DPx-4783, DPx4783, Jafrac, dPrx1, Peroxiredoxin 1
Please see the GBrowse view of Dmel\Jafrac1 or the JBrowse view of Dmel\Jafrac1 for information on other features
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Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
The group(s) of polypeptides indicated below share identical sequence to each other.
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity). Interacts with SESN1 and SESN2 (By similarity).
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
Conjugated to URM1, a ubiquitin-like protein.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jafrac1 using the Feature Mapper tool.
Comment: maternally deposited
Comment: rapidly degraded
Comment: reported as lymph gland specific anlage
Jafrac1 transcripts are detected throughout deveopment by RT-PCR and are abundant in third instar larval brain, imaginal discs and Malpighian tubules.
Jafrac1 is present throughout blastoderm embryos in both somatic cells and germline precursor cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Jafrac1 in GBrowse 2
1-42
1-42
1-42.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Jafrac1 Prx4783
Source for merge of: Jafrac1 CG1633
Relationship between "Jafrac1" and "SSP6107" is unclear; they may represent alternative transcripts of the same gene, or two separate genes.
The gene is named "Jafrac1" after the initials of people in the Santaren research group who first published on the gene.
