Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with Spt6. Interacts with Spt4 to form DSIF. DSIF interacts with trx, RNA polymerase II and with the FACT complex, which is composed of dre4/Spt16 and Ssrp/Ssrp1. DSIF can also interact with the exosome, a complex with 3'-5' exoribonuclease activity which is composed of at least Csl4, Dis3, Mtr3, Rrp4, Rrp6, Rrp40, Rrp42, Rrp46 and Ski6. DSIF may also interact with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of Cdk9 and cyclin-T (CycT).
Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spt5 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Spt5 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Spt5 CG7626
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.