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Gene Dmel\cmet

General Information
Symbol	Dmel\cmet	Species	D. melanogaster
Name	CENP-meta	Annotation symbol	CG6392
Feature type	protein_coding_gene	FlyBase ID	FBgn0040232
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	CENP-meta, Cenp-E, DmCmeta
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32E2-32E2	Sequence location	2L:11,260,823..11,269,179 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CENP-meta is referred to in FlyBase by the symbol Dmel\cmet (CG6392, FBgn0040232). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: plus-end-directed microtubule motor activity; microtubule motor activity. There is experimental evidence that it is involved in the biological process: mitotic metaphase plate congression; mitotic spindle organization; cell cycle; neurogenesis. 7 alleles are reported. The phenotypes of these alleles are annotated with: spindle microtubule; trichogen cell; mitotic cell cycle; condensed nuclear chromosome; spindle pole; spermatocyte; astral microtubule. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Kinesin, motor domain; Kinesin, motor region, conserved site; Spectrin/alpha-actinin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1624191_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cmet. Gene sequence location is 2L:11260823..11269179.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA03511 BKN25506
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32E2-32E2   Limits computationally determined from genome sequence between P{PZ}l(2)0400804008&P{PZ}cmet04431 and P{PZ}salm03602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32D-32E     (Yucel, 1999.12.30) 32E1-32E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 32E1-32E2   (determined by in situ hybridisation)   (Perrimon et al., 1996) 32E1-32E2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cmet for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cmet-RA FBtr0080215  NM_080254   7502   2013 cmet-RB FBtr0307977     7079   1958
Additional Transcript Data & Comments
Reported size (kB)	7.524 (longest cDNA) (Yucel et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cmet-PA   FBpp0079804   231.1   2013   4.76     NP_524993   AAF53088 cmet-PB   FBpp0300346   224.6   1958   4.78
Additional Polypeptide Data & Comments
Reported size (kDa)	2244 (aa); 250, 180 (kD observed); 257 (kD predicted) (Yucel et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spectrin/alpha-actinin (IPR018159) Kinesin, motor domain (IPR001752) Kinesin, motor region, conserved site (IPR019821)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53088   AC006073   AF220353 AAF32355   AQ073281   BI141747   CL705753   CO152672   CO178559   CO267682   CO269855   CO324938   CO342551   CO343531   EC082761   EC197422   EC210582   EC223826   EC234219   EC241662   EC247134   EC253587   EC256172   EC259700
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NCG0 Q9VKI0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	cmet associates with centromeric regions of chromosomes, probably kinetochores. (Yucel et al., 2000)
Marker for
Subcellular Localization
CV Term	centromere kinetochore (Yucel et al., 2000)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040232    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040232 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040232 expression level Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1518) embryo 02-04hr  (789) embryo 04-06hr  (1602) embryo 06-08hr  (1275) embryo 08-10hr  (916) embryo 10-12hr  (293) embryo 12-14hr  (443) embryo 14-16hr  (144) embryo 16-18hr  (117) embryo 18-20hr    47 embryo 20-22hr  (175) embryo 22-24hr  (188) larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2  (186) larva L3 puffstage 3-6  (427) larva L3 puffstage 7-9  (548) white prepupae new  (458) white prepupae 12hr  (913) white prepupae 24hr  (779) pupae 2d postWPP  (511) pupae 3d postWPP  (329) pupae 4d postWPP  (151) adult male 01day  (404) adult male 05day  (557) adult male 30day  (330) adult female 01day  (222) adult female 05day  (1103) adult female 30day  (1040) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1518) embryo 02-04hr    789 embryo 04-06hr  (1602) embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040232 expression level Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1518) embryo 02-04hr  (789) embryo 04-06hr  (1602) embryo 06-08hr  (1275) embryo 08-10hr  (916) embryo 10-12hr  (293) embryo 12-14hr  (443) embryo 14-16hr  (144) embryo 16-18hr  117 embryo 18-20hr    47 embryo 20-22hr  (175) embryo 22-24hr  (188) larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2  (186) larva L3 puffstage 3-6  (427) larva L3 puffstage 7-9  (548) white prepupae new  (458) white prepupae 12hr  (913) white prepupae 24hr  (779) pupae 2d postWPP  (511) pupae 3d postWPP  (329) pupae 4d postWPP  (151) adult male 01day  (404) adult male 05day  (557) adult male 30day  (330) adult female 01day  (222) adult female 05day  (1103) adult female 30day  (1040) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1518 embryo 02-04hr    789 embryo 04-06hr  1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1518 embryo 02-04hr    789 embryo 04-06hr    1602 embryo 06-08hr    1275 embryo 08-10hr    916 embryo 10-12hr    293 embryo 12-14hr    443 embryo 14-16hr    144 embryo 16-18hr    117 embryo 18-20hr    47 embryo 20-22hr    175 embryo 22-24hr    188 larva L1    15 larva L2    51 larva L3 12hr old    79 larva L3 puffstage 1-2    186 larva L3 puffstage 3-6    427 larva L3 puffstage 7-9    548 white prepupae new    458 white prepupae 12hr    913 white prepupae 24hr    779 pupae 2d postWPP    511 pupae 3d postWPP    329 pupae 4d postWPP    151 adult male 01day    404 adult male 05day    557 adult male 30day    330 adult female 01day    222 adult female 05day    1103 adult female 30day    1040 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040232    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040232 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040232 expression level Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040232 expression level Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    214.05 Larval Midgut no informative data Larval Hindgut    19.5 Larval Malpighian Tubules    47.2 Larval Fat Body    46.7 Larval Salivary Gland no informative data Larval Trachea    51.9 Larval Carcass    37.4 Adult Head    6.2 Adult Eye    3.725 Adult Brain    6.4 Adult Thoracic-Abdominal Ganglion    6.7 Adult Crop    9 Adult Midgut    6.7 Adult Hindgut    3.7 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    3.425 Adult VirginFemale Spermatheca    13.6 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    305.1 Adult Testis    237.4 Adult Male Accessory Gland    6.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    6.2   NA  Eye    3.725   NA  Brain    6.4   214.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.7   NA  Crop    9   no informative data  Midgut    6.7   19.5  Hindgut    3.7   47.2  Malpighian Tubules    no informative data   46.7  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    3.425   51.9  Trachea    NA   NA  VirginFemale Spermatheca    13.6   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    305.1   NA  Testis    237.4   NA  Male Accessory Gland    6.9   37.4  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040232 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6392-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 cmetGD11911 lethal | embryonic stage | maternal effect cmet04431 lethal | larval stage | recessive cmet04431 lethal | recessive cmet04431 viable cmetEY00718 viable, with Scer\GAL4pnr-MD237 cmetGD11911 Sterility Allele fertile cmetEY00718 Other Phenotypes Allele mitotic cell cycle defective cmetΔ mitotic cell cycle defective | recessive cmet1x1 cmetΔ neuroanatomy defective | larval stage, with Scer\GAL41407 cmetGD11911 visible, with Scer\GAL4pnr-MD237 cmetGD11911 Phenotype manifest in Allele astral microtubule cmetdsRNA.cGa centrosome | germline clone cmet1x1 condensed nuclear chromosome cmetΔ embryonic/first instar larval cuticle | maternal effect cmet04431 ganglion mother cell | larval stage, with Scer\GAL41407 cmetGD11911 mitosis & nuclear chromosome cmetΔ cmet1x1 cmetdsRNA.cGa mitosis & nuclear chromosome | germ-line clone cmetΔ cmet1x1 mitotic anaphase | germline clone cmetΔ cmet1x1 mitotic cell cycle cmetΔ cmet1x1 mitotic metaphase | germline clone cmetΔ cmet1x1 spermatocyte cmetΔ spindle microtubule cmetdsRNA.cGa spindle pole cmetdsRNA.cGa trichogen cell, with Scer\GAL4pnr-MD237 cmetGD11911
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of cmet Class Mutagen Stocks Known lesion cmet04431 P-element activity 1 Yes cmetEY00718 P-element activity 1 -- cmetΔ loss of function allele Delta2-3 1 Yes cmet1x1 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cmet Class Mutagen Stocks Known lesion cmetGD11911 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cmetGL00404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cmetdsRNA.cGa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ab-c1 (Sawamura et al., 2010) Df(2L)BSC236 (Christensen and Cook, 2006.12.5) Df(2L)BSC241 (Christensen and Cook, 2006.12.5) Df(2L)BSC242 (Christensen and Cook, 2008.4.15) Df(2L)BSC343 (Christensen and Cook, 2007.10.29) Df(2L)Exel6028 (Ryder, 2004.4.26) Df(2L)Prl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11911} NA P{TRiP.GL00404} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}cmet04431 No insertion of mobile activating element P{EPgy2}cmetEY00718 NA P{GSV1}EP-19EP-19 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Kiger et al., 2003) mitotic metaphase plate congression inferred from mutant phenotype (Yucel et al., 2000) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
kinetochore inferred from direct assay (Yucel et al., 2000) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821 (FlyBase Curators et al., 2004-) microtubule motor activity inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF027728 (FlyBase, 1992-) non-traceable author statement (Yucel, 1999.12.30) plus-end-directed microtubule motor activity inferred from sequence or structural similarity with human CENPE (Yucel et al., 2000)
Biological Process
CV term Evidence References
microtubule-based movement inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) mitotic metaphase plate congression non-traceable author statement (Yucel, 1999.12.30)
Cellular Component
CV term Evidence References
chromosome, centromeric region non-traceable author statement (Yucel, 1999.12.30) condensed chromosome outer kinetochore non-traceable author statement (Blower and Karpen, 2001) kinesin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) kinetochore non-traceable author statement (Yucel, 1999.12.30)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cmet allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72792 DroID - A comprehensive database of gene and protein interactions. • FBgn0040232 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53561
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15126 Dyak\GE12936
Curated drosophilid orthologs	Dpse\GA19559
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006472-PA Anopheles gambiae (mosquito) XP_001121311.1 Apis mellifera (honey bee) XP_001948536.1 Acyrthosiphon pisum (pea aphid) At1g59540.1 Arabidopsis thaliana (wall cress) At3g10180.1 Arabidopsis thaliana (wall cress) ENSBTAP00000011898 Bos taurus (bovine) ENSCAFP00000015964 Canis familiaris (dog) ENSCINP00000019061 Ciona intestinalis (sea squirt) JA16276 Caenorhabditis japonica (nematode) CMQ429C Cyanidioschyzon merolae (red alga) cn09232 Cryptococcus neoformans (yeast-like fungus) CPIJ012221 Culex pipens (mosquito) ENSCPOP00000004687 Cavia porcellus (guinea pig) ENSCSAVP00000017516 Ciona savignyi (sedentary tunicate) DDB0191404 Dictyostelium discoideum (amoeba) ENSECAP00000022092 Equus caballus (horse) ENSGACP00000016221 Gymnopilus aculeatus (mushroom) ENSGALP00000021544 Gallus gallus (chicken) ENSP00000265148 Homo sapiens (human) 34081 Monocosta brevicollis (choanoflagellate) ENSMODP00000037257 Monodelphis domestica (gray opossum) ENSMMUP00000025098 Macaca mulatta (rhesus monkey) ENSMUSP00000057938 Mus musculus (house mouse) XP_001604729.1 Nasonia vitripennis (wasp) ENSOANP00000010862 Ornithorynchus anatinus (platypus) LOC_Os02g53520.1 Oryza sativa (asian rice) 128486 Physcomitrella patens (moss) ENSPPYP00000016720 Pongo pygmaeus (orangutan) 78495 Phytophthora ramorum (sudden oak death pathogen) 127973 Phytophthora sojae (root rot pathogen) 831806 Populus trichocarpa (black cottonwood) ENSPTRP00000028057 Pan troglodytes (chimpanzee) ENSRNOP00000032795 Rattus norvegicus (norway rat) 129529 Sorghum bicolor (sorghum) YDL058W Saccharomyces cerevisiae (budding yeast) XP_781622.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970515.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013183 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031963 Takifugu rubripes (pufferfish Takifugu) 3707.m00058 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000046113 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14351 LH25884 LH25507 ISCW023750 FBgn0230650 FBgn0216905 FBgn0200482 FBgn0193591 FBgn0166050 JGI_V11_41086 JGI_V11_300890 FBgn0247076 FBgn0156177 FBgn0143396 FBgn0120865 FBgn0115856 FBgn0102624 FBgn0092151 FBgn0091794 CPIJ012221 BGIBMGA000862 ACYPI010110 GB17822 GB14899 AGAP006472 AAEL008890 PB26715 GLEAN_14111
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	32327 cmetΔ/CyO, y+ 11375 P{PZ}cmet04431 cn1/CyO; ry506 19807 y1 w67c23; P{EPgy2}cmetEY00718 35816 y1 sc* v1; P{TRiP.GL00404}attP2
VDRC	v35081 w1118; P{GD11911}v35081
Genomic Clones ( 2 )
	BACR09F02 BACR43K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD15655
Other clones	38461 50466 66777 73414 CK01.71D.C12 CK01.129D.G5 CK01.133D.G5 EC253587 EC256172 EC259700 EK057033 EK096127 EK151511 EK195210 EN00142 EP15113 EP17012
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040232 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53561
Antibody Information
	polyclonal (Yucel et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cmet CG6392 (Greene, 2000.4.11, FlyBase, 1996-) Source for merge of: cmet l(2)04431 (Misra, 2000.8.9)
Additional comments	Source for merge of cmet CG6392 was sequence comparison (date:000725). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell morphology is aberrant, indicative of a failure in cell cycle/mitosis progression. This phenotype is not seen in Kc167 cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) cmet is required for the maintenance of chromosomes at the metaphase plate. (Yucel et al., 2000) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. cmet gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis. (Perrimon et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080254 RefSeq (Proteins) • NP_524993 DDBJ / EMBL / GenBank • AAF32355 AAF53088 AC006073 AF220353 AQ073281 CL705753 Entrez Gene - A searchable database of RefSeq genes. • 53561 UniProtKB/TrEMBL • Q9NCG0 Q9VKI0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spectrin/alpha-actinin (IPR018159) Kinesin, motor domain (IPR001752) Kinesin, motor region, conserved site (IPR019821)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72792 DroID - A comprehensive database of gene and protein interactions. • FBgn0040232 DRSC - Results from RNAi screens. • FBgn0040232 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040232 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6392-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040232 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53561 InParanoid A subset of ortholog calls from InParanoid. • AGAP006472-PA Anopheles gambiae (mosquito) XP_001121311.1 Apis mellifera (honey bee) XP_001948536.1 Acyrthosiphon pisum (pea aphid) At1g59540.1 Arabidopsis thaliana (wall cress) At3g10180.1 Arabidopsis thaliana (wall cress) ENSBTAP00000011898 Bos taurus (bovine) ENSCAFP00000015964 Canis familiaris (dog) ENSCINP00000019061 Ciona intestinalis (sea squirt) JA16276 Caenorhabditis japonica (nematode) CMQ429C Cyanidioschyzon merolae (red alga) cn09232 Cryptococcus neoformans (yeast-like fungus) CPIJ012221 Culex pipens (mosquito) ENSCPOP00000004687 Cavia porcellus (guinea pig) ENSCSAVP00000017516 Ciona savignyi (sedentary tunicate) DDB0191404 Dictyostelium discoideum (amoeba) ENSECAP00000022092 Equus caballus (horse) ENSGACP00000016221 Gymnopilus aculeatus (mushroom) ENSGALP00000021544 Gallus gallus (chicken) ENSP00000265148 Homo sapiens (human) 34081 Monocosta brevicollis (choanoflagellate) ENSMODP00000037257 Monodelphis domestica (gray opossum) ENSMMUP00000025098 Macaca mulatta (rhesus monkey) ENSMUSP00000057938 Mus musculus (house mouse) XP_001604729.1 Nasonia vitripennis (wasp) ENSOANP00000010862 Ornithorynchus anatinus (platypus) LOC_Os02g53520.1 Oryza sativa (asian rice) 128486 Physcomitrella patens (moss) ENSPPYP00000016720 Pongo pygmaeus (orangutan) 78495 Phytophthora ramorum (sudden oak death pathogen) 127973 Phytophthora sojae (root rot pathogen) 831806 Populus trichocarpa (black cottonwood) ENSPTRP00000028057 Pan troglodytes (chimpanzee) ENSRNOP00000032795 Rattus norvegicus (norway rat) 129529 Sorghum bicolor (sorghum) YDL058W Saccharomyces cerevisiae (budding yeast) XP_781622.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970515.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013183 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031963 Takifugu rubripes (pufferfish Takifugu) 3707.m00058 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000046113 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53561 modMine - Data generated by the modENCODE project. • FBgn0040232 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14351 LH25884 LH25507 ISCW023750 FBgn0230650 FBgn0216905 FBgn0200482 FBgn0193591 FBgn0166050 JGI_V11_41086 JGI_V11_300890 FBgn0247076 FBgn0156177 FBgn0143396 FBgn0120865 FBgn0115856 FBgn0102624 FBgn0092151 FBgn0091794 CPIJ012221 BGIBMGA000862 ACYPI010110 GB17822 GB14899 AGAP006472 AAEL008890 PB26715 GLEAN_14111
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	Cenp_E (Civelekoglu-Scholey et al., 2006) Cenp-E (Mentelova et al., 2007, Cenci et al., 2008, Musarò et al., 2008, Bucciarelli et al., 2009) CENP-E meta (Brunet and Vernos, 2001) Cenp-M (Dzhindzhev et al., 2005) CENP-meta (Goshima and Vale, 2003, Goshima et al., 2007, Maiato et al., 2006) CENPmeta (Przewloka et al., 2007) Cenp-meta (Cenci et al., 2008, Bucciarelli et al., 2009) CENP-Meta (Kwon et al., 2008) CENP-META (Martins et al., 2009) CG6392 (Mount, 2001.8.14, Goldstein and Gunawardena, 2000, Greene, 2000.4.11, Przewloka et al., 2007, Goshima et al., 2007, Molnar et al., 2006, Hughes et al., 2008, Ni et al., 2011.7.19) Cmet (Miki et al., 2001) cmet (Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Foglietti et al., 2006, Christensen and Cook, 2007.10.29, Molnar et al., 2006, Christensen and Cook, 2008.4.15, Georlette et al., 2007, Wainman et al., 2009, Sawamura and Yamamoto, 2004, Rahmani et al., 2009, Sawamura et al., 2010, Neumüller et al., 2011) DmCmeta (Dagenbach and Endow, 2004, Dagenbach and Endow, 2004, Kim and Endow, 2000) KIF10 (Miki et al., 2001) l(2)04431 (Spradling et al., 1999, )
Name Synonym	CENP-meta (Yucel, 1999.12.30, Sawamura and Yamamoto, 2004, Przewloka et al., 2011) CenpMeta (Karess, 2005) Cenp-meta (Dzhindzhev et al., 2005, Musarò et al., 2008) cenp-meta (Williams et al., 2007, Wainman et al., 2009)
Secondary FlyBase IDs
	FBgn0010574 FBgn0032355
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 7 ) Review  ( 5 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Sawamura et al., 2010, Genetics 186(2): 669--676 Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility. [FBrf0212080] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...