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Gene Dmel\raps

General Information
Symbol	Dmel\raps	Species	D. melanogaster
Name	rapsynoid	Annotation symbol	CG5692
Feature type	protein_coding_gene	FlyBase ID	FBgn0040080
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Pins, rad
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98A8-98A8	Sequence location	3R:23,408,527..23,412,098 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rapsynoid is referred to in FlyBase by the symbol Dmel\raps (CG5692, FBgn0040080). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: establishment of mitotic spindle orientation; neuroblast proliferation; asymmetric neuroblast division; establishment of spindle orientation; asymmetric cell division. 23 alleles are reported. The phenotypes of these alleles are annotated with: anatomical structure; organelle; multicellular structure; organ system subdivision; organ system; embryonic/larval neuron; intracellular organelle part; spindle; stem cell; peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: GoLoco motif; Tetratricopeptide TPR-1; Tetratricopeptide repeat; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639984_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of raps. Gene sequence location is 3R:23408527..23412098.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms GTPase regulator activity Transgenic Constructs P{UAS-HA-raps.Delta1,2}
FB2012_01	Controlled Vocabulary Terms neuroblast MP2 apical References Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Cabernard et al., 2010, Nature 467(7311): 91--94 Sequence features BKN45130 BKN20298
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98A8-98A8   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98A-98B     (Schaefer, 2000.3.6) 98A-98B     (Parmentier, 2000.2.15) 98A-98B     (Yu, 2000.1.31)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\raps for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) raps-RA FBtr0085189  NM_080260   3314   658
Additional Transcript Data & Comments
Reported size (kB)	3.3 (northern blot) (Yu et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein raps-PA   FBpp0084559   71.5   658   6.73     NP_524999   AAF56721
Additional Polypeptide Data & Comments
Reported size (kDa)	658 (aa); 72 (kD predicted) (Yu et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR-1 (IPR001440) GoLoco motif (IPR003109) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141339   AA201866   AA201963   AA246454   AA246483   AA246961   AA263406   AA264779   AA264941   AA391174   AA438798   AA439647   AA441535   AA538796   AA539912   AA540075   AA540752   AA695130   AA736057   AA950460   AA979142   AA979309   AE014297 AAF56721   AF230071 AAF36967   AF242203 AAF64499   AI405187   AI455854   AI518275   AI519893   AI520272   AJ272067 CAB75734   AQ254704   AW943195   AY094817 AAM11170   BI168474   BI168532   BI231660   BI234458   BI234624   BI234736   BI239201   BI240700   BI362717   BI362726   BI366232   BI367135   BI367178   BI368454   BI370260   BI484306   BI580665   BI635921   BI638936   BT003523 AAO39527   CO273333   CO273424   CO274767   CO290444   CO293542   CO294845   CO296452   CO299892   CO305730   CO310139   CO321596   CO324688   CO325524   CO325765   CO325987   CZ470949   EC063466   EC072105   EC077399   EC083394   EC087494   EC199118   EC199777   EC204274   EC212604   EC220820   EC222211   EC223959   EC230823   EC232877   EC247465   EC257915   GH749901   GH751121   GH751530   GH751648   GH751859   GH753107   GH759533   GH770295   GH781984   GH787900   GH793843   GH795938   GH797020   GH797272   GH797292   GH797737   GH798840   GH799042   GH801469   GH804430   GH817265   GH824924   GH827748   GH828636   GH837054   GH838199   GH838498   GH852409   GH853287   GH858144   GH859496   GH860149   GH878017   GH880537   GH881143   GH888046   GH890402   GH890966   GH894418   GH894901   GH899079   GH900836   GH900862   GH912378   GH920730   GH921613   GH928037   GH929007   GH929128   GH934575
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NFR7 Q9NH88 Q9VB22
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 5   epithelial cell   • centrosome & spindle microtubule (Lecuyer et al., 2007) epithelium   • centrosome & spindle microtubule (Lecuyer et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   mitotic domain 9   (Yu et al., 2000) neuroblast   (Yu et al., 2000) neuroblast MP2 | apical   • apical cortex (Rath et al., 2002)
Additional Descriptive Data
	raps is observed as a crescent in the apical cortex in neuroblasts after delamination. It is also observed in cortical crescents in the dividing cells of procephalic mitotic domain 9. (Yu et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040080    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040080 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040080 expression level Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4492) embryo 02-04hr  (6400) embryo 04-06hr  (5002) embryo 06-08hr  (4746) embryo 08-10hr  (4345) embryo 10-12hr  (4206) embryo 12-14hr  (2875) embryo 14-16hr  (2955) embryo 16-18hr  (2420) embryo 18-20hr  (1862) embryo 20-22hr  (3106) embryo 22-24hr  (2557) larva L1  (862) larva L2  (695) larva L3 12hr old  (499) larva L3 puffstage 1-2  (593) larva L3 puffstage 3-6  (1118) larva L3 puffstage 7-9  (1536) white prepupae new  (1775) white prepupae 12hr  (1696) white prepupae 24hr  (1641) pupae 2d postWPP  (1081) pupae 3d postWPP  (715) pupae 4d postWPP  (493) adult male 01day  (598) adult male 05day  (639) adult male 30day  (634) adult female 01day  (1319) adult female 05day  (2256) adult female 30day  (2317) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4492) embryo 02-04hr  (6400) embryo 04-06hr  (5002) embryo 06-08hr  (4746) embryo 08-10hr  (4345) embryo 10-12hr  (4206) embryo 12-14hr  (2875) embryo 14-16hr  (2955) embryo 16-18hr  (2420) embryo 18-20hr  (1862) embryo 20-22hr  (3106) embryo 22-24hr  (2557) larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9  (1536) white prepupae new  (1775) white prepupae 12hr  (1696) white prepupae 24hr  (1641) pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day  (2256) adult female 30day  (2317) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040080 expression level Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4492) embryo 02-04hr  (6400) embryo 04-06hr  (5002) embryo 06-08hr  (4746) embryo 08-10hr  (4345) embryo 10-12hr  (4206) embryo 12-14hr  (2875) embryo 14-16hr  (2955) embryo 16-18hr  (2420) embryo 18-20hr  (1862) embryo 20-22hr  (3106) embryo 22-24hr  (2557) larva L1  (862) larva L2  (695) larva L3 12hr old  (499) larva L3 puffstage 1-2  (593) larva L3 puffstage 3-6  (1118) larva L3 puffstage 7-9  (1536) white prepupae new  (1775) white prepupae 12hr  (1696) white prepupae 24hr  (1641) pupae 2d postWPP  (1081) pupae 3d postWPP  (715) pupae 4d postWPP  (493) adult male 01day  (598) adult male 05day  (639) adult male 30day  (634) adult female 01day  (1319) adult female 05day  (2256) adult female 30day  (2317) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4492) embryo 02-04hr  (6400) embryo 04-06hr  (5002) embryo 06-08hr  (4746) embryo 08-10hr  (4345) embryo 10-12hr  (4206) embryo 12-14hr  (2875) embryo 14-16hr  (2955) embryo 16-18hr  2420 embryo 18-20hr  1862 embryo 20-22hr  (3106) embryo 22-24hr  (2557) larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9  1536 white prepupae new  1775 white prepupae 12hr  1696 white prepupae 24hr  1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day  2256 adult female 30day  2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4492 embryo 02-04hr    6400 embryo 04-06hr    5002 embryo 06-08hr    4746 embryo 08-10hr    4345 embryo 10-12hr    4206 embryo 12-14hr    2875 embryo 14-16hr    2955 embryo 16-18hr    2420 embryo 18-20hr    1862 embryo 20-22hr    3106 embryo 22-24hr    2557 larva L1    862 larva L2    695 larva L3 12hr old    499 larva L3 puffstage 1-2    593 larva L3 puffstage 3-6    1118 larva L3 puffstage 7-9    1536 white prepupae new    1775 white prepupae 12hr    1696 white prepupae 24hr    1641 pupae 2d postWPP    1081 pupae 3d postWPP    715 pupae 4d postWPP    493 adult male 01day    598 adult male 05day    639 adult male 30day    634 adult female 01day    1319 adult female 05day    2256 adult female 30day    2317 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040080    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040080 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040080 expression level Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040080 expression level Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.725 Larval Midgut    224.2 Larval Hindgut    323 Larval Malpighian Tubules    63.9 Larval Fat Body    101.4 Larval Salivary Gland    169.6 Larval Trachea    192.775 Larval Carcass    121.675 Adult Head    93.8 Adult Eye    99.95 Adult Brain    172.6 Adult Thoracic-Abdominal Ganglion    129.4 Adult Crop    152.2 Adult Midgut    129.1 Adult Hindgut    134.2 Adult Malpighian Tubules    64.1 Adult Fat Body    95 Adult Salivary Gland    174.1 Adult Heart    115.35 Adult VirginFemale Spermatheca    177.2 Adult InseminatedFemale Spermatheca    188 Adult Ovary    238.1 Adult Testis    35.6 Adult Male Accessory Gland    92.2 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    93.8   NA  Eye    99.95   NA  Brain    172.6   468.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    129.4   NA  Crop    152.2   224.2  Midgut    129.1   323  Hindgut    134.2   63.9  Malpighian Tubules    64.1   101.4  Fat Body    95   169.6  Salivary Gland    174.1   NA  Heart    115.35   192.775  Trachea    NA   NA  VirginFemale Spermatheca    177.2   NA  InseminatedFemale Spermatheca    188   NA  Ovary    238.1   NA  Testis    35.6   NA  Male Accessory Gland    92.2   121.675  Carcass    56.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5692-RA;CG3949-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for raps Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive raps83 raps179 raps193 viable rapsΔ24 rapsΔ50 viable, with Scer\GAL4pnr-MD237 rapsGD11737 Other Phenotypes Allele cell cycle defective rapsP62 cell cycle defective (with rapsP62) rapsP89 cell cycle defective (with rapsP89) rapsP62 cell polarity defective rapsP62 rapsP89 cell polarity defective (with rapsP62) rapsP89 cell polarity defective (with rapsP89) rapsP62 mitotic cell cycle defective raps193 rapsP62 rapsΔ50 mitotic cell cycle defective (with raps193) rapsΔ50 mitotic cell cycle defective (with rapsΔ50) raps193 mitotic cell cycle defective | embryonic stage rapsP89 neuroanatomy defective rapsP62 neuroanatomy defective, with Scer\GAL4elav-C155 rapsEP3113 neuroanatomy defective | embryonic stage rapsP89 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 rapsEP3113 tumorigenic (with rapsP62) rapsP89 tumorigenic (with rapsP89) rapsP62 visible, with Scer\GAL4pnr-MD237 rapsGD11737 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 rapsEP3113 anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 rapsEP3113 aster rapsP62 centrosome (with rapsP62) rapsP89 centrosome (with rapsP89) rapsP62 embryonic/larval neuroblast rapsP62 embryonic neuroblast & spindle rapsP62 rapsP89 ganglion mother cell GMC4-2a rapsP89 intersegmental nerve, with Scer\GAL4elav-C155 rapsEP3113 larval brain & neuroblast rapsP62 mitotic cell cycle & spindle rapsP62 rapsP89 mitotic domain 9 & epithelial cell rapsP62 mitotic domain 9 & spindle rapsP62 rapsP89 neuroblast rapsP89 neuroblast | larval stage raps193 neuroblast | P-stage rapsunspecified RP2 neuron rapsP62 rapsP89 RP2 neuron | ectopic rapsP62 rapsP89 RP2sib neuron rapsP62 rapsP89 spindle rapsΔ24 rapsΔ50 rapsP62 spindle & external sensory organ precursor cell I rapsP62 spindle & larval neuroblast rapsP62 tormogen cell, with Scer\GAL4pnr-MD237 rapsGD11737 wing margin rapsΔ50 wing margin (with raps193) rapsΔ50 wing margin (with rapsΔ50) raps193
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of raps Class Mutagen Stocks Known lesion raps193 hypomorphic allele - genetic evidence Delta2-3 1 Yes raps83 hypomorphic allele - genetic evidence Delta2-3 1 Yes rapsc06721 piggyBac transposase 1 -- rapsG16080 P-element activity 1 -- rapsG6902 P-element activity 1 -- rapsP62 loss of function allele, amorphic allele - genetic evidence Delta2-3 0 Yes raps179 hypomorphic allele - genetic evidence Delta2-3 0 Yes rapsEP3113 P-element activity 0 Yes rapsP120 Delta2-3 0 Yes rapsP17 Delta2-3 0 Yes rapsP89 loss of function allele Delta2-3 0 Yes rapsunspecified 0 -- rapsΔ24 P-element activity 0 Yes rapsΔ50 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of raps Class Mutagen Stocks Known lesion rapsGD11737 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapsHMS01462 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapshs.PP in vitro construct - regulatory fusion 1 Yes rapsJF02450 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rapsC.Hsp70Bb.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes rapsC.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes rapsScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes rapsUbi.T:Avic\GFP-YFP 0 -- rapsΔGL1,2.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC497 (Christensen et al., 2008.4.15) Df(3R)BSC498 (Christensen et al., 2008.4.15) Df(3R)BSC686 (Cook et al., 2008.12.28) Df(3R)BSC739 (Cook et al., 2009.2.28) Df(3R)IR16 (Parmentier et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11737} NA P{TRiP.HMS01462} NA P{TRiP.JF02450} NA P{UAS-HA-raps.Δ1,2} NA P{UAS-pins.Y} NA P{UAS-raps.C} NA heat-shock construct P{hs-raps.C} NA P{hs-raps.P} NA characterization construct P{UAS-pon::raps.C-pon} NA P{Ubi-pins-YFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}rapsEP3113 NA P{EP}rapsG6902 NA P{EP}rapsG16080 NA P{EP}wdbEP3106 NA P{EP}wdbEP3211 NA P{EP}wdbEP3316 NA P{EP}wdbEP3385 NA P{EP}wdbEP3559 NA P{EPgy2}wdbEY00550a NA P{GSV1}C442C442 NA miscellaneous insertions P{SUPor-P}wdbKG02977 NA P{UASp-YFP.Rab30.T21N}wdb07 NA PBac{PB}rapsc06721 NA
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with G-iα65A (Nipper et al., 2007) inferred from physical interaction with mud (Nipper et al., 2007)
Biological Process
CV term Evidence References
asymmetric cell division inferred from direct assay (Januschke and Gonzalez, 2010) inferred from mutant phenotype (Parmentier et al., 2000, Yu et al., 2003) asymmetric neuroblast division inferred from mutant phenotype (Cai et al., 2003, Bonaccorsi et al., 2007) establishment of mitotic spindle orientation inferred from mutant phenotype (Yu et al., 2003) establishment of spindle orientation inferred from mutant phenotype (Siegrist and Doe, 2005) neuroblast proliferation inferred from mutant phenotype (Caussinus and Gonzalez, 2005)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005, Nipper et al., 2007, Yu et al., 2005)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
GTPase regulator activity inferred from electronic annotation with InterPro:IPR003109 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
asymmetric cell division non-traceable author statement (Parmentier, 2000.2.15) traceable author statement (Cheah et al., 2000) asymmetric protein localization traceable author statement (Cheah et al., 2000) asymmetric protein localization involved in cell fate determination traceable author statement (Gonczy, 2002) basal protein localization traceable author statement (Peng et al., 2000) establishment of mitotic spindle localization traceable author statement (Cheah et al., 2000, Gonczy, 2002) maintenance of protein location non-traceable author statement (Schaefer and Knoblich, 2001) neuroblast fate determination traceable author statement (Cheah et al., 2000) signal transduction inferred from electronic annotation with InterPro:IPR003109 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
apical cortex traceable author statement (Ohshiro et al., 2000, Schaefer and Knoblich, 2001) apical part of cell non-traceable author statement (Peng et al., 2000) cell cortex traceable author statement (Bardin et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions raps allele Gene References rapsP62 insc (Cai et al., 2003) rapsP89 baz (Fuse et al., 2003) rapsunspecified insc (Yu et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72799 DroID - A comprehensive database of gene and protein interactions. • FBgn0040080 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53569
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16292 Dere\GG11562 Dgri\GH19252 Dmoj\GI22011 Dper\GL13702 Dpse\GA19061 Dsec\GM16343 Dsim\GD21341 Dvir\GJ10463 Dwil\GK11758 Dyak\GE23746
Curated drosophilid orthologs	Dpse\GA19061
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014195-PA Aedes aegypti (mosquito) AGAP008977-PA Anopheles gambiae (mosquito) XP_393796.3 Apis mellifera (honey bee) XP_001943489.1 Acyrthosiphon pisum (pea aphid) 89752 Branchiostoma floridae (lancelet) BGIBMGA003867-PA Bombyx mori (silk worm) ENSBTAP00000022762 Bos taurus (bovine) CN24119 Caenorhabditis brenneri (small nematode) CBP09710 Caenorhabditis briggsae (nematode) CE29783 Caenorhabditis elegans (worm) ENSCAFP00000029453 Canis familiaris (dog) ENSCINP00000018421 Ciona intestinalis (sea squirt) JA12792 Caenorhabditis japonica (nematode) CPIJ010095 Culex pipens (mosquito) ENSCPOP00000015121 Cavia porcellus (guinea pig) RP07476 Caenorhabditis remanei (nematode) 149137 Capitella spl (polychaete worm) 22062 Daphnia pulex (daphnia) ENSDARP00000026291 Danio rerio (zebra fish) ENSECAP00000012943 Equus caballus (horse) ENSGACP00000019972 Gymnopilus aculeatus (mushroom) ENSGALP00000003253 Gallus gallus (chicken) 185030 Hypsipyla robusta (cedar shoot borer) ENSP00000385510 Homo sapiens (human) 132806 Lottia gigantea (owl limpet) 39276 Monocosta brevicollis (choanoflagellate) ENSMODP00000002770 Monodelphis domestica (gray opossum) ENSMMUP00000004113 Macaca mulatta (rhesus monkey) ENSMUSP00000029482 Mus musculus (house mouse) 220143 Nematostella vectensis (starlet anemone) XP_001605711.1 Nasonia vitripennis (wasp) ENSOANP00000008527 Ornithorynchus anatinus (platypus) ENSORLP00000019607 Oryzias latipes (japanese killifish) PHUM003199-PA Pediculus humanus (human body louse) ENSPPYP00000001261 Pongo pygmaeus (orangutan) ENSPTRP00000001792 Pan troglodytes (chimpanzee) ENSRNOP00000016250 Rattus norvegicus (norway rat) Smp_194030 Schistosoma mansoni (trematode parasite) NP_001035495.1 Strongylocentrotus purpuratus (purple sea urchin) 21483 Trichoplax adhaerens (metazoa) XP_972826.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018359 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037947 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011433 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12716 NV12718 LH25768 FBgn0240903 FBgn0213769 FBgn0197743 FBgn0192778 FBgn0171258 JGI_V11_22062 FBgn0079059 FBgn0151307 FBgn0144740 FBgn0126718 FBgn0103859 FBgn0093314 CPIJ010095 BGIBMGA003867 ACYPI005773 GB15846 AGAP008977 AAEL014195 AAEL008688 PB26372 PHUM426090 GLEAN_03257
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	32607 w1118; P{EP}rapsG6902 29310 y1 v1; P{TRiP.JF02450}attP2 6491 w*; raps193/TM6B, Tb1 31808 w1118; P{EP}rapsG16080/TM6C, Sb1 35048 y1 sc* v1; P{TRiP.HMS01462}attP2 6497 w*; P{hs-raps.P}I1; raps83/TM6B, Tb1
Harvard	- PBac{PB}rapsc06721
VDRC	v27486 w1118; P{GD11737}v27486/TM3
Genomic Clones ( 1 )
	BACR15D01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 127 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33695 RE22964
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25122 GM02189 GM10902 LD03783 LD05052 LD05350 LD05416 LD06076 LD06634 LD08472 LD08649 LD09253 LD13154 LD14267 LD16510 LD18405 LD19212 LD19427 LD20552 LD30263 LD33420 LD35569 LD37744 LD39730 LD40378 RE09219 RE09293 RE30157 RE30355 RE30484 RE35631 RE37612 RE47363 RE47374 RE51729 RE52833 RE52888 RE54426 RE56718 RE67388 RE74883 SD17459 SD21342
Other clones	10786 10868 13367 29365 36975 39748 50855 69673 70001 74048 78341 97976 146402 165824 214377.58 CK01.95A.F7 CK01840 EK074016 EK110542 EK110914 EK115414 EK176848 EK186007 EK194526 EK196719 EK197419 EK203344 EK207828 EK213703 EK220561 EK249322 EP03028 RP003012816 RP003019435 RP003030075 RP003034640 RP003035860 RP003076411 RP003107938 RP003108284 RP003113869 RP003120682 RP003124716 RP003132080 RP003158914 RP003191105 RP003196472 RP003229053 RP003291108 RP003303899 RP003308286 RP003312688 RP003328605 RP003329431 RP003339881 RP003363990 RP003373274 RP003381093 RP003415315 RP003415981 RP003421327 RP003425764 RP003434294 RP003440779 RP003483403 RP003483490 RP003488390 RP003528432 RP003530872 RP003530892 RP003568540 RP003569228 RP003572165 RP003583717 RP003590575 RP003592308 RP003592893 RP003613269 RP003616047 RP003626270 RP003638396 RP003645265
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53569
Antibody Information
	polyclonal (Yu et al., 2000)
Other Information
Discoverer
Etymology
	The raps protein contains 7 tetratricopeptide repeats which are similar to those existing in "rapsyn", a mouse protein, hence the name "rapsynoid". However, raps is not a homologue of rapsyn. (Parmentier et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rad pins (Parmentier et al., 2000) Source for merge of: raps CG5692 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	baz, raps and dlg1 establish and maintain planar polarity in pI cells. (Bellaiche et al., 2001) raps is involved in the control of asymmetric divisions of neuroblasts. (Parmentier et al., 2000) In raps mutants, the asymmetric divisions of neuroblasts are altered; insc protein is no longer asymmetrically localized in the dividing neuroblast and the neuroblast division produces two daughter cells of similar sizes. However, the morphologically symmetrical divisions of raps mutant neuroblasts still lead to daughter cells with different fates, as shown by differences in gene expression. (Parmentier et al., 2000) raps and insc might orient asymmetric cell divisions by localising or locally modulating a heterotrimeric G-protein signalling cascade at the apical cell cortex. (Schaefer et al., 2000) raps is required for insc protein to asymmetrically localise. (Yu et al., 2000) Identification: identified as a protein that binds to insc in a yeast two-hybrid screen. (Yu et al., 2000) raps is required for all aspects of insc function. (Yu et al., 2000) Isolated using a yeast two-hybrid system. (Woods et al., 1997) raps encodes a putative SH3 binding protein, that co-localises with dlg1 at septate junctions. (Woods et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080260 RefSeq (Proteins) • NP_524999 DDBJ / EMBL / GenBank • AA695130 AA979309 AAF36967 AAF56721 AAF64499 AAM11170 AAO39527 AF230071 AF242203 AJ272067 AQ254704 AW943195 AY094817 BI231660 BT003523 CAB75734 CZ470949 Entrez Gene - A searchable database of RefSeq genes. • 53569 UniProtKB/TrEMBL • Q9NFR7 Q9NH88 Q9VB22
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR-1 (IPR001440) GoLoco motif (IPR003109) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72799 DroID - A comprehensive database of gene and protein interactions. • FBgn0040080 DRSC - Results from RNAi screens. • FBgn0040080 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5692-RA;CG3949-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53569 InParanoid A subset of ortholog calls from InParanoid. • AAEL014195-PA Aedes aegypti (mosquito) AGAP008977-PA Anopheles gambiae (mosquito) XP_393796.3 Apis mellifera (honey bee) XP_001943489.1 Acyrthosiphon pisum (pea aphid) 89752 Branchiostoma floridae (lancelet) BGIBMGA003867-PA Bombyx mori (silk worm) ENSBTAP00000022762 Bos taurus (bovine) CN24119 Caenorhabditis brenneri (small nematode) CBP09710 Caenorhabditis briggsae (nematode) CE29783 Caenorhabditis elegans (worm) ENSCAFP00000029453 Canis familiaris (dog) ENSCINP00000018421 Ciona intestinalis (sea squirt) JA12792 Caenorhabditis japonica (nematode) CPIJ010095 Culex pipens (mosquito) ENSCPOP00000015121 Cavia porcellus (guinea pig) RP07476 Caenorhabditis remanei (nematode) 149137 Capitella spl (polychaete worm) 22062 Daphnia pulex (daphnia) ENSDARP00000026291 Danio rerio (zebra fish) ENSECAP00000012943 Equus caballus (horse) ENSGACP00000019972 Gymnopilus aculeatus (mushroom) ENSGALP00000003253 Gallus gallus (chicken) 185030 Hypsipyla robusta (cedar shoot borer) ENSP00000385510 Homo sapiens (human) 132806 Lottia gigantea (owl limpet) 39276 Monocosta brevicollis (choanoflagellate) ENSMODP00000002770 Monodelphis domestica (gray opossum) ENSMMUP00000004113 Macaca mulatta (rhesus monkey) ENSMUSP00000029482 Mus musculus (house mouse) 220143 Nematostella vectensis (starlet anemone) XP_001605711.1 Nasonia vitripennis (wasp) ENSOANP00000008527 Ornithorynchus anatinus (platypus) ENSORLP00000019607 Oryzias latipes (japanese killifish) PHUM003199-PA Pediculus humanus (human body louse) ENSPPYP00000001261 Pongo pygmaeus (orangutan) ENSPTRP00000001792 Pan troglodytes (chimpanzee) ENSRNOP00000016250 Rattus norvegicus (norway rat) Smp_194030 Schistosoma mansoni (trematode parasite) NP_001035495.1 Strongylocentrotus purpuratus (purple sea urchin) 21483 Trichoplax adhaerens (metazoa) XP_972826.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018359 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037947 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000011433 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/partins1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53569 modMine - Data generated by the modENCODE project. • FBgn0040080 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12716 NV12718 LH25768 FBgn0240903 FBgn0213769 FBgn0197743 FBgn0192778 FBgn0171258 JGI_V11_22062 FBgn0079059 FBgn0151307 FBgn0144740 FBgn0126718 FBgn0103859 FBgn0093314 CPIJ010095 BGIBMGA003867 ACYPI005773 GB15846 AGAP008977 AAEL014195 AAEL008688 PB26372 PHUM426090 GLEAN_03257
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG5692 (Kraut et al., 2001, Kraut et al., 2001, Molnar et al., 2006, Perkins et al., 2009, Ni et al., 2011.7.19) Pins (Katanaev and Tomlinson, 2006, Yu et al., 2005, Izumi et al., 2004, Rolls et al., 2003, Dunlop et al., 2004, Hampoelz and Knoblich, 2004, Izumi et al., 2005, Betschinger and Knoblich, 2004, Roegiers and Jan, 2004, Gomes and Schweisguth, 2005, David et al., 2005, Torban et al., 2004, Schweisguth et al., 2003, Bardin et al., 2004, Bellaiche et al., 2004, Rothenberg et al., 2004, Siegrist and Doe, 2004, Hidalgo and ffrench-Constant, 2003, Wodarz and Huttner, 2003, Blumer et al., 2003, Gonczy, 2002, Izumi et al., 2003, Doe, 2001, Le Borgne et al., 2002, Roegiers et al., 2001, Knust, 2001, Ohno, 2001, Bellaiche et al., 2001, Cai et al., 2001, Schaefer et al., 2001, Budde, 2005, Ahringer, 2005, Siegrist and Doe, 2005, Sommer et al., 2007, Lee et al., 2006, Krahn and Wodarz, 2008, Jafar-Nejad et al., 2005, Hutterer et al., 2006, Yamashita et al., 2005, Dawes-Hoang and Wieschaus, 2001, Wang et al., 2005, Hampoelz et al., 2005, Lin, 2008, Chia et al., 2008, Yamashita and Fuller, 2008, Smith et al., 2007, Lee et al., 2006, Bowman et al., 2006, Slack et al., 2007, Speicher et al., 2008, Boone and Doe, 2008, Gomes et al., 2009, Cabernard and Doe, 2009, Sahota et al., 2009, Kopein and Katanaev, 2009, Mummery-Widmer et al., 2009, Januschke and Gonzalez, 2010, Smith and Prehoda, 2011, Cabernard et al., 2010) pins (Lee et al., 2006, Langevin et al., 2005, Yu et al., 2003, Le Borgne and Schweisguth, 2003, Yu et al., 2003, Yu et al., 2005, Kaltschmidt and Brand, 2002, Lee et al., 2004, Radovic and Bryant, 2003, Doe and Bowerman, 2001, Wallenfang and Matunis, 2003, Albertson and Doe, 2003, Fuse et al., 2003, Tuxworth and Chia, 2003, Ahringer, 2003, Cai et al., 2003, Chia and Yang, 2002, Adler, 2002, Doe, 2001, Schaefer and Knoblich, 2001, Wodarz, 2001, Chase, 2001, Schaefer et al., 2001, Bellaiche et al., 2001, Kraut et al., 2001, Kraut et al., 2001, Gulli and Peter, 2001, Tio et al., 2001, Parmentier et al., 2001, Leevers, 2000, Peng et al., 2000, Ohshiro et al., 2000, Brazil and Hemmings, 2000, Schaefer, 2000.3.6, Schweisguth, 2000, Schaefer et al., 2000, Jan and Jan, 2000, Yu et al., 2000, Yu, 2000.1.31, Yu et al., 2000, Wang et al., 2006, Wodarz and Gonzalez, 2006, Wang et al., 2006, Budde, 2005, Caussinus and Gonzalez, 2005, Tountas and Fortini, 2007, Jafar-Nejad, 2005, Yu et al., 2002, Bonaccorsi et al., 2007, David et al., 2005, Nipper et al., 2007, Rebollo et al., 2007, Siller et al., 2006, Izumi et al., 2006, Rath et al., 2002, Januschke and Gonzalez, 2010, Janic et al., 2010, Ségalen et al., 2010, Chang et al., 2010) PINS (Baas et al., 2004, Morrison and Kimble, 2006, Kurusu et al., 2009) rad (Radovic et al., 2000) Rad (Woods et al., 1997, ) raps (Clevers, 2005, Caussinus and Gonzalez, 2005, Zhang et al., 2007, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Molnar et al., 2006, Lecuyer et al., 2007, Cook et al., 2008.12.28, Cook et al., 2009.2.28) Raps (Sahota et al., 2009) rapsyn (Littleton and Ganetzky, 2000)
Name Synonym	Partner of Inscutable (Tepass, 2002) Partner of Inscuteable (Lai and Orgogozo, 2004, Anonymous, 2003, Roegiers and Jan, 2004, Bardin et al., 2004, Bellaiche et al., 2001, Yu et al., 2002, Lin, 2008, Chia et al., 2008, David et al., 2005, Nipper et al., 2007, Speicher et al., 2008, Boone and Doe, 2008, Sahota et al., 2009) partner of inscuteable (Skeath and Thor, 2003, Ahringer, 2003, Brazil and Hemmings, 2000, Cheah et al., 2000, Yu et al., 2000, Yu, 2000.1.31, Wodarz and Gonzalez, 2006, Tountas and Fortini, 2007, Janic et al., 2010) Rapsinoid (Kopein and Katanaev, 2009) Rapsynoid (Kraut et al., 2001, Kraut et al., 2001, Woods et al., 1997, Sahota et al., 2009, Mummery-Widmer et al., 2009) rapsynoid (Cheah et al., 2000, )
Secondary FlyBase IDs
	FBgn0020384 FBgn0039526
References ( 158 )
Generate a list of	All references relating to this gene ( 158 )
List References by type	Research paper  ( 69 ) Supplementary material  ( 6 ) Review  ( 41 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 22 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Computer file  ( 3 )
Recent research papers ( 7 )
	Smith and Prehoda, 2011, Mol. Cell 43(4): 540--549 Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. [FBrf0214708] Wee et al., 2011, J. Cell Biol. 195(3): 369--376 Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation. [FBrf0216492] Cabernard et al., 2010, Nature 467(7311): 91--94 A spindle-independent cleavage furrow positioning pathway. [FBrf0211664] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Janic et al., 2010, Science 330(6012): 1824--1827 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. [FBrf0212713] Januschke and Gonzalez, 2010, J. Cell Biol. 188(5): 693--706 The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. [FBrf0210175] Ségalen et al., 2010, Dev. Cell 19(5): 740--752 The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish. [FBrf0212266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...