Please see the JBrowse view of Dmel\κB-Ras for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
202 (aa)
Interacts with NF-kappa-B inhibitor cactus.
In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 18 and 71, which are replaced by Lys and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\κB-Ras using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\κB-Ras in JBrowse2-56
2-56.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: κB-Ras CG1669
Source for merge of: κB-Ras BcDNA:RH38596
One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG1669 (FBgn0040513), CG30503 (FBgn0050503).
FlyBase curator comment: the insertion in the "f01498" Exelixis line (PBac{WH}CG30502f01498) was originally assigned to the κB-Ras gene in FBrf0179797, resulting in the "κB-Rasf01498" (FBal0162868) allele. However, FBrf0184340 shows that the insertion is actually within CG30502.
Source for merge of κB-Ras BcDNA:RH38596 was a shared cDNA ( date:030728 ).
