Wee1-like kinase that specifically regulates Cdk1 (Cdc2) activity in the cytoplasm - Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and pre-meiotic centriole engagement in Drosophila spermatocytes
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Myt1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Myt1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Myt1 inhibitory phosphorylation of cdc2 is required for regulating multiple aspects of cell cycle behaviour during spermatogenesis. Loss of Myt1 function causes germline-associated somatic cells to undergo ectopic cell division, in both males and females.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.