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Gene Dmel\RpL38

General Information
Symbol	Dmel\RpL38	Species	D. melanogaster
Name	Ribosomal protein L38	Annotation symbol	CG18001
Feature type	protein_coding_gene	FlyBase ID	FBgn0040007
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	l(2)41Af, M(2)41A, M(2)S2, 41Af, CG40278, l(2)EMS45-72, E-2b
Genomic Location
Chromosome (arm)	2R	Recombination map	2-55.1
Cytogenetic map	41A2-41A2	Sequence location	2R:402,893..403,963 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L38 is referred to in FlyBase by the symbol Dmel\RpL38 (CG18001, FBgn0040007). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 9 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; chaeta; wing; wing hair; prothoracic gland. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein L38e. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629984_s_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL38. Gene sequence location is 2R:402893..403963.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	M(2)41A Medium Minute. Originally identified by virtue of Minute phenotype of Df(2R)M41A10; most recurrences shown to be deficiencies. Eclosion of heterozygous deficiency delayed 13 hr (Ferrus, 1975, Genetics 79: 589-99).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41A2-41A2
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41C1-41C6   h46   (Drosophila Heterochromatin Genome Project, 2004) h46-h46   (determined by in situ hybridisation)   (Dimitri, 1991)
Experimentally Determined Recombination Data
Location	2-55.1   2- (Rollins et al., 1997, Rollins et al., 1998, Marygold et al., 2005, Coelho et al., 2005)
Left of (cM)
Right of (cM)
Notes	Maps close to the centromere of the second chromosome. (Marygold et al., 2005)
Gene Model & Products
Please see the GBrowse view of Dmel\RpL38 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL38-RA FBtr0111120  NM_001042975   401   70 RpL38-RB FBtr0334985  NM_001273771   1013   70
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL38-PA   FBpp0110412   8.2   70   11.04     NP_001036440   EAA46007 RpL38-PB   FBpp0306998   8.2   70   11.04     NP_001260700   AGB93235
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L38e (IPR002675)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AABU01002769 EAA46007   AE013599 AGB93235   AY075491   AY231803   AY231997   BI231844   BI355117   BI570923   BI604965   BI636849   BI638232   BP540278   BP540343   BP540344   BP540387   BP540448   BP540663   BP541080   BP541146   BP541170   BP541171   BP541356   BP541861   BP542514   BP543133   BP543211   BP543212   BP543310   BP543311   BP544753   BP544754   BP545999   BP546083   BP546284   BP546319   BP546545   BP546704   BP548345   BP548731   BP549903   BP550567   BP551247   BP553088   BP553089   BQ103311   CO154684   CO154898   CO155024   CO155590   CO155633   CO177666   CO177673   CO180247   CO180871   CO181088   CO181942   CO181952   CO182472   CO182794   CO182968   CO183027   CO183775   CO191374   CO191596   CO191981   CO192109   CO192339   CO194020   CO194042   CO194216   CO194232   CO195497   CO195866   CO262782   CO264518   CO282731   CO291864   CO294747   CO299495   CO304144   CO305542   CO311045   CO311069   CO312717   CO312945   CO314323   CO315088   CO319626   CO322393   CO324611   AE013599 EAA46007   EC059154   EC060746   EC062122   EC062212   EC063535   EC064105   EC064758   EC076460   EC076517   EC076911   EC078717   EC082013   EC088816   EC200867   EC211899   EC215592   EC230090   EC230092   EC236790   EC248075   EC261047   EC261960   EC262033   EC266590   EV578165   EV578896   EV580317   EV580643   EV580877   EV580961   EV582380   EV584733   EV586194   EV586275   EV586308   EV586888   EV587390   EV587475   EV588199   EV588421   EV588510   EV588537   EV589047   EV589149   EV589555   EV589670   EV589831   EV590298   EV590567   EV590636   EV590698   EV590787   EV591042   EV591240   EV591651   EV592749   EV593102   EV593450   EV593793   EV594200   EV594845   EV595465   EV595607   EV595879   EV596008   EV596175   EV597470   EV597615   EV597890   EV598305   EV598459   EV599289   EV599505   EV599591   EV599758   EV600111   EV600221   EV600547   FD585733   FD585743   FD585838   FD586124   FD586206   GH739201   GH739807   GH740070   GH741115   GH741461   GH741507   GH742066   GH742648   GH742892   GH743518   GH745414   GH745520   GH745539   GH745585   GH746252   GH747028   GH761661   GH761764   GH763199   GH763410   GH764029   GH764109   GH764392   GH765017   GH765972   GH766971   GH766993   GH769207   GH769392
UniProtKB/Swiss-Prot	Q9W5N2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  (1183.2) Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (3110.825) Larval Midgut  (5609.4) Larval Hindgut  (5070.4) Larval Malpighian Tubules  (5752.3) Larval Fat Body  (7701.3) Larval Salivary Gland  (8438.5) Larval Trachea  (6143.25) Larval Carcass  (5441.075) Adult Head  (4684.6) Adult Eye  (6719.25) Adult Brain  (3228.3) Adult Thoracic-Abdominal Ganglion  (4732.8) Adult Crop  (6387.4) Adult Midgut  (5853.8) Adult Hindgut  (5325.7) Adult Malpighian Tubules  (6982) Adult Fat Body  (6481) Adult Salivary Gland  (9524.4) Adult Heart  (6518.325) Adult VirginFemale Spermatheca  (6488.8) Adult InseminatedFemale Spermatheca  (6962.5) Adult Ovary  (3613.4) Adult Testis  1183.2 Adult Male Accessory Gland  (9824.7) Adult Carcass  (5731.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3110.825 Larval Midgut    5609.4 Larval Hindgut    5070.4 Larval Malpighian Tubules    5752.3 Larval Fat Body    7701.3 Larval Salivary Gland    8438.5 Larval Trachea    6143.25 Larval Carcass    5441.075 Adult Head    4684.6 Adult Eye    6719.25 Adult Brain    3228.3 Adult Thoracic-Abdominal Ganglion    4732.8 Adult Crop    6387.4 Adult Midgut    5853.8 Adult Hindgut    5325.7 Adult Malpighian Tubules    6982 Adult Fat Body    6481 Adult Salivary Gland    9524.4 Adult Heart    6518.325 Adult VirginFemale Spermatheca    6488.8 Adult InseminatedFemale Spermatheca    6962.5 Adult Ovary    3613.4 Adult Testis    1183.2 Adult Male Accessory Gland    9824.7 Adult Carcass    5731.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4684.6   NA  Eye    6719.25   NA  Brain    3228.3   3110.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4732.8   NA  Crop    6387.4   5609.4  Midgut    5853.8   5070.4  Hindgut    5325.7   5752.3  Malpighian Tubules    6982   7701.3  Fat Body    6481   8438.5  Salivary Gland    9524.4   NA  Heart    6518.325   6143.25  Trachea    NA   NA  VirginFemale Spermatheca    6488.8   NA  InseminatedFemale Spermatheca    6962.5   NA  Ovary    3613.4   NA  Testis    1183.2   NA  Male Accessory Gland    9824.7   5441.075  Carcass    5731.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    226 central nervous system, larvae L3    173 central nervous system, pupae P8    124 head, virgin 1-day female    132 head, virgin 4-day female    139 head, virgin 20-day female    184 head, mated 1-day female    98 head, mated 4-day female    136 head, mated 20-day female    168 head, mated 1-day male    98 head, mated 4-day male    112 head, mated 20-day male    120 salivary gland, larvae L3 wandering    85 salivary gland, white prepupae    293 digestive system, larvae L3 wandering    168 digestive system, 1-day adult    142 digestive system, 4-day adult    124 digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae    112 fat body, pupae P8    160 carcass, larvae L3 wandering    165 carcass, 1-day adult    111 carcass, 4-day adult    139 carcass, 20-day adult    152 ovary, virgin 4-day female    337 ovary, mated 4-day female    162 testis, mated 4-day male    177 accessory gland, mated 4-day male    296 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (226) central nervous system, larvae L3  (173) central nervous system, pupae P8  (124) head, virgin 1-day female  (132) head, virgin 4-day female  (139) head, virgin 20-day female  (184) head, mated 1-day female  (98) head, mated 4-day female  (136) head, mated 20-day female  (168) head, mated 1-day male  (98) head, mated 4-day male  (112) head, mated 20-day male  (120) salivary gland, larvae L3 wandering  (85) salivary gland, white prepupae  (293) digestive system, larvae L3 wandering  (168) digestive system, 1-day adult  (142) digestive system, 4-day adult  (124) digestive system, 20-day adult  (99) fat body, larvae L3 wandering  (65) fat body, white prepupae  (112) fat body, pupae P8  (160) carcass, larvae L3 wandering  (165) carcass, 1-day adult  (111) carcass, 4-day adult  (139) carcass, 20-day adult  (152) ovary, virgin 4-day female  (337) ovary, mated 4-day female  (162) testis, mated 4-day male  (177) accessory gland, mated 4-day male  (296) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (226) central nervous system, larvae L3  (173) central nervous system, pupae P8  (124) head, virgin 1-day female  (132) head, virgin 4-day female  (139) head, virgin 20-day female  (184) head, mated 1-day female    98 head, mated 4-day female  (136) head, mated 20-day female  (168) head, mated 1-day male    98 head, mated 4-day male  (112) head, mated 20-day male  (120) salivary gland, larvae L3 wandering    85 salivary gland, white prepupae  (293) digestive system, larvae L3 wandering  (168) digestive system, 1-day adult  (142) digestive system, 4-day adult  (124) digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae  (112) fat body, pupae P8  (160) carcass, larvae L3 wandering  (165) carcass, 1-day adult  (111) carcass, 4-day adult  (139) carcass, 20-day adult  (152) ovary, virgin 4-day female  (337) ovary, mated 4-day female  (162) testis, mated 4-day male  (177) accessory gland, mated 4-day male  (296) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    226 central nervous system, larvae L3    173 central nervous system, pupae P8    124 head, virgin 1-day female    132 head, virgin 4-day female    139 head, virgin 20-day female    184 head, mated 1-day female    98 head, mated 4-day female    136 head, mated 20-day female    168 head, mated 1-day male    98 head, mated 4-day male    112 head, mated 20-day male    120 salivary gland, larvae L3 wandering    85 salivary gland, white prepupae    293 digestive system, larvae L3 wandering    168 digestive system, 1-day adult    142 digestive system, 4-day adult    124 digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae    112 fat body, pupae P8    160 carcass, larvae L3 wandering    165 carcass, 1-day adult    111 carcass, 4-day adult    139 carcass, 20-day adult    152 ovary, virgin 4-day female    337 ovary, mated 4-day female    162 testis, mated 4-day male    177 accessory gland, mated 4-day male    296 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    226 central nervous system, larvae L3    173 central nervous system, pupae P8    124 head, virgin 1-day female    132 head, virgin 4-day female    139 head, virgin 20-day female    184 head, mated 1-day female    98 head, mated 4-day female    136 head, mated 20-day female    168 head, mated 1-day male    98 head, mated 4-day male    112 head, mated 20-day male    120 salivary gland, larvae L3 wandering    85 salivary gland, white prepupae    293 digestive system, larvae L3 wandering    168 digestive system, 1-day adult    142 digestive system, 4-day adult    124 digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae    112 fat body, pupae P8    160 carcass, larvae L3 wandering    165 carcass, 1-day adult    111 carcass, 4-day adult    139 carcass, 20-day adult    152 ovary, virgin 4-day female    337 ovary, mated 4-day female    162 testis, mated 4-day male    177 accessory gland, mated 4-day male    296 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (226) central nervous system, larvae L3  (173) central nervous system, pupae P8  (124) head, virgin 1-day female  (132) head, virgin 4-day female  (139) head, virgin 20-day female  (184) head, mated 1-day female  (98) head, mated 4-day female  (136) head, mated 20-day female  (168) head, mated 1-day male  (98) head, mated 4-day male  (112) head, mated 20-day male  (120) salivary gland, larvae L3 wandering  (85) salivary gland, white prepupae  (293) digestive system, larvae L3 wandering  (168) digestive system, 1-day adult  (142) digestive system, 4-day adult  (124) digestive system, 20-day adult  (99) fat body, larvae L3 wandering  (65) fat body, white prepupae  (112) fat body, pupae P8  (160) carcass, larvae L3 wandering  (165) carcass, 1-day adult  (111) carcass, 4-day adult  (139) carcass, 20-day adult  (152) ovary, virgin 4-day female  (337) ovary, mated 4-day female  (162) testis, mated 4-day male  (177) accessory gland, mated 4-day male  (296) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (226) central nervous system, larvae L3  (173) central nervous system, pupae P8  124 head, virgin 1-day female  132 head, virgin 4-day female  139 head, virgin 20-day female  (184) head, mated 1-day female    98 head, mated 4-day female  136 head, mated 20-day female  (168) head, mated 1-day male    98 head, mated 4-day male  112 head, mated 20-day male  120 salivary gland, larvae L3 wandering    85 salivary gland, white prepupae  (293) digestive system, larvae L3 wandering  (168) digestive system, 1-day adult  142 digestive system, 4-day adult  124 digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae  112 fat body, pupae P8  (160) carcass, larvae L3 wandering  (165) carcass, 1-day adult  111 carcass, 4-day adult  139 carcass, 20-day adult  (152) ovary, virgin 4-day female  (337) ovary, mated 4-day female  (162) testis, mated 4-day male  (177) accessory gland, mated 4-day male  (296) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    226 central nervous system, larvae L3    173 central nervous system, pupae P8    124 head, virgin 1-day female    132 head, virgin 4-day female    139 head, virgin 20-day female    184 head, mated 1-day female    98 head, mated 4-day female    136 head, mated 20-day female    168 head, mated 1-day male    98 head, mated 4-day male    112 head, mated 20-day male    120 salivary gland, larvae L3 wandering    85 salivary gland, white prepupae    293 digestive system, larvae L3 wandering    168 digestive system, 1-day adult    142 digestive system, 4-day adult    124 digestive system, 20-day adult    99 fat body, larvae L3 wandering    65 fat body, white prepupae    112 fat body, pupae P8    160 carcass, larvae L3 wandering    165 carcass, 1-day adult    111 carcass, 4-day adult    139 carcass, 20-day adult    152 ovary, virgin 4-day female    337 ovary, mated 4-day female    162 testis, mated 4-day male    177 accessory gland, mated 4-day male    296 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    184 embryo 02-04hr    254 embryo 04-06hr    475 embryo 06-08hr    361 embryo 08-10hr    539 embryo 10-12hr    704 embryo 12-14hr    697 embryo 14-16hr    126 embryo 16-18hr    361 embryo 18-20hr    205 embryo 20-22hr    345 embryo 22-24hr    588 larva L1    313 larva L2    497 larva L3 12hr old    270 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    200 larva L3 puffstage 7-9    342 white prepupae new    401 white prepupae 12hr    350 white prepupae 24hr    256 pupae 2d postWPP    260 pupae 3d postWPP    196 pupae 4d postWPP    69 adult male 01day    123 adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day    348 adult female 30day    191 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (184) embryo 02-04hr  (254) embryo 04-06hr  (475) embryo 06-08hr  (361) embryo 08-10hr  (539) embryo 10-12hr  (704) embryo 12-14hr  (697) embryo 14-16hr  (126) embryo 16-18hr  (361) embryo 18-20hr  (205) embryo 20-22hr  (345) embryo 22-24hr  (588) larva L1  (313) larva L2  (497) larva L3 12hr old  (270) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (200) larva L3 puffstage 7-9  (342) white prepupae new  (401) white prepupae 12hr  (350) white prepupae 24hr  (256) pupae 2d postWPP  (260) pupae 3d postWPP  (196) pupae 4d postWPP  (69) adult male 01day  (123) adult male 05day  (63) adult male 30day  (51) adult female 01day  (90) adult female 05day  (348) adult female 30day  (191) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (184) embryo 02-04hr  (254) embryo 04-06hr  (475) embryo 06-08hr  (361) embryo 08-10hr  (539) embryo 10-12hr  (704) embryo 12-14hr  (697) embryo 14-16hr  (126) embryo 16-18hr  (361) embryo 18-20hr  (205) embryo 20-22hr  (345) embryo 22-24hr  (588) larva L1  (313) larva L2  (497) larva L3 12hr old  (270) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (200) larva L3 puffstage 7-9  (342) white prepupae new  (401) white prepupae 12hr  (350) white prepupae 24hr  (256) pupae 2d postWPP  (260) pupae 3d postWPP  (196) pupae 4d postWPP    69 adult male 01day  (123) adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day  (348) adult female 30day  (191) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    184 embryo 02-04hr    254 embryo 04-06hr    475 embryo 06-08hr    361 embryo 08-10hr    539 embryo 10-12hr    704 embryo 12-14hr    697 embryo 14-16hr    126 embryo 16-18hr    361 embryo 18-20hr    205 embryo 20-22hr    345 embryo 22-24hr    588 larva L1    313 larva L2    497 larva L3 12hr old    270 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    200 larva L3 puffstage 7-9    342 white prepupae new    401 white prepupae 12hr    350 white prepupae 24hr    256 pupae 2d postWPP    260 pupae 3d postWPP    196 pupae 4d postWPP    69 adult male 01day    123 adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day    348 adult female 30day    191 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    184 embryo 02-04hr    254 embryo 04-06hr    475 embryo 06-08hr    361 embryo 08-10hr    539 embryo 10-12hr    704 embryo 12-14hr    697 embryo 14-16hr    126 embryo 16-18hr    361 embryo 18-20hr    205 embryo 20-22hr    345 embryo 22-24hr    588 larva L1    313 larva L2    497 larva L3 12hr old    270 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    200 larva L3 puffstage 7-9    342 white prepupae new    401 white prepupae 12hr    350 white prepupae 24hr    256 pupae 2d postWPP    260 pupae 3d postWPP    196 pupae 4d postWPP    69 adult male 01day    123 adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day    348 adult female 30day    191 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (184) embryo 02-04hr  (254) embryo 04-06hr  (475) embryo 06-08hr  (361) embryo 08-10hr  (539) embryo 10-12hr  (704) embryo 12-14hr  (697) embryo 14-16hr  (126) embryo 16-18hr  (361) embryo 18-20hr  (205) embryo 20-22hr  (345) embryo 22-24hr  (588) larva L1  (313) larva L2  (497) larva L3 12hr old  (270) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (200) larva L3 puffstage 7-9  (342) white prepupae new  (401) white prepupae 12hr  (350) white prepupae 24hr  (256) pupae 2d postWPP  (260) pupae 3d postWPP  (196) pupae 4d postWPP  (69) adult male 01day  (123) adult male 05day  (63) adult male 30day  (51) adult female 01day  (90) adult female 05day  (348) adult female 30day  (191) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (184) embryo 02-04hr  (254) embryo 04-06hr  (475) embryo 06-08hr  (361) embryo 08-10hr  (539) embryo 10-12hr  (704) embryo 12-14hr  (697) embryo 14-16hr  126 embryo 16-18hr  (361) embryo 18-20hr  (205) embryo 20-22hr  (345) embryo 22-24hr  (588) larva L1  (313) larva L2  (497) larva L3 12hr old  (270) larva L3 puffstage 1-2  (227) larva L3 puffstage 3-6  (200) larva L3 puffstage 7-9  (342) white prepupae new  (401) white prepupae 12hr  (350) white prepupae 24hr  (256) pupae 2d postWPP  (260) pupae 3d postWPP  (196) pupae 4d postWPP    69 adult male 01day  123 adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day  (348) adult female 30day  (191) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    184 embryo 02-04hr    254 embryo 04-06hr    475 embryo 06-08hr    361 embryo 08-10hr    539 embryo 10-12hr    704 embryo 12-14hr    697 embryo 14-16hr    126 embryo 16-18hr    361 embryo 18-20hr    205 embryo 20-22hr    345 embryo 22-24hr    588 larva L1    313 larva L2    497 larva L3 12hr old    270 larva L3 puffstage 1-2    227 larva L3 puffstage 3-6    200 larva L3 puffstage 7-9    342 white prepupae new    401 white prepupae 12hr    350 white prepupae 24hr    256 pupae 2d postWPP    260 pupae 3d postWPP    196 pupae 4d postWPP    69 adult male 01day    123 adult male 05day    63 adult male 30day    51 adult female 01day    90 adult female 05day    348 adult female 30day    191 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    689 Schneider line 2 Sg4    822 embryonic 1182-4H    239 embryonic GM2    781 embryonic Kc167    1890 embryonic S1    228 embryonic S3    741 leg disc CME L1    395 wing disc CME-W2    1116 wing disc ML-DmD8    991 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    308 wing disc ML-DmD21    868 wing disc ML-DmD32    256 haltere disc ML-DmD17-c3    428 eye-antennal disc ML-DmD11    398 antennal disc ML-DmD20-c5    1293 mixed discs ML-DmD4-c1    554 CNS ML-DmBG1-c1    402 CNS ML-DmBG2-c2    628 tumorous blood cells mbn2    686 ovary fGS/OSS    111 ovary OSC    286 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (689) Schneider line 2 Sg4  (822) embryonic 1182-4H  (239) embryonic GM2  (781) embryonic Kc167  (1890) embryonic S1  (228) embryonic S3  (741) leg disc CME L1  (395) wing disc CME-W2  (1116) wing disc ML-DmD8  (991) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (308) wing disc ML-DmD21  (868) wing disc ML-DmD32  (256) haltere disc ML-DmD17-c3  (428) eye-antennal disc ML-DmD11  (398) antennal disc ML-DmD20-c5  (1293) mixed discs ML-DmD4-c1  (554) CNS ML-DmBG1-c1  (402) CNS ML-DmBG2-c2  (628) tumorous blood cells mbn2  (686) ovary fGS/OSS  (111) ovary OSC  (286) ovary OSS  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (689) Schneider line 2 Sg4  (822) embryonic 1182-4H  (239) embryonic GM2  (781) embryonic Kc167  (1890) embryonic S1  (228) embryonic S3  (741) leg disc CME L1  (395) wing disc CME-W2  (1116) wing disc ML-DmD8  (991) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (308) wing disc ML-DmD21  (868) wing disc ML-DmD32  (256) haltere disc ML-DmD17-c3  (428) eye-antennal disc ML-DmD11  (398) antennal disc ML-DmD20-c5  (1293) mixed discs ML-DmD4-c1  (554) CNS ML-DmBG1-c1  (402) CNS ML-DmBG2-c2  (628) tumorous blood cells mbn2  (686) ovary fGS/OSS  (111) ovary OSC  (286) ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    689 Schneider line 2 Sg4    822 embryonic 1182-4H    239 embryonic GM2    781 embryonic Kc167    1890 embryonic S1    228 embryonic S3    741 leg disc CME L1    395 wing disc CME-W2    1116 wing disc ML-DmD8    991 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    308 wing disc ML-DmD21    868 wing disc ML-DmD32    256 haltere disc ML-DmD17-c3    428 eye-antennal disc ML-DmD11    398 antennal disc ML-DmD20-c5    1293 mixed discs ML-DmD4-c1    554 CNS ML-DmBG1-c1    402 CNS ML-DmBG2-c2    628 tumorous blood cells mbn2    686 ovary fGS/OSS    111 ovary OSC    286 ovary OSS    78 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    689 Schneider line 2 Sg4    822 embryonic 1182-4H    239 embryonic GM2    781 embryonic Kc167    1890 embryonic S1    228 embryonic S3    741 leg disc CME L1    395 wing disc CME-W2    1116 wing disc ML-DmD8    991 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    308 wing disc ML-DmD21    868 wing disc ML-DmD32    256 haltere disc ML-DmD17-c3    428 eye-antennal disc ML-DmD11    398 antennal disc ML-DmD20-c5    1293 mixed discs ML-DmD4-c1    554 CNS ML-DmBG1-c1    402 CNS ML-DmBG2-c2    628 tumorous blood cells mbn2    686 ovary fGS/OSS    111 ovary OSC    286 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (689) Schneider line 2 Sg4  (822) embryonic 1182-4H  (239) embryonic GM2  (781) embryonic Kc167  (1890) embryonic S1  (228) embryonic S3  (741) leg disc CME L1  (395) wing disc CME-W2  (1116) wing disc ML-DmD8  (991) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (308) wing disc ML-DmD21  (868) wing disc ML-DmD32  (256) haltere disc ML-DmD17-c3  (428) eye-antennal disc ML-DmD11  (398) antennal disc ML-DmD20-c5  (1293) mixed discs ML-DmD4-c1  (554) CNS ML-DmBG1-c1  (402) CNS ML-DmBG2-c2  (628) tumorous blood cells mbn2  (686) ovary fGS/OSS  (111) ovary OSC  (286) ovary OSS  (78) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (689) Schneider line 2 Sg4  (822) embryonic 1182-4H  (239) embryonic GM2  (781) embryonic Kc167  (1890) embryonic S1  (228) embryonic S3  (741) leg disc CME L1  (395) wing disc CME-W2  (1116) wing disc ML-DmD8  (991) wing disc ML-DmD9  (154) wing disc ML-DmD16-c3  (308) wing disc ML-DmD21  (868) wing disc ML-DmD32  (256) haltere disc ML-DmD17-c3  (428) eye-antennal disc ML-DmD11  (398) antennal disc ML-DmD20-c5  (1293) mixed discs ML-DmD4-c1  (554) CNS ML-DmBG1-c1  (402) CNS ML-DmBG2-c2  (628) tumorous blood cells mbn2  (686) ovary fGS/OSS  111 ovary OSC  (286) ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    689 Schneider line 2 Sg4    822 embryonic 1182-4H    239 embryonic GM2    781 embryonic Kc167    1890 embryonic S1    228 embryonic S3    741 leg disc CME L1    395 wing disc CME-W2    1116 wing disc ML-DmD8    991 wing disc ML-DmD9    154 wing disc ML-DmD16-c3    308 wing disc ML-DmD21    868 wing disc ML-DmD32    256 haltere disc ML-DmD17-c3    428 eye-antennal disc ML-DmD11    398 antennal disc ML-DmD20-c5    1293 mixed discs ML-DmD4-c1    554 CNS ML-DmBG1-c1    402 CNS ML-DmBG2-c2    628 tumorous blood cells mbn2    686 ovary fGS/OSS    111 ovary OSC    286 ovary OSS    78 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult    111 Cadmium 50 mM 6 hrs, larvae L3    162 Cadmium 50 mM 12 hrs, larvae L3    319 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    206 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    243 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    104 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    108 Caffeine 1.5 mg/ml 4 hrs, larvae L3    275 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    234 Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult    180 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    293 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult  (111) Cadmium 50 mM 6 hrs, larvae L3  (162) Cadmium 50 mM 12 hrs, larvae L3  (319) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (206) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (243) Zinc 5 mM 12 hrs, larvae L3  (31) Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (104) Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (108) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (275) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (234) Caffeine 25 mg/ml 48 hrs, 4-day adult  (43) Paraquat 5 mM 48 hrs, 4-day adult  (180) Paraquat 10 mM 48 hrs, 4-day adult  (96) Rotenone 2 μg 12 hrs, larvae L3  (293) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult  (111) Cadmium 50 mM 6 hrs, larvae L3  (162) Cadmium 50 mM 12 hrs, larvae L3  (319) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (206) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (243) Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  104 Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (108) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (275) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (234) Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult  (180) Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3  (293) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult    111 Cadmium 50 mM 6 hrs, larvae L3    162 Cadmium 50 mM 12 hrs, larvae L3    319 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    206 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    243 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    104 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    108 Caffeine 1.5 mg/ml 4 hrs, larvae L3    275 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    234 Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult    180 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    293 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult    111 Cadmium 50 mM 6 hrs, larvae L3    162 Cadmium 50 mM 12 hrs, larvae L3    319 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    206 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    243 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    104 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    108 Caffeine 1.5 mg/ml 4 hrs, larvae L3    275 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    234 Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult    180 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    293 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult  (111) Cadmium 50 mM 6 hrs, larvae L3  (162) Cadmium 50 mM 12 hrs, larvae L3  (319) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (206) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (243) Zinc 5 mM 12 hrs, larvae L3  31 Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  (104) Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (108) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (275) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (234) Caffeine 25 mg/ml 48 hrs, 4-day adult  (43) Paraquat 5 mM 48 hrs, 4-day adult  (180) Paraquat 10 mM 48 hrs, 4-day adult  (96) Rotenone 2 μg 12 hrs, larvae L3  (293) Rotenone 8 μg 12 hrs, larvae L3  (126) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult  111 Cadmium 50 mM 6 hrs, larvae L3  (162) Cadmium 50 mM 12 hrs, larvae L3  (319) Cadmium 50 mM 48 hrs, 4-day adult  (147) Cadmium 100 mM 48 hrs, 4-day adult  (206) Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult  (243) Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult  (175) Ethanol 2.5% 3 hrs, larvae L3  104 Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  108 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (275) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (234) Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult  (180) Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3  (293) Rotenone 8 μg 12 hrs, larvae L3  126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    20 heat shock, 4-day adult    111 Cadmium 50 mM 6 hrs, larvae L3    162 Cadmium 50 mM 12 hrs, larvae L3    319 Cadmium 50 mM 48 hrs, 4-day adult    147 Cadmium 100 mM 48 hrs, 4-day adult    206 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    243 Zinc 5 mM 12 hrs, larvae L3    31 Zinc 4.5 mM 48 hrs, 4-day adult    175 Ethanol 2.5% 3 hrs, larvae L3    104 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    108 Caffeine 1.5 mg/ml 4 hrs, larvae L3    275 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    234 Caffeine 25 mg/ml 48 hrs, 4-day adult    43 Paraquat 5 mM 48 hrs, 4-day adult    180 Paraquat 10 mM 48 hrs, 4-day adult    96 Rotenone 2 μg 12 hrs, larvae L3    293 Rotenone 8 μg 12 hrs, larvae L3    126 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18001-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 RpL38GD13653 lethal (with Df(2R)247) RpL38NC21 lethal (with Df(2R)M41A2) RpL38NC21 lethal (with RpL382b1) RpL38NC21 lethal (with RpL382b2) RpL38NC21 lethal (with RpL3845-72) RpL38NC21 lethal (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 lethal | embryonic stage (with RpL382b1) RpL382b2 lethal | embryonic stage (with RpL382b2) RpL382b1 lethal | embryonic stage | recessive RpL3845-72 lethal | larval stage (with RpL382b1) RpL382b2 lethal | larval stage (with RpL382b2) RpL382b1 lethal | partially (with RpL38KPL1) RpL38NC21 lethal | partially (with RpL38NC21) RpL38KPL1 RpL38P3 lethal | partially (with RpL38P3) RpL38NC21 lethal | recessive RpL3845-72 RpL38NC21 Other Phenotypes Allele decreased cell number | dominant RpL382b2 developmental rate defective, with Scer\GAL4amn-c651 RpL38dsRNA.WIZ.Scer\UAS developmental rate defective | dominant RpL382b1 RpL382b2 RpL3845-72 increased cell size | dominant RpL382b1 RpL382b2 Minute (with RpL382b1) RpL38NC21 Minute (with RpL382b2) RpL38NC21 Minute (with RpL3845-72) RpL38NC21 Minute (with RpL38KPL1) RpL38NC21 Minute (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38P3 Minute (with RpL38P3) RpL38NC21 Minute | dominant RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38NC21 RpL38P3 visible (with RpL382b1) RpL38NC21 visible (with RpL382b2) RpL38NC21 visible (with RpL3845-72) RpL38NC21 visible (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 Phenotype manifest in Allele chaeta RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38NC21 RpL38P3 chaeta (with RpL382b1) RpL38NC21 chaeta (with RpL382b2) RpL38NC21 chaeta (with RpL3845-72) RpL38NC21 chaeta (with RpL38KPL1) RpL38NC21 chaeta (with RpL38NC21) RpL382b1 RpL382b2 RpL3845-72 RpL38KPL1 RpL38P3 chaeta (with RpL38P3) RpL38NC21 prothoracic gland, with Scer\GAL4amn-c651 RpL38dsRNA.WIZ.Scer\UAS wing (with RpL382b1) RpL38NC21 wing (with RpL382b2) RpL38NC21 wing (with RpL38NC21) RpL382b1 RpL382b2 wing hair (with RpL382b1) RpL38NC21 wing hair (with RpL38NC21) RpL382b1 wing margin (with RpL3845-72) RpL38NC21 wing margin (with RpL38NC21) RpL3845-72 wing vein | ectopic (with RpL382b1) RpL38NC21 wing vein | ectopic (with RpL382b2) RpL38NC21 wing vein | ectopic (with RpL38NC21) RpL382b1 RpL382b2
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of RpL38 Class Mutagen Stocks Known lesion RpL382b2 ethyl methanesulfonate 1 Yes RpL3845-72 loss of function allele ethyl methanesulfonate 1 Yes RpL382b1 ethyl methanesulfonate 0 Yes RpL38KPL1 0 -- RpL38NC21 ethyl methanesulfonate 0 Yes RpL38P3 0 -- RpL38unspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL38 Class Mutagen Stocks Known lesion RpL38dsRNA.WIZ.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes RpL38GD13653 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)C (Cicchetti and Loverre, 1989) Df(2L)C' (Cicchetti and Loverre, 1989) Df(2L)D (Cicchetti and Loverre, 1989) Df(2L)D' (Cicchetti and Loverre, 1989) Df(2L)F (Hilliker and Holm, 1975) Df(2L)TW65 (Cicchetti and Loverre, 1989) Df(2L)TW161 (Cicchetti and Loverre, 1989) Df(2R)34-2 (Coulthard et al., 2010) Df(2R)244 (Myster et al., 2004) Df(2R)B (Hilliker, 1976, Ganetzky, 1977) Df(2R)cb25-4 (Lyttle, 1989) Df(2R)cb25-22 (Lyttle, 1989) Df(2R)cb25-24 (Lyttle, 1989) Df(2R)cb25-29 (Lyttle, 1989) Df(2R)cb25-31 (Lyttle, 1989) Df(2R)cb25-42 (Lyttle, 1989) Df(2R)Dark2 (Myster et al., 2004) Df(2R)nap1 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)nap4 (Gambetta and Mueller, 2009.8.18) Df(2R)nap8 (Gambetta and Mueller, 2009.8.18) Df(2R)nap11 (Gambetta and Mueller, 2009.8.18) Df(2R)nap14 (Marygold et al., 2005) Df(2R)NC32 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)NC73 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)Nipped-AC25 (Rollins et al., 1999) Df(2R)Nipped-C160.1 (Rollins et al., 1999) Df(2R)PR50 (Eberl et al., 1993) Df(2R)PRB (Eberl et al., 1993) Df(2R)PRF (Eberl et al., 1993) Df(2R)rl-2J (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-6C (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-9B (Hilliker, 1976) Df(2R)rl-10G (Rollins et al., 1999, Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-14C (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-18C (Hilliker, 1976) Df(2R)rl-B (Hilliker, 1976) Df(2R)rl-D (Hilliker, 1976, Cicchetti and Loverre, 1989) Df(2R)rl-I (Hilliker, 1976) Df(2R)Rsp1 (Ganetzky, 1977) Df(2R)Rsp11 (Ganetzky, 1977) Df(2R)Rsp31 (Ganetzky, 1977) T(2;3)Nipped-C138.2 (Rollins et al., 1999) T(Y;2)J-D   Tp(2;Y)C
Disrupted in	Df(2R)247 (Myster and Peifer, 2003.9.11, Myster et al., 2004, Marygold et al., 2005, Coulthard et al., 2010) Df(2R)M41A1 (Marygold et al., 2005) Df(2R)M41A2 (Myster et al., 2004, Marygold et al., 2005, Coulthard et al., 2010, Coulthard et al., 2010) Df(2R)M41A4 (Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Eberl et al., 1993, Duffy et al., 1996) Df(2R)M41A8 (Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Cicchetti and Loverre, 1989, Dimitri et al., 1997, Gambetta and Mueller, 2009.8.18) Df(2R)M41A10 (Rollins et al., 1999, Myster et al., 2004, Marygold et al., 2005, Hilliker and Holm, 1975, Hilliker, 1976, Ganetzky, 1977, Cicchetti and Loverre, 1989, Lyttle, 1989, Eberl et al., 1993, Duffy et al., 1996, Gambetta and Mueller, 2009.8.18) Df(2R)nap19 (Marygold et al., 2005) Df(2R)NC13 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC228 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004) Df(2R)Nipped-D263.3 (Rollins et al., 1999) Df(2R)Nipped-D341.1 (Rollins et al., 1999) Df(2R)Nipped-E43 (Rollins et al., 1999) Df(2R)Nipped-E299.1 (Rollins et al., 1999) Df(2R)Nipped-E338 (Rollins et al., 1999) Df(2R)rl-1G (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-4J (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-5B (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-12E (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-13D (Hilliker, 1976, Ganetzky, 1977) Df(2R)rl-F (Hilliker, 1976, Ganetzky, 1977) In(2R)bwVDe2LCyR (Cicchetti and Loverre, 1989)
Duplicated in	Dp(2;2)BG (Kreber, 1995) Dp(2;Y)cb25-9 (Lyttle, 1989) Dp(2;Y)cb25-11 (Lyttle, 1989)
Not duplicated in	C(Y;4)cb25-1 (Lyttle, 1989) Dp(2;Y)cb25-4 (Lyttle, 1989) Dp(2;Y)cb25-22 (Lyttle, 1989) Dp(2;Y)cb25-24 (Lyttle, 1989) Dp(2;Y)cb25-29 (Lyttle, 1989) Dp(2;Y)cb25-31 (Lyttle, 1989) Dp(2;Y)cb25-42 (Lyttle, 1989)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-RpL38.RNAi} NA characterization construct P{GD13653} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}RpL38KPL1 NA P{}RpL38P3 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from direct assay (Alonso and Santaren, 2006)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with NCBI_gi:4506645 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL38 allele Gene References RpL3845-72 Chi (Rollins et al., 1999) ct (Rollins et al., 1999) mam (Rollins et al., 1999) N (Rollins et al., 1999) vg (Rollins et al., 1999) RpL38unspecified run (Duffy et al., 1996) unspecified Pi3K92E (Marygold et al., 2005, Coelho et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78269 DroID - A comprehensive database of gene and protein interactions. • FBgn0040007 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355144
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G4HB9 Dipteran inclusive ortholog search EOG6RJGB9 Insect inclusive ortholog search EOG68KQ8D Arthropod inclusive ortholog search EOG6THTB9 Metazoa inclusive ortholog search EOG6S264B
Orthologs in Drosophila Species (EOG6G4HB9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RpL38     Drosophila persimilis   Dper\GL16652     Drosophila willistoni   Dwil\GK21940     Drosophila virilis   Dvir\GJ21901     Drosophila mojavensis   Dmoj\GI20680     Drosophila grimshawi   Dgri\GH21721
Orthologs in non-Drosophila Dipterans (EOG6RJGB9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\RpL38   Anopheles gambiae Malaria mosquito  Agam\RpL38   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005613
Orthologs in non-Dipteran Insects (EOG68KQ8D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\RpL38   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004547   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17547   Atta cephalotes Leafcutter ant  Acep\ACEP15837   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12802   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10733   Linepithema humile Argentine ant  Lhum\LH24552   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18304   Solenopsis invicta Red fire ant  Sinv\SINV13484   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006876   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004859   Bombyx mori Silkmoth  Bmor\BGIBMGA005684   Pediculus humanus Human body louse  Phum\PHUM327750   Tribolium castaneum Red flour beetle  Tcas\TC006287
Orthologs in non-Insect Arthropods (EOG6THTB9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW001867
Orthologs in non-Arthropod Metazoa (EOG6S264B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rpl-38   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011111gn   Danio rerio Zebrafish  Drer\rpl38   Xenopus tropicalis Western clawed frog  Xtro\rpl38   Gallus gallus Domestic chicken  Ggal\RPL38   Mus musculus House mouse  Mmus\Rpl38   Rattus norvegicus Norway rat  Rnor\LOC100362165   Rattus norvegicus Norway rat  Rnor\Rpl38   Rattus norvegicus Norway rat  Rnor\Rpl38   Rattus norvegicus Norway rat  Rnor\Rpl38   Rattus norvegicus Norway rat  Rnor\Rpl38   Rattus norvegicus Norway rat  Rnor\LOC686066   Rattus norvegicus Norway rat  Rnor\LOC690597   Rattus norvegicus Norway rat  Rnor\LOC680353   Rattus norvegicus Norway rat  Rnor\RGD1561636   Rattus norvegicus Norway rat  Rnor\LOC678816   Rattus norvegicus Norway rat  Rnor\Rpl38   Rattus norvegicus Norway rat  Rnor\Rpl38   Homo sapiens Human  Hsap\RPL38
Human Orthologs (1)
Gene OMIM HGNC Hsap\RPL38
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	6974 y1 w*; RpL3845-72/CyO, y+ 25913 w*; RpL382b2/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
Genomic Clones ( 1 )
	BACR04F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 191 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE42506
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM29556 RE24383 RH05721 RH70473 SD18677 SD20466
Other clones	21345 45474 47483 62479 66494 70617 78306 100736 100770 102236 104735 105490 119250 146059 166279 181070 524230 524351 525033 525071 CK01.66D.E5 CK01.66D.G5 CK01.102C.C2 Dmel_dig_004125_0657_0871 Dmel_dig_004488_0676_0549 Dmel_dig_005773_0629_2037 Dmel_dig_006028_0627_2572 Dmel_dig_006279_0620_2230 Dmel_dig_015707_0597_1036 Dmel_dig_016170_0655_0633 Dmel_dig_018451_0621_0837 Dmel_dig_020458_0648_0899 Dmel_neb_000364_0181_3697 Dmel_neb_000847_0154_0336 Dmel_neb_000894_0359_3746 Dmel_neb_002477_0139_3675 Dmel_neb_002732_0405_3711 Dmel_neb_004613_0663_0376 Dmel_neb_004668_0322_2611 Dmel_neb_004794_0642_3629 Dmel_neb_007905_0685_0613 Dmel_neb_008369_0441_1320 Dmel_neb_008544_0825_2266 Dmel_neb_008733_0890_0568 Dmel_neb_009730_0153_0813 Dmel_neb_010339_0637_2893 Dmel_neb_010709_0835_2449 Dmel_neb_010953_0938_1602 Dmel_neb_011083_0119_2206 Dmel_neb_011595_0432_2206 Dmel_neb_011639_0575_2990 Dmel_neb_011646_0929_2907 Dmel_neb_011717_0417_1228 Dmel_neb_011761_0406_2762 Dmel_neb_011993_0109_0387 Dmel_neb_012241_0421_2834 Dmel_neb_012414_0915_1918 Dmel_neb_012446_0370_0713 Dmel_neb_012462_0425_0986 Dmel_neb_012573_0938_2053 Dmel_neb_012841_0361_3264 Dmel_neb_012922_0581_1110 Dmel_neb_013371_0346_2935 Dmel_neb_013635_0139_2004 Dmel_neb_013812_0436_2602 Dmel_neb_013861_0575_0834 Dmel_neb_013968_0908_1118 Dmel_neb_014026_0151_1357 Dmel_neb_014154_0945_1586 Dmel_neb_014277_0863_2433 Dmel_neb_014365_0665_3248 Dmel_neb_014431_0854_2440 Dmel_neb_014432_0687_1664 Dmel_neb_014806_0663_2609 Dmel_neb_014865_0871_0516 Dmel_neb_015057_0639_0538 Dmel_neb_015238_0188_3563 EC01290 EC13064 EC13526 EC17378 EC17528 EC22752 EC24034 EC24356 EC24437 EC26314 EC30770 EC31478 EC32526 EC33148 EC33551 EC37277 EC37314 EC37628 EC37661 EC40474 EC41731 EK054019 EK054027 EK086341 EK139449 EK161056 EK175557 EK188039 EK194351 EK198539 EK207563 EK223220 EK223256 EK229741 EK230724 EK235801 EK239005 EK243953 EK248921 EK279602 EN04605 EN05010 EN05225 EN06362 EN06449 FGA001G08 FGA002E01 FGA002H05 FGA004E08 FGA006G06 FGA010D09 FGA011A06 FGA011C03 FGB002C02 FGC006C03 FGC014A01 FGC018G12 FGC019C04 FGC019G08 FGC027F02 FGH101G06 FGH102F07 FGH104G06 FGH105B05 FGH107E09 FGH109C02 FGH126G05 FGM001E03 FGM104B06 FGM207H04 FGM211G12 FGM222E03 RM04269 RM04369 RM04569 RM04869 RM04969 RP001006443 RP001008075 RP001008268 RP001010449 RP001012982 RP001013610 RP001013753 RP001013906 RP001015359 RP001016155 RP001017001 RP001017296 RP001018913 RP001019149 RP001020438 RP001021527 RP001024553 RP001025161 RP001026424 RP001029497 RP001032356 RP001032789 RP001039310 RP001042508 RP001043398 RP001044747 RP001049355 RP001054144 RP001056166 UUGC0714
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355144
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG18001 BcDNA:RE42506 (FlyBase, 1996-) Source for merge of: RpL38 l(2)41Af M(2)41A (Dimitri et al., 2005)
Additional comments	'Nipped' mutations disrupt one or more of four recessive lethal complementation groups: l(2)41Ae, RpL38, Nipped-A and Nipped-B. (Rollins et al., 1999) Source for merge of CG18001 BcDNA:RE42506 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
	Minute gene. (Marygold et al., 2007) Deletions removing RpL38 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) Molecularly-defined mutations in RpL38 result in Minute phenotypes. (Marygold et al., 2007) Identification: as a complementation group whose members dominantly modify the small wing phenotype caused by expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096. 2 alleles of RpL38 have been recovered. (Coelho et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Transiently named CG40278 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) 'Nipped' mutations identify four essential complementation groups, l(2)41Ae, RpL38, Nipped-A and Nipped-B, that play distinct roles in regulating ct and N signalling. (Rollins et al., 1999) RpL38 has functions in wing development both acting through regulation of ct and acting independently of ct. RpL38 influences N receptro signalling or N expression during development of the wing margin, wing veins, eye and thoracic bristles. (Rollins et al., 1999) The Nipped-group genes regulate ct and Ubx. (Rollins et al., 1997) Stated to fall into the same Group IV complementation group as l(2)41Ae. (Duffy et al., 1996) Located close to the heterochromatic-euchromatic junction of 2R. (Hilliker, 1976) One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development. Medium Minute. Originally identified by virtue of Minute phenotype of Df(2R)M41A10; most recurrences shown to be deficiencies. Eclosion of heterozygous deficiency delayed 13 hr (Ferrus, 1975).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042975 NM_001273771 RefSeq (Proteins) • NP_001036440 NP_001260700 DDBJ / EMBL / GenBank • AABU01002769 AGB93235 EAA46007 Entrez Gene - A searchable database of RefSeq genes. • 3355144 UniProtKB/Swiss-Prot • Q9W5N2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L38e (IPR002675)
Linkouts
	BioGRID - A database of protein and genetic interactions • 78269 DroID - A comprehensive database of gene and protein interactions. • FBgn0040007 DRSC - Results from RNAi screens. • FBgn0040007 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18001-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355144 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355144 modMine - Data generated by the modENCODE project. • FBgn0040007
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	41Af (Dimitri et al., 2005, Cenci et al., 2003, Dimitri et al., 2003) 41Ag (Dimitri et al., 2005) BcDNA:RE42506   CG18001 (Coelho et al., 2005, Dimitri et al., 2005, Boutros et al., 2004, Marygold et al., 2007, Cammarato et al., 2011) CG40278 (Myster et al., 2004, Giot et al., 2003, Corradini et al., 2003, ) E-2b (Coelho et al., 2005, Marygold et al., 2005) GroupIV (Ganetzky, 1977, ) l(2)41Af (Marygold et al., 2005, Myster et al., 2004, Myster and Peifer, 2003.9.11, Corradini et al., 2003, Rollins et al., 1999, Duffy et al., 1996, Dimitri, 1991, Corradini et al., 2005, Dimitri et al., 2003) l(2)41Ag   l(2)41Ai   l(2)EMS4-72   l(2)EMS45-72 (Eberl et al., 1993, Lyttle, 1989, Hilliker, 1976) l(2R)A' (Hilliker and Holm, 1975) M(2)41A (Marygold et al., 2005, Dimitri et al., 2005, Myster et al., 2004, Duffy et al., 1996, Presgraves, 2003, Marygold et al., 2007) M(2)S2 (Rasmuson-Lestander et al., 1993, Kongsuwan et al., 1985, Lindsley et al., 1972, Seattle-La Jolla Drosophila Laboratories, 1971, ) M(2)S3   RpL38 (Rossi et al., 2007, Kallappagoudar et al., 2010, Gambetta and Mueller, 2009.8.18, Marygold et al., 2007, Coulthard et al., 2010, Lin et al., 2011, Abruzzi et al., 2011, Cook et al., 2012, Ladoukakis et al., 2011) Rp L38 (Alonso and Santaren, 2006)
Name Synonym	Enhancer on chromosome 2, complementation group b (Marygold et al., 2005) lethal(2)41Af   Minute(2)41A   Nipped (Rollins et al., 1997) Ribosomal protein 38 (Rossi et al., 2007) Ribosomal protein L38 (Ashburner and Marygold, 2004.7.2, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0018001 FBgn0002066 FBgn0002601 FBgn0013538 FBgn0020393 FBgn0058278 FBgn0061397
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 ) Book  ( 2 )
Recent research papers ( 5 )
	Cook et al., 2012, Genome Biol. 13(3): R21 The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. [FBrf0219066] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Ladoukakis et al., 2011, Genome Biol. 12(11): R118 Hundreds of putatively functional small open reading frames in Drosophila. [FBrf0218190] Lin et al., 2011, PLoS Genet. 7(12): e1002408 Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone. [FBrf0217066] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...