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Gene Dmel\raps

General Information
Symbol	Dmel\raps	Species	D. melanogaster
Name	rapsynoid	Annotation symbol	CG5692
Feature type	protein_coding_gene	FlyBase ID	FBgn0040080
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Pins, rad
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98A8-98A8	Sequence location	3R:23,408,562..23,412,098 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rapsynoid is referred to in FlyBase by the symbol Dmel\raps (CG5692, FBgn0040080). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: establishment of mitotic spindle orientation; neuroblast proliferation; asymmetric neuroblast division; establishment of spindle orientation; asymmetric cell division. 25 alleles are reported. The phenotypes of these alleles are annotated with: anatomical structure; multicellular structure; organelle; organ system; embryonic/larval neuron; organ system subdivision; intracellular organelle part; spindle; stem cell; eo support cell; centrosome. It has one annotated transcript and one annotated polypeptide. Protein features are: GoLoco motif; Tetratricopeptide repeat; Tetratricopeptide repeat-containing domain; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639984_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of raps. Gene sequence location is 3R:23408562..23412098.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98A8-98A8   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98A-98B     (Schaefer, 2000.3.6) 98A-98B     (Parmentier, 2000.2.15) 98A-98B     (Yu, 2000.1.31)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\raps for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) raps-RA FBtr0085189  NM_080260   3279   658
Additional Transcript Data & Comments
Reported size (kB)	3.3 (northern blot) (Yu et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein raps-PA   FBpp0084559   71.5   658   6.73     NP_524999   AAF56721
Additional Polypeptide Data & Comments
Reported size (kDa)	658 (aa); 72 (kD predicted) (Yu et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GoLoco motif (IPR003109) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Tetratricopeptide repeat (IPR019734)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141339   AA201866   AA201963   AA246454   AA246483   AA246961   AA263406   AA264779   AA264941   AA391174   AA438798   AA439647   AA441535   AA538796   AA539912   AA540075   AA540752   AA695130   AA736057   AA950460   AA979142   AA979309   AE014297 AAF56721   AF230071 AAF36967   AF242203 AAF64499   AI405187   AI455854   AI518275   AI519893   AI520272   AJ272067 CAB75734   AQ254704   AW943195   AY094817 AAM11170   BI168474   BI168532   BI231660   BI234458   BI234624   BI234736   BI239201   BI240700   BI362717   BI362726   BI366232   BI367135   BI367178   BI368454   BI370260   BI484306   BI580665   BI635921   BI638936   BT003523 AAO39527   CO273333   CO273424   CO274767   CO290444   CO293542   CO294845   CO296452   CO299892   CO305730   CO310139   CO321596   CO324688   CO325524   CO325765   CO325987   CZ470949   EC063466   EC072105   EC077399   EC083394   EC087494   EC199118   EC199777   EC204274   EC212604   EC220820   EC222211   EC223959   EC230823   EC232877   EC247465   EC257915   GH749901   GH751121   GH751530   GH751648   GH751859   GH753107   GH759533   GH770295   GH781984   GH787900   GH793843   GH795938   GH797020   GH797272   GH797292   GH797737   GH798840   GH799042   GH801469   GH804430   GH817265   GH824924   GH827748   GH828636   GH837054   GH838199   GH838498   GH852409   GH853287   GH858144   GH859496   GH860149   GH878017   GH880537   GH881143   GH888046   GH890402   GH890966   GH894418   GH894901   GH899079   GH900836   GH900862   GH912378   GH920730   GH921613   GH928037   GH929007   GH929128   GH934575
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VB22 Q9NH88 Q9NFR7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 5   epithelial cell   • centrosome & spindle microtubule (Lecuyer et al., 2007) epithelium   • centrosome & spindle microtubule (Lecuyer et al., 2007) embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   mitotic domain 9   (Yu et al., 2000) neuroblast   (Yu et al., 2000) neuroblast MP2 | apical   • apical cortex (Rath et al., 2002)
Additional Descriptive Data
	raps is observed as a crescent in the apical cortex in neuroblasts after delamination. It is also observed in cortical crescents in the dividing cells of procephalic mitotic domain 9. (Yu et al., 2000)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005, Nipper et al., 2007, Yu et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    93.8   NA  Eye    99.95   NA  Brain    172.6   468.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    129.4   NA  Crop    152.2   224.2  Midgut    129.1   323  Hindgut    134.2   63.9  Malpighian Tubules    64.1   101.4  Fat Body    95   169.6  Salivary Gland    174.1   NA  Heart    115.35   192.775  Trachea    NA   NA  VirginFemale Spermatheca    177.2   NA  InseminatedFemale Spermatheca    188   NA  Ovary    238.1   NA  Testis    35.6   NA  Male Accessory Gland    92.2   121.675  Carcass    56.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (36) ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (36) ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    22 central nervous system, pupae P8    15 head, virgin 1-day female    6 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    15 carcass, larvae L3 wandering    13 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    36 ovary, mated 4-day female    24 testis, mated 4-day male    8 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr  (85) embryo 04-06hr  (66) embryo 06-08hr  (63) embryo 08-10hr  (58) embryo 10-12hr  (56) embryo 12-14hr  (38) embryo 14-16hr  (39) embryo 16-18hr  (32) embryo 18-20hr    25 embryo 20-22hr  (41) embryo 22-24hr  (34) larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day  (30) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (60) embryo 02-04hr  (85) embryo 04-06hr  (66) embryo 06-08hr  (63) embryo 08-10hr  (58) embryo 10-12hr  (56) embryo 12-14hr  (38) embryo 14-16hr  (39) embryo 16-18hr  32 embryo 18-20hr    25 embryo 20-22hr  (41) embryo 22-24hr  (34) larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day  30 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    60 embryo 02-04hr    85 embryo 04-06hr    66 embryo 06-08hr    63 embryo 08-10hr    58 embryo 10-12hr    56 embryo 12-14hr    38 embryo 14-16hr    39 embryo 16-18hr    32 embryo 18-20hr    25 embryo 20-22hr    41 embryo 22-24hr    34 larva L1    11 larva L2    9 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    24 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    18 adult female 05day    30 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (32) embryonic 1182-4H  (28) embryonic GM2    20 embryonic Kc167    18 embryonic S1  26 embryonic S3    23 leg disc CME L1  26 wing disc CME-W2    18 wing disc ML-DmD8  26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21  (37) wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (32) antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1  (32) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  (27) tumorous blood cells mbn2  (28) ovary fGS/OSS  (30) ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  32 embryonic 1182-4H  28 embryonic GM2    20 embryonic Kc167    18 embryonic S1  26 embryonic S3    23 leg disc CME L1  26 wing disc CME-W2    18 wing disc ML-DmD8  26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21  (37) wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  32 antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1  32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2  27 tumorous blood cells mbn2  28 ovary fGS/OSS  30 ovary OSC  (34) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    28 embryonic GM2    20 embryonic Kc167    18 embryonic S1    26 embryonic S3    23 leg disc CME L1    26 wing disc CME-W2    18 wing disc ML-DmD8    26 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    37 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    28 ovary fGS/OSS    30 ovary OSC    34 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    5 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    24 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD33695 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5692-RA;CG3949-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for raps Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive raps83 raps179 raps193 viable rapsΔ24 rapsΔ50 viable, with Scer\GAL4pnr-MD237 rapsGD11737 Other Phenotypes Allele cell cycle defective rapsP62 cell cycle defective (with rapsP62) rapsP89 cell cycle defective (with rapsP89) rapsP62 cell polarity defective rapsP62 rapsP89 cell polarity defective (with rapsP62) rapsP89 cell polarity defective (with rapsP89) rapsP62 mitotic cell cycle defective raps193 rapsP62 rapsΔ50 mitotic cell cycle defective (with raps193) rapsΔ50 mitotic cell cycle defective (with rapsΔ50) raps193 mitotic cell cycle defective | embryonic stage rapsP89 neuroanatomy defective rapsP62 neuroanatomy defective, with Scer\GAL4elav-C155 rapsEP3113 neuroanatomy defective | embryonic stage rapsP89 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 rapsEP3113 tumorigenic (with rapsP62) rapsP89 tumorigenic (with rapsP89) rapsP62 visible, with Scer\GAL4pnr-MD237 rapsGD11737 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 rapsEP3113 anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 rapsEP3113 aster rapsP62 centrosome (with rapsP62) rapsP89 centrosome (with rapsP89) rapsP62 embryonic/larval neuroblast rapsP62 embryonic neuroblast rapsP62 embryonic neuroblast & spindle rapsP62 rapsP89 ganglion mother cell GMC4-2a rapsP89 intersegmental nerve, with Scer\GAL4elav-C155 rapsEP3113 larval brain & neuroblast rapsP62 mitotic cell cycle & spindle rapsP62 rapsP89 mitotic domain 9 & epithelial cell rapsP62 mitotic domain 9 & spindle rapsP62 rapsP89 neuroblast rapsP89 neuroblast | larval stage raps193 neuroblast | P-stage rapsunspecified RP2 motor neuron rapsP62 rapsP89 RP2 motor neuron | ectopic rapsP62 rapsP89 RP2sib neuron rapsP62 rapsP89 spindle rapsΔ24 rapsΔ50 rapsP62 spindle & external sensory organ precursor cell I rapsP62 spindle & larval neuroblast rapsP62 tormogen cell, with Scer\GAL4pnr-MD237 rapsGD11737 wing margin rapsΔ50 wing margin (with raps193) rapsΔ50 wing margin (with rapsΔ50) raps193
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of raps Class Mutagen Stocks Known lesion raps193 hypomorphic allele - genetic evidence Delta2-3 1 Yes raps83 hypomorphic allele - genetic evidence Delta2-3 1 Yes rapsc06721 piggyBac transposase 1 -- rapsG16080 P-element activity 1 -- rapsG6902 P-element activity 1 -- rapsMI04646 1 -- rapsP62 loss of function allele, amorphic allele - genetic evidence Delta2-3 0 Yes raps179 hypomorphic allele - genetic evidence Delta2-3 0 Yes rapsEP3113 P-element activity 0 Yes rapsP120 Delta2-3 0 Yes rapsP17 Delta2-3 0 Yes rapsP89 loss of function allele Delta2-3 0 Yes rapsunspecified 0 -- rapsΔ24 P-element activity 0 Yes rapsΔ50 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of raps Class Mutagen Stocks Known lesion rapsGD11737 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapsGL00622 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapsHMS01462 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapshs.PP in vitro construct - regulatory fusion 1 Yes rapsJF02450 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapsC.Hsp70Bb.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes rapsC.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes rapsScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes rapsUbi.T:Avic\GFP-YFP 0 -- rapsΔGL1,2.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC497 (Christensen et al., 2008.4.15) Df(3R)BSC498 (Christensen et al., 2008.4.15) Df(3R)BSC686 (Cook et al., 2008.12.28) Df(3R)BSC739 (Cook et al., 2009.2.28) Df(3R)IR16 (Parmentier et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11737} NA P{TRiP.GL00622} NA P{TRiP.HMS01462} NA P{TRiP.JF02450} NA P{UAS-HA-raps.Δ1,2} NA P{UAS-pins.Y} NA P{UAS-raps.C} NA heat-shock construct P{hs-raps.C} NA P{hs-raps.P} NA characterization construct P{UAS-pon::raps.C-pon} NA P{Ubi-pins-YFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}rapsEP3113 NA P{EP}rapsG6902 NA P{EP}rapsG16080 NA P{EP}wdbEP3106 NA P{EP}wdbEP3211 NA P{EP}wdbEP3316 NA P{EP}wdbEP3385 NA P{EP}wdbEP3559 NA P{EPgy2}wdbEY00550a NA P{GSV1}C442C442 NA miscellaneous insertions Mi{MIC}rapsMI04646 NA P{SUPor-P}wdbKG02977 NA P{UASp-YFP.Rab30.T21N}wdb07 NA PBac{PB}rapsc06721 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with G-iα65A (Nipper et al., 2007) inferred from physical interaction with mud (Nipper et al., 2007)
Biological Process
CV term Evidence References
asymmetric cell division inferred from direct assay (Januschke and Gonzalez, 2010) inferred from mutant phenotype (Parmentier et al., 2000, Yu et al., 2003) asymmetric neuroblast division inferred from mutant phenotype (Cai et al., 2003, Bonaccorsi et al., 2007) establishment of mitotic spindle orientation inferred from mutant phenotype (Yu et al., 2003) establishment of spindle orientation inferred from mutant phenotype (Siegrist and Doe, 2005) neuroblast proliferation inferred from mutant phenotype (Caussinus and Gonzalez, 2005)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005, Nipper et al., 2007, Yu et al., 2005)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
GTPase regulator activity inferred from electronic annotation with InterPro:IPR003109 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
asymmetric cell division non-traceable author statement (Parmentier, 2000.2.15) traceable author statement (Cheah et al., 2000) asymmetric protein localization traceable author statement (Cheah et al., 2000) asymmetric protein localization involved in cell fate determination traceable author statement (Gonczy, 2002) basal protein localization traceable author statement (Peng et al., 2000) establishment of mitotic spindle localization traceable author statement (Cheah et al., 2000, Gonczy, 2002) maintenance of protein location non-traceable author statement (Schaefer and Knoblich, 2001) neuroblast fate determination traceable author statement (Cheah et al., 2000)
Cellular Component
CV term Evidence References
apical cortex traceable author statement (Ohshiro et al., 2000, Schaefer and Knoblich, 2001) apical part of cell non-traceable author statement (Peng et al., 2000) cell cortex traceable author statement (Bardin et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
raps - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - CG3544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - Cyp6a22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - Drep-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - Gαi anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation (Yoshiura et al., 2012) raps - Gαo experimental knowledge based, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Yoshiura et al., 2012, Mintseris et al., 2009.11.23) raps - RhoGAP18B experimental knowledge based (Guruharsha et al., 2011) raps - Shc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - dlg1 pull down, molecular weight estimation by staining (Mauser and Prehoda, 2012) raps - gus anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - insc x-ray crystallography, pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot (Culurgioni et al., 2011, Mauser and Prehoda, 2012) raps - lok anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) raps - mud anti bait coimmunoprecipitation, western blot, pull down, molecular weight estimation by staining, fluorescence polarization spectroscopy (Mauser and Prehoda, 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions raps allele Gene References rapsP62 insc (Cai et al., 2003) rapsP89 baz (Fuse et al., 2003) rapsunspecified insc (Yu et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72799 DroID - A comprehensive database of gene and protein interactions. • FBgn0040080 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53569
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6J9NJG Dipteran inclusive ortholog search EOG61RQ3B Insect inclusive ortholog search EOG6XKT3B Arthropod inclusive ortholog search EOG6RN8QR Metazoa inclusive ortholog search EOG6ZH25C
Orthologs in Drosophila Species (EOG6J9NJG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\raps     Drosophila simulans   Dsim\GD21341 Y   Drosophila sechellia   Dsec\GM16343 Y   Drosophila erecta   Dere\GG11562 Y   Drosophila yakuba   Dyak\GE23746 Y   Drosophila ananassae   Dana\GF16292 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19061 Y   Drosophila persimilis   Dper\GL13702 Y   Drosophila willistoni   Dwil\GK11758 Y   Drosophila virilis   Dvir\GJ10463 Y   Drosophila mojavensis   Dmoj\GI22011 Y   Drosophila grimshawi   Dgri\GH19252 Y
Orthologs in non-Drosophila Dipterans (EOG61RQ3B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008688   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014195   Anopheles gambiae Malaria mosquito  Agam\AGAP008977   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010095
Orthologs in non-Dipteran Insects (EOG6XKT3B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\raps   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005926   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005928   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16435   Atta cephalotes Leafcutter ant  Acep\ACEP25307   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19036   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13282   Linepithema humile Argentine ant  Lhum\LH25768   Pogonomyrmex barbatus Red harvester ant  Pbar\PB26372   Solenopsis invicta Red fire ant  Sinv\SINV19750   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005773   Bombyx mori Silkmoth  Bmor\BGIBMGA003867   Pediculus humanus Human body louse  Phum\PHUM426090   Tribolium castaneum Red flour beetle  Tcas\TC003257
Orthologs in non-Insect Arthropods (EOG6RN8QR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Tp73
Orthologs in non-Arthropod Metazoa (EOG6ZH25C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ags-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008293gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009218gn   Danio rerio Zebrafish  Drer\gpsm2   Danio rerio Zebrafish  Drer\gpsm1b   Danio rerio Zebrafish  Drer\gpsm2l   Xenopus tropicalis Western clawed frog  Xtro\gpsm1   Xenopus tropicalis Western clawed frog  Xtro\gpsm2   Gallus gallus Domestic chicken  Ggal\GPSM1   Gallus gallus Domestic chicken  Ggal\GPSM2   Mus musculus House mouse  Mmus\Gpsm2   Mus musculus House mouse  Mmus\Gpsm1   Rattus norvegicus Norway rat  Rnor\Gpsm2   Rattus norvegicus Norway rat  Rnor\Gpsm1   Homo sapiens Human  Hsap\ENSG00000160360   Homo sapiens Human  Hsap\GPSM2
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000160360     Hsap\GPSM2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21341 Drosophila sechellia Dsec\GM16343 Drosophila erecta Dere\GG11562 Drosophila yakuba Dyak\GE23746 Drosophila ananassae Dana\GF16292 Drosophila pseudoobscura pseudoobscura Dpse\GA19061 Drosophila persimilis Dper\GL13702 Drosophila willistoni Dwil\GK11758 Drosophila virilis Dvir\GJ10463 Drosophila mojavensis Dmoj\GI22011 Drosophila grimshawi Dgri\GH19252
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	32607 w1118; P{EP}rapsG6902 29310 y1 v1; P{TRiP.JF02450}attP2 6491 w*; raps193/TM6B, Tb1 31808 w1118; P{EP}rapsG16080/TM6C, Sb1 35048 y1 sc* v1; P{TRiP.HMS01462}attP2 37479 y1 sc* v1; P{TRiP.GL00622}attP40 6497 w*; P{hs-raps.P}I1; raps83/TM6B, Tb1 38147 y1 w*; Mi{MIC}rapsMI04646/TM3, Sb1 Ser1
Harvard	- PBac{PB}rapsc06721
VDRC	v27486 w1118; P{GD11737}v27486/TM3
Genomic Clones ( 1 )
	BACR15D01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 127 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33695 RE22964
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25122 GM02189 GM10902 LD03783 LD05052 LD05350 LD05416 LD06076 LD06634 LD08472 LD08649 LD09253 LD13154 LD14267 LD16510 LD18405 LD19212 LD19427 LD20552 LD30263 LD33420 LD35569 LD37744 LD39730 LD40378 RE09219 RE09293 RE30157 RE30355 RE30484 RE35631 RE37612 RE47363 RE47374 RE51729 RE52833 RE52888 RE54426 RE56718 RE67388 RE74883 SD17459 SD21342
Other clones	10786 10868 13367 29365 36975 39748 50855 69673 70001 74048 78341 97976 146402 165824 214377.58 CK01.95A.F7 CK01840 EK074016 EK110542 EK110914 EK115414 EK176848 EK186007 EK194526 EK196719 EK197419 EK203344 EK207828 EK213703 EK220561 EK249322 EP03028 RP003012816 RP003019435 RP003030075 RP003034640 RP003035860 RP003076411 RP003107938 RP003108284 RP003113869 RP003120682 RP003124716 RP003132080 RP003158914 RP003191105 RP003196472 RP003229053 RP003291108 RP003303899 RP003308286 RP003312688 RP003328605 RP003329431 RP003339881 RP003363990 RP003373274 RP003381093 RP003415315 RP003415981 RP003421327 RP003425764 RP003434294 RP003440779 RP003483403 RP003483490 RP003488390 RP003528432 RP003530872 RP003530892 RP003568540 RP003569228 RP003572165 RP003583717 RP003590575 RP003592308 RP003592893 RP003613269 RP003616047 RP003626270 RP003638396 RP003645265
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53569
Antibody Information
	polyclonal (Yu et al., 2000)
Other Information
Discoverer
Etymology
	The raps protein contains 7 tetratricopeptide repeats which are similar to those existing in "rapsyn", a mouse protein, hence the name "rapsynoid". However, raps is not a homologue of rapsyn. (Parmentier et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rad pins (Parmentier et al., 2000) Source for merge of: raps CG5692 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	baz, raps and dlg1 establish and maintain planar polarity in pI cells. (Bellaiche et al., 2001) raps is involved in the control of asymmetric divisions of neuroblasts. (Parmentier et al., 2000) In raps mutants, the asymmetric divisions of neuroblasts are altered; insc protein is no longer asymmetrically localized in the dividing neuroblast and the neuroblast division produces two daughter cells of similar sizes. However, the morphologically symmetrical divisions of raps mutant neuroblasts still lead to daughter cells with different fates, as shown by differences in gene expression. (Parmentier et al., 2000) raps and insc might orient asymmetric cell divisions by localising or locally modulating a heterotrimeric G-protein signalling cascade at the apical cell cortex. (Schaefer et al., 2000) raps is required for insc protein to asymmetrically localise. (Yu et al., 2000) Identification: identified as a protein that binds to insc in a yeast two-hybrid screen. (Yu et al., 2000) raps is required for all aspects of insc function. (Yu et al., 2000) Isolated using a yeast two-hybrid system. (Woods et al., 1997) raps encodes a putative SH3 binding protein, that co-localises with dlg1 at septate junctions. (Woods et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080260 RefSeq (Proteins) • NP_524999 DDBJ / EMBL / GenBank • AA695130 AA979309 AAF36967 AAF56721 AAF64499 AAM11170 AAO39527 AF230071 AF242203 AJ272067 AQ254704 AW943195 AY094817 BI231660 BT003523 CAB75734 CZ470949 Entrez Gene - A searchable database of RefSeq genes. • 53569 UniProtKB/TrEMBL • Q9NFR7 Q9NH88 Q9VB22
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GoLoco motif (IPR003109) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing domain (IPR013026) Tetratricopeptide repeat (IPR019734) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD33695
Linkouts
	BioGRID - A database of protein and genetic interactions • 72799 DroID - A comprehensive database of gene and protein interactions. • FBgn0040080 DRSC - Results from RNAi screens. • FBgn0040080 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5692-RA;CG3949-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53569 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/partins1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53569 modMine - Data generated by the modENCODE project. • FBgn0040080
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG5692 (Kraut et al., 2001, Kraut et al., 2001, Molnar et al., 2006, Perkins et al., 2009, Ni et al., 2011.7.19) Pins (Katanaev and Tomlinson, 2006, Yu et al., 2005, Izumi et al., 2004, Rolls et al., 2003, Dunlop et al., 2004, Hampoelz and Knoblich, 2004, Izumi et al., 2005, Betschinger and Knoblich, 2004, Roegiers and Jan, 2004, Gomes and Schweisguth, 2005, David et al., 2005, Torban et al., 2004, Schweisguth et al., 2003, Bardin et al., 2004, Bellaiche et al., 2004, Rothenberg et al., 2003, Siegrist and Doe, 2004, Hidalgo and ffrench-Constant, 2003, Wodarz and Huttner, 2003, Blumer et al., 2003, Gonczy, 2002, Izumi et al., 2003, Doe, 2001, Le Borgne et al., 2002, Roegiers et al., 2001, Knust, 2001, Ohno, 2001, Bellaiche et al., 2001, Cai et al., 2001, Schaefer et al., 2001, Budde, 2005, Ahringer, 2005, Siegrist and Doe, 2005, Sommer et al., 2007, Lee et al., 2006, Krahn and Wodarz, 2008, Jafar-Nejad et al., 2005, Hutterer et al., 2006, Yamashita et al., 2005, Dawes-Hoang and Wieschaus, 2001, Wang et al., 2005, Hampoelz et al., 2005, Lin, 2008, Chia et al., 2008, Yamashita and Fuller, 2008, Johnston et al., 2009, Smith et al., 2007, Lee et al., 2006, Bowman et al., 2006, Slack et al., 2007, Speicher et al., 2008, Boone and Doe, 2008, Gomes et al., 2009, Cabernard and Doe, 2009, Sahota et al., 2009, Kopein and Katanaev, 2009, Mummery-Widmer et al., 2009, Januschke and Gonzalez, 2010, Smith and Prehoda, 2011, Cabernard et al., 2010, Guilgur et al., 2012, Andersen et al., 2012) pins (Lee et al., 2006, Langevin et al., 2005, Yu et al., 2003, Le Borgne and Schweisguth, 2003, Yu et al., 2003, Yu et al., 2005, Kaltschmidt and Brand, 2002, Lee et al., 2004, Radovic and Bryant, 2003, Doe and Bowerman, 2001, Wallenfang and Matunis, 2003, Albertson and Doe, 2003, Fuse et al., 2003, Tuxworth and Chia, 2003, Ahringer, 2003, Cai et al., 2003, Chia and Yang, 2002, Adler, 2002, Doe, 2001, Schaefer and Knoblich, 2001, Wodarz, 2001, Chase, 2001, Schaefer et al., 2001, Bellaiche et al., 2001, Kraut et al., 2001, Kraut et al., 2001, Gulli and Peter, 2001, Tio et al., 2001, Parmentier et al., 2001, Leevers, 2000, Peng et al., 2000, Ohshiro et al., 2000, Brazil and Hemmings, 2000, Schaefer, 2000.3.6, Schweisguth, 2000, Schaefer et al., 2000, Jan and Jan, 2000, Yu et al., 2000, Yu, 2000.1.31, Yu et al., 2000, Wang et al., 2006, Wodarz and Gonzalez, 2006, Wang et al., 2006, Budde, 2005, Caussinus and Gonzalez, 2005, Tountas and Fortini, 2007, Jafar-Nejad, 2005, Yu et al., 2002, Bonaccorsi et al., 2007, David et al., 2005, Nipper et al., 2007, Rebollo et al., 2007, Siller et al., 2006, Izumi et al., 2006, Rath et al., 2002, Wang et al., 2011, Januschke and Gonzalez, 2010, Janic et al., 2010, Ségalen et al., 2010, Chang et al., 2010, Yoshiura et al., 2012, Guilgur et al., 2012, Andersen et al., 2012) PINS (Baas et al., 2004, Morrison and Kimble, 2006, Kurusu et al., 2009) rad (Radovic et al., 2000) Rad (Woods et al., 1997, ) raps (Clevers, 2005, Caussinus and Gonzalez, 2005, Zhang et al., 2007, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Molnar et al., 2006, Lecuyer et al., 2007, Cook et al., 2008.12.28, Cook et al., 2009.2.28) Raps (Mudiganti et al., 2010, Sahota et al., 2009) rapsyn (Littleton and Ganetzky, 2000)
Name Synonym	Partner of Inscutable (Tepass, 2002) Partner of Inscuteable (Lai and Orgogozo, 2004, Anonymous, 2003, Roegiers and Jan, 2004, Bardin et al., 2004, Bellaiche et al., 2001, Yu et al., 2002, Lin, 2008, Chia et al., 2008, David et al., 2005, Nipper et al., 2007, Speicher et al., 2008, Boone and Doe, 2008, Sahota et al., 2009) partner of inscuteable (Skeath and Thor, 2003, Ahringer, 2003, Brazil and Hemmings, 2000, Cheah et al., 2000, Yu et al., 2000, Yu, 2000.1.31, Wodarz and Gonzalez, 2006, Tountas and Fortini, 2007, Janic et al., 2010) Rapsinoid (Kopein and Katanaev, 2009) Rapsynoid (Kraut et al., 2001, Kraut et al., 2001, Woods et al., 1997, Sahota et al., 2009, Mummery-Widmer et al., 2009) rapsynoid (Cheah et al., 2000, )
Secondary FlyBase IDs
	FBgn0020384 FBgn0039526
References ( 174 )
Generate a list of	All references relating to this gene ( 174 )
List References by type	Research paper  ( 80 ) Supplementary material  ( 8 ) Review  ( 41 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 22 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Website  ( 1 )
Recent research papers ( 11 )
	Andersen et al., 2012, Dev. Biol. 363(1): 258--265 Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. [FBrf0217488] Folker et al., 2012, Development 139(20): 3827--3837 Muscle length and myonuclear position are independently regulated by distinct Dynein pathways. [FBrf0219489] Guilgur et al., 2012, Development 139(3): 503--513 Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells. [FBrf0217157] Mauser and Prehoda, 2012, PLoS ONE 7(1): e29611 Inscuteable regulates the Pins-Mud spindle orientation pathway. [FBrf0218437] Rossi and Gonzalez, 2012, EMBO Rep. 13(2): 157--162 Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth. [FBrf0217341] Yoshiura et al., 2012, Dev. Cell 22(1): 79--91 Tre1 GPCR Signaling Orients Stem Cell Divisions in the Drosophila Central Nervous System. [FBrf0217269] Connell et al., 2011, Mol. Biol. Cell 22(22): 4220--4226 Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. [FBrf0216801] Culurgioni et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(52): 20998--21003 Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. [FBrf0217064] Smith and Prehoda, 2011, Mol. Cell 43(4): 540--549 Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. [FBrf0214708] Wang et al., 2011, Dev. Cell 21(3): 520--533 An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. [FBrf0215580] Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation. [FBrf0216492] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...