guanine nucleotide exchange factor that belongs to the Dbl GEF superfamily - functions as a GDP/GTP exchange factor for Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation
Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).
Phosphorylated on tyrosine residues.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vav using the Feature Mapper tool.
Expression in stage P3 pupal leg discs is restricted to presumptive leg joints.
Vav transcript is expressed ubiquitously and uniformly in early embryogenesis. From stage 11 there is ubiquitous expression with stronger domains in the central nervous system and in the midgut. Expression in the ventral midline is maintained until stage 15. At this stage Vav is expressed in all midline glial cells (MGA, MGM and MGP) and in a subset of neurons of the ventral midline.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Vav in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Vav vav
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: reduced F-actin and altered cell shape - become round and detached. Kc167 cells show change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Named "Vav" after the human ortholog.