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Gene Dmel\boi

General Information
Symbol	Dmel\boi	Species	D. melanogaster
Name	brother of ihog	Annotation symbol	CG32796
Feature type	protein_coding_gene	FlyBase ID	FBgn0040388
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	CT23737, EG:BACH59J11.2
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	3A3-3A3	Sequence location	X:2,338,200..2,364,036 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene brother of ihog is referred to in FlyBase by the symbol Dmel\boi (CG32796, FBgn0040388). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: smoothened signaling pathway. 21 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Fibronectin, type III; Immunoglobulin; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628774_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of boi. Gene sequence location is X:2338200..2364036.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN23305 HFA18598 HFA18425 References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Carreira et al., 2011, BMC Dev. Biol. 11: 32 Kemppainen et al., 2009, Mitochondrion 9(5): 353--363
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A3-3A3   Limits computationally determined from genome sequence between P{EP}EP1605 and P{EP}CG32796EP1385&P{EP}EP1160
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\boi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) boi-RA FBtr0070458  NM_166941   2717   547 boi-RB FBtr0070457  NM_166940   4183   998 boi-RD FBtr0114528  NM_001103398   4519   1110 boi-RE FBtr0303886  NM_001201611   4276   998 boi-RF FBtr0303887  NM_001201612   4469   998
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein boi-PA   FBpp0070442   60.6   547   10.20     NP_726812   AAF45782 boi-PB   FBpp0070441   109.5   998   9.02     NP_726811   AAF45784 boi-PD   FBpp0113020   121.5   1110   8.19     NP_001096868   ABW09329 boi-PE   FBpp0292889   109.5   998   9.02     NP_001188540   ADV37624 boi-PF   FBpp0292890   109.5   998   9.02     NP_001188541   ADV37625
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin (IPR013151) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45782   AE014298 AAF45784   AE014298 ABW09329   AE014298 ADV37624   AE014298 ADV37625   AI532619   AI534694   AI535017   AL133505 CAB65842   AW944517   AY061833 AAL27644   AY094843 AAM11196   BF495664   BF500878   BI162647   BI162648   BI163653   BI229290   BI229295   BI233063   BI366614   BI482763   BI621530   BI632556   BT044213   BT072906   CL632198   CO280351   CO285659   CO289939   CO300265   CO301058   CO304861   CO317197   CO318019   CO339359   CZ473784   CZ475371   CZ479518   EC062490   EC062684   EC070592   EC088551   EC203228   EC219152   EC229122   EC244728   EC245195   EC249913   EC254107   EL886102   EV577497   GH944527   GH947015   GH956771   GH962604   GH962831   GH963813   GH964644   GH966260   GH966342   GH970133   GH972577   GH973672   GH975315   GH978679
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SX52 Q95R27 Q9U1M6 Q9W4Y6 A8JUV7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0040388    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0040388 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0040388 expression level Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2037) embryo 02-04hr  (640) embryo 04-06hr  (979) embryo 06-08hr  (1771) embryo 08-10hr  (1610) embryo 10-12hr  (1578) embryo 12-14hr  (1107) embryo 14-16hr  (887) embryo 16-18hr  (509) embryo 18-20hr  (285) embryo 20-22hr  102 embryo 22-24hr  (122) larva L1  (121) larva L2  (124) larva L3 12hr old  (115) larva L3 puffstage 1-2  (247) larva L3 puffstage 3-6  (541) larva L3 puffstage 7-9  (673) white prepupae new  (858) white prepupae 12hr  (661) white prepupae 24hr  (1640) pupae 2d postWPP  (802) pupae 3d postWPP  (446) pupae 4d postWPP  (151) adult male 01day  (136) adult male 05day  (144) adult male 30day  (141) adult female 01day  (536) adult female 05day  (1031) adult female 30day  (1089) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2037) embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr  (1771) embryo 08-10hr  (1610) embryo 10-12hr  (1578) embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr  (1640) pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0040388 expression level Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2037) embryo 02-04hr  (640) embryo 04-06hr  (979) embryo 06-08hr  (1771) embryo 08-10hr  (1610) embryo 10-12hr  (1578) embryo 12-14hr  (1107) embryo 14-16hr  (887) embryo 16-18hr  (509) embryo 18-20hr  (285) embryo 20-22hr  102 embryo 22-24hr  122 larva L1  121 larva L2  124 larva L3 12hr old  115 larva L3 puffstage 1-2  (247) larva L3 puffstage 3-6  (541) larva L3 puffstage 7-9  (673) white prepupae new  (858) white prepupae 12hr  (661) white prepupae 24hr  (1640) pupae 2d postWPP  (802) pupae 3d postWPP  (446) pupae 4d postWPP  (151) adult male 01day  136 adult male 05day  (144) adult male 30day  141 adult female 01day  (536) adult female 05day  (1031) adult female 30day  (1089) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr  1771 embryo 08-10hr  1610 embryo 10-12hr  1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr  1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2037 embryo 02-04hr    640 embryo 04-06hr    979 embryo 06-08hr    1771 embryo 08-10hr    1610 embryo 10-12hr    1578 embryo 12-14hr    1107 embryo 14-16hr    887 embryo 16-18hr    509 embryo 18-20hr    285 embryo 20-22hr    102 embryo 22-24hr    122 larva L1    121 larva L2    124 larva L3 12hr old    115 larva L3 puffstage 1-2    247 larva L3 puffstage 3-6    541 larva L3 puffstage 7-9    673 white prepupae new    858 white prepupae 12hr    661 white prepupae 24hr    1640 pupae 2d postWPP    802 pupae 3d postWPP    446 pupae 4d postWPP    151 adult male 01day    136 adult male 05day    144 adult male 30day    141 adult female 01day    536 adult female 05day    1031 adult female 30day    1089 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0040388    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0040388 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0040388 expression level Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0040388 expression level Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.3 Larval Midgut    31.5 Larval Hindgut    40.1 Larval Malpighian Tubules    8.3 Larval Fat Body    12.5 Larval Salivary Gland    31.8 Larval Trachea    46.55 Larval Carcass    56.9 Adult Head    12.2 Adult Eye    11.975 Adult Brain    9.3 Adult Thoracic-Abdominal Ganglion    12.6 Adult Crop    14.8 Adult Midgut    7.6 Adult Hindgut    15.7 Adult Malpighian Tubules    9.8 Adult Fat Body    18.9 Adult Salivary Gland no informative data Adult Heart    7.575 Adult VirginFemale Spermatheca    9.2 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    169.7 Adult Testis    15.8 Adult Male Accessory Gland    8.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    12.2   NA  Eye    11.975   NA  Brain    9.3   117.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    12.6   NA  Crop    14.8   31.5  Midgut    7.6   40.1  Hindgut    15.7   8.3  Malpighian Tubules    9.8   12.5  Fat Body    18.9   31.8  Salivary Gland    no informative data   NA  Heart    7.575   46.55  Trachea    NA   NA  VirginFemale Spermatheca    9.2   NA  InseminatedFemale Spermatheca    7.7   NA  Ovary    169.7   NA  Testis    15.8   NA  Male Accessory Gland    8.5   56.9  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32796-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for boi Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable boiEY09847 viable, with Scer\GAL4pnr-MD237 boiGD60 boiGD2556 boiGD14474 boiGD14979 Sterility Allele fertile boiEY09847 Phenotype manifest in Allele
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of boi Class Mutagen Stocks Known lesion boiCB-0004-3 1 -- boid04197 P-element activity 1 -- boie01708 piggyBac transposase 1 -- boiEP1385 P-element activity 1 -- boiEY09847 P-element activity 1 -- boiG656 P-element activity 1 -- boiKG03233 1 -- boiMI00918 1 -- boiNP4065 1 -- boid06806 P-element activity 0 -- boiFN1.FN2.Act5C 0 Yes boiGG01388 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of boi Class Mutagen Stocks Known lesion boiGD14474 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes boiGD14979 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes boiGD2556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiGD60 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiKK103113 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes boiAct5C.PY in vitro construct - regulatory fusion 0 Yes boidsRNA.Scer\UAS.cIa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes boiFN1.Act5C in vitro construct - regulatory fusion 0 Yes boiFN2.Act5C in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6230 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD60} NA P{GD2556} NA P{GD14474} NA P{GD14979} NA P{KK103113} NA P{UAS-boi.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}boiEP1385 NA P{EP}boiG656 NA P{EPgy2}boiEY09847 NA P{Mae-UAS.6.11}boiGG01388 NA P{XP}boid04197 NA P{XP}boid06806 NA P{XP}CG32796d07015 NA miscellaneous insertions Mi{MIC}boiMI00918 NA P{RS3}boiCB-0004-3 NA P{SUPor-P}boiKG03233 NA PBac{RB}boie01708 NA insertion of enhancer trap binary system P{GawB}boiNP4065 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
smoothened signaling pathway inferred from mutant phenotype (Yao et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion inferred from sequence or structural similarity with UniProtKB:P97798 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions boi allele Gene References unspecified dlp (Yao et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57765 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040388 DroID - A comprehensive database of gene and protein interactions. • FBgn0040388 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31229
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH12751 Dmoj\GI15895 Dsim\GD16363 Dvir\GJ16643 Dwil\GK24917 Dyak\GE16943
Curated drosophilid orthologs	Dpse\GA17145
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008827-PA Aedes aegypti (mosquito) AGAP002040-PA Anopheles gambiae (mosquito) XP_393434.2 Apis mellifera (honey bee) XP_001952576.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000012270 Bos taurus (bovine) ENSCAFP00000015458 Canis familiaris (dog) ENSCPOP00000004916 Cavia porcellus (guinea pig) RP35274 Caenorhabditis remanei (nematode) 220775 Capitella spl (polychaete worm) ENSDARP00000081773 Danio rerio (zebra fish) ENSECAP00000015059 Equus caballus (horse) ENSGACP00000016246 Gymnopilus aculeatus (mushroom) ENSGALP00000001379 Gallus gallus (chicken) ENSP00000376458 Homo sapiens (human) 230536 Lottia gigantea (owl limpet) ENSMODP00000033643 Monodelphis domestica (gray opossum) ENSMUSP00000113977 Mus musculus (house mouse) XP_001602034.1 Nasonia vitripennis (wasp) ENSOANP00000005434 Ornithorynchus anatinus (platypus) ENSORLP00000003036 Oryzias latipes (japanese killifish) PHUM001829-PA Pediculus humanus (human body louse) ENSPTRP00000007603 Pan troglodytes (chimpanzee) XP_975643.1 Tribolium castaneum (red flour beetle) ENSTNIP00000003579 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029401 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000000039 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15443 LH24631 ISCW011274 FBgn0234431 FBgn0226876 FBgn0203827 FBgn0187983 FBgn0173781 FBgn0243683 FBgn0152061 FBgn0138644 FBgn0120230 FBgn0104900 FBgn0098948 CPIJ002017 BGIBMGA008552 ACYPI004942 GB18127 AGAP002040 AAEL008827 PB23586 PHUM299830 GLEAN_07250
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	17003 P{EP}boiEP1385 w1118 13245 y1 P{SUPor-P}boiKG03233
Harvard	- P{XP}boid04197 - PBac{RB}boie01708
Kyoto	123003 P{RS3}boiCB-0004-3 w1118
VDRC	v108265 P{KK103113}VIE-260B v869 w1118; P{GD60}v869 v3060 w1118; P{GD2556}v3060 v29593 w1118; P{GD14979}v29593 v42248 w1118; P{GD14474}v42248 v42251 w1118; P{GD14474}v42251 v29592 w1118; P{GD14979}v29592/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR21G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE01910 SD07678
Other clones	DPiM_RE01910 FI05294 RT01624
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04623 AT16030 RE03105 RE27046 RE27051 RE29339 RE52189 RE65509 RH52882 SD01373 SD04186 SD26365
Other clones	33374 40024 54471 57047 121061 123508 162996 214413.47 CK01.12D.D3 CK01.93A.F9 CK01.98B.C11 Dmel_dig_000190_0701_0298 EK072623 EK153835 EK169814 EK177803 EK179963 EK246555 EK267318 EK270028 EP01661 IP17391 RP004072157 RP004213634 RP004240161 RP004258461 RP004345763 RP004377920 RP004396921 RP004431816 RP004480616 RP004482029 RP004500557 RP004510214 RP004520720 RP004524123
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040388 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31229
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: boi CG32796 (Yao et al., 2006)
Source for database merge of	Source for merge of: EG:BACH59J11.2 CG7894 (FlyBase Genome Annotators, 2002-2003) Source for merge of: EG:BACH59J11.2 CG13756 (FlyBase, 1996-)
Additional comments	Annotations CG13756 and CG7894 merged as CG32796 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of EG:BACH59J11.2 CG13756 was sequence comparison (date:000425). (FlyBase, 1996-)
Other Comments
	iHog and boi are in the same protein family and appear to overlap functionally. (Yao et al., 2006) Epistatic experiments show that boi acts at or upstream of ptc. (Yao et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166940 NM_166941 NM_001103398 NM_001201611 NM_001201612 RefSeq (Proteins) • NP_726811 NP_726812 NP_001096868 NP_001188540 NP_001188541 DDBJ / EMBL / GenBank • AAF45782 AAF45784 AAL27644 AAM11196 ABW09329 ADV37624 ADV37625 AI532619 AI534694 AI535017 AL133505 AW944517 AY061833 AY094843 BI162647 BI162648 CAB65842 CL632198 CZ473784 CZ475371 CZ479518 Entrez Gene - A searchable database of RefSeq genes. • 31229 UniProtKB/TrEMBL • A8JUV7 Q8SX52 Q9U1M6 Q9W4Y6 Q95R27
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin (IPR013151) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57765 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0040388 DroID - A comprehensive database of gene and protein interactions. • FBgn0040388 DRSC - Results from RNAi screens. • FBgn0040388 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040388 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32796-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040388 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 216107 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31229 InParanoid A subset of ortholog calls from InParanoid. • AAEL008827-PA Aedes aegypti (mosquito) AGAP002040-PA Anopheles gambiae (mosquito) XP_393434.2 Apis mellifera (honey bee) XP_001952576.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000012270 Bos taurus (bovine) ENSCAFP00000015458 Canis familiaris (dog) ENSCPOP00000004916 Cavia porcellus (guinea pig) RP35274 Caenorhabditis remanei (nematode) 220775 Capitella spl (polychaete worm) ENSDARP00000081773 Danio rerio (zebra fish) ENSECAP00000015059 Equus caballus (horse) ENSGACP00000016246 Gymnopilus aculeatus (mushroom) ENSGALP00000001379 Gallus gallus (chicken) ENSP00000376458 Homo sapiens (human) 230536 Lottia gigantea (owl limpet) ENSMODP00000033643 Monodelphis domestica (gray opossum) ENSMUSP00000113977 Mus musculus (house mouse) XP_001602034.1 Nasonia vitripennis (wasp) ENSOANP00000005434 Ornithorynchus anatinus (platypus) ENSORLP00000003036 Oryzias latipes (japanese killifish) PHUM001829-PA Pediculus humanus (human body louse) ENSPTRP00000007603 Pan troglodytes (chimpanzee) XP_975643.1 Tribolium castaneum (red flour beetle) ENSTNIP00000003579 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029401 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000000039 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31229 modMine - Data generated by the modENCODE project. • FBgn0040388 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15443 LH24631 ISCW011274 FBgn0234431 FBgn0226876 FBgn0203827 FBgn0187983 FBgn0173781 FBgn0243683 FBgn0152061 FBgn0138644 FBgn0120230 FBgn0104900 FBgn0098948 CPIJ002017 BGIBMGA008552 ACYPI004942 GB18127 AGAP002040 AAEL008827 PB23586 PHUM299830 GLEAN_07250
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	boi (Yao et al., 2006, Chang et al., 2008, Zheng et al., 2010, Yan et al., 2010, Kemppainen et al., 2009, Reis et al., 2010) Boi (Wilson and Chuang, 2006, Chou et al., 2010) CG7894 (Benos, 2000.12.13, ) CG13756 (Benos, 2000.12.13, ) CG32796 (Yao et al., 2006, Lear et al., 2005, Lebo et al., 2009, Keleman et al., 2009.8.5, Chang et al., 2008) CT23737 (Vogel et al., 2003, Hynes and Zhao, 2000) CT33235 (Hynes and Zhao, 2000) EG:BACH59J11.2 (Benos et al., 2001, Giot et al., 2003, )
Name Synonym	brother of ihog (Yao et al., 2006, ) Brother of Ihog (Zheng et al., 2010, Chou et al., 2010) Brother of ihog (Yan et al., 2010) brother of iHog (Chang et al., 2008, Lebo et al., 2009) CG32796
Secondary FlyBase IDs
	FBgn0029618 FBgn0029619 FBgn0052796
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Chou et al., 2010, Cell 142(6): 954--966 Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. [FBrf0211838] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Yan et al., 2010, Development 137(12): 2033--2044 The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. [FBrf0210906] Zheng et al., 2010, Genes Dev. 24(1): 57--71 Genetic and biochemical definition of the Hedgehog receptor. [FBrf0209607] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...