Gene Dmel\pkaap

FlyGene Wiki Help Close All Open All

General Information

Symbol

Dmel\pkaap

Species

D. melanogaster

Name

pkaap

Annotation symbol

CG4132

Feature type

protein_coding_gene

FlyBase ID

FBgn0040079

Gene Model Status

Current

Stock availability

4 publicly available

Also Known As

BG:DS02740.4, DS02740.4

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

35F1-35F1

Sequence location

2L:16,288,292..16,291,197 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene pkaap is referred to in FlyBase by the symbol Dmel\pkaap (CG4132, FBgn0040079). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase A binding. Based on sequence similarity, it is predicted to be involved in the biological process: protein localization. 5 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Regulator of G protein signalling; Regulator of G protein signalling superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult hindgut, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640818_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of pkaap. Gene sequence location is 2L:16288292..16291197.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35F1-35F1

Limits computationally determined from genome sequence between P{EP}crp^EP721&P{lacW}crp^k07829 and P{lacW}heix^k11403&P{lacW}heix^k12401

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\pkaap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

pkaap-RA

FBtr0080826

NM_135939

2439

622

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

pkaap-PA

FBpp0080384

69.7

622

5.56

NP_609783

AAF53511

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Regulator of G protein signalling (IPR000342)

Regulator of G protein signalling superfamily (IPR016137)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult hindgut, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		150.45
Larval Midgut		26.3
Larval Hindgut		98.8
Larval Malpighian Tubules		28.8
Larval Fat Body		61.9
Larval Salivary Gland		98.3
Larval Trachea		282.825
Larval Carcass		120.8
Adult Head		148.2
Adult Eye		90.125
Adult Brain		252
Adult Thoracic-Abdominal Ganglion		360.2
Adult Crop		105.7
Adult Midgut		35.5
Adult Hindgut		102.1
Adult Malpighian Tubules		35.9
Adult Fat Body		81.3
Adult Salivary Gland		120.9
Adult Heart		78
Adult VirginFemale Spermatheca		119.3
Adult InseminatedFemale Spermatheca		132.7
Adult Ovary		188.7
Adult Testis		55.6
Adult Male Accessory Gland		62.9
Adult Carcass		140.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	148.2
NA	Eye	90.125
NA	Brain	252
150.45	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	360.2
NA	Crop	105.7
no informative data	Midgut	no informative data
98.8	Hindgut	102.1
28.8	Malpighian Tubules	35.9
61.9	Fat Body	81.3
98.3	Salivary Gland	120.9
NA	Heart	78
282.825	Trachea	NA
NA	VirginFemale Spermatheca	119.3
NA	InseminatedFemale Spermatheca	132.7
NA	Ovary	188.7
NA	Testis	55.6
NA	Male Accessory Gland	62.9
120.8	Carcass	140.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		(30)
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		9
central nervous system, pupae P8		8
head, virgin 1-day female		11
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		9
head, mated 4-day female		9
head, mated 20-day female		8
head, mated 1-day male		15
head, mated 4-day male		15
head, mated 20-day male		20
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		4
digestive system, 1-day adult		3
digestive system, 4-day adult		4
digestive system, 20-day adult		3
fat body, larvae L3 wandering		2
fat body, white prepupae		5
fat body, pupae P8		8
carcass, larvae L3 wandering		9
carcass, 1-day adult		9
carcass, 4-day adult		11
carcass, 20-day adult		9
ovary, virgin 4-day female		30
ovary, mated 4-day female		25
testis, mated 4-day male		7
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		26
embryo 02-04hr		12
embryo 04-06hr		15
embryo 06-08hr		16
embryo 08-10hr		18
embryo 10-12hr		22
embryo 12-14hr		24
embryo 14-16hr		23
embryo 16-18hr		16
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		9
larva L1		7
larva L2		10
larva L3 12hr old		6
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		9
larva L3 puffstage 7-9		9
white prepupae new		11
white prepupae 12hr		15
white prepupae 24hr		11
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		6
adult male 01day		10
adult male 05day		11
adult male 30day		10
adult female 01day		13
adult female 05day		20
adult female 30day		20
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(28)
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		(36)
wing disc ML-DmD21		11
wing disc ML-DmD32		(34)
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		(45)
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		(36)
wing disc ML-DmD21		11
wing disc ML-DmD32		(34)
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		(45)
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		28
Schneider line 2 Sg4		13
embryonic 1182-4H		25
embryonic GM2		19
embryonic Kc167		26
embryonic S1		18
embryonic S3		11
leg disc CME L1		17
wing disc CME-W2		10
wing disc ML-DmD8		9
wing disc ML-DmD9		23
wing disc ML-DmD16-c3		36
wing disc ML-DmD21		11
wing disc ML-DmD32		34
haltere disc ML-DmD17-c3		9
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		13
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		19
CNS ML-DmBG2-c2		19
tumorous blood cells mbn2		45
ovary fGS/OSS		16
ovary OSC		10
ovary OSS		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		8
cold shock, 4-day adult		6
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		20
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		3
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		19
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		18
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		18
Paraquat 10 mM 48 hrs, 4-day adult		16
Rotenone 2 μg 12 hrs, larvae L3		5
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0040079

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4132-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

pkaap^GD11225

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

pkaap^GD11225

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

pkaap^GD11225

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of pkaap	Class	Mutagen	Stocks	Known lesion
pkaap^e04176		piggyBac transposase	1	--
pkaap^MI01306			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of pkaap	Mutagen	Stocks	Known lesion
pkaap^GD11225	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
pkaap^KK102636	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
pkaap^t16.6	in vitro construct - genomic fragment	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11225}

P{KK102636}

characterization construct

P{pkaap^t16.6}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

Mi{MIC}pkaap^MI01306

PBac{RB}pkaap^e04176

insertion of mobile activating element

P{GSV1}C17^C17

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

protein kinase A binding

inferred from sequence or structural similarity with EMBL:AF037439

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

protein localization

inferred from sequence or structural similarity with EMBL:AF037439

(FlyBase, 1992-)

termination of G-protein coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000342, InterPro:IPR016137

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

pkaap allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0040079

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

34957

Orthologs

OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6575SF

Dipteran inclusive ortholog search

EOG6575G2

Insect inclusive ortholog search

EOG6PC8N8

Arthropod inclusive ortholog search

EOG6RN8QM

Metazoa inclusive ortholog search

EOG6MSRR7

Orthologs in Drosophila Species (EOG6575SF)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17978

Drosophila persimilis

Dper\GL16288

Drosophila willistoni

Dwil\GK24286

Drosophila virilis

Dvir\GJ10586

Drosophila mojavensis

Dmoj\GI17071

Drosophila grimshawi

Dgri\GH10310

Orthologs in non-Drosophila Dipterans (EOG6575G2)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007843

Anopheles gambiae

Malaria mosquito

Agam\AGAP007895

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ801777

Orthologs in non-Dipteran Insects (EOG6PC8N8)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB44662

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG018536

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH12165

Atta cephalotes

Leafcutter ant

Acep\ACEP18049

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO19801

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL15027

Linepithema humile

Argentine ant

Lhum\LH24734

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB24449

Solenopsis invicta

Red fire ant

Sinv\SINV18492

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003706

Bombyx mori

Silkmoth

Bmor\BGIBMGA006790

Pediculus humanus

Human body louse

Phum\PHUM233000

Tribolium castaneum

Red flour beetle

Tcas\TC012804

Orthologs in non-Insect Arthropods (EOG6RN8QM)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\Mid2

Ixodes scapularis

Deer tick

Isca\ISCW000072

Orthologs in non-Arthropod Metazoa (EOG6MSRR7)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\rgs-5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_004268gn

Danio rerio

Zebrafish

Drer\akap10

Xenopus tropicalis

Western clawed frog

Xtro\akap10

Gallus gallus

Domestic chicken

Ggal\AKAP10

Mus musculus

House mouse

Mmus\Akap10

Rattus norvegicus

Norway rat

Rnor\Akap10

Homo sapiens

Human

Hsap\AKAP10

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\AKAP10

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17978

Drosophila persimilis

Dper\GL16288

Drosophila willistoni

Dwil\GK24286

Drosophila virilis

Dvir\GJ10586

Drosophila mojavensis

Dmoj\GI17071

Drosophila grimshawi

Dgri\GH10310

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

32746

y¹ w^*; Mi{MIC}pkaap^MI01306

v106808

v21792

w¹¹¹⁸; P{GD11225}v21792/TM3

Genomic Clones ( 1 )

BACR01N08

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 50 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones