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Gene Dmel\RpL38

General Information
Symbol	Dmel\RpL38	Species	D. melanogaster
Name	Ribosomal protein L38	Annotation symbol	CG18001
Feature type	protein_coding_gene	FlyBase ID	FBgn0040007
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	l(2)41Af, M(2)41A, M(2)S2, 41Af, CG40278, l(2)EMS45-72, E-2b
Genomic Location
Chromosome (arm)	2R	Recombination map	2-55.1
Cytogenetic map	41A2-41A2	Sequence location	2R:403,502..403,961 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L38 is referred to in FlyBase by the symbol Dmel\RpL38 (CG18001, FBgn0040007). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 8 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; chaeta; wing; wing hair. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L38e. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629984_s_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL38. Gene sequence location is 2R:403502..403961.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	M(2)41A Medium Minute. Originally identified by virtue of Minute phenotype of Df(2R)M41A10; most recurrences shown to be deficiencies. Eclosion of heterozygous deficiency delayed 13 hr (Ferrus, 1975, Genetics 79: 589-99).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood ribosome day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood References Alonso and Santaren, 2006, J. Proteome Res. 5(8): 2025--2032 Transgenic Constructs P{GD13653}
FB2012_01	Sequence features BKN34055 HFA07818 BKN42430
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41A2-41A2
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41C1-41C6   h46   (Drosophila Heterochromatin Genome Project, 2004) h46-h46   (determined by in situ hybridisation)   (Dimitri, 1991)
Experimentally Determined Recombination Data
Location	2- (Rollins et al., 1997, Rollins et al., 1998, Marygold et al., 2005, Coelho et al., 2005) 2-55.1
Left of (cM)
Right of (cM)
Notes	Maps close to the centromere of the second chromosome. (Marygold et al., 2005)
Gene Model & Products
Please see the GBrowse view of Dmel\RpL38 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL38-RA FBtr0111120  NM_001042975   402   70
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL38-PA   FBpp0110412   8.2   70   11.04     NP_001036440   EAA46007
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L38e (IPR002675)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AABU01002769 EAA46007   AY075491   AY231803   AY231997   BI231844   BI355117   BI570923   BI604965   BI636849   BI638232   BP540278   BP540343   BP540344   BP540387   BP540448   BP540663   BP541080   BP541146   BP541170   BP541171   BP541356   BP541861   BP542514   BP543133   BP543211   BP543212   BP543310   BP543311   BP544753   BP544754   BP545999   BP546083   BP546284   BP546319   BP546545   BP546704   BP548345   BP548731   BP549903   BP550567   BP551247   BP553088   BP553089   BQ103311   CO154684   CO154898   CO155024   CO155590   CO155633   CO177666   CO177673   CO180247   CO180871   CO181088   CO181942   CO181952   CO182472   CO182794   CO182968   CO183027   CO183775   CO191374   CO191596   CO191981   CO192109   CO192339   CO194020   CO194042   CO194216   CO194232   CO195497   CO195866   CO262782   CO264518   CO282731   CO291864   CO294747   CO299495   CO304144   CO305542   CO311045   CO311069   CO312717   CO312945   CO314323   CO315088   CO319626   CO322393   CO324611   AE013599 EAA46007   EC059154   EC060746   EC062122   EC062212   EC063535   EC064105   EC064758   EC076460   EC076517   EC076911   EC078717   EC082013   EC088816   EC200867   EC211899   EC215592   EC230090   EC230092   EC236790   EC248075   EC261047   EC261960   EC262033   EC266590   EV578165   EV578896   EV580317   EV580643   EV580877   EV580961   EV582380   EV584733   EV586194   EV586275   EV586308   EV586888   EV587390   EV587475   EV588199   EV588421   EV588510   EV588537   EV589047   EV589149   EV589555   EV589670   EV589831   EV590298   EV590567   EV590636   EV590698   EV590787   EV591042   EV591240   EV591651   EV593102   EV593450   EV594200   EV594845   EV595465   EV595607   EV595879   EV596008   EV596175   EV597615   EV597890   EV598305   EV598459   EV599289   EV599505   EV599591   EV599758   EV600111   EV600221   FD585733   FD585743   FD585838   FD586124   FD586206   GH739201   GH739807   GH740070   GH741115   GH741461   GH741507   GH742066   GH742648   GH742892   GH743518   GH745414   GH745520   GH745539   GH745585   GH746252   GH747028   GH761661   GH761764   GH763199   GH763410   GH764029   GH764109   GH764392   GH765017   GH765972   GH766971   GH766993   GH769207   GH769392
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W5N2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040007    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040007 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040007 expression level Developmental Stage   Expression Level embryo 00-02hr    35197 embryo 02-04hr    48290 embryo 04-06hr    90276 embryo 06-08hr    68250 embryo 08-10hr    102225 embryo 10-12hr    133552 embryo 12-14hr    131571 embryo 14-16hr    23915 embryo 16-18hr    68373 embryo 18-20hr    38885 embryo 20-22hr    65451 embryo 22-24hr    111772 larva L1    59671 larva L2    94626 larva L3 12hr old    51368 larva L3 puffstage 1-2    43308 larva L3 puffstage 3-6    37888 larva L3 puffstage 7-9    64793 white prepupae new    76194 white prepupae 12hr    66221 white prepupae 24hr    48266 pupae 2d postWPP    48852 pupae 3d postWPP    36882 pupae 4d postWPP    13090 adult male 01day    23301 adult male 05day    11982 adult male 30day    9704 adult female 01day    17221 adult female 05day    66351 adult female 30day    36365 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  (13090) adult male 01day  (23301) adult male 05day  (11982) adult male 30day  (9704) adult female 01day  (17221) adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  (13090) adult male 01day  (23301) adult male 05day  (11982) adult male 30day  (9704) adult female 01day  (17221) adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  (13090) adult male 01day  (23301) adult male 05day  (11982) adult male 30day    9704 adult female 01day  (17221) adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35197 embryo 02-04hr    48290 embryo 04-06hr    90276 embryo 06-08hr    68250 embryo 08-10hr    102225 embryo 10-12hr    133552 embryo 12-14hr    131571 embryo 14-16hr    23915 embryo 16-18hr    68373 embryo 18-20hr    38885 embryo 20-22hr    65451 embryo 22-24hr    111772 larva L1    59671 larva L2    94626 larva L3 12hr old    51368 larva L3 puffstage 1-2    43308 larva L3 puffstage 3-6    37888 larva L3 puffstage 7-9    64793 white prepupae new    76194 white prepupae 12hr    66221 white prepupae 24hr    48266 pupae 2d postWPP    48852 pupae 3d postWPP    36882 pupae 4d postWPP    13090 adult male 01day    23301 adult male 05day    11982 adult male 30day    9704 adult female 01day    17221 adult female 05day    66351 adult female 30day    36365 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040007 expression level Developmental Stage   Expression Level embryo 00-02hr    35197 embryo 02-04hr    48290 embryo 04-06hr    90276 embryo 06-08hr    68250 embryo 08-10hr    102225 embryo 10-12hr    133552 embryo 12-14hr    131571 embryo 14-16hr    23915 embryo 16-18hr    68373 embryo 18-20hr    38885 embryo 20-22hr    65451 embryo 22-24hr    111772 larva L1    59671 larva L2    94626 larva L3 12hr old    51368 larva L3 puffstage 1-2    43308 larva L3 puffstage 3-6    37888 larva L3 puffstage 7-9    64793 white prepupae new    76194 white prepupae 12hr    66221 white prepupae 24hr    48266 pupae 2d postWPP    48852 pupae 3d postWPP    36882 pupae 4d postWPP    13090 adult male 01day    23301 adult male 05day    11982 adult male 30day    9704 adult female 01day    17221 adult female 05day    66351 adult female 30day    36365 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  (13090) adult male 01day  (23301) adult male 05day  (11982) adult male 30day  (9704) adult female 01day  (17221) adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  (13090) adult male 01day  (23301) adult male 05day  (11982) adult male 30day  (9704) adult female 01day  (17221) adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35197) embryo 02-04hr  (48290) embryo 04-06hr  (90276) embryo 06-08hr  (68250) embryo 08-10hr  (102225) embryo 10-12hr  (133552) embryo 12-14hr  (131571) embryo 14-16hr  (23915) embryo 16-18hr  (68373) embryo 18-20hr  (38885) embryo 20-22hr  (65451) embryo 22-24hr  (111772) larva L1  (59671) larva L2  (94626) larva L3 12hr old  (51368) larva L3 puffstage 1-2  (43308) larva L3 puffstage 3-6  (37888) larva L3 puffstage 7-9  (64793) white prepupae new  (76194) white prepupae 12hr  (66221) white prepupae 24hr  (48266) pupae 2d postWPP  (48852) pupae 3d postWPP  (36882) pupae 4d postWPP  13090 adult male 01day  (23301) adult male 05day  11982 adult male 30day    9704 adult female 01day  17221 adult female 05day  (66351) adult female 30day  (36365) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35197 embryo 02-04hr    48290 embryo 04-06hr    90276 embryo 06-08hr    68250 embryo 08-10hr    102225 embryo 10-12hr    133552 embryo 12-14hr    131571 embryo 14-16hr    23915 embryo 16-18hr    68373 embryo 18-20hr    38885 embryo 20-22hr    65451 embryo 22-24hr    111772 larva L1    59671 larva L2    94626 larva L3 12hr old    51368 larva L3 puffstage 1-2    43308 larva L3 puffstage 3-6    37888 larva L3 puffstage 7-9    64793 white prepupae new    76194 white prepupae 12hr    66221 white prepupae 24hr    48266 pupae 2d postWPP    48852 pupae 3d postWPP    36882 pupae 4d postWPP    13090 adult male 01day    23301 adult male 05day    11982 adult male 30day    9704 adult female 01day    17221 adult female 05day    66351 adult female 30day    36365 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040007    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040007 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040007 expression level Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040007 expression level Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  1183.2 Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4684.6   NA  Eye    6719.25   NA  Brain    3228.3   3110.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4732.8   NA  Crop    6387.4   5609.4  Midgut    5853.8   5070.4  Hindgut    5325.7   5752.3  Malpighian Tubules    6982   7701.3  Fat Body    6481   8438.5  Salivary Gland    9524.4   NA  Heart    6518.325   6143.25  Trachea    NA   NA  VirginFemale Spermatheca    6488.8   NA  InseminatedFemale Spermatheca    6962.5   NA  Ovary    3613.4   NA  Testis    1183.2   NA  Male Accessory Gland    9824.7   5441.075  Carcass    5731.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18001-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 RpL38GD13653 lethal (with Df(2R)247) RpL38NC21 lethal (with Df(2R)M41A2) RpL38NC21 lethal (with RpL382b1) RpL38NC21 lethal (with RpL382b2) RpL38NC21 lethal (with RpL3845-72) RpL38NC21 lethal (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 lethal | embryonic stage (with RpL382b1) RpL382b2 lethal | embryonic stage (with RpL382b2) RpL382b1 lethal | embryonic stage | recessive RpL3845-72 lethal | larval stage (with RpL382b1) RpL382b2 lethal | larval stage (with RpL382b2) RpL382b1 lethal | partially (with RpL38KPL1) RpL38NC21 lethal | partially (with RpL38NC21) RpL38KPL1 RpL38P3 lethal | partially (with RpL38P3) RpL38NC21 lethal | recessive RpL3845-72 RpL38NC21 Other Phenotypes Allele decreased cell number | dominant RpL382b2 developmental rate defective | dominant RpL382b1 RpL382b2 RpL3845-72 increased cell size | dominant RpL382b1 RpL382b2 Minute (with RpL382b1) RpL38NC21 Minute (with RpL382b2) RpL38NC21 Minute (with RpL3845-72) RpL38NC21 Minute (with RpL38KPL1) RpL38NC21 Minute (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38P3 Minute (with RpL38P3) RpL38NC21 Minute | dominant RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38NC21 RpL38P3 visible (with RpL382b1) RpL38NC21 visible (with RpL382b2) RpL38NC21 visible (with RpL3845-72) RpL38NC21 visible (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 Phenotype manifest in Allele chaeta RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38NC21 RpL38P3 chaeta (with RpL382b1) RpL38NC21 chaeta (with RpL382b2) RpL38NC21 chaeta (with RpL3845-72) RpL38NC21 chaeta (with RpL38KPL1) RpL38NC21 chaeta (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38P3 chaeta (with RpL38P3) RpL38NC21 wing (with RpL382b1) RpL38NC21 wing (with RpL382b2) RpL38NC21 wing (with RpL38NC21) RpL382b1 RpL382b2 wing hair (with RpL382b1) RpL38NC21 wing hair (with RpL38NC21) RpL382b1 wing margin (with RpL3845-72) RpL38NC21 wing margin (with RpL38NC21) RpL3845-72 wing vein | ectopic (with RpL382b1) RpL38NC21 wing vein | ectopic (with RpL382b2) RpL38NC21 wing vein | ectopic (with RpL38NC21) RpL382b1 RpL382b2
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of RpL38 Class Mutagen Stocks Known lesion RpL382b2 ethyl methanesulfonate 1 Yes RpL3845-72 loss of function allele ethyl methanesulfonate 1 Yes RpL382b1 ethyl methanesulfonate 0 Yes RpL38KPL1 0 -- RpL38NC21 ethyl methanesulfonate 0 Yes RpL38P3 0 -- RpL38unspecified 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL38 Class Mutagen Stocks Known lesion RpL38GD13653 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)C (Cicchetti and Loverre, 1989) Df(2L)C' (Cicchetti and Loverre, 1989) Df(2L)D (Cicchetti and Loverre, 1989) Df(2L)D' (Cicchetti and Loverre, 1989) Df(2L)F (Hilliker and Holm, 1975) Df(2L)TW65 (Cicchetti and Loverre, 1989) Df(2L)TW161 (Cicchetti and Loverre, 1989) Df(2R)34-2 (Coulthard et al., 2010) Df(2R)244 (Myster et al., 2004) Df(2R)B (Hilliker, 1976, Ganetzky, 1977) Df(2R)cb25-4 (Lyttle, 1989) Df(2R)cb25-22 (Lyttle, 1989) Df(2R)cb25-24 (Lyttle, 1989) Df(2R)cb25-29 (Lyttle, 1989) Df(2R)cb25-31 (Lyttle, 1989) Df(2R)cb25-42 (Lyttle, 1989) Df(2R)Dark2 (Myster et al., 2004) Df(2R)nap1 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)nap4 (Gambetta and Mueller, 2009.8.18) Df(2R)nap8 (Gambetta and Mueller, 2009.8.18) Df(2R)nap11 (Gambetta and Mueller, 2009.8.18) Df(2R)nap14 (Marygold et al., 2005) Df(2R)NC32 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)NC73 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)Nipped-AC25 (Rollins et al., 1999) Df(2R)Nipped-C160.1 (Rollins et al., 1999) Df(2R)PR50 (Eberl et al., 1993) Df(2R)PRB (Eberl et al., 1993) Df(2R)PRF (Eberl et al., 1993) Df(2R)rl-2J (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-6C (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-9B (Hilliker, 1976) Df(2R)rl-10G (Rollins et al., 1999, Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-14C (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-18C (Hilliker, 1976) Df(2R)rl-B (Hilliker, 1976) Df(2R)rl-D (Hilliker, 1976, Cicchetti and Loverre, 1989) Df(2R)rl-I (Hilliker, 1976) Df(2R)Rsp1 (Ganetzky, 1977) Df(2R)Rsp11 (Ganetzky, 1977) Df(2R)Rsp31 (Ganetzky, 1977) T(2;3)Nipped-C138.2 (Rollins et al., 1999) T(Y;2)J-D   Tp(2;Y)C
Disrupted in	Df(2R)247 (Myster and Peifer, 2003.9.11, Myster et al., 2004, Marygold et al., 2005, Coulthard et al., 2010) Df(2R)M41A1 (Marygold et al., 2005) Df(2R)M41A2 (Myster et al., 2004, Marygold et al., 2005, Coulthard et al., 2010, Coulthard et al., 2010) Df(2R)M41A4 (Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Eberl et al., 1993, Duffy et al., 1996) Df(2R)M41A8 (Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Cicchetti and Loverre, 1989, Dimitri et al., 1997, Gambetta and Mueller, 2009.8.18) Df(2R)M41A10 (Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Lyttle, 1989, Eberl et al., 1993, Duffy et al., 1996, Gambetta and Mueller, 2009.8.18) Df(2R)nap19 (Marygold et al., 2005) Df(2R)NC13 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC228 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004) Df(2R)Nipped-D263.3 (Rollins et al., 1999) Df(2R)Nipped-D341.1 (Rollins et al., 1999) Df(2R)Nipped-E43 (Rollins et al., 1999) Df(2R)Nipped-E299.1 (Rollins et al., 1999) Df(2R)Nipped-E338 (Rollins et al., 1999) Df(2R)rl-1G (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-4J (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-5B (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-12E (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-13D (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-F (Hilliker, 1976, Ganetzky, 1977) In(2R)bwVDe2LCyR (Cicchetti and Loverre, 1989)
Duplicated in	Dp(2;2)BG (Kreber, 1995) Dp(2;Y)cb25-9 (Lyttle, 1989) Dp(2;Y)cb25-11 (Lyttle, 1989)
Not duplicated in	C(Y;4)cb25-1 (Lyttle, 1989) Dp(2;Y)cb25-4 (Lyttle, 1989) Dp(2;Y)cb25-22 (Lyttle, 1989) Dp(2;Y)cb25-24 (Lyttle, 1989) Dp(2;Y)cb25-29 (Lyttle, 1989) Dp(2;Y)cb25-31 (Lyttle, 1989) Dp(2;Y)cb25-42 (Lyttle, 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{GD13653} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}RpL38KPL1 NA P{}RpL38P3 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL38 allele Gene References RpL3845-72 Chi (Rollins et al., 1999) ct (Rollins et al., 1999) mam (Rollins et al., 1999) N (Rollins et al., 1999) vg (Rollins et al., 1999) RpL38unspecified run (Duffy et al., 1996) unspecified Pi3K92E (Marygold et al., 2005, Coelho et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78269 DroID - A comprehensive database of gene and protein interactions. • FBgn0040007 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355144
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dyak\CG18001
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005451-PA Aedes aegypti (mosquito) AGAP010163-PA Anopheles gambiae (mosquito) XP_001120263.1 Apis mellifera (honey bee) XP_001951536.1 Acyrthosiphon pisum (pea aphid) XP_001951914.1 Acyrthosiphon pisum (pea aphid) At2g43460.1 Arabidopsis thaliana (wall cress) At3g59540.1 Arabidopsis thaliana (wall cress) 91609 Batrachochytrium dendrobatidis (chytrid fungus) 286891 Branchiostoma floridae (lancelet) XP_001897539.1 Brugia malayi (roundworm nematode) BGIBMGA005684-PA Bombyx mori (silk worm) ENSBTAP00000040182 Bos taurus (bovine) CAF0006935 Candida albicans (a form of yeast) CN06183 Caenorhabditis brenneri (small nematode) CBP04391 Caenorhabditis briggsae (nematode) CE20485 Caenorhabditis elegans (worm) ENSCAFP00000033963 Canis familiaris (dog) CAGL0A00979g Candida glabrata (haploid yeast) Chro.70450 Cryptosporidium hominis (obligate parasite) JA10657 Caenorhabditis japonica (nematode) CMJ170C Cyanidioschyzon merolae (red alga) cgd7_4050 Cryptosporidium parvum (protozoan parasite) CPIJ005613 Culex pipens (mosquito) ENSCPOP00000008072 Cavia porcellus (guinea pig) 194928 Chlamidomonas reinhardtii (green alga) RP25221 Caenorhabditis remanei (nematode) ENSCSAVP00000007300 Ciona savignyi (sedentary tunicate) 166318 Capitella spl (polychaete worm) DDB0231155 Dictyostelium discoideum (amoeba) DEHA2A07128g Debaryomyces Hansenii (yeast) ENSDARP00000005837 Danio rerio (zebra fish) ENSECAP00000016109 Equus caballus (horse) XP_648308 Entamoeba histolytica (anaerobic protozoan) XP_651276 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004313 Gymnopilus aculeatus (mushroom) ENSGALP00000002218 Gallus gallus (chicken) 185258 Hypsipyla robusta (cedar shoot borer) ENSP00000309830 Homo sapiens (human) ISCW001867-PA Ixodes scapularis (deer tick) KLLA0C18216g Kluyveromyces lactis (yeast) 211882 Lottia gigantea (owl limpet) LmjF03.0250 Leishmania major (virus) LmjF26.2220 Leishmania major (virus) 36190 Monocosta brevicollis (choanoflagellate) ENSMODP00000008283 Monodelphis domestica (gray opossum) ENSMMUP00000032317 Macaca mulatta (rhesus monkey) ENSMUSP00000102211 Mus musculus (house mouse) 226298 Nematostella vectensis (starlet anemone) XP_001607713.1 Nasonia vitripennis (wasp) ENSORLP00000013826 Oryzias latipes (japanese killifish) LOC_Os07g36254.1 Oryza sativa (asian rice) 35617 Ostreococcus tauri (green alga) PF11_0312 Plasmodium falciparum (protozoal parasite) PP03676 Pristionchus pacificus (nematode) 108135 Physcomitrella patens (moss) 224447 Physcomitrella patens (moss) ENSPPYP00000009649 Pongo pygmaeus (orangutan) 40538 Phytophthora ramorum (sudden oak death pathogen) 117827 Phytophthora sojae (root rot pathogen) 562207 Populus trichocarpa (black cottonwood) 814034 Populus trichocarpa (black cottonwood) ENSPTRP00000043853 Pan troglodytes (chimpanzee) PVX_092115 Plasmodium vivax (protozoal parasite) ENSRNOP00000042022 Rattus norvegicus (norway rat) ENSRNOP00000042288 Rattus norvegicus (norway rat) ENSRNOP00000045213 Rattus norvegicus (norway rat) ENSRNOP00000046127 Rattus norvegicus (norway rat) ENSRNOP00000050202 Rattus norvegicus (norway rat) ENSRNOP00000050353 Rattus norvegicus (norway rat) 5058984 Sorghum bicolor (sorghum) YLR325C Saccharomyces cerevisiae (budding yeast) Smp_058720.2 Schistosoma mansoni (trematode parasite) SPBC577.02 Schizosaccharomyces pombe (fission yeast) XP_001175956.1 Strongylocentrotus purpuratus (purple sea urchin) 63143 Trichoplax adhaerens (metazoa) TA21360 Theileria annulata (apicomplexan parasite) XP_970928.1 Tribolium castaneum (red flour beetle) Tc00.1047053509351.4 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017471 Tetraodon nigroviridis (green spotted pufferfish) TP01_0293 Theileria parva (parasitic protozoan) 26889 Thalassiosira pseudonana (marine diatom) ENSTRUP00000046048 Takifugu rubripes (pufferfish Takifugu) 138.m00104 Tetrahymena thermophila (ciliate protozoa) 86763.m00140 Trichomonas vaginalis (parasitic flagellated protozoan) 88546.m00227 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054097 Xenopus tropicalis (frog) YALI0B11308g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18304 NV12042 LH24552 RL38_IXOSC FBgn0223925 FBgn0209018 FBgn0154256 FBgn0143415 FBgn0129182 CPIJ005613 BGIBMGA005684 ACYPI006876 ACYPI004859 GB14397 RL38_ANOGA RL38_AEDAE PHUM327750 GLEAN_06287
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	6974 y1 w*; RpL3845-72/CyO, y+ 25913 w*; RpL382b2/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
Genomic Clones ( 1 )
	BACR04F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 187 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE42506
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM29556 RE24383 RH05721 RH70473 SD18677 SD20466
Other clones	21345 45474 47483 62479 66494 70617 78306 100736 100770 102236 104735 105490 119250 146059 166279 181070 524230 524351 525033 525071 CK01.66D.E5 CK01.66D.G5 CK01.102C.C2 Dmel_dig_004125_0657_0871 Dmel_dig_004488_0676_0549 Dmel_dig_005773_0629_2037 Dmel_dig_006028_0627_2572 Dmel_dig_006279_0620_2230 Dmel_dig_015707_0597_1036 Dmel_dig_016170_0655_0633 Dmel_dig_018451_0621_0837 Dmel_dig_020458_0648_0899 Dmel_neb_000364_0181_3697 Dmel_neb_000847_0154_0336 Dmel_neb_000894_0359_3746 Dmel_neb_002477_0139_3675 Dmel_neb_002732_0405_3711 Dmel_neb_004613_0663_0376 Dmel_neb_004668_0322_2611 Dmel_neb_007905_0685_0613 Dmel_neb_008369_0441_1320 Dmel_neb_008544_0825_2266 Dmel_neb_008733_0890_0568 Dmel_neb_009730_0153_0813 Dmel_neb_010339_0637_2893 Dmel_neb_010709_0835_2449 Dmel_neb_010953_0938_1602 Dmel_neb_011083_0119_2206 Dmel_neb_011595_0432_2206 Dmel_neb_011639_0575_2990 Dmel_neb_011646_0929_2907 Dmel_neb_011717_0417_1228 Dmel_neb_011761_0406_2762 Dmel_neb_011993_0109_0387 Dmel_neb_012241_0421_2834 Dmel_neb_012414_0915_1918 Dmel_neb_012446_0370_0713 Dmel_neb_012462_0425_0986 Dmel_neb_012841_0361_3264 Dmel_neb_012922_0581_1110 Dmel_neb_013371_0346_2935 Dmel_neb_013635_0139_2004 Dmel_neb_013812_0436_2602 Dmel_neb_013861_0575_0834 Dmel_neb_013968_0908_1118 Dmel_neb_014026_0151_1357 Dmel_neb_014277_0863_2433 Dmel_neb_014365_0665_3248 Dmel_neb_014431_0854_2440 Dmel_neb_014806_0663_2609 Dmel_neb_014865_0871_0516 Dmel_neb_015057_0639_0538 Dmel_neb_015238_0188_3563 EC01290 EC13064 EC13526 EC17378 EC17528 EC22752 EC24034 EC24356 EC24437 EC26314 EC30770 EC31478 EC32526 EC33148 EC33551 EC37277 EC37314 EC37628 EC37661 EC40474 EC41731 EK054019 EK054027 EK086341 EK139449 EK161056 EK175557 EK188039 EK194351 EK198539 EK207563 EK223220 EK223256 EK229741 EK230724 EK235801 EK239005 EK243953 EK248921 EK279602 EN04605 EN05010 EN05225 EN06362 EN06449 FGA001G08 FGA002E01 FGA002H05 FGA004E08 FGA006G06 FGA010D09 FGA011A06 FGA011C03 FGB002C02 FGC006C03 FGC014A01 FGC018G12 FGC019C04 FGC019G08 FGC027F02 FGH101G06 FGH102F07 FGH104G06 FGH105B05 FGH107E09 FGH109C02 FGH126G05 FGM001E03 FGM104B06 FGM207H04 FGM211G12 FGM222E03 RM04269 RM04369 RM04569 RM04869 RM04969 RP001006443 RP001008075 RP001008268 RP001010449 RP001012982 RP001013610 RP001013753 RP001013906 RP001015359 RP001016155 RP001017001 RP001017296 RP001018913 RP001019149 RP001020438 RP001021527 RP001024553 RP001025161 RP001026424 RP001029497 RP001032356 RP001032789 RP001039310 RP001042508 RP001043398 RP001044747 RP001049355 RP001054144 RP001056166 UUGC0714
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48289 249711 3355144
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG18001 BcDNA:RE42506 (FlyBase, 1996-) Source for merge of: RpL38 l(2)41Af M(2)41A (Dimitri et al., 2005)
Additional comments	'Nipped' mutations disrupt one or more of four recessive lethal complementation groups: l(2)41Ae, RpL38, Nipped-A and Nipped-B. (Rollins et al., 1999) Source for merge of CG18001 BcDNA:RE42506 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
	Minute gene. (Marygold et al., 2007) Deletions removing RpL38 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) Molecularly-defined mutations in RpL38 result in Minute phenotypes. (Marygold et al., 2007) Identification: as a complementation group whose members dominantly modify the small wing phenotype caused by expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096. 2 alleles of RpL38 have been recovered. (Coelho et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Transiently named CG40278 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) 'Nipped' mutations identify four essential complementation groups, l(2)41Ae, RpL38, Nipped-A and Nipped-B, that play distinct roles in regulating ct and N signalling. (Rollins et al., 1999) RpL38 has functions in wing development both acting through regulation of ct and acting independently of ct. RpL38 influences N receptro signalling or N expression during development of the wing margin, wing veins, eye and thoracic bristles. (Rollins et al., 1999) The Nipped-group genes regulate ct and Ubx. (Rollins et al., 1997) Stated to fall into the same Group IV complementation group as l(2)41Ae. (Duffy et al., 1996) Located close to the heterochromatic-euchromatic junction of 2R. (Hilliker, 1976) One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development. Medium Minute. Originally identified by virtue of Minute phenotype of Df(2R)M41A10; most recurrences shown to be deficiencies. Eclosion of heterozygous deficiency delayed 13 hr (Ferrus, 1975).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042975 RefSeq (Proteins) • NP_001036440 DDBJ / EMBL / GenBank • AABU01002769 EAA46007 Entrez Gene - A searchable database of RefSeq genes. • 3355144 UniProtKB/TrEMBL • Q9W5N2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L38e (IPR002675)
Linkouts
	BioGRID - A database of protein and genetic interactions • 78269 DroID - A comprehensive database of gene and protein interactions. • FBgn0040007 DRSC - Results from RNAi screens. • FBgn0040007 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18001-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48289 249711 3355144 InParanoid A subset of ortholog calls from InParanoid. • AAEL005451-PA Aedes aegypti (mosquito) AGAP010163-PA Anopheles gambiae (mosquito) XP_001120263.1 Apis mellifera (honey bee) XP_001951536.1 Acyrthosiphon pisum (pea aphid) XP_001951914.1 Acyrthosiphon pisum (pea aphid) At2g43460.1 Arabidopsis thaliana (wall cress) At3g59540.1 Arabidopsis thaliana (wall cress) 91609 Batrachochytrium dendrobatidis (chytrid fungus) 286891 Branchiostoma floridae (lancelet) XP_001897539.1 Brugia malayi (roundworm nematode) BGIBMGA005684-PA Bombyx mori (silk worm) ENSBTAP00000040182 Bos taurus (bovine) CAF0006935 Candida albicans (a form of yeast) CN06183 Caenorhabditis brenneri (small nematode) CBP04391 Caenorhabditis briggsae (nematode) CE20485 Caenorhabditis elegans (worm) ENSCAFP00000033963 Canis familiaris (dog) CAGL0A00979g Candida glabrata (haploid yeast) Chro.70450 Cryptosporidium hominis (obligate parasite) JA10657 Caenorhabditis japonica (nematode) CMJ170C Cyanidioschyzon merolae (red alga) cgd7_4050 Cryptosporidium parvum (protozoan parasite) CPIJ005613 Culex pipens (mosquito) ENSCPOP00000008072 Cavia porcellus (guinea pig) 194928 Chlamidomonas reinhardtii (green alga) RP25221 Caenorhabditis remanei (nematode) ENSCSAVP00000007300 Ciona savignyi (sedentary tunicate) 166318 Capitella spl (polychaete worm) DDB0231155 Dictyostelium discoideum (amoeba) DEHA2A07128g Debaryomyces Hansenii (yeast) ENSDARP00000005837 Danio rerio (zebra fish) ENSECAP00000016109 Equus caballus (horse) XP_648308 Entamoeba histolytica (anaerobic protozoan) XP_651276 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004313 Gymnopilus aculeatus (mushroom) ENSGALP00000002218 Gallus gallus (chicken) 185258 Hypsipyla robusta (cedar shoot borer) ENSP00000309830 Homo sapiens (human) ISCW001867-PA Ixodes scapularis (deer tick) KLLA0C18216g Kluyveromyces lactis (yeast) 211882 Lottia gigantea (owl limpet) LmjF03.0250 Leishmania major (virus) LmjF26.2220 Leishmania major (virus) 36190 Monocosta brevicollis (choanoflagellate) ENSMODP00000008283 Monodelphis domestica (gray opossum) ENSMMUP00000032317 Macaca mulatta (rhesus monkey) ENSMUSP00000102211 Mus musculus (house mouse) 226298 Nematostella vectensis (starlet anemone) XP_001607713.1 Nasonia vitripennis (wasp) ENSORLP00000013826 Oryzias latipes (japanese killifish) LOC_Os07g36254.1 Oryza sativa (asian rice) 35617 Ostreococcus tauri (green alga) PF11_0312 Plasmodium falciparum (protozoal parasite) PP03676 Pristionchus pacificus (nematode) 108135 Physcomitrella patens (moss) 224447 Physcomitrella patens (moss) ENSPPYP00000009649 Pongo pygmaeus (orangutan) 40538 Phytophthora ramorum (sudden oak death pathogen) 117827 Phytophthora sojae (root rot pathogen) 562207 Populus trichocarpa (black cottonwood) 814034 Populus trichocarpa (black cottonwood) ENSPTRP00000043853 Pan troglodytes (chimpanzee) PVX_092115 Plasmodium vivax (protozoal parasite) ENSRNOP00000042022 Rattus norvegicus (norway rat) ENSRNOP00000042288 Rattus norvegicus (norway rat) ENSRNOP00000045213 Rattus norvegicus (norway rat) ENSRNOP00000046127 Rattus norvegicus (norway rat) ENSRNOP00000050202 Rattus norvegicus (norway rat) ENSRNOP00000050353 Rattus norvegicus (norway rat) 5058984 Sorghum bicolor (sorghum) YLR325C Saccharomyces cerevisiae (budding yeast) Smp_058720.2 Schistosoma mansoni (trematode parasite) SPBC577.02 Schizosaccharomyces pombe (fission yeast) XP_001175956.1 Strongylocentrotus purpuratus (purple sea urchin) 63143 Trichoplax adhaerens (metazoa) TA21360 Theileria annulata (apicomplexan parasite) XP_970928.1 Tribolium castaneum (red flour beetle) Tc00.1047053509351.4 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017471 Tetraodon nigroviridis (green spotted pufferfish) TP01_0293 Theileria parva (parasitic protozoan) 26889 Thalassiosira pseudonana (marine diatom) ENSTRUP00000046048 Takifugu rubripes (pufferfish Takifugu) 138.m00104 Tetrahymena thermophila (ciliate protozoa) 86763.m00140 Trichomonas vaginalis (parasitic flagellated protozoan) 88546.m00227 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054097 Xenopus tropicalis (frog) YALI0B11308g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355144 modMine - Data generated by the modENCODE project. • FBgn0040007 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18304 NV12042 LH24552 RL38_IXOSC FBgn0223925 FBgn0209018 FBgn0154256 FBgn0143415 FBgn0129182 CPIJ005613 BGIBMGA005684 ACYPI006876 ACYPI004859 GB14397 RL38_ANOGA RL38_AEDAE PHUM327750 GLEAN_06287
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	41Af (Dimitri et al., 2005, Cenci et al., 2003, Dimitri et al., 2003) 41Ag (Dimitri et al., 2005) BcDNA:RE42506   CG18001 (Coelho et al., 2005, Dimitri et al., 2005, Boutros et al., 2004, Marygold et al., 2007, Cammarato et al., 2011) CG40278 (Myster et al., 2004, Giot et al., 2003, Corradini et al., 2003, ) E-2b (Coelho et al., 2005, Marygold et al., 2005) GroupIV (Ganetzky, 1977, ) l(2)41Af (Marygold et al., 2005, Myster et al., 2004, Myster and Peifer, 2003.9.11, Corradini et al., 2003, Rollins et al., 1999, Duffy et al., 1996, Dimitri, 1991, Corradini et al., 2005, Dimitri et al., 2003) l(2)41Ag   l(2)41Ai   l(2)EMS4-72   l(2)EMS45-72 (Eberl et al., 1993, Lyttle, 1989, Hilliker, 1976) l(2R)A' (Hilliker and Holm, 1975) M(2)41A (Marygold et al., 2005, Dimitri et al., 2005, Myster et al., 2004, Duffy et al., 1996, Presgraves, 2003, Marygold et al., 2007) M(2)S2 (Rasmuson-Lestander et al., 1993, Kongsuwan et al., 1985, Lindsley et al., 1972, Seattle-La Jolla Drosophila Laboratories, 1971, ) M(2)S3   RpL38 (Rossi et al., 2007, Gambetta and Mueller, 2009.8.18, Marygold et al., 2007, Coulthard et al., 2010) Rp L38 (Alonso and Santaren, 2006)
Name Synonym	Enhancer on chromosome 2, complementation group b (Marygold et al., 2005) lethal(2)41Af   Minute(2)41A   Nipped (Rollins et al., 1997) Ribosomal protein 38 (Rossi et al., 2007) Ribosomal protein L38 (Ashburner and Marygold, 2004.7.2, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0018001 FBgn0002066 FBgn0002601 FBgn0013538 FBgn0020393 FBgn0058278 FBgn0061397
References ( 52 )
Generate a list of	All references relating to this gene ( 52 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 2 )
Recent research papers ( 2 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Coulthard et al., 2010, Genetics 185(2): 479--495 Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...