General Information
Symbol
Dmel\klhl10
Species
D. melanogaster
Name
kelch like family member 10
Annotation Symbol
CG12423
Feature Type
FlyBase ID
FBgn0040038
Gene Model Status
Stock Availability
Gene Snapshot
Klhl10 functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation. [Date last reviewed: 2016-06-30]
Genomic Location
Cytogenetic map
Sequence location
Unmapped_Scaffold_8_D1580_D1567:53,442..85,529 [+]
Recombination map
2-
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\klhl10 or the JBrowse view of Dmel\klhl10 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0113685
2706
767
FBtr0113686
2779
767
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0112408
86.9
767
5.52
FBpp0112409
86.9
767
5.52
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

767 aa isoforms: klhl10-PA, klhl10-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\klhl10 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (4 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\klhl10 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Allele of klhl10
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    Yes
      0
      Yes
        0
        Yes
          0
          Yes
            0
            Yes
            Other relevant insertions
            Transgenic Constructs ( 7 )
            Deletions and Duplications ( 0 )
            Summary of Phenotypes
            Orthologs
            Human Orthologs (via DIOPT v7.1)
            Homo sapiens (Human) (11)
            Species\Gene Symbol
            Score
            Best Score
            Best Reverse Score
            Alignment
            Complementation?
            Transgene?
            11 of 15
            Yes
            Yes
             
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            No
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            Model Organism Orthologs (via DIOPT v7.1)
            Mus musculus (laboratory mouse) (11)
            Species\Gene Symbol
            Score
            Best Score
            Best Reverse Score
            Alignment
            Complementation?
            Transgene?
            10 of 15
            Yes
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            No
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            Rattus norvegicus (Norway rat) (9)
            10 of 13
            Yes
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            Yes
            1 of 13
            No
            No
            1 of 13
            No
            Yes
            Xenopus tropicalis (Western clawed frog) (6)
            6 of 12
            Yes
            Yes
            1 of 12
            No
            Yes
            1 of 12
            No
            Yes
            1 of 12
            No
            Yes
            1 of 12
            No
            Yes
            1 of 12
            No
            Yes
            Danio rerio (Zebrafish) (12)
            11 of 15
            Yes
            Yes
            7 of 15
            No
            Yes
            4 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            No
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            No
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            Caenorhabditis elegans (Nematode, roundworm) (3)
            2 of 15
            Yes
            Yes
            1 of 15
            No
            Yes
            1 of 15
            No
            Yes
            Arabidopsis thaliana (thale-cress) (86)
            3 of 9
            Yes
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            2 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            No
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            1 of 9
            No
            No
            1 of 9
            No
            Yes
            1 of 9
            No
            Yes
            Saccharomyces cerevisiae (Brewer's yeast) (0)
            No orthologs reported.
            Schizosaccharomyces pombe (Fission yeast) (0)
            No orthologs reported.
            Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919034V )
            Organism
            Common Name
            Gene
            AAA Syntenic Ortholog
            Multiple Dmel Genes in this Orthologous Group
            Drosophila melanogaster
            fruit fly
            Drosophila suzukii
            Spotted wing Drosophila
            Drosophila simulans
            Drosophila sechellia
            Drosophila sechellia
            Drosophila erecta
            Drosophila yakuba
            Drosophila ananassae
            Drosophila pseudoobscura pseudoobscura
            Drosophila willistoni
            Drosophila virilis
            Drosophila mojavensis
            Drosophila grimshawi
            Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505QU )
            Organism
            Common Name
            Gene
            Multiple Dmel Genes in this Orthologous Group
            Musca domestica
            House fly
            Glossina morsitans
            Tsetse fly
            Mayetiola destructor
            Hessian fly
            Aedes aegypti
            Yellow fever mosquito
            Anopheles darlingi
            American malaria mosquito
            Anopheles gambiae
            Malaria mosquito
            Culex quinquefasciatus
            Southern house mosquito
            Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05OL )
            Organism
            Common Name
            Gene
            Multiple Dmel Genes in this Orthologous Group
            Bombyx mori
            Silkmoth
            Bombyx mori
            Silkmoth
            Danaus plexippus
            Monarch butterfly
            Danaus plexippus
            Monarch butterfly
            Heliconius melpomene
            Postman butterfly
            Heliconius melpomene
            Postman butterfly
            Apis florea
            Little honeybee
            Apis florea
            Little honeybee
            Apis mellifera
            Western honey bee
            Apis mellifera
            Western honey bee
            Bombus impatiens
            Common eastern bumble bee
            Bombus impatiens
            Common eastern bumble bee
            Bombus terrestris
            Buff-tailed bumblebee
            Bombus terrestris
            Buff-tailed bumblebee
            Linepithema humile
            Argentine ant
            Linepithema humile
            Argentine ant
            Megachile rotundata
            Alfalfa leafcutting bee
            Megachile rotundata
            Alfalfa leafcutting bee
            Nasonia vitripennis
            Parasitic wasp
            Nasonia vitripennis
            Parasitic wasp
            Dendroctonus ponderosae
            Mountain pine beetle
            Dendroctonus ponderosae
            Mountain pine beetle
            Tribolium castaneum
            Red flour beetle
            Tribolium castaneum
            Red flour beetle
            Pediculus humanus
            Human body louse
            Pediculus humanus
            Human body louse
            Rhodnius prolixus
            Kissing bug
            Rhodnius prolixus
            Kissing bug
            Cimex lectularius
            Bed bug
            Cimex lectularius
            Bed bug
            Cimex lectularius
            Bed bug
            Acyrthosiphon pisum
            Pea aphid
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Zootermopsis nevadensis
            Nevada dampwood termite
            Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05KH )
            Organism
            Common Name
            Gene
            Multiple Dmel Genes in this Orthologous Group
            Strigamia maritima
            European centipede
            Strigamia maritima
            European centipede
            Strigamia maritima
            European centipede
            Ixodes scapularis
            Black-legged tick
            Ixodes scapularis
            Black-legged tick
            Ixodes scapularis
            Black-legged tick
            Tetranychus urticae
            Two-spotted spider mite
            Tetranychus urticae
            Two-spotted spider mite
            Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G063P )
            Organism
            Common Name
            Gene
            Multiple Dmel Genes in this Orthologous Group
            Strongylocentrotus purpuratus
            Purple sea urchin
            Ciona intestinalis
            Vase tunicate
            Ciona intestinalis
            Vase tunicate
            Gallus gallus
            Domestic chicken
            Human Disease Model Data
            FlyBase Human Disease Model Reports
              Alleles Reported to Model Human Disease (Disease Ontology)
              Download
              Models ( 0 )
              Allele
              Disease
              Evidence
              References
              Interactions ( 0 )
              Allele
              Disease
              Interaction
              References
              Comments ( 0 )
               
              Human Orthologs (via DIOPT v7.1)
              Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
              Homo sapiens (Human)
              Gene name
              Score
              OMIM
              OMIM Phenotype
              Complementation?
              Transgene?
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser

              Please look at the Interaction Group reports for full details of the physical interactions
              protein-protein
              Interacting group
              Assay
              References
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement

              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              Pathways
              Gene Group - Pathway Membership (FlyBase)
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              Unmapped_Scaffold_8_D1580_D1567
              Recombination map
              2-
              Cytogenetic map
              Sequence location
              Unmapped_Scaffold_8_D1580_D1567:53,442..85,529 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Heterochromatic, cytological location not yet determined.
              Experimentally Determined Recombination Data
              Location
              Left of (cM)
              Right of (cM)
              Notes
              Maps to a heterochromatic part of chromosome 2.
              Stocks and Reagents
              Stocks (7)
              Genomic Clones (7)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (27)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequences
              BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                polyclonal
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for identity of: klhl10 CG12423
                Source for database merge of
                Source for merge of: CG12423 anon-WO0140519.152
                Additional comments
                Source for merge of CG12423 anon-WO0140519.152 was sequence comparison ( date:051113 ).
                Other Comments
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 29 )
                Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMine - An integrated database for Drosophila genomics
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Synonyms and Secondary IDs (5)
                Reported As
                Name Synonyms
                CG12423
                kelch like family member 10
                Secondary FlyBase IDs
                • FBgn0044727
                • FBan0012423
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (28)