FB2020_06, released Dec 22, 2020

Gene: Dmel\Lztr1

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General Information
Symbol
Dmel\Lztr1
Species
D. melanogaster
Name
Leucine zipper like transcription regulator 1
Annotation Symbol
CG3711
Feature Type
protein_coding_gene
FlyBase ID
FBgn0040344
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

EG:BACR7A4.19

Key Links
Genomic Location
Cytogenetic map
1D2-1D2
Sequence location
X:922,889..927,582 [-]
Recombination map

1-0

RefSeq locus
NC_004354 REGION:922889..927582
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in negative regulation of Ras protein signal transduction
inferred from mutant phenotype
(assigned by UniProt )
(Bigenzahn et al., 2018)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN002355794
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the LZTR1 family. (Q9V410)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Inhibitor of Ras signaling (PubMed:30442766). Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (By similarity).
(UniProt, Q9V410)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Lztr1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lztr1-RD
FBtr0331303
NM_001272185
4056
998
Lztr1-RE
FBtr0343361
NM_130513
4335
975
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Lztr1-PD
FBpp0303735
108.9
998
8.11
NP_001259114
AGB94960
Lztr1-PE
FBpp0310018
106.4
975
7.96
NP_569869
AAF45563
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of some BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.

(UniProt, Q9V410)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lztr1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Lztr1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lztr1
Transgenic constructs containing regulatory region of Lztr1
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LZTR1
13 of 15
Yes
Yes
Hsap\FBXO42
1 of 15
No
No
Hsap\HCFC1
1 of 15
No
No
Hsap\HCFC2
1 of 15
No
No
1  
Hsap\KLHDC2
1 of 15
No
Yes
Hsap\KLHDC3
1 of 15
No
No
Hsap\KLHDC4
1 of 15
No
No
Hsap\RABEPK
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lztr1
13 of 15
Yes
Yes
Mmus\Fbxo42
1 of 15
No
No
Mmus\Hcfc1
1 of 15
No
No
Mmus\Hcfc2
1 of 15
No
No
Mmus\Klhdc3
1 of 15
No
No
Mmus\Klhdc4
1 of 15
No
No
Mmus\Rabepk
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Lztr1
11 of 13
Yes
Yes
Rnor\Klhdc2
1 of 13
No
Yes
Rnor\RGD1562104
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\lztr1
9 of 12
Yes
Yes
Xtro\klhdc2
1 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\lztr1
9 of 15
Yes
Yes
Drer\hcfc1a
1 of 15
No
No
Drer\hcfc1b
1 of 15
No
No
Drer\klhdc2
1 of 15
No
Yes
Drer\klhdc4
1 of 15
No
No
Drer\rabepk
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\F53E4.1
1 of 15
Yes
No
Cele\hcf-1
1 of 15
Yes
No
Cele\herc-1
1 of 15
Yes
No
Cele\Y50D7A.1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT1G18610
1 of 9
Yes
No
Atha\AT1G74150
1 of 9
Yes
No
Atha\AT2G36360
1 of 9
Yes
Yes
Atha\AT4G04670
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\KEL1
3 of 15
Yes
No
Scer\KEL2
3 of 15
Yes
No
Scer\KEL3
1 of 15
No
No
Scer\MDS3
1 of 15
No
Yes
Scer\PMD1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\tea3
2 of 12
Yes
Yes
Spom\tea1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902OX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004652
Drosophila simulans
Dsim\GD16450
Drosophila sechellia
Dsec\GM19013
Drosophila erecta
Dere\GG12733
Drosophila yakuba
Dyak\GE16559
Drosophila ananassae
Dana\GF22052
Drosophila pseudoobscura pseudoobscura
Dpse\GA17633
Drosophila persimilis
Dper\GL14422
Drosophila willistoni
Dwil\GK10175
Drosophila virilis
Dvir\GJ15361
Drosophila mojavensis
Dmoj\GI15003
Drosophila grimshawi
Dgri\GH12418
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501E5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021057
Musca domestica
House fly
Mdoa\17005817
Musca domestica
House fly
Mdoa\17006609
Glossina morsitans
Tsetse fly
Gmor\GMOY003908
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04292
Mayetiola destructor
Hessian fly
Mdes\Mdes007407
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000925
Anopheles darlingi
American malaria mosquito
Adar\ADAC007000
Anopheles gambiae
Malaria mosquito
Agam\AGAP004292
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017663
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01PZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012932
Danaus plexippus
Monarch butterfly
Dple\DPOGS207008-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014373
Apis florea
Little honeybee
Aflo\2376246852
Apis mellifera
Western honey bee
Amel\LZTR1
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23276
Bombus terrestris
Buff-tailed bumblebee
Bter\15204884
Linepithema humile
Argentine ant
Lhum\LH18656
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001457
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000646
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06855
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08426
Pediculus humanus
Human body louse
Phum\PHUM449130
Cimex lectularius
Bed bug
Clec\CLEC006168
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083937
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI49569
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05582
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01NW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013843
Ixodes scapularis
Black-legged tick
Isca\ISCW013315
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82846.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82845.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g04690
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g04770
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305895
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02JQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lztr1l
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016401gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lztr1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG4069
2 of 10
CG6758
2 of 10
CG12081
2 of 10
Hcf
2 of 10
slim
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LZTR1; leucine zipper like transcription regulator 1
    13 of 15
    600574
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Component of some BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
    (UniProt, Q9V410 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-0

    Cytogenetic map
    1D2-1D2
    Sequence location
    X:922,889..927,582 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    1D2-1D2
    Limits computationally determined from genome sequence between P{EP}EP1600&P{EP}EP1498 and P{EP}EP1615&P{EP}EP964
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-0

    (FlyBase, 2016)

    1-0.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (26)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Maurer et al., 2020)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Lztr1 CG3711

      (Bigenzahn et al., 2018)
      Source for database merge of

      Source for merge of: EG:BACR7A4.19 CG3711

      (FlyBase, 1996-)
      Additional comments

      Source for merge of EG:BACR7A4.19 CG3711 was sequence comparison ( date:000425 ).

      (FlyBase, 1996-)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology

      The gene is named "night owl" based on the phenotype of flies in which its function is knocked down.

      (Maurer et al., 2020)
      Identification
      External Crossreferences and Linkouts ( 40 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (7)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (42)