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Gene Dmel\CG17514

General Information
Symbol	Dmel\CG17514	Species	D. melanogaster
Name		Annotation symbol	CG17514
Feature type	protein_coding_gene	FlyBase ID	FBgn0039959
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2RHet	Recombination map
Cytogenetic map		Sequence location	2RHet:2,775,853..2,821,208 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG17514 (FBgn0039959). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation activator activity. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; Domain of unknown function DUF3554; HEAT; HEAT, type 2; Proteasome component ECM29/Translational activator GCN1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of CG17514. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of CG17514. Gene sequence location is 2RHet:2775853..2821208.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Heterochromatic, cytological location not yet determined.   (Drosophila Heterochromatin Genome Project, 2004)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG17514 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG17514-RA FBtr0113748  NM_001015316   8028   2630 CG17514-RG FBtr0334934  NM_001170371   541   41
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG17514-PA   FBpp0112471   293.9   2630   7.03     NP_001015316   EAA46127 CG17514-PG   FBpp0306953   4.6   41   5.65     NP_001163842   EFA98690
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • HEAT (IPR000357) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Proteasome component ECM29/Translational activator GCN1 (IPR026827) HEAT, type 2 (IPR021133) Domain of unknown function DUF3554 (IPR022716)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140963   AA141513   AA263255   AA694695   AA696032   AA735804   AA802280   AABU01002740 EAA46127   AI062199   AY499230 AAS80330   AY499231 AAS80331   AY499232 AAS80332   AY499233 AAS80333   AY499234 AAS80334   AY499235 AAS80335   AY499236   AY499237   AY499238   AY499239   AY499240   AY499241   BG633578   BG638089   BI581919   BI582174   BI611827   BI626050   BI638405   BP541166   BP548667   BP552860   BP556460   BT021208   CO179372   CO182021   CO185466   CO185913   CO188565   CO263904   CO269012   CO270393   CO271228   CO273995   CO275945   CO287499   CO288291   CO288493   CO290684   CO292129   CO292906   CO298012   CO298315   CO298700   CO312659   CO312810   CO315737   CO317728   CO319156   CO321747   CO321917   CO326976   CO330025   CO330121   CO333519   CO338699   CO339894   CO342082   CO343436   DN154175   CM000457 EAA46127   EC065114   EC068545   EC078486   EC079748   EC082555   EC082920   EC083475   EC083747   EC085129   EC090746   EC194821   EC195008   EC195009   EC196470   EC202489   EC204938   EC206164   EC207619   EC207852   EC215215   EC216995   EC225590   EC229633   EC230326   EC237691   EC238740   EC241115   EC242039   EC242848   EC242849   EC249985   EC250758   EC257354   EC259212   CM000457 EFA98690   EG974147   EV593261   EV600652
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7PLL6 Q5BIL6 Q6JE81 D2A6J9 Q6JE80 Q6JE78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female  (56) ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female  (56) ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    21 central nervous system, pupae P8    23 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    11 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    9 head, mated 4-day male    12 head, mated 20-day male    14 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    2 carcass, larvae L3 wandering    12 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    56 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr  (30) embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new  26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day  (31) adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr  30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new  26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day  31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    23 embryo 04-06hr    14 embryo 06-08hr    10 embryo 08-10hr    16 embryo 10-12hr    11 embryo 12-14hr    30 embryo 14-16hr    8 embryo 16-18hr    17 embryo 18-20hr    9 embryo 20-22hr    14 embryo 22-24hr    22 larva L1    12 larva L2    14 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    24 white prepupae new    26 white prepupae 12hr    22 white prepupae 24hr    24 pupae 2d postWPP    20 pupae 3d postWPP    13 pupae 4d postWPP    4 adult male 01day    8 adult male 05day    6 adult male 30day    4 adult female 01day    9 adult female 05day    31 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2  (51) embryonic Kc167    13 embryonic S1    9 embryonic S3  (32) leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8  (32) wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2  (51) embryonic Kc167    13 embryonic S1    9 embryonic S3  32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8  32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    0 embryonic 1182-4H    9 embryonic GM2    51 embryonic Kc167    13 embryonic S1    9 embryonic S3    32 leg disc CME L1    0 wing disc CME-W2    14 wing disc ML-DmD8    32 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    3 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    21 ovary fGS/OSS    7 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039959 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17514-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG17514GD9401 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG17514 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG17514 Class Mutagen Stocks Known lesion CG17514HMS01344 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG17514GD9401 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG17514NIG.17514R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.17514R} NA P{TRiP.HMS01344} NA characterization construct P{GD9401} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
translation activator activity inferred from sequence or structural similarity with Saccharomyces GCN1 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG17514 - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG17514 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG17514 - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG17514 - Cand1 experimental knowledge based (Guruharsha et al., 2011) CG17514 - Men anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG17514 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039959
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BZNMT Dipteran inclusive ortholog search EOG6WDDKN Insect inclusive ortholog search EOG6G1KB6 Arthropod inclusive ortholog search EOG6HQC03 Metazoa inclusive ortholog search EOG67168W
Orthologs in Drosophila Species (EOG6BZNMT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG17514     Drosophila pseudoobscura pseudoobscura   Dpse\GA30254     Drosophila willistoni   Dwil\GK13410     Drosophila grimshawi   Dgri\GH19589
Orthologs in non-Drosophila Dipterans (EOG6WDDKN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006187   Anopheles gambiae Malaria mosquito  Agam\AGAP001700   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001363
Orthologs in non-Dipteran Insects (EOG6G1KB6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409457   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018590   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14843   Atta cephalotes Leafcutter ant  Acep\ACEP18443   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20549   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17478   Linepithema humile Argentine ant  Lhum\LH23351   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11910   Solenopsis invicta Red fire ant  Sinv\SINV20022   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004209   Bombyx mori Silkmoth  Bmor\BGIBMGA002840   Pediculus humanus Human body louse  Phum\PHUM000250   Tribolium castaneum Red flour beetle  Tcas\TC006821
Orthologs in non-Insect Arthropods (EOG6HQC03)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_111031   Ixodes scapularis Deer tick  Isca\ISCW009790
Orthologs in non-Arthropod Metazoa (EOG67168W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gcn-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028779gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025987gn   Danio rerio Zebrafish  Drer\gcn1l1   Xenopus tropicalis Western clawed frog  Xtro\gcn1l1   Gallus gallus Domestic chicken  Ggal\GCN1L1   Mus musculus House mouse  Mmus\Gcn1l1   Rattus norvegicus Norway rat  Rnor\Gcn1l1   Homo sapiens Human  Hsap\GCN1L1
Human Orthologs (1)
Gene OMIM HGNC Hsap\GCN1L1
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	34355 y1 sc* v1; P{TRiP.HMS01344}attP2
Genomic Clones ( 0 )
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	SD20688
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH18250 RH19751 RH20126 RH66579
Other clones	CK01042 Dmel_neb_009010_0831_0681 Dmel_neb_014054_0566_2030 EK066025 EN17428 EP13804 LD07220
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039959 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355040
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001015316 NM_001170371 RefSeq (Proteins) • NP_001015316 NP_001163842 DDBJ / EMBL / GenBank • AA263255 AABU01002740 AAS80330 AAS80331 AAS80332 AAS80333 AAS80334 AAS80335 AAX33356 AY499230 AY499231 AY499232 AY499233 AY499234 AY499235 AY499236 AY499237 AY499238 AY499239 AY499240 AY499241 BT021208 EAA46127 EFA98689 EFA98690 EFA98691 Entrez Gene - A searchable database of RefSeq genes. • 3355040 UniProtKB/TrEMBL • D2A6J9 Q5BIL6 Q6JE78 Q6JE80 Q6JE81 Q7PLL6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • HEAT (IPR000357) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Proteasome component ECM29/Translational activator GCN1 (IPR026827) HEAT, type 2 (IPR021133) Domain of unknown function DUF3554 (IPR022716)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039959 DRSC - Results from RNAi screens. • FBgn0039959 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039959 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17514-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039959 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355040 modMine - Data generated by the modENCODE project. • FBgn0039959
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG17514 (Rossi et al., 2007, Drosophila Heterochromatin Genome Project, 2007, Ni et al., 2010.12.1, Wasbrough et al., 2010, Franchini et al., 2004, Japanese National Institute of Genetics, 2012.5.21, Lin et al., 2012)
Name Synonym
Secondary FlyBase IDs
	FBan0017514
References ( 16 )
Research paper	Lin et al., 2012, PLoS ONE 7(6): e39758 HP1a Targets the Drosophila KDM4A Demethylase to a Subset of Heterochromatic Genes to Regulate H3K36me3 Levels. [FBrf0218736] Rossi et al., 2007, Genetics 175(2): 595--607 Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. [FBrf0192814] Franchini et al., 2004, Mol. Biol. Evol. 21(7): 1323--1331 Retrotransposon-gene associations are widespread among D. melanogaster populations. [FBrf0180510]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Drosophila Heterochromatin Genome Project, 2007, Release 5.2 of the annotated Drosophila melanogaster heterochromatin. Release 5.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0199188] Drosophila Heterochromatin Genome Project, 2004, Release 3.2 of the annotated Drosophila melanogaster heterochromatin. Release 3.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0173307] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	Dunn, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126662] FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]