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Gene Dmel\Aplip1

General Information
Symbol	Dmel\Aplip1	Species	D. melanogaster
Name	APP-like protein interacting protein 1	Annotation symbol	CG1200
Feature type	protein_coding_gene	FlyBase ID	FBgn0040281
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	ek4, E(Khc)ek4
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61F3-61F3	Sequence location	3L:1,196,317..1,199,339 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene APP-like protein interacting protein 1 is referred to in FlyBase by the symbol Dmel\Aplip1 (CG1200, FBgn0040281). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein kinase binding; kinesin binding. There is experimental evidence that it is involved in the biological process: axon transport of mitochondrion; neuron projection morphogenesis; regulation of JNK cascade; retrograde synaptic vesicle transport; anterograde synaptic vesicle transport. 13 alleles are reported. The phenotypes of these alleles are annotated with: mitochondrion; axon. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Phosphotyrosine interaction domain; Pleckstrin homology-like domain; Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1629678_a_at partially aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Aplip1: 13 out of 14 probes fall into this exonic region. Gene sequence location is 3L:1196317..1199339.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61F3-61F3   Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F1-61F2     (Serano, 2000.2.4) 61F-61F     (Yagi, 1999.3.8)   Located on the left arm of chromosome 3.   (Gassman et al., 1997)
Experimentally Determined Recombination Data
Location	3- (Gassman et al., 1997) 3-0.0 (Gassman, 1999.3.11)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aplip1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aplip1-RA FBtr0072626  NM_167857   2390   483 Aplip1-RB FBtr0072627  NM_167856   2411   490
Additional Transcript Data & Comments
Reported size (kB)	2.4 (northern blot) (Taru et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aplip1-PA   FBpp0072522   53.1   483   5.77     NP_728574   AAF47446 Aplip1-PB   FBpp0072523   53.8   490   5.86     NP_728573   AAN11462
Additional Polypeptide Data & Comments
Reported size (kDa)	490 (aa) (Taru et al., 2002)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203102   AA697574   AE014296 AAF47446   AE014296 AAN11462   AF220194 AAL50332   AF231037 AAF34806   AI109228   AI136002   AI238739   AI402809   AI513326   AI516855   AY051495 AAK92919   BI239313   BI584734   BI586199   BI589886   BI589917   BI606291   BI609222   BI612891   BI617937   BI620821   BT001795 AAN71550   CO156195   CO189227   CO262102   CO274717   CO317493   CO322373   CO327127   CO327197   CO328439   CO336275   CO344526   DN154133   EC066639   EC072123   EC195398   EC211883   EC213345   EC219144   EC223636   EC225924   EC252595   EC257757   EC259132   EC260189   EC263967   EC267782   FD585742   FD585775   FD586963   FD587417   GH739768   GH764873   GH766770   GH768237   GH769073   GH779381   GH779834
UniProtKB/Swiss-Prot	Q9W0K0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 7 -- 8   posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic brain   (Taru et al., 2002) presumptive embryonic/larval central nervous system   (Taru et al., 2002) embryonic stage | mid -- embryonic stage | late     (Taru et al., 2002) larval stage -- adult stage     (Taru et al., 2002) adult stage   head   (Taru et al., 2002)
Additional Descriptive Data
	Aplip1 transcripts are abundant in late embryonic through adult stages and are weakly expressed in 6-12 hour embryos as observed on northern blots. Transcripts are observed in adult heads but not bodies by RT-PCR. (Taru et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain  (590.3) Adult Thoracic-Abdominal Ganglion  (542.7) Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain  590.3 Adult Thoracic-Abdominal Ganglion  542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    305.45 Larval Midgut    4.3 Larval Hindgut    3.8 Larval Malpighian Tubules    6.4 Larval Fat Body    7.3 Larval Salivary Gland    9.4 Larval Trachea    3.025 Larval Carcass    5.95 Adult Head    180.2 Adult Eye    102.95 Adult Brain    590.3 Adult Thoracic-Abdominal Ganglion    542.7 Adult Crop    4.3 Adult Midgut    5.5 Adult Hindgut    3.2 Adult Malpighian Tubules    4 Adult Fat Body    5.6 Adult Salivary Gland    6.9 Adult Heart    3.35 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    2.1 Adult Ovary    1.9 Adult Testis    2.7 Adult Male Accessory Gland    6.4 Adult Carcass    17.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    180.2   NA  Eye    102.95   NA  Brain    590.3   305.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    542.7   NA  Crop    4.3   4.3  Midgut    5.5   3.8  Hindgut    3.2   6.4  Malpighian Tubules    4   7.3  Fat Body    5.6   9.4  Salivary Gland    6.9   NA  Heart    3.35   3.025  Trachea    NA   NA  VirginFemale Spermatheca    3.2   NA  InseminatedFemale Spermatheca    2.1   NA  Ovary    1.9   NA  Testis    2.7   NA  Male Accessory Gland    6.4   5.95  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  (39) central nervous system, pupae P8  (42) head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male  (38) head, mated 4-day male  (43) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  (39) central nervous system, pupae P8  (42) head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male  (38) head, mated 4-day male  (43) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    39 central nervous system, pupae P8    42 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    23 head, mated 1-day female    19 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    38 head, mated 4-day male    43 head, mated 20-day male    44 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    11 embryo 12-14hr    14 embryo 14-16hr    20 embryo 16-18hr    18 embryo 18-20hr    17 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    15 larva L2    5 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    7 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    12 pupae 4d postWPP    11 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2  (55) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2  (55) ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    1 embryonic GM2    1 embryonic Kc167    0 embryonic S1    10 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    55 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • GH14842 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040281 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1200-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Aplip1 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage, with Scer\GAL4D42 Aplip1Scer\UAS.T:Zzzz\FLAG lethal | pupal stage, with Scer\GAL4D42 Aplip1Scer\UAS.T:Zzzz\FLAG viable Aplip1EK4 viable, with Scer\GAL4pnr-MD237 Aplip1GD7456 Sterility Allele fertile Aplip1EK4 Other Phenotypes Allele neuroanatomy defective Aplip1EK4 neuroanatomy defective, with Scer\GAL4D42 Aplip1Scer\UAS.T:Zzzz\FLAG neuroanatomy defective (with Df(3L)Fpa2) Aplip1EK4 paralytic Aplip1EK4 paralytic | larval stage | posterior Aplip1EK4 paralytic | larval stage | posterior, with Scer\GAL4D42 Aplip1Scer\UAS.T:Zzzz\FLAG paralytic | larval stage | posterior (with Df(3L)Fpa2) Aplip1EK4 Phenotype manifest in Allele axon Aplip1EK4 axon, with Scer\GAL4D42 Aplip1ΔKBD.Scer\UAS Aplip1Scer\UAS.T:Zzzz\FLAG axon (with Df(3L)Fpa2) Aplip1EK4 mitochondrion Aplip1EK4
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Aplip1 Class Mutagen Stocks Known lesion Aplip1DG20707 1 -- Aplip1EK4 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aplip1 Class Mutagen Stocks Known lesion Aplip1GD7456 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aplip1JF02049 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aplip1Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Aplip1+tHa in vitro construct - genomic fragment 0 Yes Aplip1KBD.Scer\UAS in vitro construct - amino acid replacement in vitro construct - deletion 0 Yes Aplip1KK107996 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Aplip1NIG.1200R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Aplip1P483A.Scer\UAS in vitro construct - amino acid replacement 0 Yes Aplip1P483L.Scer\UAS in vitro construct - amino acid replacement 0 Yes Aplip1Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Aplip1ΔKBD.Scer\UAS in vitro construct - amino acid replacement in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Ar14-8 (Horiuchi et al., 2005) Df(3L)bab-PG (Horiuchi et al., 2005)
Not disrupted in	Df(3L)Fpa1 (Horiuchi et al., 2005) Df(3L)Fpa2 (Horiuchi et al., 2005) Df(3L)ru-22 (Horiuchi et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7456} NA P{KK107996} NA P{NIG.1200R} NA P{TRiP.JF02049} NA P{UAS-Aplip1.FLAG} NA P{UAS-Aplip1.ΔKBD} NA P{UASp-Aplip1.EGFP} NA characterization construct P{Aplip1+tHa} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}Aplip1DG20707 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
NOT JUN kinase binding inferred from physical interaction with bsk (Taru et al., 2002) kinesin binding inferred from physical interaction with Klc (Taru et al., 2002) protein binding inferred from physical interaction with Appl (Taru et al., 2002) protein kinase binding inferred from physical interaction with hep (Taru et al., 2002)
Biological Process
CV term Evidence References
anterograde synaptic vesicle transport inferred from mutant phenotype (Horiuchi et al., 2005) axon transport of mitochondrion inferred from mutant phenotype (Horiuchi et al., 2005) neuron projection morphogenesis inferred from mutant phenotype (Sepp et al., 2008) regulation of JNK cascade inferred from physical interaction with hep (Taru et al., 2002) retrograde synaptic vesicle transport inferred from mutant phenotype (Horiuchi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
NOT JUN kinase binding inferred from sequence alignment with mouse Mapk8ip1 (Taru et al., 2002) inferred from sequence alignment with mouse Mapk8ip2 (Taru et al., 2002) kinesin binding non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) protein kinase binding non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Biological Process
CV term Evidence References
JNK cascade inferred from sequence alignment with mouse Mapk8ip1 (Taru et al., 2002) inferred from sequence alignment with mouse Mapk8ip2 (Taru et al., 2002) regulation of JNK cascade non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aplip1 - AP-1μ anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Aplip1 - PH4αEFB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aplip1 allele Gene References Aplip1EK4 Khc (Gassman et al., 1999, Martin et al., 1999) Klc (Gassman et al., 1999) unspecified Dhc64C (Horiuchi et al., 2005) Khc (Gassman et al., 1997, Horiuchi et al., 2005) Klc (Gassman et al., 1997, Horiuchi et al., 2005) Klp64D (Horiuchi et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72744 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040281 DroID - A comprehensive database of gene and protein interactions. • FBgn0040281 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53472 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W0K0
Orthologs
OrthoDB Orthologs (61) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG698VKJ Dipteran inclusive ortholog search EOG6G4GZS Insect inclusive ortholog search EOG6T76ZN Arthropod inclusive ortholog search EOG6NCJV1 Metazoa inclusive ortholog search EOG6QK4F8
Orthologs in Drosophila Species (EOG698VKJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aplip1     Drosophila sechellia   Dsec\GM14376 Y   Drosophila erecta   Dere\GG14757 Y   Drosophila yakuba   Dyak\GE21120 Y   Drosophila ananassae   Dana\GF24433 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11322 Y   Drosophila persimilis   Dper\GL15754     Drosophila persimilis   Dper\GL13207     Drosophila persimilis   Dper\GL19752     Drosophila persimilis   Dper\GL15409     Drosophila persimilis   Dper\GL18193     Drosophila persimilis   Dper\GL18194     Drosophila persimilis   Dper\GL22940     Drosophila persimilis   Dper\GL14127     Drosophila persimilis   Dper\GL19624     Drosophila persimilis   Dper\GL19986     Drosophila persimilis   Dper\GL17806     Drosophila persimilis   Dper\GL14786     Drosophila persimilis   Dper\GL20960     Drosophila persimilis   Dper\GL15358     Drosophila persimilis   Dper\GL20958 Y   Drosophila persimilis   Dper\GL15408     Drosophila persimilis   Dper\GL20959     Drosophila willistoni   Dwil\GK17331 Y   Drosophila virilis   Dvir\GJ12726 Y   Drosophila mojavensis   Dmoj\GI12603 Y   Drosophila grimshawi   Dgri\GH15822 Y
Orthologs in non-Drosophila Dipterans (EOG6G4GZS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001744   Anopheles gambiae Malaria mosquito  Agam\AGAP006021   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014158
Orthologs in non-Dipteran Insects (EOG6T76ZN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Aplip1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000432   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18870   Atta cephalotes Leafcutter ant  Acep\ACEP25121   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18221   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17268   Linepithema humile Argentine ant  Lhum\LH23953   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22741   Solenopsis invicta Red fire ant  Sinv\SINV25231   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006528   Bombyx mori Silkmoth  Bmor\BGIBMGA000570   Pediculus humanus Human body louse  Phum\PHUM501210   Tribolium castaneum Red flour beetle  Tcas\TC002493
Orthologs in non-Insect Arthropods (EOG6NCJV1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_44227   Ixodes scapularis Deer tick  Isca\ISCW007572
Orthologs in non-Arthropod Metazoa (EOG6QK4F8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\jip-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026916gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000237gn   Danio rerio Zebrafish  Drer\mapk8ip2   Danio rerio Zebrafish  Drer\ENSDARG00000091191   Danio rerio Zebrafish  Drer\ENSDARG00000090326   Xenopus tropicalis Western clawed frog  Xtro\mapk8ip1   Xenopus tropicalis Western clawed frog  Xtro\mapk8ip2   Gallus gallus Domestic chicken  Ggal\MAPK8IP1   Mus musculus House mouse  Mmus\Mapk8ip1   Mus musculus House mouse  Mmus\Mapk8ip2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006938   Rattus norvegicus Norway rat  Rnor\Mapk8ip2   Homo sapiens Human  Hsap\ENSG00000257367   Homo sapiens Human  Hsap\MAPK8IP2   Homo sapiens Human  Hsap\MAPK8IP1
Human Orthologs (3)
Gene OMIM HGNC Hsap\ENSG00000257367     Hsap\MAPK8IP2     Hsap\MAPK8IP1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM14376 Drosophila erecta Dere\GG14757 Drosophila yakuba Dyak\GE21120 Drosophila ananassae Dana\GF24433 Drosophila pseudoobscura pseudoobscura Dpse\GA11322 Drosophila persimilis Dper\GL20958 Drosophila willistoni Dwil\GK17331 Drosophila virilis Dvir\GJ12726 Drosophila mojavensis Dmoj\GI12603 Drosophila grimshawi Dgri\GH15822
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	24632 Aplip1EK4 24634 w*; P{UASp-Aplip1.EGFP}3 26024 y1 v1; P{TRiP.JF02049}attP2 21745 y1 w67c23; P{wHy}Aplip1DG20707
VDRC	v50007 w1118; P{GD7456}v50007
Genomic Clones ( 1 )
	BACR22D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14842 RH26053
Other clones	DPiM_GH14842
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08358 GH13994 GH22107 GH27437 HL02807 LD03606 RE35771 RH03402 RH03440 RH13975 RH24003 RH41880 RH48423 RH52056 RH72575
Other clones	13869 62319 63934 97452 119163 163875 214285.23 214351.30 214467.24 214467.25 527238 557686 CK01.53D.H2 CK01.93B.D3 EK043461 EK084407 EK115236 EK188013 EK190716 EK268347 EN07537 EN12210 EP05912 EP06437 EP09215 EP19438 RM04274 RM04374 RM04574 RM04774 RP001001783 RP001010040 RP001011879 RP001023780 RP001040530 RP001044753 RP001047442
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040281 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53472
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Aplip1 SP512 (Huen, 2002.5.16)
Source for database merge of	Source for merge of: Aplip1 dp1 (Suzuki, 2002.9.13) Source for merge of: Aplip1 E(Khc)ek4 (Horiuchi et al., 2005) Source for merge of: SP512 CG1200 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: as a protein that interacts with the Appl cytoplasmic domain in a yeast two-hybrid assay. (Taru et al., 2002) Identification: Protein that binds the cytoplasmic domain of Appl in a yeast two-hybrid screen. (Yagi et al., 1999) Identification: Dominant enhancer of Khc mutations. (Gassman et al., 1997) Mutations when homozygous or combined with either Khc or Klc causes organelle jams (axonal swellings filled with membrane-bounded organelles that are stalled in transit) and flipping (posterior muscle activity causing a rhythmic upward flipping of the tail during crawling). No effects are seen in combination with Dhc64C or Gl. (Gassman et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167856 NM_167857 RefSeq (Proteins) • NP_728573 NP_728574 DDBJ / EMBL / GenBank • AAF34806 AAF47446 AAK92919 AAL50332 AAN11462 AAN71550 AF220194 AF231037 AI238739 AI513326 AY051495 BI586199 BT001795 Entrez Gene - A searchable database of RefSeq genes. • 53472 UniProtKB/Swiss-Prot • Q9W0K0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH14842
Linkouts
	BioGRID - A database of protein and genetic interactions • 72744 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040281 DroID - A comprehensive database of gene and protein interactions. • FBgn0040281 DRSC - Results from RNAi screens. • FBgn0040281 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040281 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1200-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040281 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53472 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/aplip1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53472 modMine - Data generated by the modENCODE project. • FBgn0040281 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W0K0
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	APLIP1 (Horiuchi et al., 2005, Taru et al., 2002, Huen, 2002.5.16) aplip1 (Michaut et al., 2003) Aplip1 (Saxton, 2007.12.12, FlyBase Curators, 2008, Zhou et al., 2008, Horiuchi et al., 2007, Toda et al., 2008, Junion et al., 2007, Firth and Baker, 2007, Cherbas et al., 2011, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sepp et al., 2008) CG1200 (Huen, 2002.5.16, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Howell et al., 2012, Sepp et al., 2008) dp1 (Yagi, 1999.3.8, ) E(Khc)ek4 (Martin et al., 1999, Gassman, 1999.3.11, ) ek4 (Gassman et al., 2001) EK4 (Gassman et al., 1999) Ek4 (Gassman et al., 1997) JIP1 (Horiuchi et al., 2007) Jip1/2 (Horiuchi et al., 2005) SP512 (Huen, 2002.5.16, )
Name Synonym	APP-like protein interacting protein 1 (Taru et al., 2002) c-Jun N-terminal kinase (JNK)-interacting protein (Horiuchi et al., 2007)
Secondary FlyBase IDs
	FBgn0020447 FBgn0026251 FBgn0035188
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Howell et al., 2012, Immunogenetics 64(2): 155--161 A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Show all research papers ...