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Gene Dmel\boi

General Information
Symbol	Dmel\boi	Species	D. melanogaster
Name	brother of ihog	Annotation symbol	CG32796
Feature type	protein_coding_gene	FlyBase ID	FBgn0040388
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	CT23737, EG:BACH59J11.2, CG13756
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	3A3-3A3	Sequence location	X:2,338,200..2,364,076 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene brother of ihog is referred to in FlyBase by the symbol Dmel\boi (CG32796, FBgn0040388). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: smoothened signaling pathway; regulation of smoothened signaling pathway; positive regulation of cell proliferation; compound eye photoreceptor cell differentiation; compound eye development; cuticle pattern formation; imaginal disc-derived wing morphogenesis; wing disc pattern formation. 29 alleles are reported. The phenotypes of these alleles are annotated with: follicle stem cell; interfollicle cell; follicle cell. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628774_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of boi. Gene sequence location is X:2338200..2364076.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms cell surface positive regulation of cell proliferation
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A3-3A3   Limits computationally determined from genome sequence between P{EP}EP1605 and P{EP}CG32796EP1385&P{EP}EP1160
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\boi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.51 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) boi-RA FBtr0070458  NM_166941   2717   547 boi-RB FBtr0070457  NM_166940   4223   998 boi-RE FBtr0303886  NM_001201611   4316   998 boi-RF FBtr0303887  NM_001201612   4509   998 boi-RG FBtr0334883  NM_001103398   4544   1105
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein boi-PA   FBpp0070442   60.6   547   10.20     NP_726812   AAF45782 boi-PB   FBpp0070441   109.5   998   9.02     NP_726811   AAF45784 boi-PE   FBpp0292889   109.5   998   9.02     NP_001188540   ADV37624 boi-PF   FBpp0292890   109.5   998   9.02     NP_001188541   ADV37625 boi-PG   FBpp0306904   120.9   1105   8.19     NP_001096868   ABW09329
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin (IPR013151) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45782   AE014298 AAF45784   AE014298 ABW09329   AE014298 ADV37624   AE014298 ADV37625   AI532619   AI534694   AI535017   AL133505 CAB65842   AW944517   AY061833 AAL27644   AY094843 AAM11196   BF495664   BF500878   BI162647   BI162648   BI163653   BI229290   BI229295   BI233063   BI366614   BI482763   BI621530   BI632556   BT044213   BT072906   CL632198   CO280351   CO285659   CO289939   CO300265   CO301058   CO304861   CO317197   CO318019   CO339359   CZ473784   CZ475371   CZ479518   EC062490   EC062684   EC070592   EC088551   EC203228   EC219152   EC229122   EC244728   EC245195   EC249913   EC254107   EL886102   EV577497   GH944527   GH947015   GH956771   GH962604   GH962831   GH963813   GH964644   GH966260   GH966342   GH970133   GH972577   GH973672   GH975315   GH978679
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SX52 Q9W4Y6 A8JUV7 Q95R27 Q9U1M6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   amnioserosa anlage   (Fisher et al., 2012) antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) anterior midgut primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage proventriculus primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic anal pad   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic optic lobe   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with cell surface inferred from direct assay (Hartman et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland    18.4 Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass    17.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    12.2   NA  Eye    11.975   NA  Brain    9.3   117.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    12.6   NA  Crop    14.8   31.5  Midgut    7.6   40.1  Hindgut    15.7   8.3  Malpighian Tubules    9.8   12.5  Fat Body    18.9   31.8  Salivary Gland    no informative data   NA  Heart    7.575   46.55  Trachea    NA   NA  VirginFemale Spermatheca    9.2   NA  InseminatedFemale Spermatheca    7.7   NA  Ovary    169.7   NA  Testis    15.8   NA  Male Accessory Gland    8.5   56.9  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (27) central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female  (28) ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female  28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    7 central nervous system, pupae P8    3 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    5 carcass, larvae L3 wandering    15 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    28 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    8 embryo 04-06hr    12 embryo 06-08hr    22 embryo 08-10hr    20 embryo 10-12hr    19 embryo 12-14hr    14 embryo 14-16hr    11 embryo 16-18hr    6 embryo 18-20hr    4 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    1 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    11 white prepupae 12hr    8 white prepupae 24hr    20 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    7 adult female 05day    13 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21  (54) wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21  (54) wing disc ML-DmD32  (42) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5 Schneider line 2 Sg4    3 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    3 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    4 wing disc ML-DmD8    3 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    54 wing disc ML-DmD32    42 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    16 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    3 ovary fGS/OSS    14 ovary OSC    8 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE01910 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32796-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for boi Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable boiC1 boiEY09847 boiKO viable, with Scer\GAL4pnr-MD237 boiGD60 boiGD2556 boiGD14474 boiGD14979 Sterility Allele fertile boiC1 boiEY09847 boiKO Other Phenotypes Allele hyperplasia boid04197 boie01708 hyperplasia, with Scer\GAL4109-30 boiEY09847 hyperplasia, with Scer\GAL4bab1-Pgal4-2 boiGD60 hyperplasia, with Scer\GAL4bab1-Pgal4-2, boie01708 boiΔFN1.Scer\UAS hyperplasia, with Scer\GAL4bab1-Pgal4-2, boiΔFN1.Scer\UAS boie01708 hyperplasia (with boid04197) boie01708 hyperplasia (with boie01708) boid04197 visible, with Scer\GAL4ap-md544 boiEP1447 Phenotype manifest in Allele follicle cell boid04197 boie01708 follicle cell, with Scer\GAL4bab1-Pgal4-2 boiGD60 follicle cell (with boid04197) boie01708 follicle cell (with boie01708) boid04197 follicle stem cell boid04197 boie01708 follicle stem cell, with Scer\GAL4bab1-Pgal4-2 boiGD60 follicle stem cell, with Scer\GAL4bab1-Pgal4-2, boie01708 boiΔFN1.Scer\UAS follicle stem cell, with Scer\GAL4bab1-Pgal4-2, boiΔFN1.Scer\UAS boie01708 follicle stem cell (with boid04197) boie01708 follicle stem cell (with boie01708) boid04197 interfollicle cell boid04197 boie01708 interfollicle cell, with Scer\GAL4109-30 boiEY09847 interfollicle cell, with Scer\GAL4bab1-Pgal4-2 boiGD60 interfollicle cell (with boid04197) boie01708 interfollicle cell (with boie01708) boid04197 wing vein | ectopic, with Scer\GAL4ap-md544 boiEP1447
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of boi Class Mutagen Stocks Known lesion boiCB-0004-3 1 -- boid04197 hypomorphic allele - molecular evidence P-element activity 1 -- boie01708 hypomorphic allele - molecular evidence piggyBac transposase 1 -- boiEP1385 P-element activity 1 -- boiEY09847 P-element activity 1 -- boiG656 P-element activity 1 -- boiKG03233 1 -- boiMI00918 1 -- boiNP4065 1 -- boiKO amorphic allele - molecular evidence FLPase SCEI endonuclease ends-out gene targeting 0 Yes boiC1 ethyl methanesulfonate 0 Yes boid06806 P-element activity 0 -- boiEP1447 P-element activity 0 Yes boiFN1.FN2.Act5C 0 Yes boiGG01388 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of boi Class Mutagen Stocks Known lesion boiGD14474 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes boiGD14979 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes boiGD2556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiGD60 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiKK103113 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiAct5C.PY in vitro construct - regulatory fusion 0 Yes boidsRNA.Scer\UAS.cIa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes boiFN1.Act5C in vitro construct - regulatory fusion 0 Yes boiFN2.Act5C in vitro construct - regulatory fusion 0 Yes boiNIG.7894R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes boiScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes boiScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes boiΔFN1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes boiΔFN2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6230 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD60} NA P{GD2556} NA P{GD14474} NA P{GD14979} NA P{KK103113} NA P{NIG.7894R} NA P{UAS-boi.H} NA P{UAS-boi.RNAi} NA P{UAS-boi.Z} NA P{UAS-boi.ΔFN1} NA P{UAS-boi.ΔFN2} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}boiEP1385 NA P{EP}boiEP1447 NA P{EP}boiG656 NA P{EPgy2}boiEY09847 NA P{Mae-UAS.6.11}boiGG01388 NA P{XP}boid04197 NA P{XP}boid06806 NA P{XP}CG32796d07015 NA miscellaneous insertions Mi{MIC}boiMI00918 NA P{RS3}boiCB-0004-3 NA P{SUPor-P}boiKG03233 NA PBac{RB}boie01708 NA insertion of enhancer trap binary system P{GawB}boiNP4065 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye development inferred from genetic interaction with ihog (Camp et al., 2010) compound eye photoreceptor cell differentiation inferred from genetic interaction with ihog (Camp et al., 2010) cuticle pattern formation inferred from genetic interaction with ihog (Zheng et al., 2010) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011) positive regulation of cell proliferation inferred from mutant phenotype (Hartman et al., 2010) regulation of smoothened signaling pathway inferred from genetic interaction with ihog (Camp et al., 2010) smoothened signaling pathway inferred from mutant phenotype (Yao et al., 2006) wing disc pattern formation inferred from genetic interaction with ihog (Camp et al., 2010)
Cellular Component
CV term Evidence References
colocalizes_with cell surface inferred from direct assay (Hartman et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from sequence or structural similarity with UniProtKB:P97798 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
boi - CG11200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG12171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG2691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG4364 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG7518 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - CG8801 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - Elongin-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - Moe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - ihog anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) boi - mRpL11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions boi allele Gene References unspecified dlp (Yao et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57765 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040388 DroID - A comprehensive database of gene and protein interactions. • FBgn0040388 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31229 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JUV7
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VX2QM Dipteran inclusive ortholog search EOG6933RX Insect inclusive ortholog search EOG6HMH5W Arthropod inclusive ortholog search EOG6QBZMW Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6VX2QM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\boi     Drosophila simulans   Dsim\GD16363 Y   Drosophila sechellia   Dsec\GM18878     Drosophila erecta   Dere\GG12612     Drosophila yakuba   Dyak\GE16943 Y   Drosophila ananassae   Dana\GF21949     Drosophila pseudoobscura pseudoobscura   Dpse\GA22276     Drosophila persimilis   Dper\GL14456     Drosophila willistoni   Dwil\GK24917 Y   Drosophila virilis   Dvir\GJ16643 Y   Drosophila mojavensis   Dmoj\GI15895 Y   Drosophila grimshawi   Dgri\GH12751 Y
Orthologs in non-Drosophila Dipterans (EOG6933RX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008827 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002040 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002017 Y
Orthologs in non-Dipteran Insects (EOG6HMH5W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45300 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011739 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16092 Y Atta cephalotes Leafcutter ant  Acep\ACEP12620 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15430 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16524 Y Linepithema humile Argentine ant  Lhum\LH24631 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23586 Y Solenopsis invicta Red fire ant  Sinv\SINV26485 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004942 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008552 Y Pediculus humanus Human body louse  Phum\PHUM299830 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07250 Y
Orthologs in non-Insect Arthropods (EOG6QBZMW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW011274 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16363 Drosophila yakuba Dyak\GE16943 Drosophila willistoni Dwil\GK24917 Drosophila virilis Dvir\GJ16643 Drosophila mojavensis Dmoj\GI15895 Drosophila grimshawi Dgri\GH12751
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	17003 P{EP}boiEP1385 w1118 13245 y1 P{SUPor-P}boiKG03233
Harvard	- P{XP}boid04197 - PBac{RB}boie01708
Kyoto	123003 P{RS3}boiCB-0004-3 w1118
VDRC	v108265 P{KK103113}VIE-260B v869 w1118; P{GD60}v869 v3060 w1118; P{GD2556}v3060 v29593 w1118; P{GD14979}v29593 v42248 w1118; P{GD14474}v42248 v42251 w1118; P{GD14474}v42251 v29592 w1118; P{GD14979}v29592/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR21G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE01910 SD07678
Other clones	DPiM_RE01910 FI05294 RT01624
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04623 AT16030 RE03105 RE27046 RE27051 RE29339 RE52189 RE65509 RH52882 SD01373 SD04186 SD26365
Other clones	33374 40024 54471 57047 121061 123508 162996 214413.47 CK01.12D.D3 CK01.93A.F9 CK01.98B.C11 Dmel_dig_000190_0701_0298 EK072623 EK153835 EK169814 EK177803 EK179963 EK246555 EK267318 EK270028 EP01661 IP17391 RP004072157 RP004213634 RP004240161 RP004258461 RP004345763 RP004377920 RP004396921 RP004431816 RP004480616 RP004482029 RP004500557 RP004510214 RP004520720 RP004524123
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040388 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31229
Antibody Information
	polyclonal (Bilioni et al., 2013, Hartman et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: boi CG32796 (Yao et al., 2006)
Source for database merge of	Source for merge of: EG:BACH59J11.2 CG7894 (FlyBase Genome Annotators, 2002-2003) Source for merge of: EG:BACH59J11.2 CG13756 (FlyBase, 1996-)
Additional comments	Annotations CG13756 and CG7894 merged as CG32796 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of EG:BACH59J11.2 CG13756 was sequence comparison (date:000425). (FlyBase, 1996-)
Other Comments
	iHog and boi are in the same protein family and appear to overlap functionally. (Yao et al., 2006) Epistatic experiments show that boi acts at or upstream of ptc. (Yao et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166940 NM_166941 NM_001103398 NM_001201611 NM_001201612 RefSeq (Proteins) • NP_726811 NP_726812 NP_001096868 NP_001188540 NP_001188541 DDBJ / EMBL / GenBank • AAF45782 AAF45784 AAL27644 AAM11196 ABW09329 ADV37624 ADV37625 AI532619 AI534694 AI535017 AL133505 AW944517 AY061833 AY094843 BI162647 BI162648 CAB65842 CL632198 CZ473784 CZ475371 CZ479518 Entrez Gene - A searchable database of RefSeq genes. • 31229 UniProtKB/TrEMBL • A8JUV7 Q8SX52 Q9U1M6 Q9W4Y6 Q95R27
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like domain (IPR007110) Immunoglobulin (IPR013151) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE01910
Linkouts
	BioGRID - A database of protein and genetic interactions • 57765 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040388 DroID - A comprehensive database of gene and protein interactions. • FBgn0040388 DRSC - Results from RNAi screens. • FBgn0040388 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32796-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040388 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 216107 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31229 modMine - Data generated by the modENCODE project. • FBgn0040388 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A8JUV7
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	boi (Yao et al., 2006, Hartman et al., 2010, Toku et al., 2011, Chang et al., 2008, Zheng et al., 2010, Yan et al., 2010, Kemppainen et al., 2009, Reis et al., 2010, Camp et al., 2010, Carreira et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Boi (Wilson and Chuang, 2006, Chou et al., 2010) CG7894 (Benos, 2000.12.13, ) CG13756 (Benos, 2000.12.13, Camp et al., 2010) CG32796 (Yao et al., 2006, Lear et al., 2005, Lebo et al., 2009, Keleman et al., 2009.8.5, Chang et al., 2008) CT23737 (Vogel et al., 2003, Hynes and Zhao, 2000) CT33235 (Hynes and Zhao, 2000) EG:BACH59J11.2 (Benos et al., 2001, Giot et al., 2003, )
Name Synonym	brother of ihog (Yao et al., 2006, ) Brother of Ihog (Zheng et al., 2010, Chou et al., 2010, Camp et al., 2010) Brother of ihog (Yan et al., 2010) brother of iHog (Chang et al., 2008, Lebo et al., 2009) CG32796
Secondary FlyBase IDs
	FBgn0029618 FBgn0029619 FBgn0052796
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Bilioni et al., 2013, Dev. Biol. 376(2): 198--212 Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif. [FBrf0221027] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...