FlyBase Gene Report: Dmel\wds

General Information

Symbol

Dmel\wds

Species

D. melanogaster

Name

will die slowly

Annotation Symbol

CG17437

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040066

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:25310983). In neurons and together with DNA N6-methyl adenine demethylase Tet, plays a role in the maintenance of transcriptional activation for specific sets of genes (PubMed:30078725). (UniProt, Q9V3J8)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

zw8, l(1)zw8, zw-8, l(1)3Ad, EG:BACR25B3.7

Key Links

Genomic Location

Cytogenetic map

3A6-3A6

Sequence location

X:2,585,980..2,588,217 [+]

Recombination map

1-1

RefSeq locus

NC_004354 REGION:2585980..2588217

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9VCH5

(Pascual-Garcia et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables histone binding

inferred from biological aspect of ancestor with PANTHER:PTN001483578

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chromatin remodeling

inferred from direct assay

(Suganuma et al., 2008)

involved_in eye development

inferred from genetic interaction with UniProtKB:Q9VCH5

(Pascual-Garcia et al., 2014)

involved_in haltere development

inferred from mutant phenotype

(Pascual-Garcia et al., 2014)

inferred from genetic interaction with UniProtKB:Q9VCH5

(Pascual-Garcia et al., 2014)

involved_in heart development

inferred from mutant phenotype

(Zhu et al., 2024, Zhu et al., 2017)

involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process

inferred from direct assay

(Guo and Jin, 2015)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

part_of ATAC complex

inferred from direct assay

(Suganuma et al., 2012)

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

part_of MLL3/4 complex

inferred from direct assay

(Mohan et al., 2011)

part_of NSL complex

inferred from direct assay

(Raja et al., 2010)

located_in nucleus

inferred from direct assay

(Raja et al., 2010)

part_of Set1C/COMPASS complex

inferred from direct assay

(Hallson et al., 2012, Ardehali et al., 2011, Mohan et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of MLL1/2 complex

inferred from sequence or structural similarity with UniProtKB:P61964

(Mohan et al., 2011)

part_of Set1C/COMPASS complex

inferred from biological aspect of ancestor with PANTHER:PTN001483578

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the WD repeat WDR5/wds family. (Q9V3J8)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ATAC COMPLEX -: The Ada2a-containing (ATAC) complex is a metazoan histone acetyltransferase complex. It positively regulates gene transcription and, although it does not have any intrinsic remodeling activity, facilitates nucleosome sliding of ISWI and SWI-SNF families of chromatin-remodeling complexes. (Adapted from FBrf0204126).
TRR COMPLEX -: The Trithorax-related (Trr) complex is a COMPASS-like complex that mediates the methylation of histone H3K4 and demethylation of histone H3K27. (Adapted from FBrf0216343 and FBrf0218498).
COMPASS COMPLEX -: COMPASS is a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation in Drosophila. (Adapted from FBrf0216343).
TRX COMPLEX -: The Trithorax (Trx) complex is a COMPASS-like complex that mediates methylation of histone H3K4. (Adapted from FBrf0216343).

Protein Function (UniProtKB)

(UniProt, Q9V3J8)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\wds for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3J8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4CY3
4CY5

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

wds-RA

FBtr0070438

NM_080245

1634

361

wds-RB

FBtr0308566

NM_001258574

1973

361

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

wds-PA

FBpp0070422

39.0

361

8.76

FBpp0300790

39.0

361

8.76

Q9V3J8

NP_001245503

AFH07217

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

361 aa isoforms: wds-PA, wds-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722). Interacts with Set1 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6 (PubMed:21875999). Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268). Interacts with Nup98 (PubMed:25310983). Interacts (via WD repeats) with Tet (via C-terminus) (PubMed:30078725).

(UniProt, Q9V3J8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

4CY3
4CY5

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wds using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wds_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.35

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of ATAC complex

inferred from direct assay

(Suganuma et al., 2012)

inferred from physical interaction with FLYBASE:Ada2a; FB:FBgn0263738

(Suganuma et al., 2008)

part_of MLL3/4 complex

inferred from direct assay

(Mohan et al., 2011)

part_of NSL complex

inferred from direct assay

(Raja et al., 2010)

located_in nucleus

inferred from direct assay

(Raja et al., 2010)

part_of Set1C/COMPASS complex

inferred from direct assay

(Hallson et al., 2012, Ardehali et al., 2011, Mohan et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\wds in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\wds

View exonic expression by tissue for Dmel\wds

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040066

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53428/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040066

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040066

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17437

Flygut - An atlas of the Drosophila adult midgut

FBgn0040066

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\wds

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 51 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of wds

Transgenic constructs containing regulatory region of wds

Aberrations (Deficiencies and Duplications) ( 64 )

Inferred from experimentation ( 64 )

Gene duplicated in

Dp(1;2;Y)w⁺

(Kramers et al., 1991, Kramers et al., 1983, Judd et al., 1972)

Dp(1;3)DC045

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;3)w⁺67k

(Judd et al., 1972)

Gene disrupted in

Df(1)7

(Nomura and Kurokawa, 1997)

Df(1)64c4

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)HM3

(Kramers et al., 1983)

Df(1)HM406

(Kramers et al., 1983)

Df(1)K95

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)L126

(Nomura and Kurokawa, 1997)

Df(1)TEM1

(Kramers et al., 1991, Kramers et al., 1983, Lim and Snyder, 1974)

Df(1)TEM7

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974)

Df(1)TEM75

(Lim and Snyder, 1974)

Df(1)TEM501

(Kramers et al., 1991, Kramers et al., 1983, Lim and Snyder, 1974)

Df(1)w258-11

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w258-42

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w258-48

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)w-N71a

(Judd et al., 1972)

Df(1)w-rJ1

(Nomura and Kurokawa, 1997, Kramers et al., 1991, Goldberg et al., 1989, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974, Judd et al., 1972)

Df(1)X12

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)z-deb54

(Goldberg et al., 1989)

Df(1)z-deb62

(Goldberg et al., 1989)

Df(1)z-deb65

(Goldberg et al., 1989)

Df(1)z-deb72

(Goldberg et al., 1989)

Df(1)z-deb81

(Goldberg et al., 1989)

Df(1)z-deb85

(Goldberg et al., 1989)

Df(1)z-deb311

(Goldberg et al., 1989)

Df(1)z-deb511

(Goldberg et al., 1989)

Df(1)z-EM41

(Montgomery et al., 1991)

Df(1)z-EM42

(Montgomery et al., 1991)

Df(1)z-EM43

(Montgomery et al., 1991)

Df(1)z-EM44

(Montgomery et al., 1991)

Df(1)z-EM45

(Montgomery et al., 1991)

Df(1)z-EM46

(Montgomery et al., 1991)

Gene not disrupted in

Df(1)62d18

(Judd et al., 1972)

Df(1)62g18

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)64f1

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)64j4

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)65j26

(Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)202

(Nomura and Kurokawa, 1997)

Df(1)304

(Nomura and Kurokawa, 1997)

Df(1)N-8

(Kramers et al., 1991, Lin and Wolfner, 1989)

Df(1)N-54l9

(Kramers et al., 1991)

Df(1)N-264-105

(Kramers et al., 1991)

Df(1)Pgd-kz

(Kramers et al., 1991)

Df(1)Sp2F-3A

(Schalet, 1986)

Df(1)TEM6

(Lim and Snyder, 1974)

Df(1)TEM202

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975)

Df(1)TEM304

(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975, Lim and Snyder, 1974)

Df(1)w55j

(Lin and Wolfner, 1989)

Df(1)w67k30

(Kramers et al., 1991)

Df(1)w258-45

(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)

Df(1)w-rJ2

(Judd et al., 1972)

Df(1)z-deb3

(Goldberg et al., 1989)

Df(1)z-deb42

(Goldberg et al., 1989)

Df(1)z-deb59

(Goldberg et al., 1989)

Df(1)z-deb87

(Goldberg et al., 1989)

Df(1)z-deb92

(Goldberg et al., 1989)

Df(1)z-deb910

(Goldberg et al., 1989)

Gene not duplicated in

Dp(1;2)51b

(Kramers et al., 1991)

Dp(1;2)w⁺70h

(Judd et al., 1972)

Dp(1;3)N^264-58

(Judd et al., 1972)

Dp(1;3)w^m49a

(Judd et al., 1972)

Dp(1;3)w^vco

(Schalet, 1986)

Dp(1;4)w^m65g

(Judd et al., 1972)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | germline clone

wds⁶

lethal

wds^G0251

lethal, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

lethal, with Scer\GAL4^insc-Mz1407

wds^GD9379

lethal | recessive

lethal | recessive | heat sensitive

lethal - all die before end of larval stage

wds^G0251

lethal - all die before end of larval stage, with Scer\GAL4^Tub.PU

wds^KK100120

lethal - all die before end of larval stage | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

wds^GD9379

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wds^GD9379

partially lethal - majority die

partially lethal - majority die | recessive

viable, with Scer\GAL4^tin.CΔ4

wds^GD9379

Sterility

Allele

female sterile | heat sensitive

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

wds^GD9379

short lived, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

some die during larval stage

wds^G0251

some die during larval stage, with Scer\GAL4^Tub.PU

wds^KK100120

some die during larval stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

wds^GD9379

visible

Phenotype manifest in

Allele

adult heart, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

cardiac myofibril | larval stage, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

egg | germline clone

wds⁶

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

wds^HMS00746

embryonic/larval heart | larval stage, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

extracellular matrix | larval stage, with Scer\GAL4^4XHand

wds^RNAi.UAS.cUa

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

wds^HMS00746

female reproductive system

wds⁶

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

wds^GD9379

macrochaeta

ovary

posterior scutellar bristle

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (136)

Hsap\WDR5

13 of 14

Yes

Hsap\WDR5B

9 of 14

Yes

Hsap\AHI1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\WDR27

2 of 14

Yes

Hsap\WDR38

2 of 14

Yes

Hsap\WDR49

2 of 14

Hsap\WDR86

2 of 14

Yes

Hsap\WDR88

2 of 14

Yes

Hsap\WDSUB1

2 of 14

Yes

Hsap\WSB2

2 of 14

Yes

Hsap\AAMP

1 of 14

Hsap\AMBRA1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DTL

1 of 14

Hsap\EIF3I

1 of 14

Hsap\ERCC8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\WDR54

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (98)

Rnor\Wdr5

13 of 14

Yes

Rnor\Wdr5b

9 of 14

Yes

Rnor\Ahi1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Wdr27

2 of 14

Yes

Rnor\Wdr38

2 of 14

Yes

Rnor\Wdsub1

2 of 14

Yes

Rnor\Wsb2

2 of 14

Yes

Rnor\Aamp

1 of 14

Rnor\Ambra1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (99)

Mmus\Wdr5

13 of 14

Yes

Mmus\Wdr5b

9 of 14

Yes

Mmus\Ahi1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Wdr38

2 of 14

Yes

Mmus\Wdr86

2 of 14

Yes

Mmus\Wsb1

2 of 14

Yes

Mmus\Wsb2

2 of 14

Yes

Mmus\Aamp

1 of 14

Mmus\Ambra1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (72)

Xtro\wdr5

10 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100490380

1 of 13

Xtro\LOC100491248

1 of 13

Yes

Xtro\LOC100496364

1 of 13

Xtro\LOC100498290

1 of 13

Xtro\LOC101734139

1 of 13

Yes

Xtro\LOC101734744

1 of 13

Xtro\LOC116408632

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\znf366

1 of 13

Yes

Danio rerio (Zebrafish) (97)

Drer\wdr5

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\wdr61

2 of 14

Drer\wdr95

2 of 14

Drer\wdsub1

2 of 14

Yes

Drer\wsb2

2 of 14

Yes

Drer\ahi1

1 of 14

Yes

Drer\ambra1a

1 of 14

Yes

Drer\ambra1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (72)

Cele\wdr-5.1

13 of 14

Yes

Cele\wdr-5.2

6 of 14

Yes

Cele\wdr-5.3

6 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (86)

Agam\AgaP_AGAP002019

10 of 12

Yes

Agam\AgaP_AGAP012731

10 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (140)

Atha\WDR5a

11 of 13

Yes

Atha\WDR5b

6 of 13

Yes

Atha\AT1G71840

2 of 13

Atha\AT2G16405

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\LUH

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT1G01670

1 of 13

Yes

Atha\AT1G04140

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G52730

1 of 13

Atha\AT1G56030

1 of 13

Yes

Atha\AT1G64610

1 of 13

Atha\AT1G65030

1 of 13

Atha\AT1G78070

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G26490

1 of 13

Yes

Atha\AT2G37670

1 of 13

Atha\AT2G43770

1 of 13

Atha\AT2G45920

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G21520

1 of 13

Atha\AT4G28450

1 of 13

Atha\AT4G34380

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G45760

1 of 13

Yes

Atha\AT5G50120

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\DRS1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RUP2

1 of 13

Yes

Atha\SCD1

1 of 13

Atha\SMU1

1 of 13

Atha\SPA1

1 of 13

Yes

Atha\SPA2

1 of 13

Yes

Atha\SPA3

1 of 13

Yes

Atha\SPA4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\TPR1

1 of 13

Yes

Atha\TPR2

1 of 13

Yes

Atha\TPR3

1 of 13

Yes

Atha\TRIP-1

1 of 13

Atha\WDR55

1 of 13

Atha\WSIP2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (48)

Scer\SWD3

8 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Scer\TUP1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (45)

Spom\swd3

8 of 12

Yes

Spom\pop3

2 of 12

Spom\prp5

2 of 12

Spom\tup11

2 of 12

Yes

Spom\tup12

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:wds. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (86)

9 of 13

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

adp

1 of 13

ago

1 of 13

Atg16

1 of 13

Caf1-55

1 of 13

Caf1-105

1 of 13

can

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Cka

1 of 13

coro

1 of 13

CstF50

1 of 13

Ctf4

1 of 13

ebi

1 of 13

eIF3i

1 of 13

flr

1 of 13

fzr2

1 of 13

fzr

1 of 13

fzy

1 of 13

Gβ5

1 of 13

Gβ76C

1 of 13

gro

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Nle

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tex

1 of 13

thoc6

1 of 13

tws

1 of 13

U4-U6-60K

1 of 13

Uaf1

1 of 13

wcd

1 of 13

wda

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

WDY

1 of 13

wmd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

wds^HMS00746

model of congenital heart disease

CEA

(Zhu et al., 2024, Zhu et al., 2017)

wds^HMJ22657

model of congenital heart disease

CEA

(Zhu et al., 2024, Zhu et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

wds^HMS00746

model of congenital heart disease

is ameliorated by Hsap\WDR5^K7Q.UAS

(Zhu et al., 2017)

is ameliorated by Hsap\WDR5^WT.UAS

(Zhu et al., 2017)

wds^HMJ22657

model of congenital heart disease

is ameliorated by Hsap\WDR5^K7Q.UAS

(Zhu et al., 2017)

is ameliorated by Hsap\WDR5^WT.UAS

(Zhu et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WDR5; WD repeat domain 5

13 of 14

WD REPEAT-CONTAINING PROTEIN 5; WDR5

WDR5B; WD repeat domain 5B

9 of 14

621240

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

wds

Hsap\WDR5

(Zhu et al., 2017)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

wds - Ada2a

anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving

(Suganuma et al., 2012, Suganuma et al., 2010, Suganuma et al., 2008)

wds - Ada3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010, Suganuma et al., 2008)

wds - Atac1

experimental knowledge based

(Guruharsha et al., 2011)

wds - Atac2

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, molecular sieving

(Suganuma et al., 2012, Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

wds - Chrac-14

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010, Suganuma et al., 2008)

wds - D12

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

wds - Gcn5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010, Suganuma et al., 2008)

wds - Hcf

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Suganuma et al., 2010, Suganuma et al., 2008)

wds - Hsf

anti tag coimmunoprecipitation, anti tag western blot

(Zhao et al., 2023)

wds - MBD-R2

anti bait coimmunoprecipitation, western blot

(Raja et al., 2010)

wds - Mocs2B

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Suganuma et al., 2010, Suganuma et al., 2008)

wds - NC2β

anti tag coimmunoprecipitation, peptide massfingerprinting

(Suganuma et al., 2010, Suganuma et al., 2008)

wds - Nup98-96

anti bait coimmunoprecipitation, western blot

(Pascual-Garcia et al., 2014)

wds - Pa1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2011)

wds - Rcd1

anti bait coimmunoprecipitation, western blot, pull down, molecular weight estimation by staining

(Meunier et al., 2015, Raja et al., 2010)

wds - Rcd5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Raja et al., 2010)

wds - ReepA

experimental knowledge based

(Guruharsha et al., 2011)

wds - Set1

pull down, anti tag western blot

(Hallson et al., 2012)

wds - Sgf29

experimental knowledge based

(Guruharsha et al., 2011)

wds - Tet

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Yao et al., 2018)

wds - Utx

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2011)

wds - Wdr82

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2011)

wds - ash2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2011)

wds - dgt1

pull down, molecular weight estimation by staining, isothermal titration calorimetry, predetermined participant, anti tag coimmunoprecipitation, western blot

(Dias et al., 2014)

wds - mof

anti tag coimmunoprecipitation, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot

(Raja et al., 2010, Mendjan et al., 2006)

wds - nsl1

pull down, molecular weight estimation by staining, x-ray crystallography, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Dias et al., 2014, Raja et al., 2010, Mendjan et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lpt

suppressible

wds

(Chauhan et al., 2012)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9V3J8 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72718

DroID - A comprehensive database of gene and protein interactions.

FBgn0040066

MIST (protein-protein) - An integrated Molecular Interaction Database

53428

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3J8

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-1

Cytogenetic map

3A6-3A6

Sequence location

X:2,585,980..2,588,217 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3A6-3A6

Limits computationally determined from genome sequence between P{EP}CG32796^EP1385&P{EP}EP1160 and P{EP}egh^EP804

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

3A3-3A4

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.6.15)

3A8-3A8

(Hollmann, 2000.2.9)

Experimentally Determined Recombination Data

Location

1-1

(FlyBase, 2016)

1-1.0

(Comeron et al., 2012)

1-1.2

Left of (cM)

egh
Zw10

(Judd et al., 1972)

Right of (cM)

trol

(Judd et al., 1972)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

3901

wds⁷/FM7a/Dp(1;2;Y)w⁺

11849

P{lacW}wds^G0251 w^67c23/FM7c

60399

y¹ v¹; P{TRiP.HMJ22657}attP40

32952

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00746}attP2

FlyORF

F001499

M{UAS-wds.ORF}ZH-86Fb

F000936

M{UAS-wds.ORF.3xHA}ZH-86Fb

NIG-Fly

17437R-1

P{NIG.17437R}1

17437R-3

P{NIG.17437R}3

HMJ22657

y¹ v¹; P{TRiP.HMJ22657}attP40/CyO

HMS00746

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00746}attP2

VDRC

v105371

P{KK100120}VIE-260B

v38926

w¹¹¹⁸; P{GD9379}v38926

More stocks available...

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (27)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE31658

Other clones

DPiM_RE31658

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040066

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040066

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Suganuma et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: wds l(1)3Ad

(Hollmann et al., 2002)

Source for merge of: wds l(1)G0251

(Peter et al., 2002)

Source for merge of: EG:BACR25B3.7 CG17437

(FlyBase, 1996-)

Additional comments

The CG10931 gene may have been derived from the wds gene by retroposition.

(Dai et al., 2006)

Source for merge of EG:BACR25B3.7 CG17437 was sequence comparison ( date:000425 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG17437

(Çiçek et al., 2016, Hosono et al., 2015, Schertel et al., 2013, Ardehali et al., 2011, Mohan et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Dai et al., 2006, Higa et al., 2006, Benos, 2000.12.13)

EG:BACR25B3.7

(Benos et al., 2001, Benos, 2000.12.13)

WD5

(Schuettengruber et al., 2011)

WDR5

(Kondo and Perrimon, 2011)

Wds

(Zhao et al., 2023, Zhao et al., 2023, Kang et al., 2022, Cenik and Shilatifard, 2021, Chetverina et al., 2020, Yao et al., 2018, Guo and Jin, 2015, Pascual-Garcia et al., 2014, Shilatifard, 2012, Spedale et al., 2012, Mohan et al., 2011, Avet-Rochex et al., 2010, Prestel et al., 2010, Raja et al., 2010)

dWds

(Spedale et al., 2012)

l(1)16-94

l(1)3Ad

(Perrimon et al., 1989, Garcia-Bellido and Robbins, 1983)

l(1)G0251

(Schäfer et al., 1999.6.15)

l(1)zw8

(Hollmann et al., 2002, Lin and Wolfner, 1989, Paradi et al., 1983, Lim and Snyder, 1974, Shannon et al., 1972)

zw-8

(Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Liu and Lim, 1975)

zw8

(Montgomery et al., 1991, Goldberg et al., 1989, Lefevre and Watkins, 1986, Schalet, 1986, Robbins, 1983, Thierry-Mieg, 1982, Lefevre, 1981, Judd et al., 1972)

Name Synonyms

Will die slowly

(Piunti and Shilatifard, 2016, Guo and Jin, 2015)

lethal(1)3Ad

will die slowly

(Comoglio and Paro, 2014, Moran and Kyriacou, 2009, Fisher et al., 2008, Hollmann, 2000.2.9)

Secondary FlyBase IDs

FBgn0001403
FBgn0027252
FBgn0029626

Datasets (2)

Study focus (2)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

53428

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3J8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3J8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9NDM4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3J8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040066

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

53428/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040066

FlyMine - An integrated database for Drosophila genomics

FBgn0040066

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17437

MARRVEL_MODEL - MARRVEL (model organism gene)

53428

PDB - An information portal to biological macromolecular structures

4CY3
4CY5

Linkouts

BioGRID - A database of protein and genetic interactions.

72718

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040066

DroID - A comprehensive database of gene and protein interactions.

FBgn0040066

DRSC - Results frm RNAi screens

FBgn0040066

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

wds_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040066

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040066

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17437

Flygut - An atlas of the Drosophila adult midgut

FBgn0040066

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0040066

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000986

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

MIST (protein-protein) - An integrated Molecular Interaction Database

53428

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3J8

References (148)

The following external sites may use different assemblies or annotations than FlyBase.

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