Gene Dmel\CG17508

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General Information

Symbol

Dmel\CG17508

Species

D. melanogaster

Name

Annotation symbol

CG17508

Feature type

protein_coding_gene

FlyBase ID

FBgn0039970

Gene Model Status

Current

Stock availability

2 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

41F5-41F5

Sequence location

2R:1,496,140..1,499,091 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG17508 (FBgn0039970). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Domain of unknown function DUF1279. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval fat body, larval salivary gland, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639890_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG17508. Gene sequence location is 2R:1496140..1499091.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41F5-41F5

Limits computationally determined from genome sequence between P{PZ}vlc⁰⁷⁰²²&P{lacW}l(2)09851^k08138 and P{PZ}l(2)09851⁰⁹⁸⁵¹&P{lacW}Src42A^k10108

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG17508 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG17508-RA

FBtr0086071

NM_143844

1228

321

CG17508-RB

FBtr0307172

NM_001259212

1145

194

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG17508-PA

FBpp0085407

35.2

321

9.81

NP_652101

AAM68369

CG17508-PB

FBpp0298001

21.5

194

7.50

NP_001246141

AFH07896

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Domain of unknown function DUF1279 (IPR009688)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval fat body, larval salivary gland, larval trachea, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		1079.3
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		1211.8
Adult Hindgut		936.1
Adult Malpighian Tubules		1235.3
Adult Fat Body		1167.3
Adult Salivary Gland		897.9
Adult Heart		1474.325
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		1279.3
Adult Carcass		1194.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		(543.7)
Larval Hindgut		402.6
Larval Malpighian Tubules		(675.7)
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		(1079.3)
Adult Eye		(632.025)
Adult Brain		(641.8)
Adult Thoracic-Abdominal Ganglion		(703.2)
Adult Crop		(848.9)
Adult Midgut		(1211.8)
Adult Hindgut		(936.1)
Adult Malpighian Tubules		(1235.3)
Adult Fat Body		(1167.3)
Adult Salivary Gland		(897.9)
Adult Heart		(1474.325)
Adult VirginFemale Spermatheca		(1061.8)
Adult InseminatedFemale Spermatheca		(961.7)
Adult Ovary		(687.6)
Adult Testis		71
Adult Male Accessory Gland		(1279.3)
Adult Carcass		(1194.5)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		(1079.3)
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		(1211.8)
Adult Hindgut		936.1
Adult Malpighian Tubules		(1235.3)
Adult Fat Body		(1167.3)
Adult Salivary Gland		897.9
Adult Heart		(1474.325)
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		(1279.3)
Adult Carcass		(1194.5)
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		1079.3
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		1211.8
Adult Hindgut		936.1
Adult Malpighian Tubules		1235.3
Adult Fat Body		1167.3
Adult Salivary Gland		897.9
Adult Heart		1474.325
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		1279.3
Adult Carcass		1194.5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		1079.3
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		1211.8
Adult Hindgut		936.1
Adult Malpighian Tubules		1235.3
Adult Fat Body		1167.3
Adult Salivary Gland		897.9
Adult Heart		1474.325
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		1279.3
Adult Carcass		1194.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		(1079.3)
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		(848.9)
Adult Midgut		(1211.8)
Adult Hindgut		(936.1)
Adult Malpighian Tubules		(1235.3)
Adult Fat Body		(1167.3)
Adult Salivary Gland		(897.9)
Adult Heart		(1474.325)
Adult VirginFemale Spermatheca		(1061.8)
Adult InseminatedFemale Spermatheca		(961.7)
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		(1279.3)
Adult Carcass		(1194.5)
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		1079.3
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		1211.8
Adult Hindgut		936.1
Adult Malpighian Tubules		1235.3
Adult Fat Body		1167.3
Adult Salivary Gland		897.9
Adult Heart		1474.325
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		1279.3
Adult Carcass		1194.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		347.1
Larval Midgut		543.7
Larval Hindgut		402.6
Larval Malpighian Tubules		675.7
Larval Fat Body		456.4
Larval Salivary Gland		185.8
Larval Trachea		453.675
Larval Carcass		191.4
Adult Head		1079.3
Adult Eye		632.025
Adult Brain		641.8
Adult Thoracic-Abdominal Ganglion		703.2
Adult Crop		848.9
Adult Midgut		1211.8
Adult Hindgut		936.1
Adult Malpighian Tubules		1235.3
Adult Fat Body		1167.3
Adult Salivary Gland		897.9
Adult Heart		1474.325
Adult VirginFemale Spermatheca		1061.8
Adult InseminatedFemale Spermatheca		961.7
Adult Ovary		687.6
Adult Testis		71
Adult Male Accessory Gland		1279.3
Adult Carcass		1194.5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	1079.3
NA	Eye	632.025
NA	Brain	641.8
347.1	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	703.2
NA	Crop	848.9
543.7	Midgut	1211.8
402.6	Hindgut	936.1
675.7	Malpighian Tubules	1235.3
456.4	Fat Body	1167.3
185.8	Salivary Gland	897.9
NA	Heart	1474.325
453.675	Trachea	NA
NA	VirginFemale Spermatheca	1061.8
NA	InseminatedFemale Spermatheca	961.7
NA	Ovary	687.6
NA	Testis	71
NA	Male Accessory Gland	1279.3
191.4	Carcass	1194.5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		(47)
head, virgin 20-day female		(61)
head, mated 1-day female		(29)
head, mated 4-day female		(34)
head, mated 20-day female		(49)
head, mated 1-day male		(34)
head, mated 4-day male		(44)
head, mated 20-day male		(60)
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		(42)
digestive system, 1-day adult		(42)
digestive system, 4-day adult		(28)
digestive system, 20-day adult		(29)
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		(46)
carcass, larvae L3 wandering		18
carcass, 1-day adult		(31)
carcass, 4-day adult		(36)
carcass, 20-day adult		(50)
ovary, virgin 4-day female		(47)
ovary, mated 4-day female		(35)
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		(47)
head, virgin 20-day female		(61)
head, mated 1-day female		29
head, mated 4-day female		(34)
head, mated 20-day female		(49)
head, mated 1-day male		(34)
head, mated 4-day male		(44)
head, mated 20-day male		(60)
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		(42)
digestive system, 1-day adult		(42)
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		(46)
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		(36)
carcass, 20-day adult		(50)
ovary, virgin 4-day female		(47)
ovary, mated 4-day female		(35)
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		14
central nervous system, larvae L3		20
central nervous system, pupae P8		24
head, virgin 1-day female		21
head, virgin 4-day female		47
head, virgin 20-day female		61
head, mated 1-day female		29
head, mated 4-day female		34
head, mated 20-day female		49
head, mated 1-day male		34
head, mated 4-day male		44
head, mated 20-day male		60
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		11
digestive system, larvae L3 wandering		42
digestive system, 1-day adult		42
digestive system, 4-day adult		28
digestive system, 20-day adult		29
fat body, larvae L3 wandering		16
fat body, white prepupae		16
fat body, pupae P8		46
carcass, larvae L3 wandering		18
carcass, 1-day adult		31
carcass, 4-day adult		36
carcass, 20-day adult		50
ovary, virgin 4-day female		47
ovary, mated 4-day female		35
testis, mated 4-day male		9
accessory gland, mated 4-day male		23
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(49)
embryo 02-04hr		(40)
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		(27)
embryo 12-14hr		(32)
embryo 14-16hr		16
embryo 16-18hr		(28)
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		(29)
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		(46)
larva L3 puffstage 7-9		(48)
white prepupae new		(35)
white prepupae 12hr		(46)
white prepupae 24hr		(38)
pupae 2d postWPP		(41)
pupae 3d postWPP		(31)
pupae 4d postWPP		11
adult male 01day		(52)
adult male 05day		(46)
adult male 30day		(29)
adult female 01day		(27)
adult female 05day		(54)
adult female 30day		(49)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(49)
embryo 02-04hr		(40)
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		(46)
larva L3 puffstage 7-9		(48)
white prepupae new		(35)
white prepupae 12hr		(46)
white prepupae 24hr		(38)
pupae 2d postWPP		(41)
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		(52)
adult male 05day		(46)
adult male 30day		29
adult female 01day		27
adult female 05day		(54)
adult female 30day		(49)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		49
embryo 02-04hr		40
embryo 04-06hr		14
embryo 06-08hr		10
embryo 08-10hr		20
embryo 10-12hr		27
embryo 12-14hr		32
embryo 14-16hr		16
embryo 16-18hr		28
embryo 18-20hr		18
embryo 20-22hr		17
embryo 22-24hr		29
larva L1		14
larva L2		18
larva L3 12hr old		24
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		48
white prepupae new		35
white prepupae 12hr		46
white prepupae 24hr		38
pupae 2d postWPP		41
pupae 3d postWPP		31
pupae 4d postWPP		11
adult male 01day		52
adult male 05day		46
adult male 30day		29
adult female 01day		27
adult female 05day		54
adult female 30day		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(88)
Schneider line 2 Sg4		(52)
embryonic 1182-4H		20
embryonic GM2		(60)
embryonic Kc167		(54)
embryonic S1		21
embryonic S3		(37)
leg disc CME L1		22
wing disc CME-W2		(51)
wing disc ML-DmD8		(38)
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		(43)
wing disc ML-DmD32		(38)
haltere disc ML-DmD17-c3		(33)
eye-antennal disc ML-DmD11		(27)
antennal disc ML-DmD20-c5		(79)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(33)
CNS ML-DmBG2-c2		(35)
tumorous blood cells mbn2		(47)
ovary fGS/OSS		13
ovary OSC		(29)
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(88)
Schneider line 2 Sg4		(52)
embryonic 1182-4H		20
embryonic GM2		(60)
embryonic Kc167		(54)
embryonic S1		21
embryonic S3		(37)
leg disc CME L1		22
wing disc CME-W2		(51)
wing disc ML-DmD8		(38)
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		(43)
wing disc ML-DmD32		(38)
haltere disc ML-DmD17-c3		(33)
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		(79)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(33)
CNS ML-DmBG2-c2		(35)
tumorous blood cells mbn2		(47)
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		52
embryonic 1182-4H		20
embryonic GM2		60
embryonic Kc167		54
embryonic S1		21
embryonic S3		37
leg disc CME L1		22
wing disc CME-W2		51
wing disc ML-DmD8		38
wing disc ML-DmD9		15
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		38
haltere disc ML-DmD17-c3		33
eye-antennal disc ML-DmD11		27
antennal disc ML-DmD20-c5		79
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		33
CNS ML-DmBG2-c2		35
tumorous blood cells mbn2		47
ovary fGS/OSS		13
ovary OSC		29
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		(29)
Cadmium 50 mM 12 hrs, larvae L3		(45)
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		(36)
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		(50)
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		(42)
Ethanol 2.5% 3 hrs, larvae L3		(31)
Ethanol 5% 3 hrs, larvae L3		(65)
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(74)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(50)
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		(50)
Paraquat 10 mM 48 hrs, 4-day adult		(34)
Rotenone 2 μg 12 hrs, larvae L3		(42)
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		(45)
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		(36)
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		(50)
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		(42)
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		(65)
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(74)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(50)
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		(50)
Paraquat 10 mM 48 hrs, 4-day adult		(34)
Rotenone 2 μg 12 hrs, larvae L3		(42)
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		8
heat shock, 4-day adult		22
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		45
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		50
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		42
Ethanol 2.5% 3 hrs, larvae L3		31
Ethanol 5% 3 hrs, larvae L3		65
Ethanol 10% 3 hrs, larvae L3		24
Caffeine 1.5 mg/ml 4 hrs, larvae L3		74
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		50
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		50
Paraquat 10 mM 48 hrs, 4-day adult		34
Rotenone 2 μg 12 hrs, larvae L3		42
Rotenone 8 μg 12 hrs, larvae L3		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE33778

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039970

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG17508-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG17508

Stages(s) 4-6

Stages(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

CG17508^GD415

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

CG17508^GD415

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CG17508^GD415

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG17508	Class	Mutagen	Stocks	Known lesion
CG17508^MI04887			1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG17508	Class	Mutagen	Stocks	Known lesion
CG17508^GD415		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG17508^NIG.17508R		in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD415}

P{NIG.17508R}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

Mi{MIC}CG17508^MI04887

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG17508 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

72486

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039970

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

49893

Orthologs

OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6V702S

Dipteran inclusive ortholog search

EOG644KV5

Insect inclusive ortholog search

EOG6JDG3N

Arthropod inclusive ortholog search

EOG6G79F3

Metazoa inclusive ortholog search

EOG6H7F7P

Orthologs in Drosophila Species (EOG6V702S)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA29089

Drosophila persimilis

Dper\GL21148

Drosophila willistoni

Dwil\GK15336

Drosophila virilis

Dvir\GJ18221

Drosophila mojavensis

Dmoj\GI17654

Drosophila grimshawi

Dgri\GH13417

Orthologs in non-Drosophila Dipterans (EOG644KV5)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005032

Anopheles gambiae

Malaria mosquito

Agam\AGAP008432

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019413

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014707

Orthologs in non-Dipteran Insects (EOG6JDG3N)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC725167

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008242

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH16278

Atta cephalotes

Leafcutter ant

Acep\ACEP16666

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO17441

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL12477

Linepithema humile

Argentine ant

Lhum\LH21659

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB11620

Solenopsis invicta

Red fire ant

Sinv\SINV13236

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI27848

Bombyx mori

Silkmoth

Bmor\BGIBMGA005937

Pediculus humanus

Human body louse

Phum\PHUM462580

Tribolium castaneum

Red flour beetle

Tcas\TC013774

Orthologs in non-Insect Arthropods (EOG6G79F3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\Tk6

Daphnia pulex

Water flea

Dpux\comER

Ixodes scapularis

Deer tick

Isca\ISCW008194

Orthologs in non-Arthropod Metazoa (EOG6H7F7P)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027834gn

Danio rerio

Zebrafish

Drer\zgc:112435

Gallus gallus

Domestic chicken

Ggal\C20H20orf108

Mus musculus

House mouse

Mmus\2010011I20Rik

Rattus norvegicus

Norway rat

Rnor\RGD1311378

Homo sapiens

Human

Hsap\FAM210B

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\FAM210B

AAA Orthologs (3) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Dsim\GD10376

Drosophila erecta

Dere\GG23170

Drosophila yakuba

Dyak\GE11308

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

Bloomington

37860

y¹ w^*; Mi{MIC}CG17508^MI04887/SM6a

VDRC

v1487

w¹¹¹⁸; P{GD415}v1487

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 63 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

MIP27658

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0039970

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

49893

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

49893

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Domain of unknown function DUF1279 (IPR009688)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE33778

Linkouts

BioGRID - A database of protein and genetic interactions

•

72486

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039970

DRSC - Results from RNAi screens.

•

FBgn0039970

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039970

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG17508-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0039970

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

49893

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

49893

modMine - Data generated by the modENCODE project.

•

FBgn0039970

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG17508

(Rossi et al., 2007, Brandt, 2006, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 14 )

Research paper

Rossi et al., 2007, Genetics 175(2): 595--607: Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. [FBrf0192814]
Myster et al., 2004, Genetics 166(2): 807--822: Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction. [FBrf0174713]
Corradini et al., 2003, Chromosoma 112(1): 26--37: FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements. [FBrf0160459]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Brandt, 2006, Curr. Biol. 16(6):: Supplemental Data. [FBrf0208876]
Yasuhara et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(31):: Supporting Table. [FBrf0191579]

Personal communication to FlyBase

Bellen, 2012.2.2, set970.xml: set970.xml [FBrf0217351]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]