 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    20 digestive system, 4-day adult    32 digestive system, 20-day adult    19 fat body, larvae L3 wandering    18 fat body, white prepupae    31 fat body, pupae P8    41 carcass, larvae L3 wandering    45 carcass, 1-day adult    48 carcass, 4-day adult    51 carcass, 20-day adult    28 ovary, virgin 4-day female    193 ovary, mated 4-day female    210 testis, mated 4-day male    13 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (73) embryo 02-04hr  (54) embryo 04-06hr  (39) embryo 06-08hr  (43) embryo 08-10hr  (53) embryo 10-12hr  (36) embryo 12-14hr  (63) embryo 14-16hr  (27) embryo 16-18hr  (34) embryo 18-20hr  26 embryo 20-22hr  (33) embryo 22-24hr  (42) larva L1  (32) larva L2  26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (27) larva L3 puffstage 7-9  (36) white prepupae new  (37) white prepupae 12hr  (35) white prepupae 24hr  (42) pupae 2d postWPP  (43) pupae 3d postWPP  (35) pupae 4d postWPP    20 adult male 01day  (31) adult male 05day  (27) adult male 30day    17 adult female 01day  (34) adult female 05day  (74) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (73) embryo 02-04hr  (54) embryo 04-06hr  (39) embryo 06-08hr  (43) embryo 08-10hr  (53) embryo 10-12hr  (36) embryo 12-14hr  (63) embryo 14-16hr  27 embryo 16-18hr  (34) embryo 18-20hr  26 embryo 20-22hr  (33) embryo 22-24hr  (42) larva L1  32 larva L2  26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  27 larva L3 puffstage 7-9  (36) white prepupae new  (37) white prepupae 12hr  (35) white prepupae 24hr  (42) pupae 2d postWPP  (43) pupae 3d postWPP  (35) pupae 4d postWPP    20 adult male 01day  31 adult male 05day  27 adult male 30day    17 adult female 01day  (34) adult female 05day  (74) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    73 embryo 02-04hr    54 embryo 04-06hr    39 embryo 06-08hr    43 embryo 08-10hr    53 embryo 10-12hr    36 embryo 12-14hr    63 embryo 14-16hr    27 embryo 16-18hr    34 embryo 18-20hr    26 embryo 20-22hr    33 embryo 22-24hr    42 larva L1    32 larva L2    26 larva L3 12hr old    21 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    36 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    42 pupae 2d postWPP    43 pupae 3d postWPP    35 pupae 4d postWPP    20 adult male 01day    31 adult male 05day    27 adult male 30day    17 adult female 01day    34 adult female 05day    74 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC    120 ovary OSS    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    20 embryonic 1182-4H  (46) embryonic GM2  (60) embryonic Kc167  (40) embryonic S1  (57) embryonic S3  (52) leg disc CME L1  (29) wing disc CME-W2  (77) wing disc ML-DmD8  (37) wing disc ML-DmD9  (36) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21    10 wing disc ML-DmD32  (40) haltere disc ML-DmD17-c3  (81) eye-antennal disc ML-DmD11  (76) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (51) CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (58) ovary fGS/OSS  (100) ovary OSC  (120) ovary OSS  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC  (120) ovary OSS    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC    120 ovary OSS    75 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC    120 ovary OSS    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    20 embryonic 1182-4H  (46) embryonic GM2  (60) embryonic Kc167  (40) embryonic S1  (57) embryonic S3  (52) leg disc CME L1  29 wing disc CME-W2  (77) wing disc ML-DmD8  (37) wing disc ML-DmD9  (36) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21    10 wing disc ML-DmD32  (40) haltere disc ML-DmD17-c3  (81) eye-antennal disc ML-DmD11  (76) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (51) CNS ML-DmBG2-c2  (58) tumorous blood cells mbn2  (58) ovary fGS/OSS  (100) ovary OSC  (120) ovary OSS  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC  120 ovary OSS    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    20 embryonic 1182-4H    46 embryonic GM2    60 embryonic Kc167    40 embryonic S1    57 embryonic S3    52 leg disc CME L1    29 wing disc CME-W2    77 wing disc ML-DmD8    37 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    10 wing disc ML-DmD32    40 haltere disc ML-DmD17-c3    81 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    51 CNS ML-DmBG2-c2    58 tumorous blood cells mbn2    58 ovary fGS/OSS    100 ovary OSC    120 ovary OSS    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    155 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (33) heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  (32) Cadmium 50 mM 48 hrs, 4-day adult  (62) Cadmium 100 mM 48 hrs, 4-day adult  (155) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3  (28) Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  (78) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (103) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult  (155) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult  103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    155 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    155 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (33) heat shock, 4-day adult  (53) Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  32 Cadmium 50 mM 48 hrs, 4-day adult  (62) Cadmium 100 mM 48 hrs, 4-day adult  (155) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3  28 Zinc 4.5 mM 48 hrs, 4-day adult  (84) Ethanol 2.5% 3 hrs, larvae L3  (78) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (138) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (103) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult  (155) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  138 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult  103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    33 heat shock, 4-day adult    53 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    62 Cadmium 100 mM 48 hrs, 4-day adult    155 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    28 Zinc 4.5 mM 48 hrs, 4-day adult    84 Ethanol 2.5% 3 hrs, larvae L3    78 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    138 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    103 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039936 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11148-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG11148GD7214 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG11148 Class Mutagen Stocks Known lesion CG11148MB01094 1 -- CG11148MI00455 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11148 Class Mutagen Stocks Known lesion CG11148GD7214 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11148HM05106 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11148KK101931 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7214} NA P{KK101931} NA P{TRiP.HM05106} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG11148MB01094 No miscellaneous insertions Mi{MIC}CG11148MI00455 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a biological process or molecular function term for this gene. (Based on a review of available data on: 2009-05-29)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) mitotic spindle inferred from direct assay (Müller et al., 2010)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG11148 - 4EHP anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG11148 - Oscillin experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11148 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68666 DroID - A comprehensive database of gene and protein interactions. • FBgn0039936 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43842
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X3HKP Dipteran inclusive ortholog search EOG6P2Q97 Insect inclusive ortholog search EOG6K6F03 Arthropod inclusive ortholog search EOG6VHHN9 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6X3HKP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11148     Drosophila simulans   Dsim\GD24369 Y   Drosophila sechellia   Dsec\GM26766 Y   Drosophila erecta   Dere\GG16434 Y   Drosophila yakuba   Dyak\GE14500 Y   Drosophila ananassae   Dana\GF22673 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10795 Y   Drosophila persimilis   Dper\GL15610 Y   Drosophila willistoni   Dwil\GK13661 Y   Drosophila virilis   Dvir\GJ15866 Y   Drosophila mojavensis   Dmoj\GI14083 Y   Drosophila grimshawi   Dgri\GH24004 Y
Orthologs in non-Drosophila Dipterans (EOG6P2Q97)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017207   Anopheles gambiae Malaria mosquito  Agam\AGAP004310   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009719   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001658
Orthologs in non-Dipteran Insects (EOG6K6F03)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410003   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021234   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19133   Atta cephalotes Leafcutter ant  Acep\ACEP19724   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14057   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19899   Linepithema humile Argentine ant  Lhum\LH12847   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24967   Solenopsis invicta Red fire ant  Sinv\SINV19849   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005164   Acyrthosiphon pisum Pea aphid  Apim\ACYPI081393   Bombyx mori Silkmoth  Bmor\BGIBMGA012331   Pediculus humanus Human body louse  Phum\PHUM498170   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07086
Orthologs in non-Insect Arthropods (EOG6VHHN9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_53925   Daphnia pulex Water flea  Dpux\JGI_V11_301482   Ixodes scapularis Deer tick  Isca\ISCW017617
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24369 Drosophila sechellia Dsec\GM26766 Drosophila erecta Dere\GG16434 Drosophila yakuba Dyak\GE14500 Drosophila ananassae Dana\GF22673 Drosophila pseudoobscura pseudoobscura Dpse\GA10795 Drosophila persimilis Dper\GL15610 Drosophila willistoni Dwil\GK13661 Drosophila virilis Dvir\GJ15866 Drosophila mojavensis Dmoj\GI14083 Drosophila grimshawi Dgri\GH24004
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	24453 y1; Mi{ET1}CG11148MB01094 28896 y1 v1; P{TRiP.HM05106}attP2 31010 y1 w*; Mi{MIC}CG11148MI00455
VDRC	v105985 P{KK101931}VIE-260B v18158 w1118; P{GD7214}v18158 v18159 w1118; P{GD7214}v18159
Genomic Clones ( 2 )
	BACR11A04 BACR16N23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25014 LP15335 RH02748
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11460 GM02502 GM05550 GM07876 GM10767 HL07705 LD04940 LD08420 LD09727 LD10381 LD14707 LD18643 LD28159 LP15863 RE34616 RH16110 RH18049 RH51213
Other clones	10692 37253 46117 51428 55458 62189 70031 72845 76901 97878 123165 125839 155804 158454 158993 159937 161288 161657 165043 178575 214255.6 214321.2 274561 274649 282328 522071 CK01.7D.C3 CK01.13B.F7 CK01.21A.E4 CK01.31D.C7 CK01.60B.B6 CK01.132B.H8 Dmel_dig_011307_0659_2095 Dmel_dig_012890_0652_2578 Dmel_dig_013461_0640_1429 Dmel_dig_015245_0584_3364 Dmel_neb_015225_0661_1736 EC28135 EC40554 EK010710 EK014224 EK019450 EK027412 EK063439 EK068112 EK095164 EK110513 EK141239 EK149826 EK155826 EK158736 EK162433 EK164958 EK173704 EK182337 EK194134 EK197447 EK201717 EK220328 EK246262 EK261331 EK261846 EK262748 EK265235 EK270650 EK283655 EK302458 EK307713 EN01320 EP09939 EP16731 FGC008F06 FGC014D04 IP08084 IP08184 LD02885 LD33349 RP01535 RP001004808 RP001007628 RP001013879 RP001014130 RP001019679 RP001032351 RP001034041 RP001035572 RP001036286 RP001036942 RP001052939 RP001053374
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039936 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43842
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143693 NM_205878 NM_001169356 NM_001169357 RefSeq (Proteins) • NP_651950 NP_995600 NP_001162827 NP_001162828 DDBJ / EMBL / GenBank • AAF59406 AAK93031 AAS64611 AAS64612 ACZ95096 ACZ95097 AI405096 AW940962 AY051607 Entrez Gene - A searchable database of RefSeq genes. • 43842 UniProtKB/Swiss-Prot • Q7KQM6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GYF (IPR003169)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68666 DroID - A comprehensive database of gene and protein interactions. • FBgn0039936 DRSC - Results from RNAi screens. • FBgn0039936 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039936 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11148-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039936 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43842 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43842 modMine - Data generated by the modENCODE project. • FBgn0039936
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11148 (Wagner et al., 2007, Wagner et al., 2007, Pisa et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Li et al., 2007, Müller et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Pisa et al., 2009, Gene 432(1-2): 67--74 The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis. [FBrf0206831] Li et al., 2007, J. Biol. Chem. 282(52): 37605--37617 Identification and characterization of a juvenile hormone response element and its binding proteins. [FBrf0202965] Wagner et al., 2007, Mol. Cell 28(4): 692--699 A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. [FBrf0201575]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Wagner et al., 2007, Mol. Cell 28(4): Supplemental Data. [FBrf0208092] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2010.4.14, BDGP_2010_0415.GDP.xml BDGP_2010_0415.GDP.xml [FBrf0210544] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Bellen, 2007.2.1, Batch706FlyBase_cyto_update.xml Batch706FlyBase_cyto_update.xml [FBrf0191799] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Mount, 2001.8.14, Intron annotations. Intron annotations. [FBrf0137489] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]