non-visual β-arrestin that functions in GPCR desensitization - regulates the Hedgehog pathway, the Notch pathway, MAPK signaling and Toll signaling - modifies exploratory activity and olfactory sensitivity
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\krz using the Feature Mapper tool.
krz message is detected in all developmental stages, including aged adults. Early embryonic expression is ubiquitous; in later stages expression is detected in the CNS, maxillary cirri, and the antennal sense organs. In third instar larvae, expression is detected in fat bodies, the ventral part of the thoracic-abdominal ganglia, the deuterocerebrum, the eye-antennal imaginal disc, and the wing disc. In larval wing discs expression is detected in the notum region and in a thin stripe that winds throughout the wing primordium.
GBrowse - Visual display of RNA-Seq signalsView Dmel\krz in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The gene is named "kurtz" after the character in Joseph Conrad's "The Heart of Darkness" in which Conrad symbolically uses the contrast of light and dark. The character Kurtz is defined by his darkness and is a metaphor for the krz arrestin mutants, which form melanotic tumours.