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Gene Dmel\mRpL14

General Information
Symbol	Dmel\mRpL14	Species	D. melanogaster
Name	mitochondrial ribosomal protein L14	Annotation symbol	CG14048
Feature type	protein_coding_gene	FlyBase ID	FBgn0040389
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	3A1-3A1	Sequence location	X:2,238,028..2,238,682 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein L14 is referred to in FlyBase by the symbol Dmel\mRpL14 (CG14048, FBgn0040389). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein L14 domain; Ribosomal protein L14b/L23e. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639171_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpL14. Gene sequence location is X:2238028..2238682.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A1-3A1   Limits computationally determined from genome sequence between P{EP}EP1606 and P{EP}EP1605
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpL14 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpL14-RA FBtr0070405  NM_080309   653   161 mRpL14-RB FBtr0333730  NM_001272257   599   161
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpL14-PA   FBpp0070389   17.7   161   11.06     NP_525048   AAF45775 mRpL14-PB   FBpp0305877   17.7   161   11.06     NP_001259186   AGB95032
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L14b/L23e (IPR000218) Ribosomal protein L14 domain (IPR023571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45775   AE014298 AGB95032   AL133503 CAB63504   AY071662 AAL49284   AY075539 AAL68346   BI355992   BI580647   BI581418   BI581797   BQ103721   CO266052   EC233467
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4Z2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic midgut chamber   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) gastric caecum   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    313.95 Larval Midgut    105.1 Larval Hindgut    195.3 Larval Malpighian Tubules    77.5 Larval Fat Body    82.9 Larval Salivary Gland    188.4 Larval Trachea    141.925 Larval Carcass    145.225 Adult Head    155.8 Adult Eye    225.275 Adult Brain    268.6 Adult Thoracic-Abdominal Ganglion    341.7 Adult Crop    169.1 Adult Midgut    137.5 Adult Hindgut    150.1 Adult Malpighian Tubules    192 Adult Fat Body    168.1 Adult Salivary Gland    68.4 Adult Heart    136.025 Adult VirginFemale Spermatheca    183.9 Adult InseminatedFemale Spermatheca    195.2 Adult Ovary    355.9 Adult Testis    51 Adult Male Accessory Gland    153.9 Adult Carcass    158.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    155.8   NA  Eye    225.275   NA  Brain    268.6   313.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    341.7   NA  Crop    169.1   105.1  Midgut    137.5   195.3  Hindgut    150.1   77.5  Malpighian Tubules    192   82.9  Fat Body    168.1   188.4  Salivary Gland    no informative data   NA  Heart    136.025   141.925  Trachea    NA   NA  VirginFemale Spermatheca    183.9   NA  InseminatedFemale Spermatheca    195.2   NA  Ovary    355.9   NA  Testis    51   NA  Male Accessory Gland    153.9   145.225  Carcass    158.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (30) testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female  (34) ovary, mated 4-day female  30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    19 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    19 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    8 digestive system, 4-day adult    11 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    4 fat body, pupae P8    13 carcass, larvae L3 wandering    12 carcass, 1-day adult    11 carcass, 4-day adult    10 carcass, 20-day adult    9 ovary, virgin 4-day female    34 ovary, mated 4-day female    30 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (47) embryo 04-06hr  (49) embryo 06-08hr  (37) embryo 08-10hr  (30) embryo 10-12hr  (46) embryo 12-14hr  (31) embryo 14-16hr  (35) embryo 16-18hr  (37) embryo 18-20hr  (36) embryo 20-22hr  (34) embryo 22-24hr  26 larva L1  (43) larva L2  (52) larva L3 12hr old  (41) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP  (27) pupae 3d postWPP  (50) pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day  (28) adult female 05day  (39) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (47) embryo 04-06hr  (49) embryo 06-08hr  (37) embryo 08-10hr  30 embryo 10-12hr  (46) embryo 12-14hr  31 embryo 14-16hr  (35) embryo 16-18hr  (37) embryo 18-20hr  (36) embryo 20-22hr  (34) embryo 22-24hr  26 larva L1  (43) larva L2  (52) larva L3 12hr old  (41) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP  27 pupae 3d postWPP  (50) pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day  28 adult female 05day  (39) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    47 embryo 04-06hr    49 embryo 06-08hr    37 embryo 08-10hr    30 embryo 10-12hr    46 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    37 embryo 18-20hr    36 embryo 20-22hr    34 embryo 22-24hr    26 larva L1    43 larva L2    52 larva L3 12hr old    41 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    13 white prepupae 24hr    16 pupae 2d postWPP    27 pupae 3d postWPP    50 pupae 4d postWPP    19 adult male 01day    18 adult male 05day    17 adult male 30day    13 adult female 01day    28 adult female 05day    39 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    110 Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (110) Schneider line 2 Sg4  (45) embryonic 1182-4H  26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3  (28) leg disc CME L1  (33) wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  (38) wing disc ML-DmD21  (59) wing disc ML-DmD32  (27) haltere disc ML-DmD17-c3  (28) eye-antennal disc ML-DmD11  (32) antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (34) ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (110) Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    110 Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    110 Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (110) Schneider line 2 Sg4  (45) embryonic 1182-4H  26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3  28 leg disc CME L1  (33) wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9  (34) wing disc ML-DmD16-c3  (38) wing disc ML-DmD21  (59) wing disc ML-DmD32  27 haltere disc ML-DmD17-c3  28 eye-antennal disc ML-DmD11  32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS  (34) ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  110 Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    110 Schneider line 2 Sg4    45 embryonic 1182-4H    26 embryonic GM2    9 embryonic Kc167    17 embryonic S1    25 embryonic S3    28 leg disc CME L1    33 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    38 wing disc ML-DmD21    59 wing disc ML-DmD32    27 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    24 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    24 ovary fGS/OSS    34 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RH18819 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040389 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14048-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mRpL14 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpL14GD6383 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpL14GD6383 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 mRpL14GD6383
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mRpL14 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpL14 Class Mutagen Stocks Known lesion mRpL14GD6383 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mRpL14KK109122 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mRpL14GreenH-Pelican in vitro construct - coding region fusion 0 Yes mRpL14NIG.14048R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6229 (Ryder, 2004.4.26)
Duplicated in	Dp(1)weeb1 (Kemppainen et al., 2009) Dp(1)weeb2 (Kemppainen et al., 2009) Dp(1)weeb3 (Kemppainen et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6383} NA P{KK109122} NA P{NIG.14048R} NA characterization construct P{mRpL14-GreenH-Pelican} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with EMBL:AA642134 (Suzuki et al., 2001)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with EMBL:AA642134 (Suzuki et al., 2001)
Cellular Component
CV term Evidence References
mitochondrial large ribosomal subunit inferred from sequence or structural similarity with EMBL:AA642134 (Suzuki et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpL14 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57759 DroID - A comprehensive database of gene and protein interactions. • FBgn0040389 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31222
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QVCZJ Dipteran inclusive ortholog search EOG60CHS9 Insect inclusive ortholog search EOG6RN961 Arthropod inclusive ortholog search EOG65MKNX Metazoa inclusive ortholog search EOG68SVNW
Orthologs in Drosophila Species (EOG6QVCZJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mRpL14     Drosophila sechellia   Dsec\GM18887 Y   Drosophila erecta   Dere\GG12621 Y   Drosophila yakuba   Dyak\GE16952 Y   Drosophila ananassae   Dana\GF21957 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12726 Y   Drosophila persimilis   Dper\GL26911 Y   Drosophila willistoni   Dwil\GK25783 Y   Drosophila virilis   Dvir\GJ16826 Y   Drosophila mojavensis   Dmoj\GI15919 Y   Drosophila grimshawi   Dgri\GH12815 Y
Orthologs in non-Drosophila Dipterans (EOG60CHS9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004433   Anopheles gambiae Malaria mosquito  Agam\AGAP011148   Anopheles gambiae Malaria mosquito  Agam\AGAP011146   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008190
Orthologs in non-Dipteran Insects (EOG6RN961)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\mRpL14   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002140   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26696   Atta cephalotes Leafcutter ant  Acep\ACEP17453   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15383   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18259   Linepithema humile Argentine ant  Lhum\LH23810   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24188   Solenopsis invicta Red fire ant  Sinv\SINV25634   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003461   Bombyx mori Silkmoth  Bmor\BGIBMGA008301   Pediculus humanus Human body louse  Phum\PHUM307660   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07851
Orthologs in non-Insect Arthropods (EOG65MKNX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb   Ixodes scapularis Deer tick  Isca\ISCW014261
Orthologs in non-Arthropod Metazoa (EOG68SVNW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mrpl-14   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003475gn   Danio rerio Zebrafish  Drer\mrpl14   Xenopus tropicalis Western clawed frog  Xtro\mrpl14   Gallus gallus Domestic chicken  Ggal\MRPL14   Mus musculus House mouse  Mmus\Mrpl14   Rattus norvegicus Norway rat  Rnor\Mrpl14   Homo sapiens Human  Hsap\MRPL14
Human Orthologs (1)
Gene OMIM HGNC Hsap\MRPL14
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM18887 Drosophila erecta Dere\GG12621 Drosophila yakuba Dyak\GE16952 Drosophila ananassae Dana\GF21957 Drosophila pseudoobscura pseudoobscura Dpse\GA12726 Drosophila persimilis Dper\GL26911 Drosophila willistoni Dwil\GK25783 Drosophila virilis Dvir\GJ16826 Drosophila mojavensis Dmoj\GI15919 Drosophila grimshawi Dgri\GH12815
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v101423 P{KK109122}VIE-260B v39648 w1118; P{GD6383}v39648
Genomic Clones ( 2 )
	BACR13K19 BACR48O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE74864 RH18819
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE37068 RH19476
Other clones	34495 EK144813 UUGC1132
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040389 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31222
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: EG:BACH48C10.6 CG14048 (FlyBase, 1996-) Source for merge of: mRpL14 BcDNA:RH18819 (FlyBase, 1996-)
Additional comments	Source for merge of mRpL14 BcDNA:RH18819 was TrEMBL update (date:020807). (FlyBase, 1996-) Source for merge of EG:BACH48C10.6 CG14048 was sequence comparison (date:000425). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080309 NM_001272257 RefSeq (Proteins) • NP_525048 NP_001259186 DDBJ / EMBL / GenBank • AAF45775 AAL49284 AAL68346 AGB95032 AL133503 AY071662 AY075539 BI580647 BI581418 CAB63504 Entrez Gene - A searchable database of RefSeq genes. • 31222 UniProtKB/TrEMBL • Q9W4Z2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L14b/L23e (IPR000218) Ribosomal protein L14 domain (IPR023571) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH18819
Linkouts
	BioGRID - A database of protein and genetic interactions • 57759 DroID - A comprehensive database of gene and protein interactions. • FBgn0040389 DRSC - Results from RNAi screens. • FBgn0040389 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040389 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14048-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040389 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31222 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31222 modMine - Data generated by the modENCODE project. • FBgn0040389
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BcDNA:RH18819   CG14048 (Benos, 2000.12.13, Keleman et al., 2009.8.5, Marygold et al., 2007) EG:BACH48C10.6 (Benos et al., 2001, ) L14 (Suzuki et al., 2001) mRpL14 (Marygold et al., 2007, Kemppainen et al., 2009, Japanese National Institute of Genetics, 2012.5.21) mRPL14 (Zid et al., 2009)
Name Synonym	mitochondrial ribosomal protein L14 (Suzuki et al., 2001)
Secondary FlyBase IDs
	FBgn0029613 FBgn0061383
References ( 18 )
Research paper	Kemppainen et al., 2009, Mitochondrion 9(5): 353--363 Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. [FBrf0209036] Zid et al., 2009, Cell 139(1): 149--160 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. [FBrf0209084] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Benos et al., 2001, Genome Res. 11(5): 710--730 From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823] Suzuki et al., 2001, J. Biol. Chem. 276(24): 21724--21736 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. [FBrf0136752]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] Benos, 2000.12.13, FlyBase error report on Wed Dec 13 14:35:56 2000. FlyBase error report on Wed Dec 13 14:35:56 2000. [FBrf0133222]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
DNA/RNA sequence record	Benos, 1999.12.16, GenBank/EMBL/DDBJ: AL133503 Drosophila melanogaster BAC clone BACH48C10. [FBrf0141120]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]