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Gene Dmel\Trx-2

General Information
Symbol	Dmel\Trx-2	Species	D. melanogaster
Name	thioredoxin-2	Annotation symbol	CG31884
Feature type	protein_coding_gene	FlyBase ID	FBgn0040070
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	DmTrx-2, CG3864
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	30C1-30C1	Sequence location	2L:9,613,165..9,616,048 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene thioredoxin-2 is referred to in FlyBase by the symbol Dmel\Trx-2 (CG31884, FBgn0040070). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: disulfide oxidoreductase activity. There is experimental evidence that it is involved in the biological process: cell redox homeostasis; determination of adult lifespan; response to DNA damage stimulus; response to oxidative stress. 19 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Thioredoxin; Thioredoxin domain; Thioredoxin, conserved site; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629426_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Trx-2. Gene sequence location is 2L:9613165..9616048.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA03622 BKN31447
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30C1-30C1   Limits computationally determined from genome sequence between P{EP}Oatp30BEP890 and P{EP}EP361&P{EP}peloEP2160
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	2- (Seong, 2000.1.3)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Trx-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Trx-2-RA FBtr0079840  NM_078802   825   106 Trx-2-RB FBtr0079839  NM_164863   983   106
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Trx-2-PA   FBpp0079437   11.7   106   4.49     NP_523526   AAN10700 Trx-2-PB   FBpp0079436   11.7   106   4.49     NP_723475   AAN10701
Additional Polypeptide Data & Comments
Reported size (kDa)	106 (aa) (Bauer et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Thioredoxin (IPR005746) Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) Thioredoxin, conserved site (IPR017937)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140954   AA140955   AA696112   AA736186   AA801973   AE014134 AAN10700   AE014134 AAN10701   AF220362 AAF37263   AI107481   AI292484   AI294493   AI295310   AI296535   AI389473   AI404465   AI531780   AQ073432   AQ074030   AW944280   AX094064   AY060458 AAL25497   AY232202   BG640381   BH146185   BI171703   BI215123   BI215320   BI215491   BI216386   BI216956   BI228074   BI239106   BI351777   BI352680   BI353743   BI356370   BP543227   BP543228   BP544317   BP544318   BP544444   BP544445   BP544956   BP544957   BP545602   BP545603   BP555745   BP555746   BP557922   BP557923   BP558559   BP558865   BP558866   BQ102672   BQ102812   BT120324   CK658258   CK658745   CO153654   CO156876   CO181131   CO183506   CO188797   CO194682   CO195804   CO277111   CO281440   CO308049   CO321413   CO321587   CO323523   CO331648   CO336324   CO338094   CZ471113   CZ471757   CZ476496   CZ476994   EC057823   EC060230   EC073406   EC076167   EC085901   EC089062   EC203731   EC205162   EC238107   EC246306   EC250998   EC260888   EC262515   EC265841   EC266861   EV575310   EV576999   EV577906   EV578766   EV579957   EV580807   EV584364   EV585552   EV585644   EV585675   EV587575   EV592508   EV592621   EV593520   EV593713   EV593993   EV597252   EV597719   EV597796   EV597970
UniProtKB/Swiss-Prot	Q9V429
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference larval stage     (Bauer et al., 2002) imaginal disc   (Bauer et al., 2002)     (Bauer et al., 2002) Comment:expression assayed in cultured cells
Additional Descriptive Data
	Trx-2 protein is detected in larvae, imaginal discs and Schneider cells by Western blot. (Bauer et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040070    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040070 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040070 expression level Developmental Stage   Expression Level embryo 00-02hr    16264 embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr    11526 embryo 10-12hr    17384 embryo 12-14hr    11701 embryo 14-16hr    19880 embryo 16-18hr    29566 embryo 18-20hr    23552 embryo 20-22hr    21876 embryo 22-24hr    25941 larva L1    28945 larva L2    36347 larva L3 12hr old    23618 larva L3 puffstage 1-2    13378 larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9    12127 white prepupae new    12370 white prepupae 12hr    16554 white prepupae 24hr    11945 pupae 2d postWPP    11942 pupae 3d postWPP    11423 pupae 4d postWPP    12712 adult male 01day    11576 adult male 05day    11759 adult male 30day    12610 adult female 01day    15467 adult female 05day    18237 adult female 30day    18621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16264) embryo 02-04hr  (1083) embryo 04-06hr  (2051) embryo 06-08hr  (7568) embryo 08-10hr  (11526) embryo 10-12hr  (17384) embryo 12-14hr  (11701) embryo 14-16hr  (19880) embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  (13378) larva L3 puffstage 3-6  (9296) larva L3 puffstage 7-9  (12127) white prepupae new  (12370) white prepupae 12hr  (16554) white prepupae 24hr  (11945) pupae 2d postWPP  (11942) pupae 3d postWPP  (11423) pupae 4d postWPP  (12712) adult male 01day  (11576) adult male 05day  (11759) adult male 30day  (12610) adult female 01day  (15467) adult female 05day  (18237) adult female 30day  (18621) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16264) embryo 02-04hr    1083 embryo 04-06hr  (2051) embryo 06-08hr  (7568) embryo 08-10hr  (11526) embryo 10-12hr  (17384) embryo 12-14hr  (11701) embryo 14-16hr  (19880) embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  (13378) larva L3 puffstage 3-6  (9296) larva L3 puffstage 7-9  (12127) white prepupae new  (12370) white prepupae 12hr  (16554) white prepupae 24hr  (11945) pupae 2d postWPP  (11942) pupae 3d postWPP  (11423) pupae 4d postWPP  (12712) adult male 01day  (11576) adult male 05day  (11759) adult male 30day  (12610) adult female 01day  (15467) adult female 05day  (18237) adult female 30day  (18621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (16264) embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr  (11526) embryo 10-12hr  (17384) embryo 12-14hr  (11701) embryo 14-16hr  (19880) embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  (13378) larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9  (12127) white prepupae new  (12370) white prepupae 12hr  (16554) white prepupae 24hr  (11945) pupae 2d postWPP  (11942) pupae 3d postWPP  (11423) pupae 4d postWPP  (12712) adult male 01day  (11576) adult male 05day  (11759) adult male 30day  (12610) adult female 01day  (15467) adult female 05day  (18237) adult female 30day  (18621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16264 embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr    11526 embryo 10-12hr    17384 embryo 12-14hr    11701 embryo 14-16hr    19880 embryo 16-18hr    29566 embryo 18-20hr    23552 embryo 20-22hr    21876 embryo 22-24hr    25941 larva L1    28945 larva L2    36347 larva L3 12hr old    23618 larva L3 puffstage 1-2    13378 larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9    12127 white prepupae new    12370 white prepupae 12hr    16554 white prepupae 24hr    11945 pupae 2d postWPP    11942 pupae 3d postWPP    11423 pupae 4d postWPP    12712 adult male 01day    11576 adult male 05day    11759 adult male 30day    12610 adult female 01day    15467 adult female 05day    18237 adult female 30day    18621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040070 expression level Developmental Stage   Expression Level embryo 00-02hr    16264 embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr    11526 embryo 10-12hr    17384 embryo 12-14hr    11701 embryo 14-16hr    19880 embryo 16-18hr    29566 embryo 18-20hr    23552 embryo 20-22hr    21876 embryo 22-24hr    25941 larva L1    28945 larva L2    36347 larva L3 12hr old    23618 larva L3 puffstage 1-2    13378 larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9    12127 white prepupae new    12370 white prepupae 12hr    16554 white prepupae 24hr    11945 pupae 2d postWPP    11942 pupae 3d postWPP    11423 pupae 4d postWPP    12712 adult male 01day    11576 adult male 05day    11759 adult male 30day    12610 adult female 01day    15467 adult female 05day    18237 adult female 30day    18621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16264) embryo 02-04hr  (1083) embryo 04-06hr  (2051) embryo 06-08hr  (7568) embryo 08-10hr  (11526) embryo 10-12hr  (17384) embryo 12-14hr  (11701) embryo 14-16hr  (19880) embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  (13378) larva L3 puffstage 3-6  (9296) larva L3 puffstage 7-9  (12127) white prepupae new  (12370) white prepupae 12hr  (16554) white prepupae 24hr  (11945) pupae 2d postWPP  (11942) pupae 3d postWPP  (11423) pupae 4d postWPP  (12712) adult male 01day  (11576) adult male 05day  (11759) adult male 30day  (12610) adult female 01day  (15467) adult female 05day  (18237) adult female 30day  (18621) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16264) embryo 02-04hr    1083 embryo 04-06hr  2051 embryo 06-08hr  (7568) embryo 08-10hr  (11526) embryo 10-12hr  (17384) embryo 12-14hr  (11701) embryo 14-16hr  (19880) embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  (13378) larva L3 puffstage 3-6  (9296) larva L3 puffstage 7-9  (12127) white prepupae new  (12370) white prepupae 12hr  (16554) white prepupae 24hr  (11945) pupae 2d postWPP  (11942) pupae 3d postWPP  (11423) pupae 4d postWPP  (12712) adult male 01day  (11576) adult male 05day  (11759) adult male 30day  (12610) adult female 01day  (15467) adult female 05day  (18237) adult female 30day  (18621) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  16264 embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr  11526 embryo 10-12hr  17384 embryo 12-14hr  11701 embryo 14-16hr  19880 embryo 16-18hr  (29566) embryo 18-20hr  (23552) embryo 20-22hr  (21876) embryo 22-24hr  (25941) larva L1  (28945) larva L2  (36347) larva L3 12hr old  (23618) larva L3 puffstage 1-2  13378 larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9  12127 white prepupae new  12370 white prepupae 12hr  16554 white prepupae 24hr  11945 pupae 2d postWPP  11942 pupae 3d postWPP  11423 pupae 4d postWPP  12712 adult male 01day  11576 adult male 05day  11759 adult male 30day  12610 adult female 01day  15467 adult female 05day  18237 adult female 30day  18621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16264 embryo 02-04hr    1083 embryo 04-06hr    2051 embryo 06-08hr    7568 embryo 08-10hr    11526 embryo 10-12hr    17384 embryo 12-14hr    11701 embryo 14-16hr    19880 embryo 16-18hr    29566 embryo 18-20hr    23552 embryo 20-22hr    21876 embryo 22-24hr    25941 larva L1    28945 larva L2    36347 larva L3 12hr old    23618 larva L3 puffstage 1-2    13378 larva L3 puffstage 3-6    9296 larva L3 puffstage 7-9    12127 white prepupae new    12370 white prepupae 12hr    16554 white prepupae 24hr    11945 pupae 2d postWPP    11942 pupae 3d postWPP    11423 pupae 4d postWPP    12712 adult male 01day    11576 adult male 05day    11759 adult male 30day    12610 adult female 01day    15467 adult female 05day    18237 adult female 30day    18621 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040070    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040070 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040070 expression level Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut    1281.5 Larval Hindgut    1238.3 Larval Malpighian Tubules    1088.8 Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea    2040 Larval Carcass    1681.875 Adult Head    1301.3 Adult Eye    1560.65 Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop    1994.6 Adult Midgut    1486.4 Adult Hindgut    1356.5 Adult Malpighian Tubules    2833.9 Adult Fat Body    1123.3 Adult Salivary Gland    483.1 Adult Heart    1823.525 Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca    1028.1 Adult Ovary    1083.8 Adult Testis    201.7 Adult Male Accessory Gland    3128.1 Adult Carcass    1267.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (967.2) Larval Midgut  (1281.5) Larval Hindgut  (1238.3) Larval Malpighian Tubules  (1088.8) Larval Fat Body  (975.2) Larval Salivary Gland  (786.8) Larval Trachea  (2040) Larval Carcass  (1681.875) Adult Head  (1301.3) Adult Eye  (1560.65) Adult Brain  (785.4) Adult Thoracic-Abdominal Ganglion  (906.4) Adult Crop  (1994.6) Adult Midgut  (1486.4) Adult Hindgut  (1356.5) Adult Malpighian Tubules  (2833.9) Adult Fat Body  (1123.3) Adult Salivary Gland    483.1 Adult Heart  (1823.525) Adult VirginFemale Spermatheca  (735.4) Adult InseminatedFemale Spermatheca  (1028.1) Adult Ovary  (1083.8) Adult Testis    201.7 Adult Male Accessory Gland  (3128.1) Adult Carcass  (1267.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut  (1281.5) Larval Hindgut  (1238.3) Larval Malpighian Tubules  (1088.8) Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea  (2040) Larval Carcass  (1681.875) Adult Head  (1301.3) Adult Eye  (1560.65) Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop  (1994.6) Adult Midgut  (1486.4) Adult Hindgut  (1356.5) Adult Malpighian Tubules  (2833.9) Adult Fat Body  (1123.3) Adult Salivary Gland    483.1 Adult Heart  (1823.525) Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca  1028.1 Adult Ovary  (1083.8) Adult Testis    201.7 Adult Male Accessory Gland  (3128.1) Adult Carcass  (1267.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut    1281.5 Larval Hindgut    1238.3 Larval Malpighian Tubules    1088.8 Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea    2040 Larval Carcass    1681.875 Adult Head    1301.3 Adult Eye    1560.65 Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop    1994.6 Adult Midgut    1486.4 Adult Hindgut    1356.5 Adult Malpighian Tubules    2833.9 Adult Fat Body    1123.3 Adult Salivary Gland    483.1 Adult Heart    1823.525 Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca    1028.1 Adult Ovary    1083.8 Adult Testis    201.7 Adult Male Accessory Gland    3128.1 Adult Carcass    1267.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040070 expression level Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut    1281.5 Larval Hindgut    1238.3 Larval Malpighian Tubules    1088.8 Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea    2040 Larval Carcass    1681.875 Adult Head    1301.3 Adult Eye    1560.65 Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop    1994.6 Adult Midgut    1486.4 Adult Hindgut    1356.5 Adult Malpighian Tubules    2833.9 Adult Fat Body    1123.3 Adult Salivary Gland    483.1 Adult Heart    1823.525 Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca    1028.1 Adult Ovary    1083.8 Adult Testis    201.7 Adult Male Accessory Gland    3128.1 Adult Carcass    1267.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (967.2) Larval Midgut  (1281.5) Larval Hindgut  (1238.3) Larval Malpighian Tubules  (1088.8) Larval Fat Body  (975.2) Larval Salivary Gland  786.8 Larval Trachea  (2040) Larval Carcass  (1681.875) Adult Head  (1301.3) Adult Eye  (1560.65) Adult Brain  785.4 Adult Thoracic-Abdominal Ganglion  (906.4) Adult Crop  (1994.6) Adult Midgut  (1486.4) Adult Hindgut  (1356.5) Adult Malpighian Tubules  (2833.9) Adult Fat Body  (1123.3) Adult Salivary Gland    483.1 Adult Heart  (1823.525) Adult VirginFemale Spermatheca  735.4 Adult InseminatedFemale Spermatheca  (1028.1) Adult Ovary  (1083.8) Adult Testis    201.7 Adult Male Accessory Gland  (3128.1) Adult Carcass  (1267.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut  1281.5 Larval Hindgut  1238.3 Larval Malpighian Tubules  1088.8 Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea  (2040) Larval Carcass  1681.875 Adult Head  1301.3 Adult Eye  1560.65 Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop  (1994.6) Adult Midgut  1486.4 Adult Hindgut  1356.5 Adult Malpighian Tubules  (2833.9) Adult Fat Body  1123.3 Adult Salivary Gland    483.1 Adult Heart  (1823.525) Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca  1028.1 Adult Ovary  1083.8 Adult Testis    201.7 Adult Male Accessory Gland  (3128.1) Adult Carcass  1267.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    967.2 Larval Midgut    1281.5 Larval Hindgut    1238.3 Larval Malpighian Tubules    1088.8 Larval Fat Body    975.2 Larval Salivary Gland    786.8 Larval Trachea    2040 Larval Carcass    1681.875 Adult Head    1301.3 Adult Eye    1560.65 Adult Brain    785.4 Adult Thoracic-Abdominal Ganglion    906.4 Adult Crop    1994.6 Adult Midgut    1486.4 Adult Hindgut    1356.5 Adult Malpighian Tubules    2833.9 Adult Fat Body    1123.3 Adult Salivary Gland    483.1 Adult Heart    1823.525 Adult VirginFemale Spermatheca    735.4 Adult InseminatedFemale Spermatheca    1028.1 Adult Ovary    1083.8 Adult Testis    201.7 Adult Male Accessory Gland    3128.1 Adult Carcass    1267.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1301.3   NA  Eye    1560.65   NA  Brain    785.4   967.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    906.4   NA  Crop    1994.6   1281.5  Midgut    1486.4   1238.3  Hindgut    1356.5   1088.8  Malpighian Tubules    2833.9   975.2  Fat Body    1123.3   786.8  Salivary Gland    483.1   NA  Heart    1823.525   2040  Trachea    NA   NA  VirginFemale Spermatheca    735.4   NA  InseminatedFemale Spermatheca    1028.1   NA  Ovary    1083.8   NA  Testis    201.7   NA  Male Accessory Gland    3128.1   1681.875  Carcass    1267.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040070 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31884-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Trx-21 viable, with Scer\GAL4pnr-MD237 Trx-2GD10505 Sterility Allele fertile Trx-21 Other Phenotypes Allele chemical resistant, with Scer\GAL4Act5C.PI Trx-2Scer\UAS.cUa chemical sensitive Trx-21 locomotor behavior defective | conditional Trx-21 long lived, with Scer\GAL4hs.PB Trx-2GS2114 short lived Trx-21 Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Trx-2 Class Mutagen Stocks Known lesion Trx-2BG02804 P-element activity 1 -- Trx-2CB-0705-3 1 -- Trx-2d00706 P-element activity 1 -- Trx-2d08967 P-element activity 1 -- Trx-2GE14911 1 -- Trx-21 amorphic allele - molecular evidence P-element activity 0 Yes Trx-2c06949 piggyBac transposase 0 -- Trx-2d09882 P-element activity 0 -- Trx-2EP2018 P-element activity 0 Yes Trx-2EP2252 P-element activity 0 Yes Trx-2gcm2 P-element activity 0 Yes Trx-2GS-A866 Delta2-3 0 -- Trx-2GS2114 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Trx-2 Class Mutagen Stocks Known lesion Trx-2GD10505 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Trx-2HMS00603 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Trx-2HMS00989 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Trx-2KK111447 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Trx-2GD17264 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Trx-2Scer\UAS.cUa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7042 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10505} NA P{GD17264} NA P{KK111447} NA P{TRiP.HMS00603} NA P{TRiP.HMS00989} NA P{UAS-Trx-2.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}Trx-2BG02804 NA P{RS3}Trx-2CB-0705-3 NA P{SUPor-P}GlcAT-SKG07111 NA PBac{PB}Trx-2c06949 NA insertion of mobile activating element P{EP}Trx-2EP2018 NA P{EP}Trx-2EP2252 NA P{EP}Trx-2GE14911 NA P{GSV1}Trx-2GS2114 NA P{GSV1}Trx-2GS-A866 NA P{XP}Trx-2d00706 NA P{XP}Trx-2d02943 NA P{XP}Trx-2d08967 NA P{XP}Trx-2d09882 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
disulfide oxidoreductase activity inferred from direct assay (assigned by UniProtKB) (Bauer et al., 2002)
Biological Process
CV term Evidence References
cell redox homeostasis inferred from direct assay (assigned by UniProtKB) (Bauer et al., 2002) determination of adult lifespan inferred from mutant phenotype (Svensson and Larsson, 2007) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) response to oxidative stress inferred from mutant phenotype (Svensson and Larsson, 2007)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Svensson et al., 2003)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
disulfide oxidoreductase activity inferred from sequence or structural similarity with Saccharomyces TRX1 (FlyBase, 1992-) non-traceable author statement (Seong, 2000.1.3) electron carrier activity inferred from electronic annotation with InterPro:IPR005746 (FlyBase Curators et al., 2004-) protein disulfide oxidoreductase activity inferred from electronic annotation with InterPro:IPR005746 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
glycerol ether metabolic process inferred from electronic annotation with InterPro:IPR005746 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Trx-2 allele Gene References unspecified ct (Krupp et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60380 DroID - A comprehensive database of gene and protein interactions. • FBgn0040070 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34281
Orthologs
Genome-wide drosophilid orthologs	Dana\Trx-2 Dere\Trx-2 Dgri\Trx-2 Dmoj\Trx-2 Dpse\Trx-2 Dsec\Trx-2 Dsim\Trx-2 Dvir\Trx-2 Dwil\Trx-2 Dyak\Trx-2
Curated drosophilid orthologs	Dana\Trx-2 (Svensson et al., 2007) Dere\Trx-2 (Svensson et al., 2007) Dgri\Trx-2 (Svensson et al., 2007) Dmoj\Trx-2 (Svensson et al., 2007) Dper\Trx-2 (Svensson et al., 2007) Dpse\Trx-2 (Svensson et al., 2007) Dsec\Trx-2 (Svensson et al., 2007) Dsim\Trx-2 (Svensson et al., 2007) Dvir\Trx-2 (Svensson et al., 2007) Dwil\Trx-2 (Svensson et al., 2007) Dyak\Trx-2 (Svensson et al., 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010777-PA Aedes aegypti (mosquito) AGAP009584-PA Anopheles gambiae (mosquito) XP_392963.1 Apis mellifera (honey bee) XP_001949773.1 Acyrthosiphon pisum (pea aphid) 7466 Batrachochytrium dendrobatidis (chytrid fungus) 85415 Batrachochytrium dendrobatidis (chytrid fungus) 100902 Branchiostoma floridae (lancelet) 92174 Branchiostoma floridae (lancelet) ENSBTAP00000041860 Bos taurus (bovine) CAL0000819 Candida albicans (a form of yeast) CN05615 Caenorhabditis brenneri (small nematode) CN24120 Caenorhabditis brenneri (small nematode) CBP09217 Caenorhabditis briggsae (nematode) CE21928 Caenorhabditis elegans (worm) ENSCAFP00000004307 Canis familiaris (dog) CAGL0E00583g Candida glabrata (haploid yeast) CAGL0K00803g Candida glabrata (haploid yeast) Chro.40188 Cryptosporidium hominis (obligate parasite) ENSCINP00000024533 Ciona intestinalis (sea squirt) JA02533 Caenorhabditis japonica (nematode) cn03304 Cryptococcus neoformans (yeast-like fungus) cgd4_1650 Cryptosporidium parvum (protozoan parasite) CPIJ012011 Culex pipens (mosquito) ENSCPOP00000013833 Cavia porcellus (guinea pig) ENSCPOP00000019817 Cavia porcellus (guinea pig) 129976 Chlamidomonas reinhardtii (green alga) RP08559 Caenorhabditis remanei (nematode) DDB0233050 Dictyostelium discoideum (amoeba) DEHA2G04488g Debaryomyces Hansenii (yeast) 230730 Daphnia pulex (daphnia) ENSDARP00000064788 Danio rerio (zebra fish) ENSECAP00000011207 Equus caballus (horse) XP_656726 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000025320 Gymnopilus aculeatus (mushroom) ENSGALP00000025280 Gallus gallus (chicken) GL50803_8064 Giardia lamblia (flagellated protozoan) ENSP00000363641 Homo sapiens (human) ISCW006034-PA Ixodes scapularis (deer tick) KLLA0E16347g Kluyveromyces lactis (yeast) 203919 Lottia gigantea (owl limpet) 34641 Monocosta brevicollis (choanoflagellate) ENSMODP00000038282 Monodelphis domestica (gray opossum) ENSMMUP00000004552 Macaca mulatta (rhesus monkey) ENSMMUP00000013528 Macaca mulatta (rhesus monkey) ENSMMUP00000021320 Macaca mulatta (rhesus monkey) ENSMUSP00000030051 Mus musculus (house mouse) 162401 Nematostella vectensis (starlet anemone) ENSOANP00000011094 Ornithorynchus anatinus (platypus) ENSORLP00000009493 Oryzias latipes (japanese killifish) LOC_Os07g08840.1 Oryza sativa (asian rice) 7739 Ostreococcus tauri (green alga) PHUM005477-PA Pediculus humanus (human body louse) PP14687 Pristionchus pacificus (nematode) 185663 Physcomitrella patens (moss) ENSPPYP00000021834 Pongo pygmaeus (orangutan) 710146 Populus trichocarpa (black cottonwood) 818765 Populus trichocarpa (black cottonwood) ENSPTRP00000036292 Pan troglodytes (chimpanzee) ENSRNOP00000016447 Rattus norvegicus (norway rat) YGR209C Saccharomyces cerevisiae (budding yeast) Smp_008070 Schistosoma mansoni (trematode parasite) SPAC7D4.07c Schizosaccharomyces pombe (fission yeast) XP_001178739.1 Strongylocentrotus purpuratus (purple sea urchin) 62227 Trichoplax adhaerens (metazoa) XP_967987.1 Tribolium castaneum (red flour beetle) Tc00.1047053507723.189 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016857 Tetraodon nigroviridis (green spotted pufferfish) 19991 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009633 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000005532 Xenopus tropicalis (frog) YALI0F01496g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18420 NV13156 LH19179 ISCW006034 FBgn0234312 FBgn0082378 FBgn0227063 FBgn0225830 FBgn0205474 FBgn0203759 FBgn0194995 FBgn0172488 FBgn0167587 JGI_V11_230730 FBgn0077337 FBgn0076561 FBgn0151935 FBgn0133846 FBgn0133821 FBgn0029752 FBgn0131821 FBgn0118157 FBgn0110716 FBgn0102355 FBgn0099774 FBgn0097955 CPIJ012011 BGIBMGA008120 ACYPI009665 GB15855 TRX1 AAEL010777 PHUM156960 GLEAN_15376
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	26884 w*; P{EP}Trx-2GE14911 12826 w1118; P{GT1}Trx-2BG02804 33721 y1 sc* v1; P{TRiP.HMS00603}attP2 34019 y1 sc* v1; P{TRiP.HMS00989}attP2
Harvard	- P{XP}Trx-2d00706 - P{XP}Trx-2d08967
Kyoto	123290 w1118; P{RS3}Trx-2CB-0705-3
VDRC	v104629 P{KK111447}VIE-260B v36297 w1118; P{GD10505}v36297 v36298 w1118; P{GD10505}v36298
Genomic Clones ( 1 )
	BACR24A22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 86 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE24425 SD03042
Other clones	yak-ad_thioredoxin
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05181 GH15403 GH20654 GH24203 GM03658 GM05086 GM16088 GM20353 GM24939 HL08133 LP07876 LP08906 LP10475 LP15070 LP15957 RE13533 RE21342 RE21687 RE22006 RE23510 RE24455 RE25496 RE35510 RE42495 SD11382
Other clones	1644 42277 61230 101180 149588 153152 153510 273508 273574 CK01.51B.A8 CK01034 Dmel_dig_000276_0701_3699 Dmel_dig_004035_0690_0558 Dmel_dig_006207_0722_0455 Dmel_dig_006933_0692_1739 Dmel_dig_009994_0666_3375 Dmel_dig_013185_0655_0367 Dmel_dig_016438_0648_2289 Dmel_dig_018206_0619_2527 Dmel_dig_018746_0656_0612 Dmel_dig_018893_0582_2318 Dmel_neb_003632_0950_0306 Dmel_neb_011884_0889_2787 Dmel_neb_012833_0820_2442 Dmel_neb_013065_0682_1764 Dmel_neb_014613_0072_2572 Dmel_neb_014691_0573_3326 Dmel_neb_015088_0575_1439 Dmel_neb_015583_0695_2369 Dmel_neb_015907_0623_1095 Dmel_neb_016019_0899_0568 EC13590 EC25858 EC39033 EC41007 EK041936 EK122961 EK157158 EK185629 EK185959 EK190708 EK256524 EK300763 EN02521 EN09461 EN12317 EN15934 FGC019D01 FGC025C02 FGC025H08 FGC028G01 FGC032B11 FGM236H09 FGM311H12 FGM315F11 FGM317E04 UUGC0052 UUGC0200
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040070 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34281
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: thioredoxin CG3864 (Bayraktaroglu, 2000.8.7) Source for merge of: Trx-2 anon-WO0118547.188 (FlyBase, 1996-)
Additional comments	Source for merge of Trx-2 anon-WO0118547.188 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Trx-2, not dhd, is the substrate of Jafrac1. (Bauer et al., 2002) Area matching Drosophila ESTS AA736186 and AA801973. Thses ESTs have sequence similarity to Thioredoxin genes. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078802 NM_164863 RefSeq (Proteins) • NP_523526 NP_723475 DDBJ / EMBL / GenBank • AA736186 AA801973 AAF37263 AAL25497 AAN10700 AAN10701 AF220362 AI292484 AI404465 AI531780 AQ073432 AQ074030 AW944280 AX094064 AY060458 BH146185 CZ471113 CZ471757 CZ476496 CZ476994 Entrez Gene - A searchable database of RefSeq genes. • 34281 UniProtKB/Swiss-Prot • Q9V429
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Thioredoxin (IPR005746) Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) Thioredoxin, conserved site (IPR017937)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60380 DroID - A comprehensive database of gene and protein interactions. • FBgn0040070 DRSC - Results from RNAi screens. • FBgn0040070 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040070 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31884-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040070 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34281 InParanoid A subset of ortholog calls from InParanoid. • AAEL010777-PA Aedes aegypti (mosquito) AGAP009584-PA Anopheles gambiae (mosquito) XP_392963.1 Apis mellifera (honey bee) XP_001949773.1 Acyrthosiphon pisum (pea aphid) 7466 Batrachochytrium dendrobatidis (chytrid fungus) 85415 Batrachochytrium dendrobatidis (chytrid fungus) 100902 Branchiostoma floridae (lancelet) 92174 Branchiostoma floridae (lancelet) ENSBTAP00000041860 Bos taurus (bovine) CAL0000819 Candida albicans (a form of yeast) CN05615 Caenorhabditis brenneri (small nematode) CN24120 Caenorhabditis brenneri (small nematode) CBP09217 Caenorhabditis briggsae (nematode) CE21928 Caenorhabditis elegans (worm) ENSCAFP00000004307 Canis familiaris (dog) CAGL0E00583g Candida glabrata (haploid yeast) CAGL0K00803g Candida glabrata (haploid yeast) Chro.40188 Cryptosporidium hominis (obligate parasite) ENSCINP00000024533 Ciona intestinalis (sea squirt) JA02533 Caenorhabditis japonica (nematode) cn03304 Cryptococcus neoformans (yeast-like fungus) cgd4_1650 Cryptosporidium parvum (protozoan parasite) CPIJ012011 Culex pipens (mosquito) ENSCPOP00000013833 Cavia porcellus (guinea pig) ENSCPOP00000019817 Cavia porcellus (guinea pig) 129976 Chlamidomonas reinhardtii (green alga) RP08559 Caenorhabditis remanei (nematode) DDB0233050 Dictyostelium discoideum (amoeba) DEHA2G04488g Debaryomyces Hansenii (yeast) 230730 Daphnia pulex (daphnia) ENSDARP00000064788 Danio rerio (zebra fish) ENSECAP00000011207 Equus caballus (horse) XP_656726 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000025320 Gymnopilus aculeatus (mushroom) ENSGALP00000025280 Gallus gallus (chicken) GL50803_8064 Giardia lamblia (flagellated protozoan) ENSP00000363641 Homo sapiens (human) ISCW006034-PA Ixodes scapularis (deer tick) KLLA0E16347g Kluyveromyces lactis (yeast) 203919 Lottia gigantea (owl limpet) 34641 Monocosta brevicollis (choanoflagellate) ENSMODP00000038282 Monodelphis domestica (gray opossum) ENSMMUP00000004552 Macaca mulatta (rhesus monkey) ENSMMUP00000013528 Macaca mulatta (rhesus monkey) ENSMMUP00000021320 Macaca mulatta (rhesus monkey) ENSMUSP00000030051 Mus musculus (house mouse) 162401 Nematostella vectensis (starlet anemone) ENSOANP00000011094 Ornithorynchus anatinus (platypus) ENSORLP00000009493 Oryzias latipes (japanese killifish) LOC_Os07g08840.1 Oryza sativa (asian rice) 7739 Ostreococcus tauri (green alga) PHUM005477-PA Pediculus humanus (human body louse) PP14687 Pristionchus pacificus (nematode) 185663 Physcomitrella patens (moss) ENSPPYP00000021834 Pongo pygmaeus (orangutan) 710146 Populus trichocarpa (black cottonwood) 818765 Populus trichocarpa (black cottonwood) ENSPTRP00000036292 Pan troglodytes (chimpanzee) ENSRNOP00000016447 Rattus norvegicus (norway rat) YGR209C Saccharomyces cerevisiae (budding yeast) Smp_008070 Schistosoma mansoni (trematode parasite) SPAC7D4.07c Schizosaccharomyces pombe (fission yeast) XP_001178739.1 Strongylocentrotus purpuratus (purple sea urchin) 62227 Trichoplax adhaerens (metazoa) XP_967987.1 Tribolium castaneum (red flour beetle) Tc00.1047053507723.189 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016857 Tetraodon nigroviridis (green spotted pufferfish) 19991 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009633 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000005532 Xenopus tropicalis (frog) YALI0F01496g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34281 modMine - Data generated by the modENCODE project. • FBgn0040070 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18420 NV13156 LH19179 ISCW006034 FBgn0234312 FBgn0082378 FBgn0227063 FBgn0225830 FBgn0205474 FBgn0203759 FBgn0194995 FBgn0172488 FBgn0167587 JGI_V11_230730 FBgn0077337 FBgn0076561 FBgn0151935 FBgn0133846 FBgn0133821 FBgn0029752 FBgn0131821 FBgn0118157 FBgn0110716 FBgn0102355 FBgn0099774 FBgn0097955 CPIJ012011 BGIBMGA008120 ACYPI009665 GB15855 TRX1 AAEL010777 PHUM156960 GLEAN_15376
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	31884 (Ravi et al., 2009) anon-WO0118547.188   CG3864 (Asha et al., 2003, Seong et al., 2001, ) CG31884 (Joza et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011) DmelTrx-2 (Svensson et al., 2007) DmTrx-2 (Jacob et al., 2005, Bauer et al., 2003, Joza et al., 2008, Cheng et al., 2007, Huang et al., 2008, Huang et al., 2008) dmtrx-2 (Bauer et al., 2002) Trx (Wahl et al., 2005) Trx-2 (Umeda-Kameyama et al., 2007, Svensson et al., 2007, Levis, 2009.3.18, Bartkuhn et al., 2009, List et al., 2009, Svensson and Larsson, 2007, Svensson et al., 2003, Greene et al., 2005, Tsuda et al., 2010)
Name Synonym	thioredoxin (Jasper et al., 2002, Alfonso and Jones, 2002, Kammerer and Giangrande, 2001, Cheng et al., 2007, Huang et al., 2008) thioredoxin-2 (Bauer et al., 2002, Cammarato et al., 2011) Thioredoxin-2 (Svensson et al., 2007, Svensson and Larsson, 2007, Greene et al., 2005)
Secondary FlyBase IDs
	FBgn0032134 FBgn0051884 FBgn0062183
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Tsuda et al., 2010, FEBS Lett. 584(15): 3398--3401 Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. [FBrf0211377] Show all research papers ...