SP512, E(Khc)ek4, dp1
Gene model reviewed during 5.48
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
Forms homo- and heterooligomeric complexes. Binds Hep, a dual specificity protein kinase in the JNK pathway, but not its downstream target bsk. The C-terminal region interacts with the kinesin light chain protein, Klc, and the C-terminal PTY motif of amyloid-beta protein precursor-like protein, Appl.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aplip1 using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
GBrowse - Visual display of RNA-Seq signalsView Dmel\Aplip1 in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Aplip1 SP512
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: as a protein that interacts with the Appl cytoplasmic domain in a yeast two-hybrid assay.
Identification: Protein that binds the cytoplasmic domain of Appl in a yeast two-hybrid screen.
Mutations when homozygous or combined with either Khc or Klc causes organelle jams (axonal swellings filled with membrane-bounded organelles that are stalled in transit) and flipping (posterior muscle activity causing a rhythmic upward flipping of the tail during crawling). No effects are seen in combination with Dhc64C or Gl.