FlyBase Gene Report: Dmel\conu

General Information

Symbol

Dmel\conu

Species

D. melanogaster

Name

conundrum

Annotation Symbol

CG17082

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039994

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

conundrum (conu) encodes a Rho GTPase activating protein (RhoGAP) that negatively regulates Rho1 activity at the cell cortex via interaction with the product of Moe. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

41C1-41C1

Sequence location

2R:4,744,348..4,758,048 [+]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:4744348..4758048

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from direct assay

(Neisch et al., 2013)

enables protein binding

inferred from physical interaction with FLYBASE:Moe; FB:FBgn0011661

(Neisch et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables GTPase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000384138

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of cell population proliferation

inferred from genetic interaction with FLYBASE:Moe; FB:FBgn0011661

(Neisch et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in regulation of actin filament polymerization

inferred from biological aspect of ancestor with PANTHER:PTN001029630

(GO Reference Genome Project, 2011-)

involved_in regulation of small GTPase mediated signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000384138

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000198

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Neisch et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000384138

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

conundrum (conu) encodes a Rho GTPase activating protein (RhoGAP) that negatively regulates Rho1 activity at the cell cortex via interaction with the product of Moe. [Date last reviewed: 2019-03-21]

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS -: RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).

Protein Function (UniProtKB)

GTPase-activating protein (GAP) for Rho1; functions with the ERM protein Moe to regulate Rho1 and control proliferation in the developing epithelium. Recruited by Moe to the cell cortex where it negatively regulates Rho1 activity. Can also promote cell proliferation independently of its GAP activity, perhaps by acting with Arf6 to positively regulate Rac1.

(UniProt, Q8T0G4)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\conu for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8T0G4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Evidence supports alternative transcription start site within intronic TE (RNA-Seq junction data). May be specific to sequenced strain; not included in gene model.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

conu-RA

FBtr0111287

NM_001042989

2210

629

conu-RB

FBtr0111288

NM_001042993

2276

629

conu-RD

FBtr0111285

NM_001042992

2091

629

conu-RG

FBtr0302385

NM_001042990

2098

629

conu-RI

FBtr0345008

NM_001042991

2070

629

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

conu-PA

FBpp0110498

71.7

629

7.34

FBpp0110554

71.7

629

7.34

FBpp0110582

71.7

629

7.34

FBpp0291580

71.7

629

7.34

FBpp0311259

71.7

629

7.34

Q8T0G4

NP_001036456

EAA45994

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

629 aa isoforms: conu-PA, conu-PB, conu-PD, conu-PG, conu-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Moe (via FERM domain).

(UniProt, Q8T0G4)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q8T0G4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\conu using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.90

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Neisch et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\conu in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\conu

View exonic expression by tissue for Dmel\conu

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039994

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355133/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039994

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039994

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039994

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40286

Flygut - An atlas of the Drosophila adult midgut

FBgn0039994

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of conu

Transgenic constructs containing regulatory region of conu

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)M41A2

(Myster et al., 2004)

Df(2R)M41A8

(Myster et al., 2004)

Df(2R)M41A10

(Myster et al., 2004)

Df(2R)Nipped-D

(Myster et al., 2004)

Gene partially disrupted in

Df(2R)conu⁶

(Neisch et al., 2013)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Sterility

Allele

fertile

conu^LL04815

Other Phenotypes

Allele

abnormal cell shape, with Scer\GAL4^en-e16E

increased cell size, with Scer\GAL4^ap-md544

conu^{GAP.UAS.Tag:Myr(Unk),Tag:FLAG}

increased occurrence of cell division | larval stage, with Scer\GAL4^en-e16E

conu^{UAS.Tag:Myr(Unk),Tag:FLAG}

neoplasia, with Scer\GAL4^ap-md544

conu^{UAS.Tag:Myr(Unk),Tag:FLAG}

neoplasia, with Scer\GAL4^en-e16E

conu^{UAS.Tag:Myr(Unk),Tag:FLAG}

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PF

wing disc, with Scer\GAL4^ap-md544

wing disc, with Scer\GAL4^dpp.blk1

conu^{UAS.Tag:Myr(Unk),Tag:FLAG}

wing disc, with Scer\GAL4^en-e16E

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (56)

Hsap\ARHGAP18

11 of 14

Yes

Hsap\ARHGAP28

10 of 14

Yes

Hsap\ARHGAP40

10 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (45)

Rnor\Arhgap18

11 of 14

Yes

Rnor\Arhgap28

9 of 14

Yes

Rnor\Arhgap40

9 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Arhgap18

11 of 14

Yes

Mmus\Arhgap28

10 of 14

Yes

Mmus\Arhgap40

8 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (39)

Xtro\arhgap18

8 of 13

Yes

Xtro\arhgap40

8 of 13

Yes

Xtro\arhgap28

6 of 13

Yes

Xtro\abr

1 of 13

Xtro\arap2

1 of 13

Xtro\arhgap4

1 of 13

Yes

Xtro\arhgap5

1 of 13

Xtro\arhgap10

1 of 13

Xtro\arhgap11a.1

1 of 13

Yes

Xtro\arhgap11a.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (58)

Drer\arhgap18

8 of 14

Yes

Drer\arhgap28

7 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\arhgap23a

1 of 14

Drer\arhgap23b

1 of 14

Drer\arhgap24

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100535133

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-247j9.1

1 of 14

Drer\si:dkey-33c9.6

1 of 14

Drer\si:dkey-91m11.5

1 of 14

Drer\si:dkey-191m6.4

1 of 14

Drer\si:dkey-219e20.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\chin-1

1 of 14

Yes

Cele\F23H11.4

1 of 14

Yes

Cele\gei-1

1 of 14

Yes

Cele\hum-7

1 of 14

Yes

Cele\pac-1

1 of 14

Yes

Cele\rga-1

1 of 14

Yes

Cele\rga-2

1 of 14

Yes

Cele\rga-3

1 of 14

Yes

Cele\rga-6

1 of 14

Yes

Cele\rga-8

1 of 14

Yes

Cele\rrc-1

1 of 14

Yes

Cele\spv-1

1 of 14

Yes

Cele\srgp-1

1 of 14

Yes

Cele\T04C9.1

1 of 14

Yes

Cele\tag-325

1 of 14

Yes

Cele\Y92H12BL.7

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP008833

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\AT1G08340

2 of 13

Yes

Atha\AT3G11490

2 of 13

Yes

Atha\AT4G03100

2 of 13

Yes

Atha\AT5G22400

2 of 13

Yes

Atha\ROPGAP3

2 of 13

Yes

Atha\AT5G12150

1 of 13

Atha\AT5G19390

1 of 13

Atha\REN1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\LRG1

2 of 13

Yes

Scer\RGD1

2 of 13

Yes

Scer\BEM2

1 of 13

Scer\BEM3

1 of 13

Scer\RGA1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rga1

1 of 12

Yes

Spom\rga2

1 of 12

Yes

Spom\rga3

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:conu. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tum

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARHGAP18; Rho GTPase activating protein 18

11 of 14

613351

ARHGAP28; Rho GTPase activating protein 28

10 of 14

610592

ARHGAP40; Rho GTPase activating protein 40

10 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

conu - Moe

anti tag coimmunoprecipitation, western blot, anti tag western blot, two hybrid

(Neisch et al., 2013)

conu - Rho1

anti tag coimmunoprecipitation, anti tag western blot

(Neisch et al., 2013)

conu - RhoBTB

anti tag coimmunoprecipitation, anti tag western blot

(Neisch et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

conu

enhanceable

Arf6

(Neisch et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Moe

suppressible

conu

(Neisch et al., 2013)

Moe

enhanceable

conu

(Neisch et al., 2013)

Rac1

enhanceable

conu

(Neisch et al., 2013)

Rho1

suppressible

conu

(Neisch et al., 2013)

External Data

Subunit Structure (UniProtKB)

Interacts with Moe (via FERM domain).

(UniProt, Q8T0G4 )

Linkouts

BioGRID - A database of protein and genetic interactions.

78258

DroID - A comprehensive database of gene and protein interactions.

FBgn0039994

MIST (genetic) - An integrated Molecular Interaction Database

3355133

MIST (protein-protein) - An integrated Molecular Interaction Database

3355133

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41C1-41C1

Sequence location

2R:4,744,348..4,758,048 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41C1-41C1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

41C1-41C6

h46

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

600558

w^*; P{UAS-conu.Flag}35.2

25522

w¹¹¹⁸; Mi{ET1}conu^MB06749

53460

y¹ w^*; Mi{MIC}conu^MI10102

600559

w^*; P{UAS-conu.Flag}20.1/TM6B, Tb⁺

600560

w^*; P{UAS-conu.RNAi.2}9.1; P{UAS-conu.RNAi.2}24.1

67488

y¹ w^*; Mi{Trojan-GAL4.0}conu^{MI10102-TG4.0}/SM6a

Kyoto

141352

y^* w^*; P{neoFRT}40A PBac{SAstopDsRed}conu^LL04815 P{FRT(w^hs)}G13 cn¹ bw¹/CyO, S^* bw¹

VDRC

v104232

P{KK114590}VIE-260B

v318843

PBac{fTRG01324.sfGFP-TVPTBF}VK00033

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD04957

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039994

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039994

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Neisch et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Transiently named CG40286 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17082 BcDNA:LD04957

(FlyBase, 1996-)

Additional comments

Source for merge of CG17082 BcDNA:LD04957 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: conu CG17082

(Neisch et al., 2013)

Nomenclature comments

Etymology

Named 'conundrum' owing to its unexpected phenotypes.

(Neisch et al., 2013)

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BcDNA:LD04957

CG17082

(Sarov et al., 2016, Neisch et al., 2013, Di Stefano et al., 2011, Keleman et al., 2009.8.5, Rossi et al., 2007, Brandt, 2006)

CG40286

(Giot et al., 2003)

Conu

(Fic et al., 2021, Segal et al., 2018)

conu

(di Pietro et al., 2023, Messina et al., 2022, Nakamura et al., 2017, Gene Disruption Project members, 2016-)

Name Synonyms

conundrum

Secondary FlyBase IDs

FBan0017082
FBgn0047230
FBgn0058286

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3355133

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8T0G4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8T0G4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8T0G4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039994

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355133/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039994

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039994

FlyMine - An integrated database for Drosophila genomics

FBgn0039994

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17082

MARRVEL_MODEL - MARRVEL (model organism gene)

3355133

Linkouts

BioGRID - A database of protein and genetic interactions.

78258

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039994

DroID - A comprehensive database of gene and protein interactions.

FBgn0039994

DRSC - Results frm RNAi screens

FBgn0039994

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039994

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039994

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40286

Flygut - An atlas of the Drosophila adult midgut

FBgn0039994

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039994

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013626

MIST (genetic) - An integrated Molecular Interaction Database

3355133

MIST (protein-protein) - An integrated Molecular Interaction Database

3355133

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (35)

The following external sites may use different assemblies or annotations than FlyBase.

-0.90

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