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Gene Dmel\dyn-p25

General Information
Symbol	Dmel\dyn-p25	Species	D. melanogaster
Name	dynactin-subunit-p25	Annotation symbol	CG10846
Feature type	protein_coding_gene	FlyBase ID	FBgn0040228
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	l(2)35Bf, l(2)br2, p25, br2, BG:DS00929.1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35B8-35B8	Sequence location	2L:15,005,733..15,006,607 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dynactin-subunit-p25 is referred to in FlyBase by the symbol Dmel\dyn-p25 (CG10846, FBgn0040228). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: transferase activity. There is experimental evidence that it is involved in the biological process: positive regulation of retrograde axon cargo transport. 17 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; mesothoracic tergum; wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Bacterial transferase hexapeptide repeat; Trimeric LpxA-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623231_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of dyn-p25. Gene sequence location is 2L:15005733..15006607.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)35Bf Escapers show thin, short bristles and outstretched wings. l(2)35Bf3 partially complements l(2)35Bf1 and l(2)35Bf2 for viability; female-sterile alleles recovered by Lindsley.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms positive regulation of retrograde axon cargo transport
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35B8-35B8   Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)	Su(H) (Woodruff and Ashburner, 1979)
Right of (cM)	l(2)35Be (Woodruff and Ashburner, 1979)
Notes	Excision of l(2)35Bck08808 indicates that the gene order is mol, dyn-p25, l(2)35Be, l(2)35Bc, l(2)35Bd. (Ashburner et al., 1999.10.12) Complementation analysis establishes the following gene order (distal to proximal): dyn-p25, l(2)35Be, l(2)35Bc. (Ashburner et al., 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\dyn-p25 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dyn-p25-RA FBtr0080693  NM_165097   730   189
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dyn-p25-PA   FBpp0080255   20.6   189   8.44     NP_723893   AAF53426
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Trimeric LpxA-like (IPR011004) Bacterial transferase hexapeptide repeat (IPR001451)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53426   AE003411 AAF44905   AF224265 AAF34709   AI386834   BG633017   CO152870   CO275427   CZ467742   EC072170   EC261745
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJQ6 Q9NHE4 Q7KT78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    158.2 Larval Midgut    158.8 Larval Hindgut    164.2 Larval Malpighian Tubules    221.9 Larval Fat Body    99.3 Larval Salivary Gland    226.7 Larval Trachea    248.3 Larval Carcass    189.9 Adult Head    118.6 Adult Eye    171.325 Adult Brain    160 Adult Thoracic-Abdominal Ganglion    162.2 Adult Crop    160.3 Adult Midgut    174.3 Adult Hindgut    203.1 Adult Malpighian Tubules    104.4 Adult Fat Body    89.2 Adult Salivary Gland    197 Adult Heart    106.85 Adult VirginFemale Spermatheca    96.8 Adult InseminatedFemale Spermatheca    123.2 Adult Ovary    115.3 Adult Testis    97.4 Adult Male Accessory Gland    109.5 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    118.6   NA  Eye    171.325   NA  Brain    160   158.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    162.2   NA  Crop    160.3   158.8  Midgut    174.3   164.2  Hindgut    203.1   221.9  Malpighian Tubules    104.4   99.3  Fat Body    89.2   226.7  Salivary Gland    197   NA  Heart    106.85   248.3  Trachea    NA   NA  VirginFemale Spermatheca    96.8   NA  InseminatedFemale Spermatheca    123.2   NA  Ovary    115.3   NA  Testis    97.4   NA  Male Accessory Gland    109.5   189.9  Carcass    96.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    2 head, mated 20-day male    6 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    4 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr  (35) embryo 04-06hr  (31) embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (29) white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  26 embryo 02-04hr  (35) embryo 04-06hr  31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    26 embryo 02-04hr    35 embryo 04-06hr    31 embryo 06-08hr    20 embryo 08-10hr    20 embryo 10-12hr    24 embryo 12-14hr    14 embryo 14-16hr    18 embryo 16-18hr    18 embryo 18-20hr    20 embryo 20-22hr    21 embryo 22-24hr    22 larva L1    17 larva L2    17 larva L3 12hr old    15 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    29 white prepupae new    25 white prepupae 12hr    23 white prepupae 24hr    22 pupae 2d postWPP    24 pupae 3d postWPP    17 pupae 4d postWPP    24 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    18 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    17 embryonic 1182-4H    16 embryonic GM2    15 embryonic Kc167    18 embryonic S1    14 embryonic S3    10 leg disc CME L1    8 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    23 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    10 ovary fGS/OSS    4 ovary OSC    2 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040228 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10846-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 dyn-p25GD3469 lethal | recessive dyn-p253 dyn-p254 dyn-p255 dyn-p256 dyn-p25c02174 partially lethal - majority die | adult stage, with Scer\GAL4pnr-MD237 dyn-p25GD3469 Sterility Allele female sterile dyn-p258 male sterile dyn-p25Z4556 male sterile (with Df(2L)64j) dyn-p25Z4556 male sterile (with Df(2L)A400) dyn-p25Z4556 male sterile (with Df(2L)b80k) dyn-p25Z4556 male sterile (with dyn-p254) dyn-p25Z4556 male sterile (with dyn-p258) dyn-p25Z4556 male sterile (with dyn-p25Z4556) dyn-p254 dyn-p258 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 dyn-p25GD3469 Phenotype manifest in Allele macrochaeta dyn-p251 dyn-p252 dyn-p253 macrochaeta & thorax (with Df(2L)64j) dyn-p25Z4556 macrochaeta & thorax (with Df(2L)A400) dyn-p25Z4556 mesothoracic tergum, with Scer\GAL4pnr-MD237 dyn-p25GD3469 wing dyn-p251 dyn-p252 dyn-p253
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of dyn-p25 Class Mutagen Stocks Known lesion dyn-p255 ethyl methanesulfonate 2 -- dyn-p25c02174 piggyBac transposase 2 -- dyn-p253 ethyl methanesulfonate 1 -- dyn-p25f02738 1 -- dyn-p25MI00921 1 -- dyn-p25Z4556 1 -- dyn-p251 ethyl methanesulfonate 0 -- dyn-p252 ethyl methanesulfonate 0 -- dyn-p254 ethyl methanesulfonate 0 -- dyn-p256 ethyl methanesulfonate 0 -- dyn-p257 ethyl methanesulfonate 0 -- dyn-p258 ethyl methanesulfonate 0 -- dyn-p25QL53 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dyn-p25 Class Mutagen Stocks Known lesion dyn-p25GD3469 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dyn-p25HM05233 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dyn-p25KK107799 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dyn-p25NIG.10846R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)A47 (Ashburner et al., 1982) Df(2L)A63 (Ashburner et al., 1982) Df(2L)A178 (Ashburner et al., 1982) Df(2L)A217 (Ashburner et al., 1982) Df(2L)A245 (Ashburner et al., 1982) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A266 (Ashburner et al., 1982) Df(2L)A379 (Ashburner et al., 1982) Df(2L)A445 (Ashburner et al., 1982) Df(2L)AntpCtxrv1 (Roote, 1996.8) Df(2L)b75 (Woodruff and Ashburner, 1979) Df(2L)b84a7 (Furukawa et al., 1992) Df(2L)el77 (Woodruff and Ashburner, 1979) Df(2L)fn2 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn3 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn7 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn36 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)k08808-rv70 (Roote, 2000.6.13) Df(2L)rd9 (Furukawa et al., 1992) Df(2L)Sco-1 (Ashburner, 1982) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Ashburner, 1982, Gubb et al., 1984) Df(2L)TE35BC-3 (Ashburner, 1982, Gubb et al., 1984) Df(2L)TE35BC-24 (Iyengar et al., 1999, Gubb et al., 1984) Df(2L)TE35D-2 (Furukawa et al., 1992) Df(2L)TE35D-6 (Furukawa et al., 1992) Df(2L)TE35D-13 (Furukawa et al., 1992) Df(2L)TE35D-15 (Furukawa et al., 1992) Df(2L)TE35D-18 (Furukawa et al., 1992) Df(2L)W (Woodruff and Ashburner, 1979) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979) T(2;3)Scorv7 (Woodruff and Ashburner, 1979) T(Y;2)J165DP58P (Woodruff and Ashburner, 1979) T(Y;2)R15DJ165P (Woodruff and Ashburner, 1979)
Disrupted in	Df(2L)64j (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner, 1982, Furukawa et al., 1992, Roote, 2010.1.4) Df(2L)A48 (Ashburner et al., 1982) Df(2L)A72 (Ashburner et al., 1982) Df(2L)A215 (Ashburner et al., 1982) Df(2L)A220 (Ashburner et al., 1982) Df(2L)A246 (Ashburner et al., 1982) Df(2L)A263 (Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)A264 (Ashburner et al., 1982) Df(2L)A267 (Ashburner et al., 1982) Df(2L)A376 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)A377 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)A400 (Ashburner et al., 1982, Ashburner, 1982, Roote, 2010.1.4) Df(2L)ARR1 (Ashburner, 1982, Furukawa et al., 1992) Df(2L)b80k (Roote, 2010.1.4) Df(2L)b84a3 (Furukawa et al., 1992) Df(2L)b84h50 (Furukawa et al., 1992) Df(2L)do1 (Ashburner, 1982) Df(2L)ED1050 (Roote, 2004.6.24) Df(2L)el28 (Furukawa et al., 1992) Df(2L)Exel7061 (Ryder, 2004.4.26) Df(2L)fn1 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn5 (O'Donnell et al., 1977, Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)fn12 (Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn15 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn26 (Ashburner et al., 1982) Df(2L)fn27 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn30 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn31 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner, 1982) Df(2L)osp29 (Furukawa et al., 1992) Df(2L)Scorv4 (Woodruff and Ashburner, 1979) Df(2L)Scorv23 (Ashburner, 1982) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35BC-4 (Ashburner, 1982, Gubb et al., 1984) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984, Furukawa et al., 1992) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984, Furukawa et al., 1992) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) In(2L)75c (Woodruff and Ashburner, 1979, Ashburner, 1982) In(2L)C158LScorv11R (Ashburner and Harrington, 1984) In(2L)C158LScorv17R (Ashburner and Harrington, 1984) In(2L)TE35B-13 (Gubb et al., 1985) In(2LR)noc4LScorv9R (Ashburner and Harrington, 1984) In(2LR)TE35B-6LScorv9R (Ashburner and Harrington, 1984) T(Y;2)A80DR15P (Woodruff and Ashburner, 1979) Tp(2;2)A446 (Ashburner et al., 1982) Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984) Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984)
Duplicated in	Dp(2;1)Scorv23 (Ashburner, 1982) Dp(2;2)GYL (Ashburner, 1982) Dp(2;2)GYS (Ashburner, 1982) In(2L)C163.41LC158R (Ashburner, 1982) In(2L)Scorv17LC158R (Ashburner, 1982)
Not duplicated in	Dp(2;2)Adh3 (Ashburner, 1982)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3469} NA P{KK107799} NA P{NIG.10846R} NA P{TRiP.HM05233} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}dyn-p25MI00921 NA PBac{PB}dyn-p25c02174 NA PBac{WH}dyn-p25f02738 NA insertion of enhancer trap P{lacW}molSH1330 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of retrograde axon cargo transport inferred from mutant phenotype (Yang et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transferase activity inferred from electronic annotation with InterPro:IPR011004 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
microtubule-based movement inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
dynactin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Eckley, 2000.1.12)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dyn-p25 - Arp1 experimental knowledge based (Guruharsha et al., 2011) dyn-p25 - Arp10 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) dyn-p25 - CG12042 experimental knowledge based (Guruharsha et al., 2011) dyn-p25 - Dmn experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dyn-p25 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60892 DroID - A comprehensive database of gene and protein interactions. • FBgn0040228 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34873
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG673QBR Dipteran inclusive ortholog search EOG60K882 Insect inclusive ortholog search EOG6HT7PN Arthropod inclusive ortholog search EOG6S7H6D Metazoa inclusive ortholog search EOG6G7QT7
Orthologs in Drosophila Species (EOG673QBR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dyn-p25     Drosophila simulans   Dsim\GD23985 Y   Drosophila sechellia   Dsec\GM15840 Y   Drosophila erecta   Dere\GG25135 Y   Drosophila yakuba   Dyak\GE19054 Y   Drosophila ananassae   Dana\GF14899 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10595 Y   Drosophila persimilis   Dper\GL26020 Y   Drosophila willistoni   Dwil\GK18306 Y   Drosophila virilis   Dvir\GJ11828 Y   Drosophila mojavensis   Dmoj\GI13204 Y   Drosophila grimshawi   Dgri\GH10910 Y
Orthologs in non-Drosophila Dipterans (EOG60K882)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007566   Anopheles gambiae Malaria mosquito  Agam\AGAP013747   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003121
Orthologs in non-Dipteran Insects (EOG6HT7PN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.2266   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010823   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10288   Atta cephalotes Leafcutter ant  Acep\ACEP20873   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20917   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18983   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22366   Linepithema humile Argentine ant  Lhum\LH10994   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17937   Solenopsis invicta Red fire ant  Sinv\SINV19886   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004169   Bombyx mori Silkmoth  Bmor\BGIBMGA005274   Pediculus humanus Human body louse  Phum\PHUM101570   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08312
Orthologs in non-Insect Arthropods (EOG6S7H6D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_230296   Daphnia pulex Water flea  Dpux\JGI_V11_106006   Ixodes scapularis Deer tick  Isca\ISCW010831
Orthologs in non-Arthropod Metazoa (EOG6G7QT7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dnc-5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028205gn   Danio rerio Zebrafish  Drer\dctn5   Xenopus tropicalis Western clawed frog  Xtro\dctn5   Gallus gallus Domestic chicken  Ggal\DCTN5   Mus musculus House mouse  Mmus\Dctn5   Rattus norvegicus Norway rat  Rnor\Dctn5   Homo sapiens Human  Hsap\DCTN5
Human Orthologs (1)
Gene OMIM HGNC Hsap\DCTN5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23985 Drosophila sechellia Dsec\GM15840 Drosophila erecta Dere\GG25135 Drosophila yakuba Dyak\GE19054 Drosophila ananassae Dana\GF14899 Drosophila pseudoobscura pseudoobscura Dpse\GA10595 Drosophila persimilis Dper\GL26020 Drosophila willistoni Dwil\GK18306 Drosophila virilis Dvir\GJ11828 Drosophila mojavensis Dmoj\GI13204 Drosophila grimshawi Dgri\GH10910
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	3214 b1 Adhn4 dyn-p255/CyO 30467 Adhn7 dyn-p253 cn1/CyO 10853 w1118; PBac{PB}dyn-p25c02174/CyO 29643 dyn-p25Z4556 cn1 bw1/CyO 34123 y1 w*; Mi{MIC}dyn-p25MI00921 30491 y1 sc* v1; P{TRiP.HM05233}attP2/TM3, Sb1
Harvard	- PBac{PB}dyn-p25c02174 - PBac{WH}dyn-p25f02738
Kyoto	101301 b1 Adhn4 dyn-p255 / CyO, Cy1 dplv1 pr1 cn2
VDRC	v104352 P{KK107799}VIE-260B v8057 w1118; P{GD3469}v8057 v8058 w1118; P{GD3469}v8058
Genomic Clones ( 1 )
	BACR03D18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH17154
Other clones	14897 475298 EK117552 EN00632 GH18338
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040228 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34873
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: dynactin-subunit-p25 BG:DS00929.1 (Bayraktaroglu, 2000.8.7) Source for merge of: dyn-p25 l(2)35Bf (Roote, 2004.9.30)
Additional comments	"BG:DS00929.1" may correspond to "l(2)35Bf" or "l(2)35Be". "BG:DS00929.16", "BG:DS00929.1" or "BG:DS00929.2" may correspond to "l(2)35Bf". (Ashburner et al., 1999.10.12)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165097 RefSeq (Proteins) • NP_723893 DDBJ / EMBL / GenBank • AAF34709 AAF44905 AAF53426 AAN10884 AE003411 AF224265 AI386834 CZ467742 Entrez Gene - A searchable database of RefSeq genes. • 34873 UniProtKB/TrEMBL • Q7KT78 Q9NHE4 Q9VJQ6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Trimeric LpxA-like (IPR011004) Bacterial transferase hexapeptide repeat (IPR001451)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60892 DroID - A comprehensive database of gene and protein interactions. • FBgn0040228 DRSC - Results from RNAi screens. • FBgn0040228 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040228 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10846-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040228 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34873 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34873 modMine - Data generated by the modENCODE project. • FBgn0040228
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BG:DS00929.1 (Ashburner et al., 1999, Ashburner et al., 1999.10.12, ) br2 (Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984) C4 (O'Donnell et al., 1977) CG10846 (Goldstein and Gunawardena, 2000, Perkins et al., 2009, Keleman et al., 2009.8.5) DS00929.1 (Reese et al., 2000) dyn-p25 (Roote, 2010.1.4, Yang et al., 2008, Japanese National Institute of Genetics, 2012.5.21) l(2)35Bf (Ashburner et al., 1999, Spradling et al., 1995, Roote, 2001.5.23, Roote, 1997.6.6, Iyengar et al., 1999, Ashburner et al., 1999.10.12, ) l(2)br2 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, ) p25 (Parisi et al., 2004, Li et al., 2008, Yang et al., 2008)
Name Synonym	dynactin, p25 subunit (Tekotte and Davis, 2002) dynactin-subunit-p25 (Bloomington Drosophila Stock Center, 2004.9.23) lethal 2 in the black-reduced region (Woodruff and Ashburner, 1979) lethal(2)35Bf   lethal group C4 (O'Donnell et al., 1977)
Secondary FlyBase IDs
	FBgn0001976 FBgn0028929
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 9 ) Review  ( 2 ) Personal communication to FlyBase  ( 22 ) FlyBase analysis  ( 2 ) Stock list  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 1 )
	Lindsley et al., 2013, PLoS ONE 8(2): e55915 Anent the Genomics of Spermatogenesis in Drosophila melanogaster. [FBrf0220812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...