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Gene Dmel\primo-1

General Information
Symbol	Dmel\primo-1	Species	D. melanogaster
Name	primo-1	Annotation symbol	CG33748
Feature type	protein_coding_gene	FlyBase ID	FBgn0040077
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	87F12-87F12	Sequence location	3R:9,535,748..9,537,557 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene primo-1 is referred to in FlyBase by the symbol Dmel\primo-1 (CG33748, FBgn0040077). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine phosphatase activity; acid phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein dephosphorylation. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Phosphotyrosine protein phosphatase I superfamily; Protein-tyrosine phosphatase, low molecular weight; Protein-tyrosine phosphatase, low molecular weight, mammalian; Protein-tyrosine phosphatase/arsenate reductase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638265_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of primo-2 expression signal. See the GBrowse view of primo-2 to determine the overlapping gene(s). Gene sequence location is 3R:9535748..9537557.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F12-87F12   Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\primo-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722 Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) primo-1-RA FBtr0091747  NM_001032016   1327   155 primo-1-RB FBtr0091748  NM_001032015   767   155
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Miller et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein primo-1-PA   FBpp0099893   17.6   155   7.35     NP_001027187   AAN13591 primo-1-PB   FBpp0099895   17.6   155   7.35     NP_001027186   AAO41564
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	A 155 amino acid protein is predicted, but the mRNA may be longer at the 5' end. (Miller et al., 2000)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase/arsenate reductase (IPR000106) Protein-tyrosine phosphatase, low molecular weight, mammalian (IPR002115) Protein-tyrosine phosphatase, low molecular weight (IPR017867) Phosphotyrosine protein phosphatase I superfamily (IPR023485)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAN13591   AE014297 AAO41564   AY232144   BE977060   BE978833   BF490100   BF498766   BF506766   BT120134   CO181966   EV582745
UniProtKB/Swiss-Prot	P82890
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference larval stage     (Miller et al., 2000) pupal stage     (Miller et al., 2000) pupal stage P6   primary pigment cell   (Miller et al., 2000) Comment:24 hr APF pharate adult stage P8   cone cell   (Miller et al., 2000) Comment:48 hr APF primary pigment cell   (Miller et al., 2000) Comment:48 hr APF adult stage     (Miller et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040077    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040077 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040077 expression level Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2041) embryo 02-04hr  (1440) embryo 04-06hr  (1255) embryo 06-08hr  (909) embryo 08-10hr  (715) embryo 10-12hr  (888) embryo 12-14hr  (516) embryo 14-16hr  (549) embryo 16-18hr  (477) embryo 18-20hr  (538) embryo 20-22hr  (712) embryo 22-24hr  (603) larva L1  (1176) larva L2  (1826) larva L3 12hr old  (1850) larva L3 puffstage 1-2  (1545) larva L3 puffstage 3-6  (1582) larva L3 puffstage 7-9  (1552) white prepupae new  (1316) white prepupae 12hr  (1722) white prepupae 24hr  (2297) pupae 2d postWPP  (2665) pupae 3d postWPP  (2572) pupae 4d postWPP  (2278) adult male 01day  (3800) adult male 05day  (4819) adult male 30day  (4643) adult female 01day  (1525) adult female 05day  (1751) adult female 30day  (1848) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2041) embryo 02-04hr  1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2  (1826) larva L3 12hr old  (1850) larva L3 puffstage 1-2  (1545) larva L3 puffstage 3-6  (1582) larva L3 puffstage 7-9  (1552) white prepupae new    1316 white prepupae 12hr  (1722) white prepupae 24hr  (2297) pupae 2d postWPP  (2665) pupae 3d postWPP  (2572) pupae 4d postWPP  (2278) adult male 01day  (3800) adult male 05day  (4819) adult male 30day  (4643) adult female 01day  (1525) adult female 05day  (1751) adult female 30day  (1848) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040077 expression level Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2041) embryo 02-04hr  (1440) embryo 04-06hr  (1255) embryo 06-08hr  (909) embryo 08-10hr  (715) embryo 10-12hr  (888) embryo 12-14hr  (516) embryo 14-16hr  (549) embryo 16-18hr  (477) embryo 18-20hr  (538) embryo 20-22hr  (712) embryo 22-24hr  (603) larva L1  (1176) larva L2  (1826) larva L3 12hr old  (1850) larva L3 puffstage 1-2  (1545) larva L3 puffstage 3-6  (1582) larva L3 puffstage 7-9  (1552) white prepupae new  (1316) white prepupae 12hr  (1722) white prepupae 24hr  (2297) pupae 2d postWPP  (2665) pupae 3d postWPP  (2572) pupae 4d postWPP  (2278) adult male 01day  (3800) adult male 05day  (4819) adult male 30day  (4643) adult female 01day  (1525) adult female 05day  (1751) adult female 30day  (1848) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2041 embryo 02-04hr  1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2  1826 larva L3 12hr old  1850 larva L3 puffstage 1-2  1545 larva L3 puffstage 3-6  1582 larva L3 puffstage 7-9  1552 white prepupae new    1316 white prepupae 12hr  1722 white prepupae 24hr  2297 pupae 2d postWPP  (2665) pupae 3d postWPP  (2572) pupae 4d postWPP  2278 adult male 01day  (3800) adult male 05day  (4819) adult male 30day  (4643) adult female 01day  1525 adult female 05day  1751 adult female 30day  1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2041 embryo 02-04hr    1440 embryo 04-06hr    1255 embryo 06-08hr    909 embryo 08-10hr    715 embryo 10-12hr    888 embryo 12-14hr    516 embryo 14-16hr    549 embryo 16-18hr    477 embryo 18-20hr    538 embryo 20-22hr    712 embryo 22-24hr    603 larva L1    1176 larva L2    1826 larva L3 12hr old    1850 larva L3 puffstage 1-2    1545 larva L3 puffstage 3-6    1582 larva L3 puffstage 7-9    1552 white prepupae new    1316 white prepupae 12hr    1722 white prepupae 24hr    2297 pupae 2d postWPP    2665 pupae 3d postWPP    2572 pupae 4d postWPP    2278 adult male 01day    3800 adult male 05day    4819 adult male 30day    4643 adult female 01day    1525 adult female 05day    1751 adult female 30day    1848 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040077    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040077 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040077 expression level Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis  (544.7) Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040077 expression level Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis  544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    165.975 Larval Midgut    106.4 Larval Hindgut    224.9 Larval Malpighian Tubules    187.4 Larval Fat Body    298.8 Larval Salivary Gland    134.7 Larval Trachea    261.125 Larval Carcass    206.7 Adult Head    374.8 Adult Eye    316.175 Adult Brain    312.7 Adult Thoracic-Abdominal Ganglion    374.1 Adult Crop    333.6 Adult Midgut    257.7 Adult Hindgut    406.7 Adult Malpighian Tubules    272 Adult Fat Body    213.9 Adult Salivary Gland    262.2 Adult Heart    229.375 Adult VirginFemale Spermatheca    312.8 Adult InseminatedFemale Spermatheca    312.7 Adult Ovary    333.4 Adult Testis    544.7 Adult Male Accessory Gland    287.6 Adult Carcass    236.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    374.8   NA  Eye    316.175   NA  Brain    312.7   165.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    374.1   NA  Crop    333.6   106.4  Midgut    257.7   224.9  Hindgut    406.7   187.4  Malpighian Tubules    272   298.8  Fat Body    213.9   134.7  Salivary Gland    262.2   NA  Heart    229.375   261.125  Trachea    NA   NA  VirginFemale Spermatheca    312.8   NA  InseminatedFemale Spermatheca    312.7   NA  Ovary    333.4   NA  Testis    544.7   NA  Male Accessory Gland    287.6   206.7  Carcass    236.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040077
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable primo-1f03836 Sterility Allele fertile primo-1f03836 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of primo-1 Class Mutagen Stocks Known lesion primo-1f03836 piggyBac transposase 2 Yes primo-1EY21742 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of primo-1 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}primo-1f03836 NA insertion of mobile activating element P{EPgy2}primo-2EY21742 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
acid phosphatase activity inferred from electronic annotation with InterPro:IPR002115 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) non-membrane spanning protein tyrosine phosphatase activity inferred from electronic annotation with InterPro:IPR002115 (FlyBase Curators et al., 2004-) protein tyrosine phosphatase activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from sequence or structural similarity with EMBL:Y17344 (FlyBase, 1992-) inferred from sequence or structural similarity with rat Acp1 (Curators, 2008--) inferred from sequence or structural similarity with Saccharomyces LTP1 (Curators, 2008--) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from sequence or structural similarity with EMBL:AY039215 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR002115 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions primo-1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0040077 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772179
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18147 Dere\GG17025 Dgri\GH14046 Dmoj\GI24420 Dper\GL24448 Dpse\GA16170 Dsec\GM25909 Dsim\GD20477 Dvir\GJ14279 Dwil\GK13063 Dyak\primo-1
Curated drosophilid orthologs	Dpse\GA16170   Dyak\primo-1
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003165-PA Aedes aegypti (mosquito) AGAP004079-PA Anopheles gambiae (mosquito) 85660 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA003637-PA Bombyx mori (silk worm) ENSBTAP00000027314 Bos taurus (bovine) CAL0002489 Candida albicans (a form of yeast) CN15014 Caenorhabditis brenneri (small nematode) CE43089 Caenorhabditis elegans (worm) CAGL0D01320g Candida glabrata (haploid yeast) ENSCINP00000026582 Ciona intestinalis (sea squirt) ENSCINP00000028937 Ciona intestinalis (sea squirt) CME061C Cyanidioschyzon merolae (red alga) cn02212 Cryptococcus neoformans (yeast-like fungus) CPIJ008291 Culex pipens (mosquito) ENSCPOP00000002601 Cavia porcellus (guinea pig) ENSCSAVP00000006550 Ciona savignyi (sedentary tunicate) 18659 Capitella spl (polychaete worm) DDB0266663 Dictyostelium discoideum (amoeba) DEHA2F04026g Debaryomyces Hansenii (yeast) 188255 Daphnia pulex (daphnia) ENSECAP00000008037 Equus caballus (horse) NP_415502.4 Escherichia coli K12 (bacteria) NP_416565.1 Escherichia coli K12 (bacteria) XP_653357 Entamoeba histolytica (anaerobic protozoan) XP_656359 Entamoeba histolytica (anaerobic protozoan) ENSGALP00000026345 Gallus gallus (chicken) ENSP00000272065 Homo sapiens (human) KLLA0B09174g Kluyveromyces lactis (yeast) 205193 Lottia gigantea (owl limpet) ENSMMUP00000022496 Macaca mulatta (rhesus monkey) ENSMUSP00000106509 Mus musculus (house mouse) ENSOANP00000003596 Ornithorynchus anatinus (platypus) PHUM003678-PA Pediculus humanus (human body louse) 119767 Physcomitrella patens (moss) ENSPPYP00000014169 Pongo pygmaeus (orangutan) 71541 Phytophthora ramorum (sudden oak death pathogen) 108262 Phytophthora sojae (root rot pathogen) ENSPTRP00000019951 Pan troglodytes (chimpanzee) ENSRNOP00000007287 Rattus norvegicus (norway rat) YPR073C Saccharomyces cerevisiae (budding yeast) SPAC1071.12c Schizosaccharomyces pombe (fission yeast) XP_796467.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015204 Tetraodon nigroviridis (green spotted pufferfish) 86141.m00119 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12008 NV11881 LH14423 ISCW015645 ISCW015354 FBgn0241535 FBgn0067937 FBgn0215072 FBgn0215069 FBgn0201494 FBgn0201493 FBgn0191947 FBgn0191948 FBgn0180765 FBgn0180764 JGI_V11_188255 FBgn0076186 FBgn0162037 FBgn0147142 FBgn0147143 FBgn0040076 FBgn0121522 FBgn0121521 FBgn0109253 FBgn0109252 FBgn0095164 FBgn0095165 CPIJ008291 BGIBMGA003637 ACYPI006806 GB16933 AGAP004079 AAEL003165 PB26039 PHUM447820 GLEAN_02004
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	18699 w1118; PBac{WH}primo-1f03836 primo-2f03836 22499 y1 w67c23; P{EPgy2}primo-2EY21742 primo-1EY21742
Harvard	- PBac{WH}primo-1f03836
Genomic Clones ( 2 )
	BACR03J04 BACR30G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT28881
Other clones	TA01420 yak-ad_primo
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09335 AT13237 AT26384
Other clones	bs59d02 bs83d09 Dmel_dig_006823_0706_3741 EC17588
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040077 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318675 3772179
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: primo-1 CG9599 (Bayraktaroglu, 2000.11.2)
Additional comments	Dicistronic annotation CG31311 split out into separate annotations for each open reading frame, CG33747 and CG33748, in release 4.2 of the genome annotation. CG33747 corresponds to primo-2 and CG33748 corresponds to primo-1. (FlyBase Genome Annotators, 2005) Annotation CG9599 split into CG31469, CG31311 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by primo-2 and primo-1. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001032015 NM_001032016 RefSeq (Proteins) • NP_001027186 NP_001027187 DDBJ / EMBL / GenBank • AAF54981.3 AAN13590.2 AAN13591 AAN13591.2 AAO41564 AAO41564.1 AAO41565 AAO41565.1 AY089477 Entrez Gene - A searchable database of RefSeq genes. • 3772179 UniProtKB/Swiss-Prot • P82890
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase/arsenate reductase (IPR000106) Protein-tyrosine phosphatase, low molecular weight, mammalian (IPR002115) Protein-tyrosine phosphatase, low molecular weight (IPR017867) Phosphotyrosine protein phosphatase I superfamily (IPR023485)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0040077 DRSC - Results from RNAi screens. • FBgn0040077 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040077 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040077 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318675 3772179 InParanoid A subset of ortholog calls from InParanoid. • AAEL003165-PA Aedes aegypti (mosquito) AGAP004079-PA Anopheles gambiae (mosquito) 85660 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA003637-PA Bombyx mori (silk worm) ENSBTAP00000027314 Bos taurus (bovine) CAL0002489 Candida albicans (a form of yeast) CN15014 Caenorhabditis brenneri (small nematode) CE43089 Caenorhabditis elegans (worm) CAGL0D01320g Candida glabrata (haploid yeast) ENSCINP00000026582 Ciona intestinalis (sea squirt) ENSCINP00000028937 Ciona intestinalis (sea squirt) CME061C Cyanidioschyzon merolae (red alga) cn02212 Cryptococcus neoformans (yeast-like fungus) CPIJ008291 Culex pipens (mosquito) ENSCPOP00000002601 Cavia porcellus (guinea pig) ENSCSAVP00000006550 Ciona savignyi (sedentary tunicate) 18659 Capitella spl (polychaete worm) DDB0266663 Dictyostelium discoideum (amoeba) DEHA2F04026g Debaryomyces Hansenii (yeast) 188255 Daphnia pulex (daphnia) ENSECAP00000008037 Equus caballus (horse) NP_415502.4 Escherichia coli K12 (bacteria) NP_416565.1 Escherichia coli K12 (bacteria) XP_653357 Entamoeba histolytica (anaerobic protozoan) XP_656359 Entamoeba histolytica (anaerobic protozoan) ENSGALP00000026345 Gallus gallus (chicken) ENSP00000272065 Homo sapiens (human) KLLA0B09174g Kluyveromyces lactis (yeast) 205193 Lottia gigantea (owl limpet) ENSMMUP00000022496 Macaca mulatta (rhesus monkey) ENSMUSP00000106509 Mus musculus (house mouse) ENSOANP00000003596 Ornithorynchus anatinus (platypus) PHUM003678-PA Pediculus humanus (human body louse) 119767 Physcomitrella patens (moss) ENSPPYP00000014169 Pongo pygmaeus (orangutan) 71541 Phytophthora ramorum (sudden oak death pathogen) 108262 Phytophthora sojae (root rot pathogen) ENSPTRP00000019951 Pan troglodytes (chimpanzee) ENSRNOP00000007287 Rattus norvegicus (norway rat) YPR073C Saccharomyces cerevisiae (budding yeast) SPAC1071.12c Schizosaccharomyces pombe (fission yeast) XP_796467.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000015204 Tetraodon nigroviridis (green spotted pufferfish) 86141.m00119 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772179 modMine - Data generated by the modENCODE project. • FBgn0040077 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12008 NV11881 LH14423 ISCW015645 ISCW015354 FBgn0241535 FBgn0067937 FBgn0215072 FBgn0215069 FBgn0201494 FBgn0201493 FBgn0191947 FBgn0191948 FBgn0180765 FBgn0180764 JGI_V11_188255 FBgn0076186 FBgn0162037 FBgn0147142 FBgn0147143 FBgn0040076 FBgn0121522 FBgn0121521 FBgn0109253 FBgn0109252 FBgn0095164 FBgn0095165 CPIJ008291 BGIBMGA003637 ACYPI006806 GB16933 AGAP004079 AAEL003165 PB26039 PHUM447820 GLEAN_02004
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG9599 (Morrison et al., 2000, ) CG31311   CG33748   LMW-PTP (Morrison et al., 2000) primo (Miller et al., 2000) primo-1
Name Synonym	primo-1
Secondary FlyBase IDs
	FBgn0038174 FBgn0051311 FBgn0053748 FBpp0082304 FBpp0082305 FBpp0082306 FBpp0082307 FBpp0082308 FBtr0082839 FBtr0082840 FBtr0082841 FBtr0082842 FBtr0082843
References ( 14 )
Research paper	Miller et al., 2000, Gene 243(1-2): 1--9 The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. [FBrf0125124]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Morrison et al., 2000, J. Cell Biol. 150(2): Table S1. Drosophila protein kinases and phosphatases. [FBrf0132098]
Personal communication to FlyBase	Bellen, 2006.8.3, MBBatch686_2.xml MBBatch686_2.xml [FBrf0191805] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Bayraktaroglu, 2000.11.2, Current list of possibly CG-able known genes. Current list of possibly CG-able known genes. [FBrf0131225]
FlyBase analysis	Curators, 2008--, Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. [FBrf0202953] FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. [FBrf0182792] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: P82890 LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE 1 (EC 3.1.3.48) (LOW MOLECULAR WEIGHT CYTOSOLIC ACID PHOSPHATASE 1) (EC 3.1.3.2) (PTPASE 1). [FBrf0136591]
Curated genome annotation	Dunn, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126662]