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Gene Dmel\cid

General Information
Symbol	Dmel\cid	Species	D. melanogaster
Name	centromere identifier	Annotation symbol	CG13329
Feature type	protein_coding_gene	FlyBase ID	FBgn0040477
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	CENP-A, cenH3, CID/CENP-A, cenpA, CENP-A/CID, CenH3Cid
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50A11-50A11	Sequence location	2R:9,373,122..9,374,136 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene centromere identifier is referred to in FlyBase by the symbol Dmel\cid (CG13329, FBgn0040477). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule motor activity. There is experimental evidence that it is involved in the biological process: mitotic metaphase plate congression; mitotic spindle elongation; kinetochore assembly; chromosome segregation; mitosis; mitotic spindle organization; kinetochore organization; spindle assembly; neurogenesis. 26 alleles are reported. The phenotypes of these alleles are annotated with: cell cycle; cell cycle process; external compound sense organ; organelle; organ system subdivision; M phase; nucleus; cellular process; sense organ; nuclear part; eo support cell; cellular component organization or biogenesis. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone H3; Histone core; Histone-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1625258_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cid. Gene sequence location is 2R:9373122..9374136.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A11-50A11   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50A-50A     (Ahmad, 2000.3.13)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cid for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cid-RA FBtr0087667  NM_079006   1015   225
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cid-PA   FBpp0086787   26.0   225   10.72     NP_523730   AAF58371
Additional Polypeptide Data & Comments
Reported size (kDa)	225 (aa) (Henikoff et al., 2000)
Comments	cid protein was used as a marker for kinetochores during early embryogenesis. (Maiato et al., 2002)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone H3 (IPR000164) Histone core (IPR007125) Histone-fold (IPR009072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58371   AF259371 AAF72652   AY126929 AAM80987   AY126930 AAM80988   AY126931 AAM80989   AY126932 AAM80990   AY126933 AAM80991   AY128465 AAM75058   BI162970   BI215069   BT132835   EC054875   EV576947   GH779336
UniProtKB/Swiss-Prot	Q9V6Q2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Maiato et al., 2002) immunolocalization Stage Tissue/Position (including subcellular localization) Reference fertilized egg stage   female pronucleus   • chromatin (Loppin et al., 2001) male pronucleus   • chromatin (Loppin et al., 2001) embryonic stage   cell   • kinetochore (Jager et al., 2005) adult stage   spermatid   • kinetochore (Loppin et al., 2001)   cell   • chromosome, centromeric region (Schittenhelm et al., 2007) Comment:Localization observed at interphase and during mitosis; assayed in S2R+ cells
Additional Descriptive Data
	Protein can be detected as 4 distinct foci of staining at the centromere region of chromatids of developing spermatozoa. While staining cannot be detected in very late spermatids and mature spermatozoa, the highly compact nature of the sperm nuclei have been shown to exclude antibodies and therefore prevent visualization of proteins associated with these structures. Shortly after fertilization protein can be detected again as discrete spots on the apposed pronuclei. (Loppin et al., 2001)
Marker for
	kinetochore
Subcellular Localization (GO Cellular Component)
CV term Evidence References
condensed nuclear chromosome inner kinetochore inferred from direct assay (Blower and Karpen, 2001) inferred from direct assay (assigned by UniProtKB) (Henikoff et al., 2000) condensed nuclear chromosome, centromeric region inferred from direct assay (Schuh et al., 2007) kinetochore inferred from direct assay (Schittenhelm et al., 2007) nuclear nucleosome inferred from physical interaction with His2A, His2B, His4 (Dalal et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    61.25 Larval Midgut    10 Larval Hindgut    14.6 Larval Malpighian Tubules    6.7 Larval Fat Body    11.8 Larval Salivary Gland    15.7 Larval Trachea    18.65 Larval Carcass    11.925 Adult Head    6.7 Adult Eye    3.725 Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    58.6 Adult Crop    2.7 Adult Midgut    10 Adult Hindgut    5.9 Adult Malpighian Tubules    5.1 Adult Fat Body    8.4 Adult Salivary Gland    10 Adult Heart    6.425 Adult VirginFemale Spermatheca    10.9 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    283.1 Adult Testis    17.5 Adult Male Accessory Gland    5.6 Adult Carcass    12 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    6.7   NA  Eye    3.725   NA  Brain    8.8   61.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    58.6   NA  Crop    2.7   no informative data  Midgut    no informative data   14.6  Hindgut    5.9   6.7  Malpighian Tubules    5.1   no informative data  Fat Body    8.4   15.7  Salivary Gland    no informative data   NA  Heart    6.425   18.65  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    6.4   NA  Ovary    283.1   NA  Testis    17.5   NA  Male Accessory Gland    5.6   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female  (44) ovary, mated 4-day female  (40) testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female  (44) ovary, mated 4-day female  (40) testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    5 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    2 carcass, 20-day adult    1 ovary, virgin 4-day female    44 ovary, mated 4-day female    40 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72) embryo 02-04hr    18 embryo 04-06hr  (38) embryo 06-08hr  (30) embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day  (30) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72) embryo 02-04hr    18 embryo 04-06hr  (38) embryo 06-08hr  30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day  30 adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    18 embryo 04-06hr    38 embryo 06-08hr    30 embryo 08-10hr    15 embryo 10-12hr    11 embryo 12-14hr    3 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    0 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    1 adult male 05day    2 adult male 30day    2 adult female 01day    16 adult female 05day    30 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS  (28) ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS  28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    10 embryonic 1182-4H    5 embryonic GM2    2 embryonic Kc167    8 embryonic S1    9 embryonic S3    9 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    15 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    5 ovary fGS/OSS    28 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3  (27) Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3  27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040477 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13329-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal cidGD4436 cidT12-1 cidT22-4 lethal | embryonic stage 15 cidT11-2 cidT12-1 cidT21-3 cidT22-4 lethal | embryonic stage 15 (with cidT11-2) cidT12-1 cidT21-3 cidT22-4 lethal | embryonic stage 15 (with cidT12-1) cidT11-2 cidT21-3 cidT22-4 lethal | embryonic stage 15 (with cidT21-3) cidT11-2 cidT12-1 cidT22-4 lethal | embryonic stage 15 (with cidT22-4) cidT11-2 cidT12-1 cidT21-3 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 cidGD4436 Other Phenotypes Allele cell cycle defective (with cidT11-2) cidT22-4 cell cycle defective (with cidT22-4) cidT11-2 mitotic cell cycle defective ciddsRNA.cBa ciddsRNA.cPa neuroanatomy defective (with cidT11-2) cidT22-4 neuroanatomy defective (with cidT22-4) cidT11-2 neuroanatomy defective | larval stage cidGD4436 visible, with Scer\GAL4ey.PH cidScer\UAS.cJa cidScer\UAS.P\T.T:Hsap\MYC visible, with Scer\GAL4GMR.PF cidScer\UAS.cJa visible, with Scer\GAL4pnr-MD237 cidGD4436 Phenotype manifest in Allele anaphase (with cidT11-2) cidT22-4 anaphase (with cidT22-4) cidT11-2 anaphase & condensed nuclear chromosome ciddsRNA.cBa chromosome (with cidT11-2) cidT22-4 chromosome (with cidT22-4) cidT11-2 condensed nuclear chromosome ciddsRNA.cPa embryonic/larval neuroblast | larval stage cidGD4436 eye, with Scer\GAL4ey.PH cidScer\UAS.cJa cidScer\UAS.P\T.T:Hsap\MYC eye, with Scer\GAL4GMR.PF cidScer\UAS.cJa ganglion mother cell | larval stage cidGD4436 mesothoracic tergum, with Scer\GAL4pnr-MD237 cidGD4436 metaphase ciddsRNA.cPa metaphase plate (with cidT11-2) cidT22-4 metaphase plate (with cidT22-4) cidT11-2 mitotic anaphase ciddsRNA.cBa mitotic cell cycle ciddsRNA.cBa nucleus ciddsRNA.cPa nucleus (with cidT11-2) cidT22-4 nucleus (with cidT22-4) cidT11-2 ommatidium, with Scer\GAL4GMR.PF cidScer\UAS.cJa spindle ciddsRNA.cPa telophase (with cidT11-2) cidT22-4 telophase (with cidT22-4) cidT11-2 trichogen cell, with Scer\GAL4pnr-MD237 cidGD4436
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of cid Class Mutagen Stocks Known lesion cidG5950 P-element activity 1 -- cidT11-2 ethyl methanesulfonate 1 Yes cidT21-3 ethyl methanesulfonate 1 Yes cidT22-4 loss of function allele ethyl methanesulfonate 1 Yes cid00 natural population 0 Yes cid01 natural population 0 Yes cid05 natural population 0 Yes cid14 natural population 0 Yes cid15 natural population 0 Yes cidT12-1 loss of function allele 0 Yes cidZim216 natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cid Class Mutagen Stocks Known lesion cidGD4436 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cidHMS02160 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cidKK110670 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cidT:Avic\GFP in vitro construct - coding region fusion 1 Yes ciddsRNA.cBa in vitro construct - RNAi 0 Yes ciddsRNA.cPa in vitro construct - RNAi 0 Yes cidhs.T:Avic\GFP in vitro construct - coding region fusion 0 Yes cidMtnA.BLRP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cidMtnA.BLRPmut in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cidMtnA.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cidScer\UAS.cJa in vitro construct - regulatory fusion 0 Yes cidScer\UAS.P\T.cJa in vitro construct - regulatory fusion 0 Yes cidScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cidT:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - genomic fragment 0 Yes cidT:Disc\RFP-mRFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4436} NA P{KK110670} NA P{TRiP.HMS02160} NA P{UASp-cid.J} NA P{UASp-cid-myc} NA heat-shock construct P{hs-cid.GFP} NA characterization construct P{gcid-EGFP-cid} NA P{gcid-mRFP-cid} NA P{GFP-cid.H} NA P{MtnA-BLRP-cid} NA P{MtnA-BLRPmut-cid} NA P{MtnA-cid-TAP} NA P{UAS-cid::His3.hx2H3} NA P{UASp-cid::His3.hx2H3.myc} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cidG5950 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
microtubule motor activity inferred from direct assay (assigned by UniProtKB) (Blower and Karpen, 2001)
Biological Process
CV term Evidence References
chromosome segregation inferred from mutant phenotype (Przewloka et al., 2007) kinetochore assembly inferred from mutant phenotype (Blower et al., 2006) kinetochore organization inferred from direct assay (assigned by UniProtKB) (Blower and Karpen, 2001) mitosis inferred from mutant phenotype (Blower et al., 2006) mitotic metaphase plate congression inferred from mutant phenotype (Przewloka et al., 2007) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) spindle assembly inferred from mutant phenotype (Blower et al., 2006)
Cellular Component
CV term Evidence References
condensed nuclear chromosome, centromeric region inferred from direct assay (Schuh et al., 2007) condensed nuclear chromosome inner kinetochore inferred from direct assay (Blower and Karpen, 2001) inferred from direct assay (assigned by UniProtKB) (Henikoff et al., 2000) kinetochore inferred from direct assay (Schittenhelm et al., 2007) nuclear nucleosome inferred from physical interaction with His2A, His2B, His4 (Dalal et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR000164, InterPro:IPR007125, InterPro:IPR009072 (FlyBase Curators et al., 2004-) traceable author statement (Talbert and Henikoff, 2000) protein heterodimerization activity inferred from electronic annotation with InterPro:IPR009072 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
chromatin assembly or disassembly inferred from sequence or structural similarity with UniProtKB:P16105 (FlyBase, 1992-) nucleosome assembly inferred from electronic annotation with InterPro:IPR000164 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
chromosome, centromeric region non-traceable author statement (Ahmad et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cid allele Gene References unspecified Cenp-C (Heeger et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62254 DroID - A comprehensive database of gene and protein interactions. • FBgn0040477 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36495
Orthologs
OrthoDB Orthologs (13) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6KKZPP Dipteran inclusive ortholog search EOG6ZKJWR Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6KKZPP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cid     Drosophila simulans   Dsim\cid Y   Drosophila sechellia   Dsec\cid Y   Drosophila erecta   Dere\cid Y   Drosophila yakuba   Dyak\cid Y   Drosophila ananassae   Dana\cid Y   Drosophila pseudoobscura pseudoobscura   Dpse\cid Y   Drosophila persimilis   Dper\GL17403 Y   Drosophila willistoni   Dwil\GK10722 Y   Drosophila virilis   Dvir\GJ19757 Y   Drosophila mojavensis   Dmoj\GI18331 Y   Drosophila grimshawi   Dgri\GH23161 Y
Orthologs in non-Drosophila Dipterans (EOG6ZKJWR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009296
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\cid Drosophila sechellia Dsec\cid Drosophila erecta Dere\cid Drosophila yakuba Dyak\cid Drosophila ananassae Dana\cid Drosophila pseudoobscura pseudoobscura Dpse\cid Drosophila persimilis Dper\GL17403 Drosophila willistoni Dwil\GK10722 Drosophila virilis Dvir\GJ19757 Drosophila mojavensis Dmoj\GI18331 Drosophila grimshawi Dgri\GH23161
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	25047 w1118; P{GFP-cid.H}8-10 27628 w1118; cidT11-2/SM5 29695 y1 w*; P{EP}cidG5950/CyO 40912 y1 sc* v1; P{TRiP.HMS02160}attP2 27629 w1118; cidT21-3/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7 27627 w1118; al1 b1 cidT22-4 c1 sp1/SM5
VDRC	v102090 P{KK110670}VIE-260B v43856 w1118; P{GD4436}v43856 v43857 w1118; P{GD4436}v43857
Genomic Clones ( 2 )
	BACR36J03 BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE21270
Other clones	FI17120
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE02255
Other clones	Dmel_dig_012930_0590_1219 EC054875 RP001043965
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040477 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36495
Antibody Information
	polyclonal (Henikoff et al., 2000, Jager et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cid BcDNA:RE21270 (FlyBase, 1996-) Source for merge of: cid CG13329 (FlyBase, 1996-)
Additional comments	Source for merge of cid BcDNA:RE21270 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of cid CG13329 was sequence comparison (date:000601). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle and the formation of aberrantly long spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) New incorporation of cid protein into centromeres takes place during anaphase of the syncytial divisions of embryos. This incorporation is independent of DNA replication and of normal pulling forces generated by the mitotic spindle, but is strictly coupled to mitotic progression. (Schuh et al., 2007) SL2 cells treated with dsRNA against cid show mitotic arrest and chromosomes are displaced from the metaphase plate. (Muller et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079006 RefSeq (Proteins) • NP_523730 DDBJ / EMBL / GenBank • AAF58371 AAF72652 AAM75058 AAM80987 AAM80988 AAM80989 AAM80990 AAM80991 AF259371 AY126929 AY126930 AY126931 AY126932 AY126933 AY128465 BI215069 Entrez Gene - A searchable database of RefSeq genes. • 36495 UniProtKB/Swiss-Prot • Q9V6Q2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone H3 (IPR000164) Histone core (IPR007125) Histone-fold (IPR009072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62254 DroID - A comprehensive database of gene and protein interactions. • FBgn0040477 DRSC - Results from RNAi screens. • FBgn0040477 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040477 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13329-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040477 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36495 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/centid1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36495 modMine - Data generated by the modENCODE project. • FBgn0040477
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	BcDNA:RE21270   cenH3 (Furuyama et al., 2005) CenH3 (Furuyama et al., 2006, Moreno-Moreno et al., 2011, Dalal et al., 2007, Dalal et al., 2007, Furuyama and Henikoff, 2009, Podhraski et al., 2010, Wang et al., 2008, Furuyama and Henikoff, 2006) CenH3/CID (Podhraski et al., 2010) CenH3Cid (Morris and Moazed, 2007) CenH3CID (Podhraski et al., 2010) CENP-A (Blower et al., 2006, Gunjan, 2006, Polo, 2006, Cavalli, 2002, Cleveland et al., 2003, Blower et al., 2003, Sullivan and Karpen, 2001, Grewal and Elgin, 2007, Schuh et al., 2007, Schuh et al., 2007, Przewloka et al., 2007, Lam et al., 2005, Goshima et al., 2008, Erhardt et al., 2008, Savvidou et al., 2005, Kwon et al., 2008, Laycock et al., 2006, Przewloka et al., 2011, Phansalkar et al., 2012) cenpA (Brust-Mascher and Scholey, 2002, Brust-Mascher and Scholey, 2001) Cenp-A (Lehner et al., 2007, Schittenhelm et al., 2007, Pandey et al., 2007, Schittenhelm et al., 2009, Schittenhelm et al., 2010, Althoff et al., 2012) CenpA (Somma et al., 2008, Meireles et al., 2011) CENPA (Brust-Mascher et al., 2009) CENP-A/CID (Sullivan and Karpen, 2001) CENP-A/Cid (Adams et al., 2001) CenpA/CID (Erhardt et al., 2007) CENP-C (Podhraski et al., 2010) CG13329 (Henikoff, 2000.4.2, Goshima et al., 2007, Keleman et al., 2009.8.5, Veenstra et al., 2008, Ni et al., 2010.12.1) CID (Muller et al., 2006, Chlamydas et al., 2009, Deshpande et al., 2005, Perez-Mongiovi et al., 2005, Webber et al., 2004, Furuyama et al., 2005, Erhardt et al., 2005, Parry et al., 2003, Sullivan and Karpen, 2001, Grewal and Elgin, 2007, Anonymous, 2006, Mentelova et al., 2007, Mellone et al., 2007, Dunleavy et al., 2005, Thomas et al., 2005, Pane et al., 2011, Cullen et al., 2005, Przewloka et al., 2007, Maiato et al., 2006, Huang and Raff, 2002, Zhang and Karpen, 2008, Gao et al., 2008, Olszak et al., 2011, Tsai et al., 2011, Oliveira et al., 2005, Orr and Sunkel, 2011, Salvany et al., 2009, Moutinho-Pereira et al., 2010, Heun et al., 2006, Erhardt et al., 2008, Orr et al., 2007, Savvidou et al., 2005, Khetani and Bickel, 2007, Laycock et al., 2006, Cesario et al., 2006, Thakar et al., 2006, Maresca and Salmon, 2009, Williams et al., 2007, Fanti et al., 2008, Gause et al., 2008, Liu et al., 2009, Brittle et al., 2007, Brust-Mascher et al., 2009, Mische et al., 2008, Furuyama and Henikoff, 2009, Matos et al., 2009, Yang and Fan, 2008, Klattenhoff et al., 2009, Yokoyama et al., 2009, Meyer et al., 2010, Yan et al., 2010, Nishiyama et al., 2010, Pek and Kai, 2011, Venkei et al., 2011, Przewloka et al., 2011, Sullivan and Karpen, 2004, Hughes et al., 2011, Furuyama and Henikoff, 2006, Pek et al., 2012, Venkei et al., 2012) Cid (Gilliland et al., 2007, Logarinho et al., 2004, Perrod and Gasser, 2003, Rogers et al., 2004, Aquadro et al., 2001, Malik et al., 2002, Griffis et al., 2007, Schittenhelm et al., 2007, Goshima and Vale, 2005, Cullen et al., 2005, Goshima et al., 2007, Weissmann et al., 2003, Siller et al., 2005, Ahmad and Henikoff, 2002, Pauli et al., 2008, Royou et al., 2008, Buster et al., 2007, Chang et al., 2003, Coelho et al., 2003, Kwon et al., 2008, Martins et al., 2009, Ding et al., 2009, Reis et al., 2009, Pimenta-Marques et al., 2008, McCleland et al., 2009, Rath et al., 2009, Sakai et al., 2009, Royou et al., 2010, Oliveira et al., 2010, Orsi et al., 2010, Schittenhelm et al., 2010, Maheshwari and Barbash, 2012, Van Damme et al., 2011, Meireles et al., 2011, Althoff et al., 2012) cid (Blower et al., 2006, Moreno-Moreno et al., 2006, Jones and Holloway, 2007, Morris and Moazed, 2007, Schuh et al., 2007, Schittenhelm et al., 2009, Sainz et al., 2003, Schuh et al., 2007, Heeger et al., 2005, Sedat, 2008.5.22, Jager et al., 2005, Colombie et al., 2006, Somma et al., 2008, May and Schiek, 2009, Pandey et al., 2007, Cook, 2009.6.17, Kaufman, 2009.6.18, Cook, 2009.6.17, Pauli et al., 2008, Dubruille et al., 2010, Wang et al., 2010, Neumüller et al., 2011, Kalajdzic et al., 2012, Oliveira et al., 2010) CID/CENP-A (Heidmann et al., 2005, Sullivan et al., 2002, Sullivan and Karpen, 2001, Zaratiegui, 2007, Przewloka et al., 2007) CidMel (Vermaak et al., 2002)
Name Synonym	centromere identifier (Ahmad et al., 2000, Sainz et al., 2003, Erhardt et al., 2008, Thakar et al., 2006) Centromere Identifier (Moutinho-Pereira et al., 2010) Centromere identifier (Ding et al., 2009, Pimenta-Marques et al., 2008) Centromere identifier protein (Van Damme et al., 2011) centromere protein A (Cullen et al., 2005, Erhardt et al., 2008)
Secondary FlyBase IDs
	FBgn0033843 FBgn0063052
References ( 206 )
Generate a list of	All references relating to this gene ( 206 )
List References by type	Research paper  ( 132 ) Supplementary material  ( 9 ) Review  ( 19 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 26 ) FlyBase analysis  ( 2 ) Letter  ( 2 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 23 )
	Althoff et al., 2012, Mol. Biol. Cell 23(12): 2275--2291 Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1. [FBrf0218626] Dunleavy et al., 2012, PLoS Biol. 10(12): e1001460 The Cell Cycle Timing of Centromeric Chromatin Assembly in Drosophila Meiosis Is Distinct from Mitosis Yet Requires CAL1 and CENP-C. [FBrf0220464] Kalajdzic et al., 2012, PLoS ONE 7(6): e40296 Use of mutagenesis, genetic mapping and next generation transcriptomics to investigate insecticide resistance mechanisms. [FBrf0218826] Maheshwari and Barbash, 2012, PLoS Genet. 8(3): e1002597 Cis-by-Trans Regulatory Divergence Causes the Asymmetric Lethal Effects of an Ancestral Hybrid Incompatibility Gene. [FBrf0217900] Moutinho-Santos et al., 2012, J. Cell Sci. 125(3): 576--583 POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. [FBrf0217659] Pek et al., 2012, Development 139(24): 4505--4513 Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila. [FBrf0220058] Phansalkar et al., 2012, Chromosome Res. 20(5): 493--504 Evolutionary insights into the role of the essential centromere protein CAL1 in Drosophila. [FBrf0219033] Raychaudhuri et al., 2012, PLoS Biol. 10(12): e1001434 Transgenerational propagation and quantitative maintenance of paternal centromeres depends on cid/cenp-a presence in Drosophila sperm. [FBrf0220497] Venkei et al., 2012, Open Biol. 2(2): 110032 Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore. [FBrf0218508] Zhang et al., 2012, Mol. Cell 45(2): 263--269 Assembly of Drosophila Centromeric Nucleosomes Requires CID Dimerization. [FBrf0217338] Hughes et al., 2011, PLoS Genet. 7(8): e1002209 Gamma-Tubulin Is Required for Bipolar Spindle Assembly and for Proper Kinetochore Microtubule Attachments during Prometaphase I in Drosophila Oocytes. [FBrf0214729] Meireles et al., 2011, PLoS ONE 6(9): e24174 Kebab: Kinetochore and EB1 Associated Basic Protein That Dynamically Changes Its Localisation during Drosophila Mitosis. [FBrf0215262] Moreno-Moreno et al., 2011, Curr. Biol. 21(17): 1488--1493 The F Box Protein Partner of Paired Regulates Stability of Drosophila Centromeric Histone H3, CenH3(CID). [FBrf0215570] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Olszak et al., 2011, Nat. Cell Biol. 13(7): 799--808 Heterochromatin boundaries are hotspots for de novo kinetochore formation. [FBrf0214065] Orr and Sunkel, 2011, Chromosoma 120(1): 83--96 Drosophila CENP-C is essential for centromere identity. [FBrf0212897] Pane et al., 2011, EMBO J. 30(22): 4601--4615 The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. [FBrf0217070] Pek and Kai, 2011, Curr. Biol. 21(1): 39--44 A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718] Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Tanneti et al., 2011, Curr. Biol. 21(21): 1852--1857 A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes. [FBrf0216648] Tsai et al., 2011, Chromosoma 120(4): 335--351 Homolog pairing and sister chromatid cohesion in heterochromatin in Drosophila male meiosis I. [FBrf0214501] Van Damme et al., 2011, PLoS Genet. 7(7): e1002169 NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. [FBrf0214337] Venkei et al., 2011, Genetics 187(1): 131--140 Drosophila mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. [FBrf0212773] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...