FB2021_06, released December 14, 2021

Gene: Dmel\Sulf1

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General Information
Symbol
Dmel\Sulf1
Species
D. melanogaster
Name
Sulfated
Annotation Symbol
CG6725
Feature Type
protein_coding_gene
FlyBase ID
FBgn0040271
Gene Model Status
Current
Stock Availability
8 publicly available
Enzyme Name (EC)
N-acetylglucosamine-6-sulfatase (3.1.6.14)
Gene Summary
Sulfated (Sulf1) encodes a heparan sulfate modifying enzyme, which extracellularly removes specific 6-O-sulfate groups from heparan sulfate in a post-synthetic manner. It regulates Wg signaling by reducing extracellular wg protein levels. It also regulates Hh signaling by acting as a positive regulator in cells producing the product of hh and a negative regulator in cells receiving the product of hh. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Neu5

Key Links
Genomic Location
Cytogenetic map
89B12-89B12
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:16310542..16339575
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables N-acetylglucosamine-6-sulfatase activity
inferred from mutant phenotype
(Kleinschmit et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables glycosaminoglycan binding
inferred from biological aspect of ancestor with PANTHER:PTN000038170
(assigned by GO_Central )
(Gaudet et al., 2011)
enables N-acetylglucosamine-6-sulfatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000038170
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in heparin metabolic process
inferred from genetic interaction with FLYBASE:Hs6st; FB:FBgn0038755
(Kleinschmit et al., 2010)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Inaki et al., 2007)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(You et al., 2011, Kleinschmit et al., 2010)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Sulf1; FB:FBgn0040271
(Butchar et al., 2012)
involved_in negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Wojcinski et al., 2011)
involved_in positive regulation of smoothened signaling pathway
inferred from mutant phenotype
(Wojcinski et al., 2011)
involved_in synaptic target inhibition
inferred from mutant phenotype
(Inaki et al., 2007)
involved_in wing disc anterior/posterior pattern formation
inferred from mutant phenotype
(Wojcinski et al., 2011)
involved_in wing disc dorsal/ventral pattern formation
inferred from mutant phenotype
(You et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(You et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the sulfatase family. (Q9VEX0)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate (3.1.6.14)
Predictions / Assertions
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate (3.1.6.14)
Summaries
Gene Snapshot
Sulfated (Sulf1) encodes a heparan sulfate modifying enzyme, which extracellularly removes specific 6-O-sulfate groups from heparan sulfate in a post-synthetic manner. It regulates Wg signaling by reducing extracellular wg protein levels. It also regulates Hh signaling by acting as a positive regulator in cells producing the product of hh and a negative regulator in cells receiving the product of hh. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Positive Regulators of Hedgehog Signaling Pathway -
Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
Negative Regulators of Wnt-TCF Signaling Pathway -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Gene Group (FlyBase)
N-ACETYLGLUCOSAMINE-6-SULFATASES -
N-acetylglucosamine-6-sulfatases hydrolyse 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sulf1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Antisense UTR: 5' UTR of one isoform is antisense to CG44044 on opposite strand.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sulf1-RA
FBtr0083273
NM_080248
4835
1114
Sulf1-RB
FBtr0334699
NM_001275697
5042
1114
Sulf1-RC
FBtr0334700
NM_001275698
4401
1114
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Sulf1-PA
FBpp0082725
127.3
1114
8.64
NP_524987
AAF55296
Sulf1-PB
FBpp0306754
127.3
1114
8.64
NP_001262626
AGB96006
Sulf1-PC
FBpp0306755
127.3
1114
8.64
NP_001262627
AGB96007
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1114 aa isoforms: Sulf1-PA, Sulf1-PB, Sulf1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Post Translational Modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

(UniProt, Q9VEX0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sulf1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
ventral neurectoderm | restricted
(Stathopoulos et al., 2002)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
antennal primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
pars intercerebralis primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic pars intercerebralis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic small intestine
(Fisher et al., 2012)
embryonic stomatogastric nervous system
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic/larval somatic muscle cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
median neuroblast MNB interneuron
(Kearney et al., 2004)
MP1 neuron
(Kearney et al., 2004)
embryonic stage 16
muscle cell of ventral longitudinal muscle 1 | restricted
(Inaki et al., 2007)
muscle cell of A1-7 ventral longitudinal muscle 2 | restricted
(Inaki et al., 2007)
larval stage
morphogenetic furrow
(Kleinschmit et al., 2010)
embryonic/larval brain | restricted
(Kleinschmit et al., 2010)
anterior-posterior compartment boundary of the wing disc
(Kleinschmit et al., 2010)
dorsal-ventral compartment boundary of the wing disc
(Kleinschmit et al., 2010)
third instar larval stage
presumptive wing vein
(Butchar et al., 2012)
early third instar larval stage
wing pouch | central
(Wojcinski et al., 2011)
wing disc anterior compartment | restricted
(Wojcinski et al., 2011)
wing disc posterior compartment | restricted
(Wojcinski et al., 2011)
late third instar larval stage
wing disc | striped
(Wojcinski et al., 2011)
wing margin
(Wojcinski et al., 2011)
presumptive wing vein L2

Comment: weaker

(Wojcinski et al., 2011)
presumptive wing vein L3

Comment: stronger

(Wojcinski et al., 2011)
presumptive wing vein L4

Comment: stronger

(Wojcinski et al., 2011)
presumptive wing vein L5

Comment: weaker

(Wojcinski et al., 2011)
dorsal-ventral compartment boundary of the wing disc

Comment: weaker

(Wojcinski et al., 2011)
Additional Descriptive Data

Sulf1 is expressed in all provein regions in the wing imaginal disc.

(Butchar et al., 2012)

Sulf1 is first detected in early first instar larvae in the central region of the wing pouch and in several spots located in the notum region of the disc. In the pouch, expression is further patterned during mid- to late- third instar stages. The domain in the central region of the wing pouch appears much broader. At late third instar larval stages, regionalization of the Sulf1 epxression domain occurs, defining stripes along the AP and DV axes reminiscent of provein domains L1 to L5. A lower level of staining is seen in the presumptive L3-L4 intervein region. Comparison to kn and dpp markers shows that expression is initially restricted to the anterior compartment but starting in mid-third instar larval stages extends to the posterior compartment. At the late third instar larval stage, Sulf1 is highly expressed in the L3 and L4 provein domains. In addition, expression is seen in L2 and L5 proveins and along the DV boundary.

(Wojcinski et al., 2011)

Sulf1 is expressed at the morphogenetic furrow and in the central brain region in larvae. It is also expressed at high levels near the AP and DV compartment boundaries in wing discs.

(Kleinschmit et al., 2010)

Sulf1 displays weak and non-uniform staining in the lateral neurogenic ectoderm.

(Stathopoulos et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
early third instar larval stage -- late third instar larval stage
wing disc | ubiquitous
(You et al., 2011)
late third instar larval stage
anterior-posterior compartment boundary of the wing disc | vicinity of
(You et al., 2011)
dorsal-ventral compartment boundary of the wing disc | vicinity of
(You et al., 2011)
Additional Descriptive Data

Sulf1 protein is ubiquitously distributed in early third instar wing discs. At late third instar, Sulf1 protein is highly upregulated along each side of the dorsal/ventral and anterior/posterior compartment boundaries.

(You et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(You et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sulf1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sulf1
Transgenic constructs containing regulatory region of Sulf1
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel6269
(Ryder, 2004.4.26)
Df(3R)Exel7329
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal immune response | adult stage
abnormal immune response | adult stage, with Scer\GAL4Mef2.PU
abnormal immune response | adult stage, with Scer\GAL4NP0001
abnormal immune response | adult stage, with Scer\GAL4NP6267
abnormal immune response | adult stage, with Scer\GAL4Tub.PU
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4hh-Gal4
decreased occurrence of cell division | adult stage, with Scer\GAL4Mef2.PU
decreased occurrence of cell division | adult stage, with Scer\GAL4NP0001
decreased occurrence of cell division | adult stage, with Scer\GAL4Tub.PU
increased occurrence of cell division (with Sulf1KO.Cherry)
increased occurrence of cell division (with Sulf1ΔP1)
increased occurrence of cell division | adult stage
increased occurrence of cell division | adult stage, with Scer\GAL4Mef2.PU
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4A9
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4bbg-C96
visible, with Scer\GAL4dpp.PU
visible, with Scer\GAL4en.PU
visible, with Scer\GAL4hh.PU
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4vn-GAL4
visible | somatic clone
visible | somatic clone, with Scer\GAL4unspecified
Phenotype manifest in
Allele
1st posterior cell
1st posterior cell, with Scer\GAL4ap-md544
1st posterior cell, with Scer\GAL4dpp.PU
1st posterior cell, with Scer\GAL4hh.PU
1st posterior cell | somatic clone
1st posterior cell | somatic clone, with Scer\GAL4unspecified
adult posterior midgut epithelium
adult posterior midgut epithelium, with Scer\GAL4Mef2.PU
adult posterior midgut epithelium, with Scer\GAL4NP0001
adult posterior midgut epithelium, with Scer\GAL4Tub.PU
adult posterior midgut epithelium (with Sulf1KO.Cherry)
adult posterior midgut epithelium (with Sulf1ΔP1)
anterior crossvein, with Scer\GAL4en.PU
anterior crossvein, with Scer\GAL4vn-GAL4
anterior wing margin
anterior wing margin (with Df(3R)sbd26)
dendritic tree | cell non-autonomous | third instar larval stage, with Scer\GAL4hh-Gal4
distal dendrite | cell non-autonomous | third instar larval stage, with Scer\GAL4hh-Gal4
external sensory organ precursor cell | increased number | third instar larval stage
eye
imaginal tracheoblast
larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage, with Scer\GAL4hh-Gal4
mechanosensory chaeta | increased number
mesothoracic tergum, with Scer\GAL4pnr-MD237
posterior crossvein, with Scer\GAL4en.PU
taste bristle | increased number
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4hh.PU
wing, with Scer\GAL4vn-GAL4
wing blade
wing blade, with Scer\GAL4ap-md544
wing margin
wing margin, with Scer\GAL4en.PU
wing margin, with Scer\GAL4hh.PU
wing margin bristle
wing margin bristle, with Scer\GAL4A9
wing margin bristle, with Scer\GAL4bbg-C96
wing margin bristle | increased number
wing margin bristle | increased number (with Df(3R)sbd26)
wing vein L2 | somatic clone
wing vein L4, with Scer\GAL4en.PU
wing vein L5, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SULF1
13 of 15
Yes
Yes
Hsap\SULF2
13 of 15
Yes
Yes
Hsap\ARSE
3 of 15
No
Yes
Hsap\ARSA
2 of 15
No
No
3  
Hsap\ARSD
2 of 15
No
Yes
Hsap\ARSF
2 of 15
No
Yes
Hsap\ARSH
2 of 15
No
Yes
Hsap\ARSI
2 of 15
No
No
Hsap\ARSJ
2 of 15
No
No
Hsap\ARSK
2 of 15
No
Yes
Hsap\GNS
2 of 15
No
No
Hsap\STS
2 of 15
No
Yes
Hsap\ARSB
1 of 15
No
No
Hsap\ARSG
1 of 15
No
No
Hsap\GALNS
1 of 15
No
No
Hsap\IDS
1 of 15
No
No
Hsap\SGSH
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Sulf2
13 of 15
Yes
Yes
Mmus\Sulf1
12 of 15
No
Yes
Mmus\Arsa
2 of 15
No
No
Mmus\Arsi
2 of 15
No
No
Mmus\Arsj
2 of 15
No
No
Mmus\Arsk
2 of 15
No
Yes
Mmus\Gns
2 of 15
No
No
Mmus\Arsb
1 of 15
No
No
Mmus\Arsg
1 of 15
No
No
Mmus\Galns
1 of 15
No
No
Mmus\Ids
1 of 15
No
No
Mmus\Sgsh
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Sulf1
11 of 13
Yes
Yes
Rnor\Sulf2
11 of 13
Yes
Yes
Rnor\Arse
3 of 13
No
Yes
Rnor\Arsa
2 of 13
No
Yes
Rnor\Arsi
2 of 13
No
No
Rnor\Arsk
2 of 13
No
Yes
Rnor\Gns
2 of 13
No
No
Rnor\Sts
2 of 13
No
Yes
Rnor\Arsb
1 of 13
No
No
Rnor\Arsg
1 of 13
No
No
Rnor\Galns
1 of 13
No
No
Rnor\LOC100909505
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\sulf1
8 of 12
Yes
Yes
Xtro\sulf2
8 of 12
Yes
Yes
Xtro\arsa.1
2 of 12
No
Yes
Xtro\arsd
2 of 12
No
Yes
Xtro\arsh
2 of 12
No
Yes
Xtro\arsi
2 of 12
No
No
Xtro\arsj
2 of 12
No
No
Xtro\arsk
2 of 12
No
Yes
Xtro\gns
2 of 12
No
No
Xtro\sts
2 of 12
No
Yes
Xtro\arsb
1 of 12
No
No
Xtro\galns
1 of 12
No
No
Xtro\ids
1 of 12
No
No
Xtro\sgsh
1 of 12
No
No
Danio rerio (Zebrafish) (18)
Drer\sulf1
13 of 15
Yes
Yes
Drer\sulf2a
12 of 15
No
Yes
Drer\sulf2b
9 of 15
No
Yes
Drer\gnsb
3 of 15
No
No
Drer\arsa
2 of 15
No
Yes
Drer\arsia
2 of 15
No
No
Drer\arsib
2 of 15
No
No
Drer\arsj
2 of 15
No
No
Drer\arsk
2 of 15
No
Yes
Drer\gnsa
2 of 15
No
No
Drer\si:dkey-174i8.1
2 of 15
No
No
Drer\arsg
1 of 15
No
No
Drer\arsh
1 of 15
No
Yes
Drer\galns
1 of 15
No
No
Drer\ids
1 of 15
No
No
Drer\LOC101884179
1 of 15
No
Yes
Drer\sgsh
1 of 15
No
No
Drer\sts
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\sul-1
12 of 15
Yes
Yes
Cele\sul-2
1 of 15
No
No
Cele\sul-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190255 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010328
Drosophila simulans
Dsim\GD20299
Drosophila sechellia
Dsec\GM15446
Drosophila erecta
Dere\GG20070
Drosophila yakuba
Dyak\GE26324
Drosophila ananassae
Dana\GF16526
Drosophila pseudoobscura pseudoobscura
Dpse\GA19814
Drosophila persimilis
Dper\GL22250
Drosophila willistoni
Dwil\GK13512
Drosophila virilis
Dvir\GJ23505
Drosophila mojavensis
Dmoj\GI24652
Drosophila grimshawi
Dgri\GH18078
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500H4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008300
Glossina morsitans
Tsetse fly
Gmor\GMOY007264
Glossina morsitans
Tsetse fly
Gmor\GMOY007708
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00216
Mayetiola destructor
Hessian fly
Mdes\Mdes006405
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008362
Anopheles darlingi
American malaria mosquito
Adar\ADAC006793
Anopheles gambiae
Malaria mosquito
Agam\AGAP003374
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017041
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FA0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007569
Bombyx mori
Silkmoth
Bmor\BGIBMGA007568
Bombyx mori
Silkmoth
Bmor\BGIBMGA007570
Danaus plexippus
Monarch butterfly
Dple\DPOGS204292-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015191
Apis florea
Little honeybee
Aflo\3302027604
Apis mellifera
Western honey bee
Amel\Sulf1
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10785
Bombus terrestris
Buff-tailed bumblebee
Bter\15213500
Linepithema humile
Argentine ant
Lhum\LH19741
Linepithema humile
Argentine ant
Lhum\LH19740
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024e3
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024e2
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003376
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05092
Tribolium castaneum
Red flour beetle
Tcas\TC014039
Pediculus humanus
Human body louse
Phum\PHUM074950
Rhodnius prolixus
Kissing bug
Rpro\RPRC003831
Cimex lectularius
Bed bug
Clec\CLEC007741
Cimex lectularius
Bed bug
Clec\CLEC007739
Cimex lectularius
Bed bug
Clec\CLEC007740
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003667
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02369
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F9G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010622
Ixodes scapularis
Black-legged tick
Isca\ISCW016852
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71610.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71614.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305315
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OHI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sulf1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sulf1_1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG18278
4 of 10
CG30059
3 of 10
Sgsh
3 of 10
CG7402
2 of 10
CG7408
2 of 10
CG32191
2 of 10
Ids
2 of 10
CG8646
1 of 10
CG32187
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    ARSL; arylsulfatase L
    model of  X-linked chondrodysplasia punctata 1
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SULF1; sulfatase 1
    13 of 15
    610012
        SULF2; sulfatase 2
        13 of 15
        610013
            ARSL; arylsulfatase L
            3 of 15
            300180
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Sulf1
            suppressible
            dally
            (You et al., 2011, Kleinschmit et al., 2010)
            Sulf1
            suppressible
            Egfr
            (Takemura and Nakato, 2017)
            Sulf1
            suppressible
            Hs6st
            (Kleinschmit et al., 2010)
            Sulf1
            enhanceable
            Notum
            (You et al., 2011)
            Sulf1
            suppressible
            ptc
            (Takemura and Nakato, 2017)
            Sulf1
            suppressible
            Stat92E
            (Takemura and Nakato, 2017)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            dlp
            enhanceable
            Sulf1
            (You et al., 2011)
            Egfr
            suppressible
            Sulf1
            (Butchar et al., 2012)
            vn
            suppressible
            Sulf1
            (Butchar et al., 2012)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Negative Regulators of EGFR Signaling Pathway -
            Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
            Negative Regulators of Hedgehog Signaling Pathway -
            Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
            Positive Regulators of Hedgehog Signaling Pathway -
            Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
            Negative Regulators of Wnt-TCF Signaling Pathway -
            Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-58
            Cytogenetic map
            89B12-89B12
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            89B12-89B12
            Limits computationally determined from genome sequence between P{PZ}gish04895&P{EP}EP3171 and P{lacW}CSN5L4032
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            89B-89B
            (Standiford, 1999.12.3)
            Experimentally Determined Recombination Data
            Location

            3-58

            (FlyBase, 2016)

            3-58.3

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (22)
            cDNA Clones (69)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (You et al., 2011)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: Sulf1 CG6725

            (Bayraktaroglu, 2000.8.7)
            Additional comments
            Other Comments

            Sulf1 acts as a positive regulator of hh signaling in hh producing cells and a negative regulator of hh signaling in hh receiving cells.

            (Wojcinski et al., 2011)

            Sulf1 is required for normal pattern formation in the embryonic cuticle.

            (Standiford et al., 2001)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 46 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (74)