FlyBase Gene Report: Dmel\l(1)G0469

General Information

Symbol

Dmel\l(1)G0469

Species

D. melanogaster

Name

lethal (1) G0469

Annotation Symbol

CG32597

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040153

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

12E4-12E4

Sequence location

X:14,203,961..14,211,457 [-]

Recombination map

1-48

RefSeq locus

NC_004354 REGION:14203961..14211457

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2012-06-01 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

There is no information supporting a Biological Process term for this gene. (Based on a review of available data on: 2012-06-01 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2012-06-01 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\l(1)G0469 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

l(1)G0469-RA

FBtr0073927

NM_167395

1761

321

l(1)G0469-RC

FBtr0333428

NM_001103510

2729

338

l(1)G0469-RD

FBtr0333429

NM_001272614

3709

321

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

l(1)G0469-PA

FBpp0073744

35.7

321

9.18

NP_727763

AAF48353

l(1)G0469-PC

FBpp0305619

37.6

338

9.41

NP_001096980

ABW09412

l(1)G0469-PD

FBpp0305620

35.7

321

9.18

NP_001259543

AGB95385

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

321 aa isoforms: l(1)G0469-PA, l(1)G0469-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(1)G0469 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

l(1)G0469_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\l(1)G0469 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\l(1)G0469

View exonic expression by tissue for Dmel\l(1)G0469

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040153

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0040153

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG32597-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32597

Flygut - An atlas of the Drosophila adult midgut

FBgn0040153

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of l(1)G0469

Transgenic constructs containing regulatory region of l(1)G0469

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of prepupal stage

l(1)G0469^G0469

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

some die during prepupal stage | recessive

l(1)G0469^G0469

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LRAT

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Lrat

2 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Lrat

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\LOC101733311

1 of 12

Yes

Xtro\lrat

1 of 12

Yes

Xtro\pla2g16

1 of 12

Yes

Xtro\rarres3

1 of 12

Yes

Danio rerio (Zebrafish) (4)

Drer\lrata

1 of 15

Yes

Drer\lratb.2

1 of 15

Yes

Drer\si:dkey-30k22.5

1 of 15

Yes

Drer\zgc:194275

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190C6V )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA25812

Drosophila persimilis

Dper\GL13005

Drosophila willistoni

Dwil\GK25177

Drosophila virilis

Dvir\GJ14707

Drosophila mojavensis

Dmoj\GI15053

Drosophila grimshawi

Dgri\GH12456

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C30 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017975

Glossina morsitans

Tsetse fly

Gmor\GMOY006057

Mayetiola destructor

Hessian fly

Mdes\Mdes005251

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002950

Anopheles darlingi

American malaria mosquito

Adar\ADAC001689

Anopheles gambiae

Malaria mosquito

Agam\AGAP002459

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013079

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0E98 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS212331-PA

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025912

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025367

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG017336

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG029641

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG022466

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG035709

Tribolium castaneum

Red flour beetle

Tcas\TC002510

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0E81 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001759

Strigamia maritima

European centipede

Smar\SMAR002915

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_115643

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0040153

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-48

Cytogenetic map

12E4-12E4

Sequence location

X:14,203,961..14,211,457 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

12E4-12E4

Limits computationally determined from genome sequence between P{EP}EP1595^EP1595 and P{EP}l(1)G0007^EP764

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

12E3-12E7

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.12.2)

Experimentally Determined Recombination Data

Location

1-48

(FlyBase, 2016)

1-45.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

15393

y¹ w^67c23 P{EPgy2}l(1)G0469^EY02030

63022

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05296}attP40

41434

y¹ w^* Mi{MIC}Prp16^MI05854 l(1)G0469^MI05854

Kyoto

111930

y¹ w^* P{lacW}l(1)G0469^G0469 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

VDRC

v107978

P{KK112381}VIE-260B

v26982

w¹¹¹⁸; P{GD13450}v26982

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH27568

Other clones

DPiM_GH27568

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040153

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040153

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32371

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG11595 CG12482

(Peter et al., 2002, FlyBase, 1996-)

Source for merge of: l(1)G0469 anon-WO03040301.232

(FlyBase, 1996-)

Additional comments

Annotations CG11595, CG12482 merged as CG32597 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG11595 CG12482 was a shared cDNA ( date:010720 ).

(Peter et al., 2002, FlyBase, 1996-)

Source for merge of l(1)G0469 anon-WO03040301.232 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32371

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis