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Gene Dmel\Alk

General Information
Symbol	Dmel\Alk	Species	D. melanogaster
Name	Alk	Annotation symbol	CG8250
Feature type	protein_coding_gene	FlyBase ID	FBgn0040505
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	DAlk
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	53C12-53C13	Sequence location	2R:12,512,798..12,527,516 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Alk is referred to in FlyBase by the symbol Dmel\Alk (CG8250, FBgn0040505). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane receptor protein tyrosine kinase activity. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; single-organism developmental process; cellular component organization or biogenesis; system development; regulation of multicellular organismal process; neuron differentiation; compound eye photoreceptor development; digestive tract development; macromolecule modification; regulation of growth; regulation of developmental process; positive regulation of ERK1 and ERK2 cascade; sensory organ development; mesoderm development; visceral muscle development. 27 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval midgut; lamellocyte; visceral mesoderm; embryonic somatic muscle; neuromuscular junction; embryonic/larval digestive system; embryonic myoblast; hemocyte; wing; embryonic visceral muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Concanavalin A-like lectin/glucanases superfamily; Low-density lipoprotein (LDL) receptor class A repeat; MAM domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, receptor class II, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1638700_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Alk. Gene sequence location is 2R:12512798..12527516.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 53C12-53C13   Limits computationally determined from genome sequence between P{PZ}Sema-2a03021&P{PZ}Cdk405428 and P{EP}BEST:SD02913EP2148&P{lacW}Dekk09907
Experimentally Determined Cytological Location
Cytogenetic map Notes References 53-53   (determined by in situ hybridisation)   (Loren et al., 2001) 53C-53D     (Palmer, 2000.2.17)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Alk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Alk-RA FBtr0087118  NM_144343   8655   1701 Alk-RB FBtr0331926  NM_001274098   9402   1701
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Alk-PA   FBpp0086264   185.6   1701   6.55     NP_652600   AAF57973 Alk-PB   FBpp0304259   185.6   1701   6.55     NP_001261027   AGB93559
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) MAM domain (IPR000998) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) Tyrosine-protein kinase, receptor class II, conserved site (IPR002011) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Tyrosine-protein kinase, catalytic domain (IPR020635) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140717   AA140718   AE013599 AAF57973   AC004287   AF236106 AAF36990   AE013599 AGB93559   AI259614   AI297784   AW944007   AY095061 AAM11389   CO264805   CO267638   CO283474   CO284522   CO297028   CO304999   CO310979   CO313442   CO318329   CO322325   CO339154   DN154003   EC051959   EC051971   EC054969   EC055278   EC055478   EC056361   EC069004   EC073502   EC076641   EC203249   EC209819   EC224864   EC236424   EC245066   EC245369   EC250079   EC251696   ES690751
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KJ08 Q8SWV4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   fusion competent cell of visceral mesoderm   • plasma membrane (Stute et al., 2004) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   visceral mesoderm | restricted   • plasma membrane (Stute et al., 2004) myoblast | subset   • plasma membrane (Stute et al., 2004) muscle founder cell of visceral mesoderm   • plasma membrane (Stute et al., 2004) third instar larval stage   embryonic/larval brain | restricted   (Gouzi et al., 2011) ventral nerve cord   (Gouzi et al., 2011) mushroom body calyx   (Gouzi et al., 2011) adult stage   adult brain | restricted   (Gouzi et al., 2011) calyx of adult mushroom body   (Gouzi et al., 2011) optic lobe   (Gouzi et al., 2011) protocerebral bridge   (Gouzi et al., 2011) subesophageal ganglion   (Gouzi et al., 2011) adult antennal lobe   (Gouzi et al., 2011)
Additional Descriptive Data
	Expression of Alk protein is observed in both muscle founder cells and in fusion-competent myoblasts in the visceral mesoderm, and is localized to the cell membrane. (Stute et al., 2004) Alk protein is expressed throughout the third instar larval and adult brain. In the adult, labelling is stronger in the mushroom body calyx (dendrites of Kenyon cells), protocerebral bridge, antennal lobe, subesophageal ganglion and optic lobe. Alk protein is not detected in the mushroom body lobes (axons of Kenyon cells). The expression of Alk protein is similar but more widespread than labelling with Scer\GAL4Alk.38. (Gouzi et al., 2011)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{Alk-GAL4.6.5} Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   visceral mesoderm   (Englund et al., 2003) embryonic stage 11 -- 12   visceral mesoderm   (Loren et al., 2001)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain  (574.3) Adult Thoracic-Abdominal Ganglion  506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain  574.3 Adult Thoracic-Abdominal Ganglion  506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    334.85 Larval Midgut    2.6 Larval Hindgut    4.2 Larval Malpighian Tubules    2.9 Larval Fat Body    0.7 Larval Salivary Gland    2.7 Larval Trachea    2.525 Larval Carcass    7.3 Adult Head    128 Adult Eye    44.5 Adult Brain    574.3 Adult Thoracic-Abdominal Ganglion    506.1 Adult Crop    9.4 Adult Midgut    3.5 Adult Hindgut    5 Adult Malpighian Tubules    5.2 Adult Fat Body    17.3 Adult Salivary Gland    11.3 Adult Heart    13.6 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    28.1 Adult Ovary    0.7 Adult Testis    3.1 Adult Male Accessory Gland    9.5 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    128   NA  Eye    44.5   NA  Brain    574.3   334.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    506.1   NA  Crop    9.4   2.6  Midgut    3.5   4.2  Hindgut    5   2.9  Malpighian Tubules    5.2   0.7  Fat Body    17.3   2.7  Salivary Gland    no informative data   NA  Heart    13.6   2.525  Trachea    NA   NA  VirginFemale Spermatheca    14   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.7   NA  Testis    3.1   NA  Male Accessory Gland    9.5   7.3  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3  (28) central nervous system, pupae P8  (54) head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male  (27) head, mated 4-day male  (34) head, mated 20-day male  (30) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3  28 central nervous system, pupae P8  (54) head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male  27 head, mated 4-day male  (34) head, mated 20-day male  30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    28 central nervous system, pupae P8    54 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    13 head, mated 1-day female    17 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    27 head, mated 4-day male    34 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    15 carcass, larvae L3 wandering    8 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    8 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    5 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    6 adult male 30day    5 adult female 01day    3 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    14 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    19 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    5 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040505 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8250-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4Act5C.PI AlkScer\UAS.cLa lethal | embryonic stage | recessive Alk1 lethal | first instar larval stage | recessive Alk1 lethal | larval stage, with Scer\GAL4Alk.38 AlkScer\UAS.cLa lethal | somatic clone, with Scer\GAL4Act5C.PI AlkScer\UAS.cLa partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 AlkGD42 viable, with Scer\GAL4elav-C155 Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa Other Phenotypes Allele cell migration defective | embryonic stage 13 Alk1 decreased cell size | adult stage, with Scer\GAL4Ras64B.PW Alkact.Scer\UAS.T:Ivir\HA1 AlkScer\UAS.cLa increased cell death | embryonic stage 13 Alk1 increased cell size | adult stage, with Scer\GAL4Ras64B.PW AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 learning defective | adult stage, with Scer\GAL4Alk.38, Scer\GAL80ts.αTub84B Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa learning defective | adult stage, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa learning defective | adult stage, with Scer\GAL4Ras64B.PW, Scer\GAL80ts.αTub84B Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa locomotor rhythm defective Alk1 locomotor rhythm defective, with Scer\GAL4elav-C155 AlkScer\UAS.cRa locomotor rhythm defective, with Scer\GAL4how-24B AlkScer\UAS.cRa neuroanatomy defective | somatic clone Alk1 Alk8 Alk9 neuroanatomy defective | somatic clone, with Scer\GAL4Act5C.PI AlkEC.Scer\UAS.T:Hsap\MYC neurophysiology defective Alk1 size defective | pupal stage, with Scer\GAL4386Y Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa size defective | pupal stage, with Scer\GAL4Alk.38 Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 size defective | pupal stage, with Scer\GAL4elav-C155 Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa size defective | pupal stage, with Scer\GAL4Ras64B.PW Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC AlkGD42 AlkScer\UAS.cLa Phenotype manifest in Allele axon & photoreceptor cell R8 | somatic clone Alk1 Alk8 Alk9 axon & photoreceptor cell R8 | somatic clone, with Scer\GAL4Act5C.PI AlkEC.Scer\UAS.T:Hsap\MYC embryonic/larval digestive system Alk1 embryonic/larval midgut Alk1 embryonic myoblast Alk10 embryonic somatic muscle, with Scer\GAL4twi.PG AlkScer\UAS.cLa embryonic somatic muscle | ectopic AlkdsRNA.cLa embryonic visceral muscle, with Scer\GAL4twi.PG AlkScer\UAS.cLa hemocyte, with Scer\GAL4He.PZ AlkScer\UAS.cLa Alkact.Scer\UAS.T:Ivir\HA1 hemocyte, with Scer\GAL4Hml.PG Alkact.Scer\UAS.T:Ivir\HA1 lamellocyte, with Scer\GAL4He.PZ AlkScer\UAS.cLa longitudinal visceral muscle primordium | embryonic stage 13 Alk1 muscle founder cell & circular visceral muscle primordium Alkmili muscle founder cell & visceral mesoderm, with Scer\GAL4twi.PG AlkScer\UAS.cLa muscle founder cell & visceral muscle primordium AlkdsRNA.cLa Alkmili muscle founder cell & visceral muscle primordium, with Scer\GAL4twi.2PE AlkScer\UAS.DN muscle founder cell & visceral muscle primordium | ectopic Alkbap3.PL muscle founder cell | embryonic stage Alk1 neuromuscular junction Alk1 optic cartridge | somatic clone Alk1 visceral mesoderm Alk1 Alk10 visceral mesoderm, with Scer\GAL4twi.PG AlkEC.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL4Ras64B.PW AlkGD42 AlkScer\UAS.cLa Alkact.Scer\UAS.T:Ivir\HA1 AlkEC.Scer\UAS.T:Hsap\MYC wing disc | somatic clone, with Scer\GAL4Act5C.PI AlkScer\UAS.cLa
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of Alk Class Mutagen Stocks Known lesion Alkf01491 1 -- AlkMB06458 1 -- Alk10 ethyl methanesulfonate 0 Yes Alk11 ethyl methanesulfonate 0 Yes Alk1 loss of function allele ethyl methanesulfonate 0 Yes Alk2 ethyl methanesulfonate 0 Yes Alk3 ethyl methanesulfonate 0 -- Alk4 ethyl methanesulfonate 0 Yes Alk5 ethyl methanesulfonate 0 Yes Alk6 ethyl methanesulfonate 0 Yes Alk7 ethyl methanesulfonate 0 Yes Alk8 ethyl methanesulfonate 0 Yes Alk9 ethyl methanesulfonate 0 Yes Alkmili ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Alk Class Mutagen Stocks Known lesion AlkGD42 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AlkJF02668 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AlkKK102942 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Alkact.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes Alkbap3.PL in vitro construct - regulatory fusion 0 Yes AlkdsRNA.cLa in vitro construct - RNAi 0 Yes AlkEC.Scer\UAS.T:Hsap\MYC antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AlkGD14395 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AlkGD2538 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AlkScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes AlkScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes AlkScer\UAS.DN in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes AlkScer\UAS.T:Hsap\NPM1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Alk-21 (Loren et al., 2003) Df(2R)Exel6064 (Ryder, 2004.4.26) Df(2R)Exel7144 (Ryder, 2004.4.26) Df(2R)ΔAlk21 (Stute et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD42} NA P{GD2538} NA P{GD14395} NA P{KK102942} NA P{TRiP.JF02668} NA P{UAS-Alk.act.HA} NA P{UAS-Alk.DN} NA P{UAS-Alk.EC.MYC} NA P{UAS-Alk.L} NA P{UAS-Alk.R} NA P{UAS-NPM:Alk} NA GAL4 construct P{Alk-GAL4.38} No characterization construct P{Alk-GAL4.6.5} NA P{bap.3-Alk} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GB}CB02658 NA PBac{WH}Alkf01491 NA insertion of enhancer trap binary system Mi{ET1}AlkMB06458 No
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
activation of MAPKK activity inferred from mutant phenotype (Loren et al., 2003) axon guidance inferred from mutant phenotype (Bazigou et al., 2007) compound eye photoreceptor development inferred from mutant phenotype (Bazigou et al., 2007) digestive tract development inferred from mutant phenotype (Loren et al., 2003) mesoderm development inferred from mutant phenotype (Bazigou et al., 2007) negative regulation of cell size inferred from mutant phenotype (Gouzi et al., 2011) positive regulation of ERK1 and ERK2 cascade inferred from mutant phenotype (Gouzi et al., 2011) regulation of growth inferred from mutant phenotype (Gouzi et al., 2011) regulation of hemocyte differentiation inferred from mutant phenotype (Zettervall et al., 2004) regulation of olfactory learning inferred from mutant phenotype (Gouzi et al., 2011) visceral muscle development inferred from mutant phenotype (Englund et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002011, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity non-traceable author statement (Morrison et al., 2000) receptor signaling protein tyrosine kinase activity non-traceable author statement (Palmer, 2000.2.17) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity with mouse Alk (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000) transmembrane receptor protein tyrosine kinase signaling pathway inferred from electronic annotation with InterPro:IPR002011 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
plasma membrane inferred from sequence or structural similarity with mouse Alk (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Alk allele Gene References AlkScer\UAS.T:Hsap\NPM1 jeb (Lee et al., 2003)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0040505 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53425
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PVPHZ Dipteran inclusive ortholog search EOG6Q855D Insect inclusive ortholog search EOG6WM3PN Arthropod inclusive ortholog search EOG6QZ61V Metazoa inclusive ortholog search EOG6KT2BK
Orthologs in Drosophila Species (EOG6PVPHZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Alk     Drosophila simulans   Dsim\GD25528 Y   Drosophila sechellia   Dsec\GM20045     Drosophila erecta   Dere\GG22256 Y   Drosophila yakuba   Dyak\GE14049 Y   Drosophila ananassae   Dana\GF13459 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20930 Y   Drosophila persimilis   Dper\GL11825 Y   Drosophila willistoni   Dwil\GK10731 Y   Drosophila virilis   Dvir\GJ21359 Y   Drosophila mojavensis   Dmoj\GI18496 Y   Drosophila grimshawi   Dgri\GH22710 Y
Orthologs in non-Drosophila Dipterans (EOG6Q855D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003969   Anopheles gambiae Malaria mosquito  Agam\AGAP012070   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010280   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019761
Orthologs in non-Dipteran Insects (EOG6WM3PN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43446   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009337   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14298   Atta cephalotes Leafcutter ant  Acep\ACEP18847   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17229   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17980   Linepithema humile Argentine ant  Lhum\LH12259   Linepithema humile Argentine ant  Lhum\LH14527   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13110   Solenopsis invicta Red fire ant  Sinv\SINV17733   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009861   Bombyx mori Silkmoth  Bmor\BGIBMGA000152   Pediculus humanus Human body louse  Phum\PHUM583770   Tribolium castaneum Red flour beetle  Tcas\TC002114
Orthologs in non-Insect Arthropods (EOG6QZ61V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\HLA-DPB1   Daphnia pulex Water flea  Dpux\JGI_V11_302114   Ixodes scapularis Deer tick  Isca\ISCW000831   Ixodes scapularis Deer tick  Isca\ISCW008499
Orthologs in non-Arthropod Metazoa (EOG6KT2BK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T10H9.2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017036gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023900gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017693gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024660gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028424gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011275gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007624gn Y Danio rerio Zebrafish  Drer\ltk Y Danio rerio Zebrafish  Drer\ros1 Y Danio rerio Zebrafish  Drer\alk Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000000055 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031142 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000008615 Y Gallus gallus Domestic chicken  Ggal\ALK Y Gallus gallus Domestic chicken  Ggal\ROS1 Y Mus musculus House mouse  Mmus\Ros1 Y Mus musculus House mouse  Mmus\Ltk Y Mus musculus House mouse  Mmus\Alk Y Rattus norvegicus Norway rat  Rnor\Ros1 Y Rattus norvegicus Norway rat  Rnor\Ltk Y Rattus norvegicus Norway rat  Rnor\Alk Y Homo sapiens Human  Hsap\ROS1 Y Homo sapiens Human  Hsap\LTK Y Homo sapiens Human  Hsap\ALK Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\ROS1     Hsap\LTK     Hsap\ALK
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25528 Drosophila erecta Dere\GG22256 Drosophila yakuba Dyak\GE14049 Drosophila ananassae Dana\GF13459 Drosophila pseudoobscura pseudoobscura Dpse\GA20930 Drosophila persimilis Dper\GL11825 Drosophila willistoni Dwil\GK10731 Drosophila virilis Dvir\GJ21359 Drosophila mojavensis Dmoj\GI18496 Drosophila grimshawi Dgri\GH22710
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	25509 w1118; Mi{ET1}AlkMB06458 27518 y1 v1; P{TRiP.JF02668}attP2
Harvard	- PBac{WH}Alkf01491
VDRC	v107083 P{KK102942}VIE-260B v11446 w1118 P{GD42}v11446
Genomic Clones ( 1 )
	BACR36P23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP03070
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP12161
Other clones	EC051959 EC051971 EC054969 EC055278 EC055478 EC056361 EK140355 EK150559 EK151306 EK163353 EK166227 EK187906 EK215753 EK223106 EK232943 EK246864 EK271551 EP00960
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0040505 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53425
Antibody Information
	polyclonal antibody (Stute et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Alk CG8250 (Palmer, 2000.5.27)
Additional comments
Other Comments
	Alk is required in target neurons in the lamina for the correct formation of adult R cell projections. (Bazigou et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_144343 NM_001274098 RefSeq (Proteins) • NP_652600 NP_001261027 DDBJ / EMBL / GenBank • AA140717 AA140718 AAF36990 AAF57973 AAM11389 AC004287 AF236106 AGB93559 AI259614 AI297784 AW944007 AY095061 Entrez Gene - A searchable database of RefSeq genes. • 53425 UniProtKB/TrEMBL • Q7KJ08 Q8SWV4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) MAM domain (IPR000998) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) Tyrosine-protein kinase, receptor class II, conserved site (IPR002011) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Tyrosine-protein kinase, catalytic domain (IPR020635) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0040505 DRSC - Results from RNAi screens. • FBgn0040505 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040505 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8250-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0040505 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53425 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/alk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53425 modMine - Data generated by the modENCODE project. • FBgn0040505
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	ALK (Grabbe et al., 2004, Schönherr et al., 2011, Wolfstetter et al., 2009, Michaut et al., 2011) Alk (Bazigou et al., 2007, Loren et al., 2003, Bazigou et al., 2007, Bartolome and Charlesworth, 2006, Shirinian et al., 2007, Varshney and Palmer, 2007, Varshney and Palmer, 2006, Popichenko et al., 2007, Leatherbarrow and Halfon, 2009, Eriksson et al., 2010, Gouzi et al., 2011, Rohrbough and Broadie, 2010, Reim et al., 2012) CG8250 (Morrison et al., 2000, Palmer, 2000.5.27, Keleman et al., 2009.8.5, Perkins et al., 2009) DAlk (Loren et al., 2003, Weiss et al., 2003, Loren et al., 2001, Loren et al., 2001, Loren et al., 2001, Weiss et al., 2006, Loren et al., 2003) dALK (Loren et al., 2001) DAlk53 (Loren et al., 2001) mili (Stute et al., 2004)
Name Synonym	Alk   Anaplastic Lymphoma Kinase (Shirinian et al., 2007) Anaplastic lymphoma kinase (Varshney and Palmer, 2007, Varshney and Palmer, 2006, Rohrbough and Broadie, 2010, Reim et al., 2012) anaplastic lymphoma kinase (Schönherr et al., 2011, Popichenko et al., 2007, Franco et al., 2011)
Secondary FlyBase IDs
	FBgn0034146
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 9 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 10 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 9 )
	Rohrbough et al., 2013, Dev. Neurobiol. 73(3): 189--208 Jelly belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture. [FBrf0220771] Reim et al., 2012, Dev. Biol. 368(1): 28--43 The FGF8-related signals Pyramus and Thisbe promote pathfinding, substrate adhesion, and survival of migrating longitudinal gut muscle founder cells. [FBrf0218673] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Gouzi et al., 2011, PLoS Genet. 7(9): e1002281 The receptor tyrosine kinase alk controls neurofibromin functions in Drosophila growth and learning. [FBrf0216258] Lasek et al., 2011, PLoS ONE 6(7): e22636 An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. [FBrf0214569] Michaut et al., 2011, Dev. Growth Differ. 53(9): 982--993 Analyzing the function of a hox gene: An evolutionary approach. [FBrf0216990] Schönherr et al., 2011, Transl. Oncol. 4(4): 258--265 The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo. [FBrf0214568] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...