FB2025_01 , released February 20, 2025
Gene: Dmel\Trx2
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General Information
Symbol
Dmel\Trx2
Species
D. melanogaster
Name
Thioredoxin 2
Annotation Symbol
CG31884
Feature Type
protein_coding_gene
FlyBase ID
FBgn0040070
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. (UniProt, Q9V429)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Trx-2, thioredoxin, DmTrx-2

Key Links
Genomic Location
Cytogenetic map
30C1-30C1
Sequence location
Recombination map
2-36
RefSeq locus
NT_033779 REGION:9613166..9616404
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables disulfide oxidoreductase activity
inferred from direct assay
(Bauer et al., 2002)
enables glutathione disulfide oxidoreductase activity
inferred from direct assay
(Bauer et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein-disulfide reductase activity
inferred from electronic annotation with InterPro:IPR005746
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in cell redox homeostasis
inferred from direct assay
(Bauer et al., 2002)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Svensson and Larsson, 2007)
involved_in response to oxidative stress
inferred from mutant phenotype
(Svensson and Larsson, 2007)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Svensson et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from sequence model
(Mondal and Singh, 2022)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the thioredoxin family. (Q9V429)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
THIOREDOXINS -
Thioredoxins reduce disulfide bonds in other proteins using the two cysteines of their conserved active site (WCGPC). They are kept in a reduced, active form by thioredoxin reductase, TrxR, which converts TrxS[[2]] to Trx(SH)[[2]] using NADPH. Thioredoxins have diverse in vivo functions including protection against oxidative stress, redox modification of other proteins, and as an electron donor for ribonucleotide reductase in DNA synthesis. Some thioredoxins are specific to particular organs or cellular compartments. (Adapted from FBrf0200723 and PMID:23397885.)
Protein Function (UniProtKB)
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.
(UniProt, Q9V429)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Trx2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V429)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Trx2-RA
FBtr0079840
NM_078802
790
106
Trx2-RB
FBtr0079839
NM_164863
1338
106
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Trx2-PA
FBpp0079437
11.7
106
4.49
Q9V429
NP_523526
AAN10700
Trx2-PB
FBpp0079436
11.7
106
4.49
Q9V429
NP_723475
AAN10701
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

106 aa isoforms: Trx2-PA, Trx2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

106 (aa)

(Bauer et al., 2002)
Comments
External Data
Subunit Structure (UniProtKB)

Monomer.

(UniProt, Q9V429)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Trx2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
primary spermatocyte
• nucleus
(Svensson et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
(Bauer et al., 2002)
imaginal disc
(Bauer et al., 2002)

Comment: expression assayed in cultured cells

(Bauer et al., 2002)
Additional Descriptive Data

Trx-2 protein is detected in larvae, imaginal discs and Schneider cells by Western blot.

(Bauer et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Svensson et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Trx2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Trx2
Transgenic constructs containing regulatory region of Trx2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7042
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (27)
Hsap\TXN
13 of 14
Yes
Yes
3  
Hsap\TXNDC2
7 of 14
No
Yes
Hsap\TXNDC8
5 of 14
No
Yes
Hsap\TXN2
4 of 14
No
No
Hsap\TXNL1
3 of 14
No
No
1  
Hsap\NME8
2 of 14
No
No
Hsap\NME9
2 of 14
No
No
Hsap\AGR2
1 of 14
No
Yes
Hsap\AGR3
1 of 14
No
Yes
Hsap\DNAJC10
1 of 14
No
No
Hsap\ERP44
1 of 14
No
No
1  
Hsap\GLRX3
1 of 14
No
No
Hsap\GLRX5
1 of 14
No
No
Hsap\NXN
1 of 14
No
Yes
Hsap\NXNL1
1 of 14
No
Yes
Hsap\NXNL2
1 of 14
No
Yes
Hsap\P4HB
1 of 14
No
No
1  
Hsap\PDIA2
1 of 14
No
No
Hsap\PDIA3
1 of 14
No
No
Hsap\PDIA4
1 of 14
No
No
Hsap\PDIA5
1 of 14
No
No
1  
Hsap\PDIA6
1 of 14
No
No
Hsap\PITHD1
1 of 14
No
No
1  
Hsap\TXNDC5
1 of 14
No
No
Hsap\TXNDC9
1 of 14
No
No
1  
Hsap\TXNDC12
1 of 14
No
Yes
Hsap\TXNDC15
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Txn1
11 of 14
Yes
Yes
Rnor\Txndc8
5 of 14
No
Yes
Rnor\Txn2
4 of 14
No
No
Rnor\Txndc2
4 of 14
No
Yes
Rnor\Txnl1
3 of 14
No
No
Rnor\Agr2
1 of 14
No
Yes
Rnor\Agr3
1 of 14
No
Yes
Rnor\Dnajc10
1 of 14
No
No
Rnor\Glrx3
1 of 14
No
No
Rnor\Glrx5
1 of 14
No
No
Rnor\Nme8
1 of 14
No
No
Rnor\Nxnl1
1 of 14
No
Yes
Rnor\Nxnl2
1 of 14
No
Yes
Rnor\Nxn
1 of 14
No
Yes
Rnor\Pdia3
1 of 14
No
No
Rnor\Pdia4
1 of 14
No
No
Rnor\Txndc5
1 of 14
No
No
Rnor\Txndc12
1 of 14
No
Yes
Rnor\Txndc15
1 of 14
No
No
Mus musculus (laboratory mouse) (20)
Mmus\Txn1
10 of 14
Yes
Yes
Mmus\Txndc8
5 of 14
No
Yes
Mmus\Txn2
4 of 14
No
No
Mmus\Txndc2
4 of 14
No
Yes
Mmus\Txnl1
3 of 14
No
No
Mmus\Nme8
2 of 14
No
No
Mmus\Agr2
1 of 14
No
Yes
Mmus\Agr3
1 of 14
No
Yes
Mmus\Dnajc10
1 of 14
No
No
Mmus\Glrx3
1 of 14
No
No
Mmus\Nme9
1 of 14
No
No
Mmus\Nxnl1
1 of 14
No
Yes
Mmus\Nxnl2
1 of 14
No
Yes
Mmus\Nxn
1 of 14
No
Yes
Mmus\Pdia3
1 of 14
No
No
Mmus\Pdia4
1 of 14
No
No
Mmus\Pithd1
1 of 14
No
No
Mmus\Txndc5
1 of 14
No
No
Mmus\Txndc12
1 of 14
No
Yes
Mmus\Txndc15
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\XB5909790
10 of 13
Yes
Yes
Xtro\LOC100498224
6 of 13
No
No
Xtro\txn
6 of 13
No
Yes
Xtro\LOC100498068
5 of 13
No
Yes
Xtro\XB5961763
4 of 13
No
Yes
Xtro\txn2
3 of 13
No
No
Xtro\ag1
1 of 13
No
Yes
Xtro\agr2
1 of 13
No
Yes
Xtro\agr3
1 of 13
No
Yes
Xtro\arcn1
1 of 13
No
No
Xtro\cblb
1 of 13
No
No
Xtro\glrx3
1 of 13
No
No
Xtro\glrx5
1 of 13
No
No
Xtro\LOC100497910
1 of 13
No
Yes
Xtro\nxnl1
1 of 13
No
Yes
Xtro\nxnl2
1 of 13
No
Yes
Xtro\nxn
1 of 13
No
Yes
Xtro\p4hb
1 of 13
No
No
Xtro\pdia3
1 of 13
No
No
Xtro\txndc5
1 of 13
No
No
Xtro\txndc15
1 of 13
No
No
Xtro\txnl1
1 of 13
No
No
Xtro\ulk4
1 of 13
No
Yes
Danio rerio (Zebrafish) (22)
Drer\txn
13 of 14
Yes
Yes
Drer\zgc:56493
13 of 14
Yes
Yes
Drer\txn2
4 of 14
No
No
Drer\txnl1
3 of 14
No
No
Drer\agr1
1 of 14
No
Yes
Drer\agr2
1 of 14
No
Yes
Drer\dnajc10
1 of 14
No
No
Drer\glrx3
1 of 14
No
No
Drer\nme9
1 of 14
No
No
Drer\nxn
1 of 14
No
Yes
Drer\nxnl1
1 of 14
No
Yes
Drer\nxnl2
1 of 14
No
Yes
Drer\pdia2
1 of 14
No
No
Drer\pdia3
1 of 14
No
No
Drer\pdia4
1 of 14
No
No
Drer\pdia6
1 of 14
No
No
Drer\pdia7
1 of 14
No
No
Drer\pdia8
1 of 14
No
No
Drer\pithd1
1 of 14
No
No
Drer\tmx3b
1 of 14
No
No
Drer\txndc5
1 of 14
No
No
Drer\txndc12
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (34)
Cele\trx-4
10 of 14
Yes
Yes
Cele\trx-1
7 of 14
No
No
Cele\Y55F3AR.2
6 of 14
No
Yes
Cele\trx-2
4 of 14
No
No
Cele\txl-1
3 of 14
No
No
Cele\png-1
2 of 14
No
No
Cele\W01B11.6
2 of 14
No
Yes
Cele\C14B9.2
1 of 14
No
No
Cele\C30H6.8
1 of 14
No
Yes
Cele\C32D5.8
1 of 14
No
Yes
Cele\C35B1.5
1 of 14
No
Yes
Cele\dnj-27
1 of 14
No
No
Cele\F10D7.3
1 of 14
No
No
Cele\F17B5.1
1 of 14
No
Yes
Cele\F29B9.5
1 of 14
No
Yes
Cele\glrx-3
1 of 14
No
No
Cele\glrx-5
1 of 14
No
No
Cele\pdi-1
1 of 14
No
No
Cele\pdi-2
1 of 14
No
No
Cele\pdi-3
1 of 14
No
No
Cele\pdi-6
1 of 14
No
No
Cele\R05H5.3
1 of 14
No
Yes
Cele\T05F1.11
1 of 14
No
Yes
Cele\T20D4.7
1 of 14
No
Yes
Cele\T28A11.13
1 of 14
No
Yes
Cele\trx-3
1 of 14
No
Yes
Cele\trx-5
1 of 14
No
Yes
Cele\txdc-12.1
1 of 14
No
Yes
Cele\txdc-12.2
1 of 14
No
Yes
Cele\Y49E10.4
1 of 14
No
No
Cele\Y52E8A.3
1 of 14
No
Yes
Cele\Y73B6BL.12
1 of 14
No
No
Cele\ZK353.9
1 of 14
No
No
Cele\ZK973.11
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (16)
Agam\TRX1
11 of 12
Yes
Yes
Agam\AgaP_AGAP012940
4 of 12
No
Yes
Agam\AgaP_AGAP012275
3 of 12
No
No
Agam\TRX2
3 of 12
No
No
Agam\TRX3
3 of 12
No
No
Agam\AgaP_AGAP005462
2 of 12
No
No
Agam\AgaP_AGAP000044
1 of 12
No
No
Agam\AgaP_AGAP001919
1 of 12
No
No
Agam\AgaP_AGAP002500
1 of 12
No
No
Agam\AgaP_AGAP003415
1 of 12
No
No
Agam\AgaP_AGAP007393
1 of 12
No
No
Agam\AgaP_AGAP008252
1 of 12
No
No
Agam\AgaP_AGAP010217
1 of 12
No
No
Agam\AgaP_AGAP010236
1 of 12
No
No
Agam\AgaP_AGAP010237
1 of 12
No
No
Agam\AgaP_AGAP012407
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (60)
Atha\TRX2
12 of 13
Yes
Yes
Atha\TRX1
11 of 13
No
Yes
Atha\TRX3
11 of 13
No
Yes
Atha\TRX5
11 of 13
No
Yes
Atha\ATTRX4
10 of 13
No
Yes
Atha\TH9
9 of 13
No
Yes
Atha\TH7
8 of 13
No
Yes
Atha\TH8
7 of 13
No
Yes
Atha\AT3G56420
6 of 13
No
Yes
Atha\CXXS1
6 of 13
No
Yes
Atha\CXXS2
5 of 13
No
Yes
Atha\ATHM2
4 of 13
No
No
Atha\TDX
4 of 13
No
No
Atha\THM1
4 of 13
No
No
Atha\THX
4 of 13
No
No
Atha\TO1
4 of 13
No
Yes
Atha\TO2
4 of 13
No
Yes
Atha\TRXF1
4 of 13
No
Yes
Atha\TRXF2
4 of 13
No
Yes
Atha\TRX-M4
4 of 13
No
No
Atha\TY1
4 of 13
No
No
Atha\ty2
4 of 13
No
No
Atha\ACHT1
3 of 13
No
Yes
Atha\ACHT2
3 of 13
No
Yes
Atha\ACHT3
3 of 13
No
Yes
Atha\ACHT4
3 of 13
No
Yes
Atha\ACHT5
3 of 13
No
Yes
Atha\AT3G04780
3 of 13
No
No
Atha\AT3G53220
3 of 13
No
Yes
Atha\TRX z
3 of 13
No
Yes
Atha\AT4G12170
2 of 13
No
No
Atha\ATHM3
2 of 13
No
No
Atha\CDSP32
2 of 13
No
Yes
Atha\HCF164
2 of 13
No
Yes
Atha\NTRC
2 of 13
No
Yes
Atha\TTL1
2 of 13
No
Yes
Atha\TTL2
2 of 13
No
Yes
Atha\TTL3
2 of 13
No
Yes
Atha\WCRKC1
2 of 13
No
Yes
Atha\WCRKC2
2 of 13
No
Yes
Atha\AT1G07700
1 of 13
No
Yes
Atha\AT1G52990
1 of 13
No
No
Atha\AT1G60420
1 of 13
No
Yes
Atha\AT2G25950
1 of 13
No
No
Atha\AT4G31240
1 of 13
No
Yes
Atha\AT4G32580
1 of 13
No
No
Atha\CXIP1
1 of 13
No
No
Atha\CXIP2
1 of 13
No
No
Atha\GRX4
1 of 13
No
No
Atha\GRXS17
1 of 13
No
No
Atha\PDIL1-1
1 of 13
No
No
Atha\PDIL1-2
1 of 13
No
No
Atha\PDIL1-3
1 of 13
No
No
Atha\PDIL1-4
1 of 13
No
No
Atha\PDIL2-2
1 of 13
No
No
Atha\PDIL2-3
1 of 13
No
No
Atha\PDIL5-1
1 of 13
No
No
Atha\PDIL5-2
1 of 13
No
No
Atha\TTL4
1 of 13
No
No
Atha\UNE5
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\TRX1
10 of 13
Yes
Yes
Scer\TRX2
10 of 13
Yes
Yes
Scer\TRX3
10 of 13
Yes
Yes
Scer\GRX3
1 of 13
No
No
Scer\GRX4
1 of 13
No
No
Scer\GRX5
1 of 13
No
No
Scer\PLP1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\trx1
10 of 12
Yes
Yes
Spom\trx2
6 of 12
No
No
Spom\txl1
2 of 12
No
No
Spom\grx4
1 of 12
No
No
Spom\SPAC1F5.02
1 of 12
No
No
Spom\SPAC17H9.14c
1 of 12
No
No
Spom\SPBP35G2.02
1 of 12
No
No
Escherichia coli (enterobacterium) (3)
Ecol\trxA
6 of 11
Yes
No
Ecol\cnoX
3 of 11
No
No
Ecol\trxC
3 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Trx2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
dhd
11 of 13
TrxT
11 of 13
CG13473
10 of 13
CG8517
5 of 13
CG8993
5 of 13
CG14221
4 of 13
Txl
4 of 13
CG3719
3 of 13
CG18130
3 of 13
CaBP1
1 of 13
CG6153
1 of 13
CG9302
1 of 13
ERp60
1 of 13
Grx3
1 of 13
Grx5
1 of 13
Pdi
1 of 13
prtp
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TXN; thioredoxin
    13 of 14
    187700
         
        TXNDC2; thioredoxin domain containing 2
        7 of 14
        617790
            TXNDC8; thioredoxin domain containing 8
            5 of 14
            617789
                TXN2; thioredoxin 2
                4 of 14
                609063
                TXNL1; thioredoxin like 1
                3 of 14
                603049
                     
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Show/hide secondary interactors 
                    (data from AllianceMine provided by esyN)
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Other Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Trx2 - AnxB10
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Ar1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Ar2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Arc1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG11267
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG14715
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG1532
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG18787
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG2852
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG6432
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG7049
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG8993
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - CG9391
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Calr
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Ccs
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Chd64
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Cyp1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Df31
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Eno
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Fkbp12
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Fkbp14
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Got1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - GstO3
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Gtpx
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - HINT1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Hpf1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Ipp
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Trx2 - Mdh2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - NO66
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Trx2 - Nacα
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Nlp
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Ntf-2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - PCNA
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Pdi
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Prx6c
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Rae1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - RpS21
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Sh3β
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Sod1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Sumo
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Treh
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Trxr1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Uch
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Uev1A
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - Wdr82
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - awd
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - cib
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - fabp
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - narya
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - rdhB
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - regucalcin
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - rhi
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - scu
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Trx2 - αTry
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Show/hide secondary interactors 
                    (data from AllianceMine provided by esyN)
                    esyN Network Key:
                    Suppression
                    Enhancement
                    Other Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    AIF
                    suppressible
                    Trx2
                    (Joza et al., 2008)
                    ct
                    suppressible
                    Trx2
                    (Krupp et al., 2005)
                    External Data
                    Subunit Structure (UniProtKB)
                    Monomer.
                    (UniProt, Q9V429 )
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                    External Data
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2L
                    Recombination map
                    2-36
                    Cytogenetic map
                    30C1-30C1
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    30C1-30C1
                    Limits computationally determined from genome sequence between P{EP}Oatp30BEP890 and P{EP}EP361&P{EP}peloEP2160
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    2-36

                    (FlyBase, 2016)

                    2-31.3

                    (Comeron et al., 2012)

                    2-

                    (Seong, 2000.1.3)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (15)
                    Genomic Clones (14)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (71)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          Trx-2, not dhd, is the substrate of Jafrac1.

                          (Bauer et al., 2002)

                          Area matching Drosophila ESTS AA736186 and AA801973. Thses ESTs have sequence similarity to Thioredoxin genes.

                          (Davies, 2001.3.15)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: thioredoxin CG3864

                          (Bayraktaroglu, 2000.8.7)

                          Source for merge of: Trx-2 anon-WO0118547.188

                          (FlyBase, 1996-)
                          Additional comments

                          Source for merge of Trx-2 anon-WO0118547.188 was sequence comparison ( date:051113 ).

                          (FlyBase, 1996-)
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Trx2 Trx-2

                          (FlyBase, 2009-)
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (18)
                          Reported As
                          Symbol Synonym
                          31884
                          (Ravi et al., 2009)
                          CG31884
                          (National Institute of Genetics Fly Stocks, 2022-, Choo et al., 2015, Kim et al., 2015, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Joza et al., 2008)
                          CG3864
                          (Asha et al., 2003, Seong et al., 2001)
                          DTrx-2
                          (Song et al., 2007)
                          DmTrx-2
                          (Huang et al., 2008, Huang et al., 2008, Joza et al., 2008, Cheng et al., 2007, Jacob et al., 2005, Bauer et al., 2003)
                          DmelTrx-2
                          (Svensson et al., 2007)
                          TRX2
                          (Emelyanov and Fyodorov, 2016)
                          Trx
                          (Wahl et al., 2005)
                          Trx-2
                          (AlOkda and Van Raamsdonk, 2023, Sebastian et al., 2022, Girard et al., 2021, Uçkun et al., 2021, Jeon et al., 2020, Kockel et al., 2019, Levis, 2018.8.30, Oberacker et al., 2018, Petrova et al., 2018, Hu et al., 2017.6.13, Aradska et al., 2015, Choo et al., 2015, Kim et al., 2015, Chen et al., 2014, Luck et al., 2014, Hung et al., 2013, Pezzulo et al., 2012, Wang et al., 2012, Tsuda et al., 2010, Bartkuhn et al., 2009, Levis, 2009.3.18, List et al., 2009, Jin et al., 2008, Svensson and Larsson, 2007, Svensson et al., 2007, Umeda-Kameyama et al., 2007, Greene et al., 2005, Girardot et al., 2004, Stanyon et al., 2004, Svensson et al., 2003)
                          Trx2
                          (Tsuji et al., 2024, Mondal and Singh, 2022, Sakakibara et al., 2018)
                          anon-WO0118547.188
                          dmtrx-2
                          (Bauer et al., 2002)
                          trx-2
                          (Petrova et al., 2018)
                          Name Synonyms
                          Thioredoxin 2
                          Thioredoxin-2
                          (Worley and Hariharan, 2022, Svensson and Larsson, 2007, Svensson et al., 2007, Greene et al., 2005)
                          thioredoxin
                          (Huang et al., 2008, Cheng et al., 2007, Song et al., 2007, Alfonso and Jones, 2002, Jasper et al., 2002, Kammerer and Giangrande, 2001)
                          thioredoxin 2
                          (Emelyanov and Fyodorov, 2016)
                          thioredoxin-2
                          (Kim et al., 2015, Zhan et al., 2013, Cammarato et al., 2011, Bauer et al., 2002)
                          Secondary FlyBase IDs
                          • FBgn0032134
                          • FBgn0051884
                          • FBgn0062183
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 62 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          PDB - An information portal to biological macromolecular structures
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                          References (97)