• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Kat60

General Information
Symbol	Dmel\Kat60	Species	D. melanogaster
Name	Katanin 60	Annotation symbol	CG10229
Feature type	protein_coding_gene	FlyBase ID	FBgn0040208
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Katanin-60
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82F6-82F6	Sequence location	3R:1,053,011..1,057,931 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Katanin 60 is referred to in FlyBase by the symbol Dmel\Kat60 (CG10229, FBgn0040208). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; microtubule-severing ATPase activity. There is experimental evidence that it is involved in the biological process: chaeta development; wing disc development; plus-end specific microtubule depolymerization; negative regulation of cell migration; microtubule depolymerization; cytoplasmic microtubule organization; mitotic anaphase A; mitotic sister chromatid segregation; microtubule severing. 11 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; Kenyon cell; mushroom body alpha-lobe. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Vps4 oligomerisation, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626706_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of katanin-60. Gene sequence location is 3R:1053011..1057931.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82F6-82F6   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82F-82F     (Huang, 2000.1.11)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Kat60 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Kat60-RA FBtr0078827  NM_080258   2563   572 Kat60-RB FBtr0334909  NM_001275347   2662   605
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Kat60-PA   FBpp0078469   63.3   572   8.44     NP_524997   AAF52059 Kat60-PB   FBpp0306930   66.9   605   8.31     NP_001262276   AGB95659
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Vps4 oligomerisation, C-terminal (IPR015415) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391809   AA567295   AA696629   AA816700   AE014297 AAF52059   AF223064 AAF34687   AE014297 AGB95659   AI258398   AI531281   AI531289   AY071142 AAL48764   BI231056   BI240528   BI242734   BI243112   BI243220   BI243221   BI352472   BI367046   BI368026   BI368389   BI372137   BI374768   BI375705   BI375883   BI482312   BI486157   BI565134   BI577360   BI578763   BI580229   BI614816   BI615326   BI625158   BI636094   BP559597   BP559598   BT126082   BT133173   CK657754   CK659353   CO177399   CO179879   CO180049   CO265655   CO277989   CO283204   CO284439   CO313177   CO339465   CO344634   CZ488535   EC060968   EC072874   EC084016   EC241545   EC247677   EC248470   EC252613   EC256737   EV588688   FE426492   FE862636   FE862685   FE862989   FE863178   FE863274   FE863303   GH738962   GH738975   GH739195   GH740020   GH741240   GH745291   GH762053   GH762571   GH763423   GH763711   GH765795   GH767145   GH767914   GO254382
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VN89 Q8SZ40 Q9NHF1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (Zhang et al., 2011) cell leading edge inferred from direct assay (Zhang et al., 2011) centrosome inferred from direct assay (Zhang et al., 2007) chromosome inferred from direct assay (Zhang et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary  526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary  526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    405.2 Larval Midgut    217.1 Larval Hindgut    250.6 Larval Malpighian Tubules    292.8 Larval Fat Body    181 Larval Salivary Gland    284.3 Larval Trachea    228.3 Larval Carcass    255.2 Adult Head    166.7 Adult Eye    170.7 Adult Brain    275.8 Adult Thoracic-Abdominal Ganglion    237 Adult Crop    249.4 Adult Midgut    204.1 Adult Hindgut    223.2 Adult Malpighian Tubules    191.1 Adult Fat Body    127.4 Adult Salivary Gland    289 Adult Heart    133.4 Adult VirginFemale Spermatheca    136.4 Adult InseminatedFemale Spermatheca    127 Adult Ovary    526.7 Adult Testis    95.7 Adult Male Accessory Gland    203.1 Adult Carcass    154.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    166.7   NA  Eye    170.7   NA  Brain    275.8   405.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    237   NA  Crop    249.4   217.1  Midgut    204.1   250.6  Hindgut    223.2   292.8  Malpighian Tubules    191.1   181  Fat Body    127.4   284.3  Salivary Gland    289   NA  Heart    133.4   228.3  Trachea    NA   NA  VirginFemale Spermatheca    136.4   NA  InseminatedFemale Spermatheca    127   NA  Ovary    526.7   NA  Testis    95.7   NA  Male Accessory Gland    203.1   255.2  Carcass    154.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (42) central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae    19 digestive system, larvae L3 wandering  (42) digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering  (30) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (61) testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (42) central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae    19 digestive system, larvae L3 wandering  (42) digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering  30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (61) testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    42 central nervous system, pupae P8    21 head, virgin 1-day female    17 head, virgin 4-day female    12 head, virgin 20-day female    10 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    18 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    42 digestive system, 1-day adult    12 digestive system, 4-day adult    17 digestive system, 20-day adult    21 fat body, larvae L3 wandering    8 fat body, white prepupae    13 fat body, pupae P8    16 carcass, larvae L3 wandering    30 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    58 ovary, mated 4-day female    61 testis, mated 4-day male    15 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (49) embryo 04-06hr  (42) embryo 06-08hr  (46) embryo 08-10hr  (42) embryo 10-12hr  (29) embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr  26 embryo 20-22hr  (27) embryo 22-24hr  (28) larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (28) white prepupae new  (32) white prepupae 12hr  (39) white prepupae 24hr  (36) pupae 2d postWPP  26 pupae 3d postWPP    23 pupae 4d postWPP  (36) adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (49) embryo 04-06hr  (42) embryo 06-08hr  (46) embryo 08-10hr  (42) embryo 10-12hr  29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr  26 embryo 20-22hr  27 embryo 22-24hr  28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  28 white prepupae new  32 white prepupae 12hr  (39) white prepupae 24hr  (36) pupae 2d postWPP  26 pupae 3d postWPP    23 pupae 4d postWPP  (36) adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    49 embryo 04-06hr    42 embryo 06-08hr    46 embryo 08-10hr    42 embryo 10-12hr    29 embryo 12-14hr    24 embryo 14-16hr    22 embryo 16-18hr    18 embryo 18-20hr    26 embryo 20-22hr    27 embryo 22-24hr    28 larva L1    17 larva L2    13 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    28 white prepupae new    32 white prepupae 12hr    39 white prepupae 24hr    36 pupae 2d postWPP    26 pupae 3d postWPP    23 pupae 4d postWPP    36 adult male 01day    14 adult male 05day    14 adult male 30day    14 adult female 01day    23 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2  (39) embryonic Kc167  (28) embryonic S1  (34) embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9  26 wing disc ML-DmD16-c3  (30) wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3  (31) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  (29) ovary fGS/OSS  (54) ovary OSC  (37) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (41) Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2  (39) embryonic Kc167  28 embryonic S1  (34) embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9  26 wing disc ML-DmD16-c3  30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3  31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  29 ovary fGS/OSS  (54) ovary OSC  (37) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    41 Schneider line 2 Sg4    23 embryonic 1182-4H    22 embryonic GM2    39 embryonic Kc167    28 embryonic S1    34 embryonic S3    12 leg disc CME L1    21 wing disc CME-W2    21 wing disc ML-DmD8    24 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    20 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    29 ovary fGS/OSS    54 ovary OSC    37 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  (28) Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (63) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (45) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (40) Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult  28 Cadmium 100 mM 48 hrs, 4-day adult  (55) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (63) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (45) Caffeine 25 mg/ml 48 hrs, 4-day adult  (34) Paraquat 5 mM 48 hrs, 4-day adult  (40) Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    17 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    28 Cadmium 100 mM 48 hrs, 4-day adult    55 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    63 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    45 Caffeine 25 mg/ml 48 hrs, 4-day adult    34 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE17942 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040208 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10229-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Kat60 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Kat60GD6908 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL47B Kat60UY1645 Phenotype manifest in Allele Kenyon cell, with Scer\GAL47B Kat60UY1645 mushroom body, with Scer\GAL47B Kat60UY1645 mushroom body & axon, with Scer\GAL47B Kat60UY1645 mushroom body alpha-lobe, with Scer\GAL47B Kat60UY1645
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Kat60 Class Mutagen Stocks Known lesion Kat60EY05593 P-element activity 1 -- Kat60f05910 piggyBac transposase 1 -- Kat60MB06739 1 -- Kat60NP7437 1 -- Kat60UY1645 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Kat60 Class Mutagen Stocks Known lesion Kat60GD6908 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Kat60GL00481 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kat60JF03012 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kat60KK108203 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kat60NIG.10229R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Kat60Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.10229R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Kat60EY05593 NA P{Mae-UAS.6.11}Kat60UY1645 NA insertion of enhancer trap binary system Mi{ET1}Kat60MB06739 No P{GawB}Kat60NP7437 No miscellaneous insertions PBac{WH}Kat60f05910 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
microtubule-severing ATPase activity inferred from direct assay (Zhang et al., 2011) inferred from mutant phenotype (Zhang et al., 2007) protein binding inferred from physical interaction with Myo10A (Liu et al., 2008)
Biological Process
CV term Evidence References
chaeta development inferred from genetic interaction with Ssdp (Bronstein et al., 2010) cytoplasmic microtubule organization inferred from mutant phenotype (Zhang et al., 2011) microtubule depolymerization inferred from direct assay (Zhang et al., 2011) microtubule severing inferred from direct assay (Zhang et al., 2011) inferred from mutant phenotype (Zhang et al., 2007) mitotic anaphase A inferred from mutant phenotype (Zhang et al., 2007) mitotic sister chromatid segregation inferred from mutant phenotype (Zhang et al., 2007) negative regulation of cell migration inferred from mutant phenotype (Zhang et al., 2011) plus-end specific microtubule depolymerization inferred from mutant phenotype (Zhang et al., 2007) wing disc development inferred from genetic interaction with ap (Bronstein et al., 2010) inferred from genetic interaction with Bx (Bronstein et al., 2010)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Zhang et al., 2011) cell leading edge inferred from direct assay (Zhang et al., 2011) centrosome inferred from direct assay (Zhang et al., 2007) chromosome inferred from direct assay (Zhang et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960 (FlyBase Curators et al., 2004-) microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) microtubule severing inferred from sequence or structural similarity with NCBI_gi:3283072 (Goldstein and Gunawardena, 2000) non-traceable author statement (Huang, 2000.1.11)
Cellular Component
CV term Evidence References
katanin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF052191 (FlyBase, 1992-) inferred from sequence or structural similarity with NCBI_gi:3283072 (Goldstein and Gunawardena, 2000) non-traceable author statement (Huang, 2000.1.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Kat60 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72797 DroID - A comprehensive database of gene and protein interactions. • FBgn0040208 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53566
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69W314 Dipteran inclusive ortholog search EOG6CZBQ8 Insect inclusive ortholog search EOG63TXR1 Arthropod inclusive ortholog search EOG6BG7BF Metazoa inclusive ortholog search EOG642350
Orthologs in Drosophila Species (EOG69W314)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Kat60     Drosophila simulans   Dsim\GD19637 Y   Drosophila sechellia   Dsec\GM10656 Y   Drosophila erecta   Dere\GG11155 Y   Drosophila yakuba   Dyak\GE25304 Y   Drosophila ananassae   Dana\GF16069 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10173 Y   Drosophila persimilis   Dper\GL22198 Y   Drosophila willistoni   Dwil\GK14289 Y   Drosophila virilis   Dvir\GJ11019 Y   Drosophila mojavensis   Dmoj\GI10218 Y   Drosophila grimshawi   Dgri\GH22753 Y
Orthologs in non-Drosophila Dipterans (EOG6CZBQ8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007637   Anopheles gambiae Malaria mosquito  Agam\AGAP001783   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010164
Orthologs in non-Dipteran Insects (EOG63TXR1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44515 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003042 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12071 Y Atta cephalotes Leafcutter ant  Acep\ACEP10105 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20273 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22587 Y Linepithema humile Argentine ant  Lhum\LH20808 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24515 Y Solenopsis invicta Red fire ant  Sinv\SINV18505 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003099 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001206 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010271 Y Pediculus humanus Human body louse  Phum\PHUM599850 Y Pediculus humanus Human body louse  Phum\PHUM080400 Y Tribolium castaneum Red flour beetle  Tcas\TC013585 Y
Orthologs in non-Insect Arthropods (EOG6BG7BF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305607 Y Daphnia pulex Water flea  Dpux\Ring1 Y Ixodes scapularis Deer tick  Isca\ISCW015571 Y
Orthologs in non-Arthropod Metazoa (EOG642350)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mei-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001000gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007977gn Y Danio rerio Zebrafish  Drer\katna1 Y Danio rerio Zebrafish  Drer\katnal2 Y Xenopus tropicalis Western clawed frog  Xtro\katnal1 Y Xenopus tropicalis Western clawed frog  Xtro\katnal2 Y Xenopus tropicalis Western clawed frog  Xtro\katna1 Y Gallus gallus Domestic chicken  Ggal\KATNAL2 Y Gallus gallus Domestic chicken  Ggal\KATNAL1 Y Gallus gallus Domestic chicken  Ggal\KATNA1 Y Mus musculus House mouse  Mmus\Katnal1 Y Rattus norvegicus Norway rat  Rnor\Katnal1 Y Rattus norvegicus Norway rat  Rnor\Katna1 Y Rattus norvegicus Norway rat  Rnor\Katnal2 Y Homo sapiens Human  Hsap\KATNAL1 Y Homo sapiens Human  Hsap\KATNA1 Y Homo sapiens Human  Hsap\KATNAL2 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\KATNAL1     Hsap\KATNA1     Hsap\KATNAL2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19637 Drosophila sechellia Dsec\GM10656 Drosophila erecta Dere\GG11155 Drosophila yakuba Dyak\GE25304 Drosophila ananassae Dana\GF16069 Drosophila pseudoobscura pseudoobscura Dpse\GA10173 Drosophila persimilis Dper\GL22198 Drosophila willistoni Dwil\GK14289 Drosophila virilis Dvir\GJ11019 Drosophila mojavensis Dmoj\GI10218 Drosophila grimshawi Dgri\GH22753
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	25251 w1118; Mi{ET1}Kat60MB06739 28375 y1 v1; P{TRiP.JF03012}attP2 15953 y1 w67c23; P{EPgy2}Kat60EY05593 35634 y1 sc* v1; P{TRiP.GL00481}attP40 7345 y1 w67c23; P{Mae-UAS.6.11}Kat60UY1645
Harvard	- PBac{WH}Kat60f05910
Kyoto	105456 y* w*; P{GawB}Kat60NP7437 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v106487 P{KK108203}VIE-260B v38368 w1118; P{GD6908}v38368 v38369 w1118; P{GD6908}v38369
Genomic Clones ( 1 )
	BACR01D10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE17942 RE37382
Other clones	FI18748
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02283 GM08035 GM19421 LD04260 LD10709 LP01587 LP17063 LP24292 RE37381 RE40144 RE40668 RE40789 RE40791 RE52719 RE53927 RE54354 RE59018 RE62441 RE63569 RE63784 RE64988 RE69539 RE71026 RE72679 RE74382 RH44290 RH44932 RH62825 RH65155 SD02251 SD02263 SD17662
Other clones	16614 31088 33278 81561 106256 214437.78 214469.66 CK01.65C.D2 Dmel_neb_013535_0149_3425 EC00433 EC00833 EK053345 EK127963 EK143316 EK162607 EK166051 EK231819 EP02052 EP19637 FGM321G11 RM05184 RM05384 RM06184 RM06284 RM06384 RM06484 RM06584 RP01224 RP001002767 RP001003114 RP001003840 RP001004709 RP001005195 RP001005470 RP001007535 RP001013214 RP001017004 RP001021109 RP001026482 RP001044161 RP001054776
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040208 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53566
Antibody Information
	polyclonal (Zhang et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: katanin-60 CG10229 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080258 NM_001275347 RefSeq (Proteins) • NP_524997 NP_001262276 DDBJ / EMBL / GenBank • AAF34687 AAF52059 AAL48764 AF223064 AGB95659 AY071142 BI231056 CZ488535 Entrez Gene - A searchable database of RefSeq genes. • 53566 UniProtKB/TrEMBL • Q8SZ40 Q9NHF1 Q9VN89
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Vps4 oligomerisation, C-terminal (IPR015415) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE17942
Linkouts
	BioGRID - A database of protein and genetic interactions • 72797 DroID - A comprehensive database of gene and protein interactions. • FBgn0040208 DRSC - Results from RNAi screens. • FBgn0040208 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040208 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10229-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040208 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53566 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53566 modMine - Data generated by the modENCODE project. • FBgn0040208
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG10229 (Goldstein and Gunawardena, 2000, Goldstein and Gunawardena, 2000, Liu et al., 2008, Zhang et al., 2007, Cuttell et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Gandhi et al., 2007, Bronstein et al., 2010, Ni et al., 2011.7.19, Derré et al., 2007) DmCG10229 (Frohlich, 2001) Dm-Kat60 (Zhang et al., 2011) kat60 (Widmann and Dahmann, 2009) Kat60   Katanin-60 (Liu et al., 2008) katanin-60 (Zhang et al., 2007, Derré et al., 2007, Taniguchi et al., 2007, Robida et al., 2007, Bronstein et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Katanin 60 (Cuttell et al., 2008) katanin60-dm (Kammermeier et al., 2003)
Name Synonym	katanin (Zhang et al., 2007) Katanin-60 (Díaz-Valencia et al., 2011) katanin 60 (Huang, 2000.1.11) Katanin 60
Secondary FlyBase IDs
	FBgn0037300
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Chen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(29): 11842--11847 Axon injury and stress trigger a microtubule-based neuroprotective pathway. [FBrf0218884] Díaz-Valencia et al., 2011, Biophys. J. 100(10): 2440--2449 Drosophila katanin-60 depolymerizes and severs at microtubule defects. [FBrf0213660] Zhang et al., 2011, Nat. Cell Biol. 13(4): 361--369 Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration. [FBrf0213357] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...