FB2020_02, released Apr 14, 2020

Gene: Dmel\Alk

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General Information
Symbol
Dmel\Alk
Species
D. melanogaster
Name
Anaplastic lymphoma kinase
Annotation Symbol
CG8250
Feature Type
protein_coding_gene
FlyBase ID
FBgn0040505
Gene Model Status
Current
Stock Availability
6 publicly available
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
Anaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

DAlk

Key Links
Genomic Location
Cytogenetic map
53C12-53C13
Sequence location
2R:16,625,293..16,640,011 [-]
Recombination map

2-80

RefSeq locus
NT_033778 REGION:16625293..16640011
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding; transmembrane receptor protein tyrosine kinase activity
Predictions / Assertions
ATP binding; transmembrane receptor protein tyrosine kinase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Alk or the JBrowse view of Dmel\Alk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Alk-RA
FBtr0087118
NM_144343
8655
1701
Alk-RB
FBtr0331926
NM_001274098
9402
1701
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Alk-PA
FBpp0086264
185.6
1701
6.55
NP_652600
AAF57973
Alk-PB
FBpp0304259
185.6
1701
6.55
NP_001261027
AGB93559
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1701 aa isoforms: Alk-PA, Alk-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:cnk; FB:FBgn0286070
(Wolfstetter et al., 2017)
transmembrane receptor protein tyrosine kinase activity
inferred from direct assay
(Yang et al., 2007, Lee et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002011, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
activation of MAPKK activity
inferred from mutant phenotype
(Loren et al., 2003)
axon guidance
inferred from mutant phenotype
(Bazigou et al., 2007)
compound eye photoreceptor development
inferred from mutant phenotype
(Bazigou et al., 2007)
digestive tract development
inferred from mutant phenotype
(Loren et al., 2003)
mesoderm development
inferred from mutant phenotype
(Bazigou et al., 2007)
negative regulation of cell size
inferred from mutant phenotype
(Gouzi et al., 2011)
negative regulation of neuromuscular synaptic transmission
inferred from mutant phenotype
(Rohrbough et al., 2013)
positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Gouzi et al., 2011)
positive regulation of MAPK cascade
inferred from mutant phenotype
(Rohrbough et al., 2013)
regulation of growth
inferred from mutant phenotype
(Gouzi et al., 2011)
regulation of olfactory learning
inferred from mutant phenotype
(Gouzi et al., 2011)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from direct assay
(Yang et al., 2007)
visceral muscle development
inferred from mutant phenotype
(Englund et al., 2003, Lee et al., 2003)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
multicellular organism development
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000699407
(assigned by GO_Central )
(Gaudet et al., 2011)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
subsynaptic reticulum
inferred from direct assay
(Rohrbough et al., 2013)
type Ib terminal bouton
inferred from direct assay
(Rohrbough et al., 2013)
type Is terminal bouton
inferred from direct assay
(Rohrbough et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
fusion competent cell of visceral mesoderm
(Stute et al., 2004)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral mesoderm | restricted
(Stute et al., 2004)
myoblast | subset
(Stute et al., 2004)
muscle founder cell of visceral mesoderm
(Stute et al., 2004)
adult stage
adult brain | restricted
(Gouzi et al., 2011)
calyx of adult mushroom body
(Gouzi et al., 2011)
adult optic lobe
(Gouzi et al., 2011)
protocerebral bridge
(Gouzi et al., 2011)
subesophageal ganglion
(Gouzi et al., 2011)
adult antennal lobe
(Gouzi et al., 2011)
third instar larval stage
embryonic/larval brain | restricted
(Gouzi et al., 2011)
ventral nerve cord
(Gouzi et al., 2011)
mushroom body calyx
(Gouzi et al., 2011)
wandering third instar larval stage
embryonic/larval neuromuscular junction
(Rohrbough et al., 2013)
embryonic stage 17
embryonic/larval neuromuscular junction

Comment: type Ib boutons

(Rohrbough and Broadie, 2010)
tract

Comment: synapse

(Rohrbough and Broadie, 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Alk protein is expressed throughout the third instar larval and adult brain. In the adult, labelling is stronger in the mushroom body calyx (dendrites of Kenyon cells), protocerebral bridge, antennal lobe, subesophageal ganglion and optic lobe. Alk protein is not detected in the mushroom body lobes (axons of Kenyon cells). The expression of Alk protein is similar but more widespread than labelling with Scer\GAL4Alk.38.

(Gouzi et al., 2011)

Alk is concentrated postsynaptically at larval glutamergic neuromusclular junction synapses. It is strongly expressed in type Ib boutons and is more weakly localized at type Is boutons. Alk superimposed extensively with the anti-HRP labeled presynaptic membrane, but had a much broader domain and was localized to the surrounding postsynaptic muscle. In mature embryos, Alk is present in developing CNS synapses.

(Rohrbough and Broadie, 2010)

Expression of Alk protein is observed in both muscle founder cells and in fusion-competent myoblasts in the visceral mesoderm, and is localized to the cell membrane.

(Stute et al., 2004)
Marker for
 
visceral mesoderm
(Eriksson et al., 2010)
Subcellular Localization
CV Term
Evidence
References
subsynaptic reticulum
inferred from direct assay
(Rohrbough et al., 2013)
type Ib terminal bouton
inferred from direct assay
(Rohrbough et al., 2013)
type Is terminal bouton
inferred from direct assay
(Rohrbough et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Alk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Alk
Transgenic constructs containing regulatory region of Alk
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage, with Scer\GAL4Act5C.PI
lethal | embryonic stage | recessive
lethal | first instar larval stage | recessive
lethal | heat sensitive
lethal | heat sensitive (with Alk1)
lethal | heat sensitive (with Alkts)
lethal | somatic clone, with Scer\GAL4Act5C.PI
lethal - all die before end of larval stage, with Scer\GAL4Alk.38
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4elav-C155
Other Phenotypes
Allele
cell migration defective | embryonic stage 13
decreased cell size | adult stage, with Scer\GAL4Ras64B.PW
increased cell death | embryonic stage 13
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | larval stage, with Scer\GAL4Hml.PG
increased cell size | adult stage, with Scer\GAL4Ras64B.PW
learning defective | adult stage, with Scer\GAL4Alk.38, Scer\GAL80ts.αTub84B
learning defective | adult stage, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
learning defective | adult stage, with Scer\GAL4Ras64B.PW, Scer\GAL80ts.αTub84B
locomotor behavior defective | adult stage
locomotor rhythm defective
locomotor rhythm defective, with Scer\GAL4elav-C155
locomotor rhythm defective, with Scer\GAL4how-24B
neuroanatomy defective | somatic clone
neuroanatomy defective | somatic clone, with Scer\GAL4Act5C.PI
neurophysiology defective
neurophysiology defective | third instar larval stage
neurophysiology defective | third instar larval stage, with Scer\GAL4how-24B, Scer\GAL4twi.PG
neurophysiology defective | third instar larval stage (with Alkf01491)
neurophysiology defective | third instar larval stage (with Alkts)
size defective | pupal stage, with Scer\GAL4386Y
size defective | pupal stage, with Scer\GAL4Alk.38
size defective | pupal stage, with Scer\GAL4elav-C155
size defective | pupal stage, with Scer\GAL4Ras64B.PW
sleep defective, with Scer\GAL4007Y
sleep defective, with Scer\GAL430Y
sleep defective, with Scer\GAL430Y, Scer\GAL80Mef2.mb247
sleep defective, with Scer\GAL4121Y
sleep defective, with Scer\GAL4238Y
sleep defective, with Scer\GAL4386Y
sleep defective, with Scer\GAL41471
sleep defective, with Scer\GAL4c309
sleep defective, with Scer\GAL4c309, Scer\GAL80Mef2.mb247
sleep defective, with Scer\GAL4c320
sleep defective, with Scer\GAL4c453
sleep defective, with Scer\GAL4ChAT.7.4
sleep defective, with Scer\GAL4elav.PU
sleep defective, with Scer\GAL4ey-OK107
sleep defective, with Scer\GAL4H24
sleep defective, with Scer\GAL4MJ63
sleep defective, with Scer\GAL4NP1131
sleep defective, with Scer\GAL4nSyb.PS
sleep defective (with Alk1)
sleep defective (with Alkts)
sleep defective (with Df(2R)Exel7144)
sleep defective |  :heat sensitive | conditional
sleep defective | heat sensitive (with Alk1)
sleep defective | heat sensitive (with Alkts)
sleep defective | heat sensitive (with Df(2R)Exel7144)
sleep defective | recessive | heat sensitive
some die during larval stage, with Scer\GAL4Alk.38
some die during pupal stage, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4sev.PU
Phenotype manifest in
Allele
axon & photoreceptor cell R8 | somatic clone
axon & photoreceptor cell R8 | somatic clone, with Scer\GAL4Act5C.PI
embryonic/larval digestive system
embryonic/larval gut | first instar larval stage, with Scer\GAL4how-24B, Scer\GAL4twi.PG
embryonic/larval midgut
embryonic myoblast
embryonic somatic muscle, with Scer\GAL4twi.PG
embryonic visceral muscle, with Scer\GAL4twi.PG
eye, with Scer\GAL4sev.EP
eye, with Scer\GAL4sev.PU
hemocyte, with Scer\GAL4He.PZ
hemocyte, with Scer\GAL4Hml.PG
lamellocyte, with Scer\GAL4He.PZ
longitudinal visceral muscle primordium | embryonic stage 13
midgut
muscle founder cell & circular visceral muscle primordium
muscle founder cell & visceral mesoderm, with Scer\GAL4twi.PG
muscle founder cell & visceral muscle primordium
muscle founder cell & visceral muscle primordium, with Scer\GAL4twi.2PE
muscle founder cell & visceral muscle primordium | ectopic
muscle founder cell | embryonic stage
neuromuscular junction
ommatidium | adult stage, with Scer\GAL4sev.PU
optic cartridge | somatic clone
visceral mesoderm
visceral mesoderm, with Scer\GAL4twi.PG
wing, with Scer\GAL4Ras64B.PW
wing disc | somatic clone, with Scer\GAL4Act5C.PI
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALK
12 of 15
Yes
Yes
 
Hsap\LTK
11 of 15
No
Yes
Hsap\ROS1
2 of 15
No
No
Hsap\INSRR
1 of 15
No
No
Hsap\MALRD1
1 of 15
No
Yes
Hsap\MAMDC4
1 of 15
No
Yes
Hsap\MET
1 of 15
No
Yes
Hsap\MST1R
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Alk
12 of 15
Yes
Yes
Mmus\Ltk
9 of 15
No
Yes
Mmus\Ros1
2 of 15
No
No
Mmus\Insrr
1 of 15
No
No
Mmus\Malrd1
1 of 15
No
Yes
Mmus\Met
1 of 15
No
Yes
Mmus\Mst1r
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
Rnor\Alk
8 of 13
Yes
Yes
Rnor\Ltk
4 of 13
No
Yes
Rnor\Ros1
2 of 13
No
No
Rnor\LOC103694423
1 of 13
No
No
Rnor\LOC108351182
1 of 13
No
Yes
Rnor\Mst1r
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\ltk
3 of 12
Yes
Yes
Xtro\alk
2 of 12
No
Yes
Xtro\met
1 of 12
No
Yes
Xtro\mst1r
1 of 12
No
Yes
Xtro\ros1
1 of 12
No
No
Danio rerio (Zebrafish) (7)
Drer\ltk
10 of 15
Yes
Yes
Drer\alk
3 of 15
No
Yes
Drer\ros1
2 of 15
No
No
Drer\malrd1
1 of 15
No
Yes
Drer\met
1 of 15
No
Yes
Drer\mst1ra
1 of 15
No
Yes
Drer\mst1rb
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\scd-2
11 of 15
Yes
Yes
Cele\rol-3
2 of 15
No
No
Cele\F09A5.2
1 of 15
No
No
Cele\F11E6.8
1 of 15
No
Yes
Cele\svh-2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\AT1G73660
1 of 9
Yes
No
Atha\AT5G57610
1 of 9
Yes
Yes
Atha\CERK1
1 of 9
Yes
Yes
Atha\EDR1
1 of 9
Yes
Yes
Atha\RLK
1 of 9
Yes
Yes
Atha\SRF5
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SCH9
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900FD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003295
Drosophila simulans
Dsim\GD25528
Drosophila sechellia
Dsec\GM20045
Drosophila erecta
Dere\GG22256
Drosophila yakuba
Dyak\GE14049
Drosophila ananassae
Dana\GF13459
Drosophila pseudoobscura pseudoobscura
Dpse\GA20930
Drosophila persimilis
Dper\GL11825
Drosophila willistoni
Dwil\GK10731
Drosophila virilis
Dvir\GJ21359
Drosophila mojavensis
Dmoj\GI18496
Drosophila grimshawi
Dgri\GH22710
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915009H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022037
Glossina morsitans
Tsetse fly
Gmor\GMOY009400
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02198
Mayetiola destructor
Hessian fly
Mdes\Mdes005892
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003969
Anopheles darlingi
American malaria mosquito
Adar\ADAC003676
Anopheles gambiae
Malaria mosquito
Agam\AGAP012070
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010280
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019761
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00BR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000152
Danaus plexippus
Monarch butterfly
Dple\DPOGS205518-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003801
Apis florea
Little honeybee
Aflo\2169835092
Apis mellifera
Western honey bee
Amel\GB43446
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20301
Bombus terrestris
Buff-tailed bumblebee
Bter\15214675
Linepithema humile
Argentine ant
Lhum\LH14527
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003029
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009337
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03800
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03801
Tribolium castaneum
Red flour beetle
Tcas\TC002114
Pediculus humanus
Human body louse
Phum\PHUM583770
Rhodnius prolixus
Kissing bug
Rpro\RPRC000576
Cimex lectularius
Bed bug
Clec\CLEC005237
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009861
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI24195
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00987
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00B8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013008
Ixodes scapularis
Black-legged tick
Isca\ISCW000831
Ixodes scapularis
Black-legged tick
Isca\ISCW008499
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58431.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58430.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76790.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02010
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_187767
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_99610
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0150 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-C10orf112L_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-C10orf112
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AlkL_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1970
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alk_1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sev
4 of 10
btl
2 of 10
Cad96Ca
2 of 10
CG3277
2 of 10
Ddr
2 of 10
dnt
2 of 10
drl
2 of 10
Egfr
2 of 10
Eph
2 of 10
htl
2 of 10
InR
2 of 10
Nrk
2 of 10
Pvr
2 of 10
Ret
2 of 10
Ror
2 of 10
Tie
2 of 10
Drl-2
1 of 10
Sdr
1 of 10
tor
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 6 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ALK; ALK receptor tyrosine kinase
12 of 15
105590
     
    LTK; leukocyte receptor tyrosine kinase
    11 of 15
    151520
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Alk - cnk
        two hybrid
        (Wolfstetter et al., 2017)
        Alk - jeb
        affinity technology, fluorescence microscopy, inferred by author, tag visualisation, enzyme linked immunosorbent assay, anti bait coimmunoprecipitation, western blot
        (Englund et al., 2003, Lee et al., 2003)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Alk
        suppressible
        cnk
        (Wolfstetter et al., 2017)
        Alk
        suppressible
        Nf1
        (Bai and Sehgal, 2015)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Nf1
        suppressible
        Alk
        (Walker et al., 2013, Gouzi et al., 2011)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-80

        Cytogenetic map
        53C12-53C13
        Sequence location
        2R:16,625,293..16,640,011 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        53C12-53C13
        Limits computationally determined from genome sequence between P{PZ}Sema-2a03021&P{PZ}Cdk405428 and P{EP}BEST:SD02913EP2148&P{lacW}Dekk09907
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        53-53
        (determined by in situ hybridisation)
        (Loren et al., 2001)
        53C-53D
        (Palmer, 2000.2.17)
        Experimentally Determined Recombination Data
        Location

        2-80

        (FlyBase, 2016)

        2-83.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (20)
        cDNA Clones (20)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal antibody

          (Stute et al., 2004)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: Alk CG8250

          (Palmer, 2000.5.27)
          Additional comments
          Other Comments

          Alk is required in target neurons in the lamina for the correct formation of adult R cell projections.

          (Bazigou et al., 2007)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)
          Origin and Etymology
          Discoverer
          Etymology

          Named 'Alk' / 'Anaplastic lymphoma kinase' because of shared homology with mammalian ALK.

          (Loren et al., 2001)
          Identification
          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (12)
          Reported As
          Symbol Synonym
          ALK
          (Lanet and Maurange, 2014, Michaut et al., 2011, Schönherr et al., 2011, Wolfstetter et al., 2009, Grabbe et al., 2004)
          Alk
          (Mele and Johnson, 2019, Pahl et al., 2019, Neuert et al., 2017, Tomita et al., 2017, Wolfstetter et al., 2017, Rohde et al., 2016, Strigini and Leulier, 2016, Yadav et al., 2016, Bai and Sehgal, 2015, Grotewiel and Bettinger, 2015, Nässel et al., 2015, Hugosson et al., 2014, Lanet and Maurange, 2014, Mulakkal et al., 2014, Pecot et al., 2014, Salazar-Jaramillo et al., 2014, Hallberg and Palmer, 2013, Jin et al., 2013, Koyama et al., 2013, Kwon et al., 2013, Muñoz-Soriano et al., 2013, Pecot et al., 2013, Sopko and Perrimon, 2013, Dani et al., 2012, Grewal, 2012, Homem and Knoblich, 2012, Reim et al., 2012, Rodriguez et al., 2012, Gouzi et al., 2011, Hadjieconomou et al., 2011, Eriksson et al., 2010, Rohrbough and Broadie, 2010, Leatherbarrow and Halfon, 2009, Bazigou et al., 2007, Bazigou et al., 2007, Popichenko et al., 2007, Shirinian et al., 2007, Varshney and Palmer, 2007, Bartolome and Charlesworth, 2006, Varshney and Palmer, 2006, Loren et al., 2003)
          CG8250
          (Neuert et al., 2017, Vogel et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009, Morrison et al., 2000, Palmer, 2000.5.27)
          DAlk
          (Weiss et al., 2006, Loren et al., 2003, Loren et al., 2003, Weiss et al., 2003, Loren et al., 2001, Loren et al., 2001, Loren et al., 2001)
          DAlk53
          (Loren et al., 2001)
          alk
          (Lanet and Maurange, 2014, Popichenko et al., 2013, Rohrbough et al., 2013)
          dALK
          (Walker et al., 2013, Loren et al., 2001)
          dAlk
          (Yang et al., 2007)
          mili
          (Stute et al., 2004)
          Name Synonyms
          Alk
          Anaplastic Lymphoma Kinase
          (Mirth and Shingleton, 2012, Shirinian et al., 2007)
          Anaplastic lymphoma kinase
          (Mele and Johnson, 2019, Tomita et al., 2017, Lanet and Maurange, 2014, Pecot et al., 2013, Reim et al., 2012, Rohrbough and Broadie, 2010, Varshney and Palmer, 2007, Varshney and Palmer, 2006)
          anaplastic lymphoma kinase
          (Pecot et al., 2014, Koyama et al., 2013, Grewal, 2012, Kaun et al., 2012, Franco et al., 2011, Schönherr et al., 2011, Popichenko et al., 2007)
          Secondary FlyBase IDs
          • FBgn0034146
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (117)