FB2025_01 , released February 20, 2025
Gene: Dmel\CG17450
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General Information
Symbol
Dmel\CG17450
Species
D. melanogaster
Name
Annotation Symbol
CG17450
Feature Type
protein_coding_gene
FlyBase ID
FBgn0040028
Gene Model Status
Current
Stock Availability
1 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
20A4-20A4
Sequence location
Recombination map
1-66
RefSeq locus
NC_004354 REGION:21605884..21608920
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural constituent of cytoskeleton
inferred from sequence or structural similarity with SGD:S000002764
(Gene Ontology Curators, 2002-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cilium assembly
inferred from biological aspect of ancestor with PANTHER:PTN000462267
(GO Reference Genome Project, 2011-)
involved_in cilium movement involved in cell motility
inferred from electronic annotation with InterPro:IPR000435
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000462267
(GO Reference Genome Project, 2011-)
involved_in flagellated sperm motility
inferred from sequence or structural similarity with MGI:MGI:1918312
(Gene Ontology Curators, 2002-)
involved_in microtubule nucleation
inferred from sequence or structural similarity with SGD:S000002764
(Gene Ontology Curators, 2002-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with MGI:MGI:1918312
(Gene Ontology Curators, 2002-)
is_active_in microtubule cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000462267
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG17450 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG17450-RA
FBtr0070056
NM_167762
1838
520
CG17450-RB
FBtr0070057
NM_167761
1995
601
CG17450-RC
FBtr0345920
NM_001298592
1922
520
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CG17450-PA
FBpp0070055
59.1
520
7.85
Q8I044
NP_728439
AAG22461
CG17450-PB
FBpp0070056
69.3
601
7.85
Q8IRZ1
NP_728438
AAN08998
CG17450-PC
FBpp0311835
59.1
520
7.85
Q8I044
NP_001285521
AHN59991
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

520 aa isoforms: CG17450-PA, CG17450-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG17450 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.03

Transcript Expression
mutational analysis
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
chordotonal neuron
(Zur Lage et al., 2019)
adult stage | male
spermatogonium

Comment: data from FlyAtlas

(Zur Lage et al., 2019)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Dorus et al., 2008)
Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of CG17450 was assayed in motile ciliated cell types. Expression was observed in both chordotonal neurons and testis (sperm).

(Zur Lage et al., 2019)

At least two of the three highly related tektin family genes (CG17450, CG32819, and CG32820) have enhance expression in the testis.

(Dorus et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG17450 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG17450
Transgenic constructs containing regulatory region of CG17450
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\TEKT3
5 of 14
Yes
No
1  
Hsap\TEKT5
3 of 14
No
No
1  
Hsap\TEKT1
2 of 14
No
No
Hsap\TEKT2
2 of 14
No
No
Hsap\TEKT4
2 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Tekt3
5 of 14
Yes
No
Rnor\Tekt5
3 of 14
No
No
Rnor\Tekt1
2 of 14
No
No
Rnor\Tekt2
2 of 14
No
No
Rnor\Tekt4
2 of 14
No
No
Rnor\RGD1565057
1 of 14
No
Yes
Mus musculus (laboratory mouse) (5)
Mmus\Tekt3
5 of 14
Yes
No
Mmus\Tekt1
2 of 14
No
No
Mmus\Tekt4
2 of 14
No
No
Mmus\Tekt5
2 of 14
No
No
Mmus\Tekt2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\tekt3
2 of 13
Yes
No
Xtro\LOC100496565
1 of 13
No
No
Xtro\tekt1
1 of 13
No
No
Xtro\tekt2
1 of 13
No
No
Xtro\tekt4
1 of 13
No
No
Danio rerio (Zebrafish) (4)
Drer\tekt3
5 of 14
Yes
No
Drer\tekt4
2 of 14
No
No
Drer\tekt1
1 of 14
No
No
Drer\tekt2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\R02E12.4
2 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP000219
3 of 12
Yes
No
Agam\AgaP_AGAP007334
2 of 12
No
No
Agam\AgaP_AGAP008275
2 of 12
No
No
Agam\AgaP_AGAP010031
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CG17450. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
CG32819
5 of 13
CG32820
4 of 13
CG3085
3 of 13
Tektin-A
3 of 13
Tektin-C
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TEKT3; tektin 3
    model of  spermatogenic failure 81
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TEKT3; tektin 3
    5 of 14
    612683
     
    TEKT5; tektin 5
    3 of 14
    618686
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Summary of Genetic Interactions
        esyN Network Diagram
        Other Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-66
        Cytogenetic map
        20A4-20A4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        20A4-20A4
        Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-66

        (FlyBase, 2016)

        1-66.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (1)
        Genomic Clones (9)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (44)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (2)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 32 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Flygut - An atlas of the Drosophila adult midgut
              References (20)