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Gene Dmel\Myt1

General Information
Symbol	Dmel\Myt1	Species	D. melanogaster
Name	Myt1	Annotation symbol	CG32417
Feature type	protein_coding_gene	FlyBase ID	FBgn0040298
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Dmyt1, CG10569
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64E7-64E7	Sequence location	3L:5,770,576..5,772,691 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Myt1 is referred to in FlyBase by the symbol Dmel\Myt1 (CG32417, FBgn0040298). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine/tyrosine kinase activity. There is experimental evidence for 11 unique biological process terms, many of which group under: cell cycle; cell cycle process; single-organism developmental process; M phase of meiotic cell cycle; multicellular organism reproduction; cellular process; gamete generation; biological regulation; meiosis; cell proliferation. 10 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye disc; tertiary pigment cell; primary spermatocyte; eye photoreceptor cell; ommatidial precursor cluster; ommatidium; secondary pigment cell; meiotic cell cycle. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Tyrosine/threonine-protein kinase, Cdc2 inhibitor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632292_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Myt1. Gene sequence location is 3L:5770576..5772691.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64E7-64E7   Limits computationally determined from genome sequence between P{PZ}sinu06524 and P{PZ}Bre101640
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64D-64F   (determined by in situ hybridisation)   (Jin et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Myt1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Myt1-RA FBtr0077118  NM_139730   1940   533
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Myt1-PA   FBpp0076824   61.1   533   7.58     NP_647987   AAF50747
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Tyrosine/threonine-protein kinase, Cdc2 inhibitor (IPR016235) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50747   AF215861 AAF32288   AI061900   AI109610   AI402149   AY047577 AAK77309   BF494462   BI234710   BI236495   CO185235   CO186052   CO283289   EC051032   EC053543   EC053549   EC055032   EC082713   EV578671
UniProtKB/Swiss-Prot	Q9NI63
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Golgi apparatus inferred from direct assay (assigned by UniProtKB) (Cornwell et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.4 Larval Midgut    38.1 Larval Hindgut    48.1 Larval Malpighian Tubules    36.5 Larval Fat Body    55 Larval Salivary Gland    51.8 Larval Trachea    83.6 Larval Carcass    48.125 Adult Head    44.5 Adult Eye    67.575 Adult Brain    78.1 Adult Thoracic-Abdominal Ganglion    89.1 Adult Crop    61.1 Adult Midgut    42.2 Adult Hindgut    43.8 Adult Malpighian Tubules    31.9 Adult Fat Body    41.8 Adult Salivary Gland    65.5 Adult Heart    51.875 Adult VirginFemale Spermatheca    49.8 Adult InseminatedFemale Spermatheca    51.9 Adult Ovary    253.4 Adult Testis    40.5 Adult Male Accessory Gland    54.1 Adult Carcass    47.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    44.5   NA  Eye    67.575   NA  Brain    78.1   74.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89.1   NA  Crop    61.1   38.1  Midgut    42.2   48.1  Hindgut    43.8   36.5  Malpighian Tubules    31.9   55  Fat Body    41.8   51.8  Salivary Gland    65.5   NA  Heart    51.875   83.6  Trachea    NA   NA  VirginFemale Spermatheca    49.8   NA  InseminatedFemale Spermatheca    51.9   NA  Ovary    253.4   NA  Testis    40.5   NA  Male Accessory Gland    54.1   48.125  Carcass    47.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female  (27) ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female  27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    4 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    21 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    8 embryo 04-06hr    10 embryo 06-08hr    12 embryo 08-10hr    9 embryo 10-12hr    6 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    1 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    12 adult female 05day    23 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    11 embryonic 1182-4H    12 embryonic GM2    7 embryonic Kc167    6 embryonic S1    12 embryonic S3    8 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    15 wing disc ML-DmD21    15 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    12 ovary OSC    8 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    2 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32418-RA;CG32417-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect (with Df(3L)64D-F) Myt11 viable, with Scer\GAL4pnr-MD237 Myt1GD10889 Sterility Allele male sterile (with Df(3L)64D-F) Myt11 Other Phenotypes Allele mitotic cell cycle defective Myt11 visible Myt1GMR.PP visible, with Scer\GAL4GMR.PF Myt1Scer\UAS.cPa Phenotype manifest in Allele cyst cell & nucleus (with Df(3L)64D-F) Myt11 eye disc Myt1GMR.PP eye photoreceptor cell Myt1GMR.PP eye photoreceptor cell | supernumerary Myt1GMR.PP macrochaeta & adult head (with Df(3L)64D-F) Myt11 macrochaeta & adult thorax (with Df(3L)64D-F) Myt11 macrochaeta & eye (with Df(3L)64D-F) Myt11 meiotic cell cycle (with Df(3L)64D-F) Myt11 mitotic cell cycle & cystoblast (with Df(3L)64D-F) Myt11 mitotic cell cycle & cystocyte (with Df(3L)64D-F) Myt11 ommatidial precursor cluster Myt1GMR.PP ommatidium Myt1GMR.PP ommatidium, with Scer\GAL4GMR.PF Myt1Scer\UAS.cPa primary spermatocyte (with Df(3L)64D-F) Myt11 rhabdomere Myt1GMR.PP secondary pigment cell Myt1GMR.PP tertiary pigment cell Myt1GMR.PP
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Myt1 Class Mutagen Stocks Known lesion Myt11 ethyl methanesulfonate 0 Yes Myt12 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Myt1 Class Mutagen Stocks Known lesion Myt1GD10889 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Myt1GL00216 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Myt1KK102559 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Myt1+t3.6 in vitro construct - genomic fragment 0 Yes Myt1GMR.PP in vitro construct - regulatory fusion 0 Yes Myt1NIG.10569R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Myt1Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Myt1Scer\UAS.P\T.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6107 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10889} NA P{KK102559} NA P{NIG.10569R} NA P{TRiP.GL00216} NA P{UAS-Myt1.P} NA P{UASp-Myt1.P} NA characterization construct P{GMR-Myt1.P} NA P{myt1+t3.6} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein serine/threonine/tyrosine kinase activity inferred from direct assay (assigned by UniProtKB) (Price et al., 2002)
Biological Process
CV term Evidence References
female meiosis inferred from mutant phenotype (Jin et al., 2005) G2/M transition of mitotic cell cycle inferred from mutant phenotype (assigned by UniProtKB) (Price et al., 2002) germarium-derived cystoblast division inferred from mutant phenotype (Jin et al., 2005) male meiosis inferred from mutant phenotype (Jin et al., 2005) meiosis inferred from mutant phenotype (Jin et al., 2005) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) negative regulation of mitotic cell cycle inferred from mutant phenotype (assigned by UniProtKB) (Price et al., 2002) positive regulation of cell size inferred from genetic interaction with gig (Cully et al., 2010) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Price et al., 2002) spermatocyte division inferred from mutant phenotype (Jin et al., 2005) spermatogonial cell division inferred from mutant phenotype (Jin et al., 2005)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (assigned by UniProtKB) (Cornwell et al., 2002)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity inferred from sequence or structural similarity (Campbell, 1999.12.13) non-traceable author statement (Morrison et al., 2000) protein serine/threonine/tyrosine kinase activity inferred from sequence or structural similarity (Jin et al., 2000) inferred from sequence or structural similarity with EMBL:BC025061 (FlyBase Genome Annotators, 2002-2003) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271, InterPro:IPR016235 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
G2/M transition of mitotic cell cycle non-traceable author statement (Jin et al., 2003) male germ-line stem cell division non-traceable author statement (Jin et al., 2003) protein phosphorylation inferred from sequence or structural similarity with EMBL:BC025061 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Jin et al., 2003) membrane inferred from electronic annotation with InterPro:IPR016235 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Myt1 allele Gene References Myt1GMR.PP cdc2 (Price et al., 2002) Dl (Price et al., 2002) p53 (Price et al., 2002) stg (Price et al., 2002) wee (Price et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64110 DroID - A comprehensive database of gene and protein interactions. • FBgn0040298 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38649 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NI63
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69KG9C Dipteran inclusive ortholog search EOG6J11HK Insect inclusive ortholog search EOG6MGR3Q Arthropod inclusive ortholog search EOG6BVQ90 Metazoa inclusive ortholog search EOG6SR8QP
Orthologs in Drosophila Species (EOG69KG9C)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Myt1     Drosophila simulans   Dsim\GD13175 Y   Drosophila sechellia   Dsec\GM13898 Y   Drosophila erecta   Dere\GG14113 Y   Drosophila yakuba   Dyak\GE20537 Y   Drosophila ananassae   Dana\GF10446 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16888 Y   Drosophila persimilis   Dper\GL16314 Y   Drosophila willistoni   Dwil\GK17296 Y   Drosophila virilis   Dvir\GJ12168 Y   Drosophila mojavensis   Dmoj\GI11942 Y   Drosophila grimshawi   Dgri\GH15232 Y
Orthologs in non-Drosophila Dipterans (EOG6J11HK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006140   Anopheles gambiae Malaria mosquito  Agam\AGAP001950   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003568
Orthologs in non-Dipteran Insects (EOG6MGR3Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\TC004776
Orthologs in non-Insect Arthropods (EOG6BVQ90)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_323973   Daphnia pulex Water flea  Dpux\Bdkrb1   Ixodes scapularis Deer tick  Isca\ISCW015956
Orthologs in non-Arthropod Metazoa (EOG6SR8QP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\wee-1.1   Caenorhabditis elegans Nematode  Cele\wee-1.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015704gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008280gn   Danio rerio Zebrafish  Drer\ENSDARG00000074730   Xenopus tropicalis Western clawed frog  Xtro\pkmyt1   Mus musculus House mouse  Mmus\Pkmyt1   Rattus norvegicus Norway rat  Rnor\Pkmyt1   Homo sapiens Human  Hsap\PKMYT1
Human Orthologs (1)
Gene OMIM HGNC Hsap\PKMYT1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13175 Drosophila sechellia Dsec\GM13898 Drosophila erecta Dere\GG14113 Drosophila yakuba Dyak\GE20537 Drosophila ananassae Dana\GF10446 Drosophila pseudoobscura pseudoobscura Dpse\GA16888 Drosophila persimilis Dper\GL16314 Drosophila willistoni Dwil\GK17296 Drosophila virilis Dvir\GJ12168 Drosophila mojavensis Dmoj\GI11942 Drosophila grimshawi Dgri\GH15232
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	35312 y1 sc* v1; P{TRiP.GL00216}attP2
VDRC	v105157 P{KK102559}VIE-260B v34547 w1118; P{GD10889}v34547
Genomic Clones ( 1 )
	BACR29P05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08848
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03070 LD34963 RE30458 RE32556
Other clones	CK01.128A.A12 Dmel_dig_006564_0596_0716 EC29980 EC051032 EC053543 EC053549 EC055032 EK015501 EK162802
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38649
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Myt1 CG10569 (Bayraktaroglu, 2000.8.7)
Additional comments	Annotation CG10569 split into CG32417 (Myt1) and CG32418 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Myt1 inhibitory phosphorylation of cdc2 is required for regulating multiple aspects of cell cycle behaviour during spermatogenesis. Loss of Myt1 function causes germline-associated somatic cells to undergo ectopic cell division, in both males and females. (Jin et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139730 RefSeq (Proteins) • NP_647987 DDBJ / EMBL / GenBank • AAF32288 AAF50747 AAK77309 AF215861 AI061900 AI109610 AI402149 AY047577 Entrez Gene - A searchable database of RefSeq genes. • 38649 UniProtKB/Swiss-Prot • Q9NI63
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Tyrosine/threonine-protein kinase, Cdc2 inhibitor (IPR016235) Protein kinase, ATP binding site (IPR017441)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64110 DroID - A comprehensive database of gene and protein interactions. • FBgn0040298 DRSC - Results from RNAi screens. • FBgn0040298 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32418-RA;CG32417-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38649 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/myt1-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38649 modMine - Data generated by the modENCODE project. • FBgn0040298 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9NI63
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG10569 (Morrison et al., 2000, Jin, 2000.5.15, Fernández-Ayala et al., 2010) CG32417 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) Dmyt1 (Fichelson and Gho, 2004, Jin et al., 2003, Price et al., 2002, Jin et al., 2002, Price et al., 2002, Campbell et al., 2001, Jin et al., 2001, Jin et al., 2000) dMyt1 (Jin et al., 2004) myt1 (Jin et al., 2005, Goldbach et al., 2006, Jin et al., 2008) MYT 1 (O'Farrell, 2001) Myt1 (Glavic et al., 2009, Kondo and Perrimon, 2011, Tokusumi et al., 2012, Japanese National Institute of Genetics, 2012.5.21) MYT1 (Cully et al., 2010)
Name Synonym	Myt1
Secondary FlyBase IDs
	FBgn0035634 FBgn0052417
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...